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DNASE1 (deoxyribonuclease 1)

Identity

Alias_namesDNL1
deoxyribonuclease I
Other aliasDRNI
HGNC (Hugo) DNASE1
LocusID (NCBI) 1773
Atlas_Id 43229
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 3652939 and ends at 3658095 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TSPAN31 (12q14.1) / DNASE1 (16p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DNASE1   2956
Cards
Entrez_Gene (NCBI)DNASE1  1773  deoxyribonuclease 1
AliasesDNL1; DRNI
GeneCards (Weizmann)DNASE1
Ensembl hg19 (Hinxton)ENSG00000213918 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000213918 [Gene_View]  chr16:3652939-3658095 [Contig_View]  DNASE1 [Vega]
ICGC DataPortalENSG00000213918
TCGA cBioPortalDNASE1
AceView (NCBI)DNASE1
Genatlas (Paris)DNASE1
WikiGenes1773
SOURCE (Princeton)DNASE1
Genetics Home Reference (NIH)DNASE1
Genomic and cartography
GoldenPath hg38 (UCSC)DNASE1  -     chr16:3652939-3658095 +  16p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DNASE1  -     16p13.3   [Description]    (hg19-Feb_2009)
EnsemblDNASE1 - 16p13.3 [CytoView hg19]  DNASE1 - 16p13.3 [CytoView hg38]
Mapping of homologs : NCBIDNASE1 [Mapview hg19]  DNASE1 [Mapview hg38]
OMIM125505   152700   
Gene and transcription
Genbank (Entrez)AB188151 AB188152 AI378682 AJ298844 AK095412
RefSeq transcript (Entrez)NM_005223
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DNASE1
Cluster EST : UnigeneHs.733045 [ NCBI ]
CGAP (NCI)Hs.733045
Alternative Splicing GalleryENSG00000213918
Gene ExpressionDNASE1 [ NCBI-GEO ]   DNASE1 [ EBI - ARRAY_EXPRESS ]   DNASE1 [ SEEK ]   DNASE1 [ MEM ]
Gene Expression Viewer (FireBrowse)DNASE1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1773
GTEX Portal (Tissue expression)DNASE1
Human Protein AtlasENSG00000213918-DNASE1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP24855   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP24855  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP24855
Splice isoforms : SwissVarP24855
Catalytic activity : Enzyme3.1.21.1 [ Enzyme-Expasy ]   3.1.21.13.1.21.1 [ IntEnz-EBI ]   3.1.21.1 [ BRENDA ]   3.1.21.1 [ KEGG ]   
PhosPhoSitePlusP24855
Domaine pattern : Prosite (Expaxy)DNASE_I_1 (PS00919)    DNASE_I_2 (PS00918)   
Domains : Interpro (EBI)Deoxyribonuclease-1_AS    DNase_I    DNASE_I_2    Endo/exonuclease/phosphatase   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)DNaseIc (SM00476)  
Conserved Domain (NCBI)DNASE1
DMDM Disease mutations1773
Blocks (Seattle)DNASE1
PDB (SRS)4AWN   
PDB (PDBSum)4AWN   
PDB (IMB)4AWN   
PDB (RSDB)4AWN   
Structural Biology KnowledgeBase4AWN   
SCOP (Structural Classification of Proteins)4AWN   
CATH (Classification of proteins structures)4AWN   
SuperfamilyP24855
Human Protein Atlas [tissue]ENSG00000213918-DNASE1 [tissue]
Peptide AtlasP24855
HPRD00509
IPIIPI00031065   IPI00908434   
Protein Interaction databases
DIP (DOE-UCLA)P24855
IntAct (EBI)P24855
FunCoupENSG00000213918
BioGRIDDNASE1
STRING (EMBL)DNASE1
ZODIACDNASE1
Ontologies - Pathways
QuickGOP24855
Ontology : AmiGOactin binding  deoxyribonuclease I activity  protein binding  extracellular region  nuclear envelope  DNA catabolic process  apoptotic process  extracellular exosome  nucleic acid phosphodiester bond hydrolysis  
Ontology : EGO-EBIactin binding  deoxyribonuclease I activity  protein binding  extracellular region  nuclear envelope  DNA catabolic process  apoptotic process  extracellular exosome  nucleic acid phosphodiester bond hydrolysis  
NDEx NetworkDNASE1
Atlas of Cancer Signalling NetworkDNASE1
Wikipedia pathwaysDNASE1
Orthology - Evolution
OrthoDB1773
GeneTree (enSembl)ENSG00000213918
Phylogenetic Trees/Animal Genes : TreeFamDNASE1
HOVERGENP24855
HOGENOMP24855
Homologs : HomoloGeneDNASE1
Homology/Alignments : Family Browser (UCSC)DNASE1
Gene fusions - Rearrangements
Tumor Fusion PortalDNASE1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDNASE1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DNASE1
dbVarDNASE1
ClinVarDNASE1
1000_GenomesDNASE1 
Exome Variant ServerDNASE1
ExAC (Exome Aggregation Consortium)ENSG00000213918
GNOMAD BrowserENSG00000213918
Genetic variants : HAPMAP1773
Genomic Variants (DGV)DNASE1 [DGVbeta]
DECIPHERDNASE1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDNASE1 
Mutations
ICGC Data PortalDNASE1 
TCGA Data PortalDNASE1 
Broad Tumor PortalDNASE1
OASIS PortalDNASE1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDNASE1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDNASE1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DNASE1
DgiDB (Drug Gene Interaction Database)DNASE1
DoCM (Curated mutations)DNASE1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DNASE1 (select a term)
intoGenDNASE1
Cancer3DDNASE1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM125505    152700   
Orphanet
DisGeNETDNASE1
MedgenDNASE1
Genetic Testing Registry DNASE1
NextProtP24855 [Medical]
TSGene1773
GENETestsDNASE1
Target ValidationDNASE1
Huge Navigator DNASE1 [HugePedia]
snp3D : Map Gene to Disease1773
BioCentury BCIQDNASE1
ClinGenDNASE1 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1773
Chemical/Pharm GKB GenePA27427
Clinical trialDNASE1
Miscellaneous
canSAR (ICR)DNASE1 (select the gene name)
Probes
Litterature
PubMed81 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDNASE1
EVEXDNASE1
GoPubMedDNASE1
iHOPDNASE1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:10:57 CET 2017

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