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DNAJC3 (DnaJ heat shock protein family (Hsp40) member C3)

Identity

Alias_namesPRKRI
DnaJ (Hsp40) homolog
Alias_symbol (synonym)P58
P58IPK
HP58
ERdj6
Other aliasACPHD
HGNC (Hugo) DNAJC3
LocusID (NCBI) 5611
Atlas_Id 47117
Location 13q32.1  [Link to chromosome band 13q32]
Location_base_pair Starts at 96329393 and ends at 96447243 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AKT2 (19q13.2) / DNAJC3 (13q32.1)CELF1 (11p11.2) / DNAJC3 (13q32.1)DNAJC3 (13q32.1) / CBFA2T2 (20q11.21)
DNAJC3 (13q32.1) / DNAJC3 (13q32.1)DNAJC3 (13q32.1) / FAM222B (17q11.2)DNAJC3 (13q32.1) / GPC6 (13q31.3)
DNAJC3 (13q32.1) / NPC2 (14q24.3)DNAJC3 (13q32.1) / VWA8 (13q14.11)WNK1 (12p13.33) / DNAJC3 (13q32.1)
DNAJC3 13q32.1 / GPC6 13q31.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DNAJC3   9439
Cards
Entrez_Gene (NCBI)DNAJC3  5611  DnaJ heat shock protein family (Hsp40) member C3
AliasesACPHD; ERdj6; HP58; P58; 
P58IPK; PRKRI
GeneCards (Weizmann)DNAJC3
Ensembl hg19 (Hinxton)ENSG00000102580 [Gene_View]  chr13:96329393-96447243 [Contig_View]  DNAJC3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000102580 [Gene_View]  chr13:96329393-96447243 [Contig_View]  DNAJC3 [Vega]
ICGC DataPortalENSG00000102580
TCGA cBioPortalDNAJC3
AceView (NCBI)DNAJC3
Genatlas (Paris)DNAJC3
WikiGenes5611
SOURCE (Princeton)DNAJC3
Genetics Home Reference (NIH)DNAJC3
Genomic and cartography
GoldenPath hg19 (UCSC)DNAJC3  -     chr13:96329393-96447243 +  13q32.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DNAJC3  -     13q32.1   [Description]    (hg38-Dec_2013)
EnsemblDNAJC3 - 13q32.1 [CytoView hg19]  DNAJC3 - 13q32.1 [CytoView hg38]
Mapping of homologs : NCBIDNAJC3 [Mapview hg19]  DNAJC3 [Mapview hg38]
OMIM601184   616192   
Gene and transcription
Genbank (Entrez)AA430108 AF339773 AF339835 AK024941 AK292947
RefSeq transcript (Entrez)NM_006260
RefSeq genomic (Entrez)NC_000013 NC_018924 NG_041830 NT_009952 NW_004929389
Consensus coding sequences : CCDS (NCBI)DNAJC3
Cluster EST : UnigeneHs.59214 [ NCBI ]
CGAP (NCI)Hs.59214
Alternative Splicing GalleryENSG00000102580
Gene ExpressionDNAJC3 [ NCBI-GEO ]   DNAJC3 [ EBI - ARRAY_EXPRESS ]   DNAJC3 [ SEEK ]   DNAJC3 [ MEM ]
Gene Expression Viewer (FireBrowse)DNAJC3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5611
GTEX Portal (Tissue expression)DNAJC3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13217   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13217  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13217
Splice isoforms : SwissVarQ13217
PhosPhoSitePlusQ13217
Domaine pattern : Prosite (Expaxy)DNAJ_2 (PS50076)    TPR (PS50005)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)DnaJ_domain    DNAJC3    TPR-contain_dom    TPR-like_helical_dom    TPR_1    TPR_repeat   
Domain families : Pfam (Sanger)DnaJ (PF00226)    TPR_1 (PF00515)    TPR_11 (PF13414)    TPR_8 (PF13181)   
Domain families : Pfam (NCBI)pfam00226    pfam00515    pfam13414    pfam13181   
Domain families : Smart (EMBL)DnaJ (SM00271)  TPR (SM00028)  
Conserved Domain (NCBI)DNAJC3
DMDM Disease mutations5611
Blocks (Seattle)DNAJC3
PDB (SRS)2Y4T    2Y4U   
PDB (PDBSum)2Y4T    2Y4U   
PDB (IMB)2Y4T    2Y4U   
PDB (RSDB)2Y4T    2Y4U   
Structural Biology KnowledgeBase2Y4T    2Y4U   
SCOP (Structural Classification of Proteins)2Y4T    2Y4U   
CATH (Classification of proteins structures)2Y4T    2Y4U   
SuperfamilyQ13217
Human Protein AtlasENSG00000102580
Peptide AtlasQ13217
HPRD03114
IPIIPI00006713   
Protein Interaction databases
DIP (DOE-UCLA)Q13217
IntAct (EBI)Q13217
FunCoupENSG00000102580
BioGRIDDNAJC3
STRING (EMBL)DNAJC3
ZODIACDNAJC3
Ontologies - Pathways
QuickGOQ13217
