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DNASE1 (deoxyribonuclease I)

Identity

Other namesDNL1
DRNI
HGNC (Hugo) DNASE1
LocusID (NCBI) 1773
Location 16p13.3
Location_base_pair Starts at 3702940 and ends at 3708096 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

Nomenclature
HGNC (Hugo)DNASE1   2956
Entrez_Gene (NCBI)DNASE1  1773  deoxyribonuclease I
Cards
GeneCards (Weizmann)DNASE1
Ensembl (Hinxton) [Gene_View]  chr16:3702940-3708096 [Contig_View]  DNASE1 [Vega]
AceView (NCBI)DNASE1
Genatlas (Paris)DNASE1
SOURCE (Stanford)NM_005223
Genomic and cartography
GoldenPath (UCSC)DNASE1  -  16p13.3   chr16:3702940-3708096 +  16p13.3   [Description]    (hg19-Feb_2009)
EnsemblDNASE1 - 16p13.3 [CytoView]
Mapping of homologs : NCBIDNASE1 [Mapview]
OMIM125505   152700   
Gene and transcription
Genbank (Entrez)AB188151 AB188152 AI378682 AJ298844 AK095412
RefSeq transcript (SRS)NM_005223
RefSeq transcript (Entrez)NM_005223
RefSeq genomic (SRS)AC_000148 NC_000016 NC_018927 NG_009285 NT_010393 NW_001838341 NW_004078085
RefSeq genomic (Entrez)AC_000148 NC_000016 NC_018927 NG_009285 NT_010393 NW_001838341 NW_004078085
Consensus coding sequences : CCDS (NCBI)DNASE1
Cluster EST : UnigeneHs.733045 [ SRS ] Hs.733045 [ NCBI ]
CGAP (NCI)Hs.733045
Alternative Splicing : Fast-db (Paris)GSHG0010907
Gene ExpressionDNASE1 [ NCBI-GEO ]   DNASE1 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP24855 (SRS) P24855 (Uniprot)
NextProtP24855
With graphics : InterProP24855
Splice isoforms : SwissVarP24855(Swissvar)
Domaine pattern : Prosite (SRS)DNASE_I_1 (PS00919)    DNASE_I_2 (PS00918)   
Domaine pattern : Prosite (Expaxy)DNASE_I_1 (PS00919)    DNASE_I_2 (PS00918)   
Domains : Interpro (SRS)Deoxyribonuclease-1_AS    DNase_I-like    DNase_I_euk    Endo/exonuclease/phosphatase   
Domains : Interpro (EBI)Deoxyribonuclease-1_AS    DNase_I-like    DNase_I_euk    Endo/exonuclease/phosphatase   
Related proteins : CluSTrP24855
Domain families : Pfam (SRS)Exo_endo_phos (PF03372)   
Domain families : Pfam (Sanger)Exo_endo_phos (PF03372)   
Domain families : Pfam (NCBI)pfam03372   
Domain families : Smart (EMBL)DNaseIc (SM00476)  
DMDM1773
Blocks (Seattle)P24855
PDB (SRS)4AWN   
PDB (PDBSum)4AWN   
PDB (IMB)4AWN   
PDB (RSDB)4AWN   
HPRD00509
IPIIPI00031065   IPI00908434   
Protein Interaction databases
DIP (DOE-UCLA)P24855
IntAct (EBI)P24855
REACTOMEDNASE1
Protein Interaction Database1773
BioGRIDDNASE1
InParanoidP24855
Interologous Interaction database P24855
IntegromeDBDNASE1
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)DNASE1
SNP (GeneSNP Utah)DNASE1
SNP : HGBaseDNASE1
Genetic variants : HAPMAPDNASE1
Somatic Mutations in Cancer : COSMICDNASE1 
CONAN: Copy Number AnalysisDNASE1 
Mutations and Diseases : HGMDDNASE1
OMIM125505    152700   
GENETests125505    152700   
Disease Genetic AssociationDNASE1
Huge Navigator DNASE1 [HugePedia]  DNASE1 [HugeCancerGEM]
Genomic VariantsDNASE1  DNASE1 [DGVbeta]
ClinVarDNASE1
snp3D : Map Gene to Disease1773
General knowledge
Homologs : HomoloGeneDNASE1
Homology/Alignments : Family Browser (UCSC)DNASE1
Phylogenetic Trees/Animal Genes : TreeFamDNASE1
Catalytic activity : Enzyme3.1.21.1 [ Enzyme-Expasy ]   3.1.21.1 [ Enzyme-SRS ]   3.1.21.1 [ IntEnz-EBI ]   3.1.21.1 [ BRENDA ]   3.1.21.1 [ KEGG ]   
Chemical/Protein Interactions : CTD1773
Chemical/Pharm GKB GenePA27427
Clinical trialDNASE1
Ontology : AmiGOactin binding  deoxyribonuclease I activity  protein binding  extracellular region  nuclear envelope  DNA catabolic process  apoptotic process  
Ontology : EGO-EBIactin binding  deoxyribonuclease I activity  protein binding  extracellular region  nuclear envelope  DNA catabolic process  apoptotic process  
Other databases
Probes
Litterature
PubMed64 Pubmed reference(s) in Entrez
PubGeneDNASE1
iHOPDNASE1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 14 17:34:10 CEST 2013
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