Ontology : AmiGOprotein kinase inhibitor activity  cytoplasm  endoplasmic reticulum  endoplasmic reticulum lumen  smooth endoplasmic reticulum  cytosol  membrane  protein kinase binding  endoplasmic reticulum Sec complex  positive regulation of translation initiation in response to endoplasmic reticulum stress  IRE1-mediated unfolded protein response  negative regulation of apoptotic process  chaperone binding  proteolysis involved in cellular protein catabolic process  defense response to virus  misfolded protein binding  extracellular exosome  cellular response to cold  extracellular vesicle  negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation  negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation  negative regulation of cyclin-dependent protein kinase activity  
Ontology : EGO-EBIprotein kinase inhibitor activity  cytoplasm  endoplasmic reticulum  endoplasmic reticulum lumen  smooth endoplasmic reticulum  cytosol  membrane  protein kinase binding  endoplasmic reticulum Sec complex  positive regulation of translation initiation in response to endoplasmic reticulum stress  IRE1-mediated unfolded protein response  negative regulation of apoptotic process  chaperone binding  proteolysis involved in cellular protein catabolic process  defense response to virus  misfolded protein binding  extracellular exosome  cellular response to cold  extracellular vesicle  negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation  negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation  negative regulation of cyclin-dependent protein kinase activity  
Pathways : BIOCARTADouble Stranded RNA Induced Gene Expression [Genes]   
Pathways : KEGGProtein processing in endoplasmic reticulum    Influenza A   
NDEx NetworkDNAJC3
Atlas of Cancer Signalling NetworkDNAJC3
Wikipedia pathwaysDNAJC3
Orthology - Evolution
OrthoDB5611
GeneTree (enSembl)ENSG00000102580
Phylogenetic Trees/Animal Genes : TreeFamDNAJC3
HOVERGENQ13217
HOGENOMQ13217
Homologs : HomoloGeneDNAJC3
Homology/Alignments : Family Browser (UCSC)DNAJC3
Gene fusions - Rearrangements
Fusion : MitelmanDNAJC3/GPC6 [13q32.1/13q31.3]  
Fusion: TCGADNAJC3 13q32.1 GPC6 13q31.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDNAJC3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DNAJC3
dbVarDNAJC3
ClinVarDNAJC3
1000_GenomesDNAJC3 
Exome Variant ServerDNAJC3
ExAC (Exome Aggregation Consortium)DNAJC3 (select the gene name)
Genetic variants : HAPMAP5611
Genomic Variants (DGV)DNAJC3 [DGVbeta]
DECIPHER (Syndromes)13:96329393-96447243  ENSG00000102580
CONAN: Copy Number AnalysisDNAJC3 
Mutations
ICGC Data PortalDNAJC3 
TCGA Data PortalDNAJC3 
Broad Tumor PortalDNAJC3
OASIS PortalDNAJC3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDNAJC3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDNAJC3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DNAJC3
DgiDB (Drug Gene Interaction Database)DNAJC3
DoCM (Curated mutations)DNAJC3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DNAJC3 (select a term)
intoGenDNAJC3
Cancer3DDNAJC3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601184    616192   
Orphanet23517   
MedgenDNAJC3
Genetic Testing Registry DNAJC3
NextProtQ13217 [Medical]
TSGene5611
GENETestsDNAJC3
Huge Navigator DNAJC3 [HugePedia]
snp3D : Map Gene to Disease5611
BioCentury BCIQDNAJC3
ClinGenDNAJC3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5611
Chemical/Pharm GKB GenePA27420
Clinical trialDNAJC3
Miscellaneous
canSAR (ICR)DNAJC3 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDNAJC3
EVEXDNAJC3
GoPubMedDNAJC3
iHOPDNAJC3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:03:36 CET 2017

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