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DNASE1L2 (deoxyribonuclease 1 like 2)

Identity

Alias_namesdeoxyribonuclease I like 2
Alias_symbol (synonym)DNAS1L2
Other alias
HGNC (Hugo) DNASE1L2
LocusID (NCBI) 1775
Atlas_Id 62574
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 2236467 and ends at 2238711 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DNASE1L2   2958
Cards
Entrez_Gene (NCBI)DNASE1L2  1775  deoxyribonuclease 1 like 2
AliasesDNAS1L2
GeneCards (Weizmann)DNASE1L2
Ensembl hg19 (Hinxton)ENSG00000167968 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167968 [Gene_View]  chr16:2236467-2238711 [Contig_View]  DNASE1L2 [Vega]
ICGC DataPortalENSG00000167968
TCGA cBioPortalDNASE1L2
AceView (NCBI)DNASE1L2
Genatlas (Paris)DNASE1L2
WikiGenes1775
SOURCE (Princeton)DNASE1L2
Genetics Home Reference (NIH)DNASE1L2
Genomic and cartography
GoldenPath hg38 (UCSC)DNASE1L2  -     chr16:2236467-2238711 +  16p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DNASE1L2  -     16p13.3   [Description]    (hg19-Feb_2009)
EnsemblDNASE1L2 - 16p13.3 [CytoView hg19]  DNASE1L2 - 16p13.3 [CytoView hg38]
Mapping of homologs : NCBIDNASE1L2 [Mapview hg19]  DNASE1L2 [Mapview hg38]
OMIM602622   
Gene and transcription
Genbank (Entrez)AK098028 AY298957 BC035205 BC063710 U62647
RefSeq transcript (Entrez)NM_001301680 NM_001374
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DNASE1L2
Cluster EST : UnigeneHs.103503 [ NCBI ]
CGAP (NCI)Hs.103503
Alternative Splicing GalleryENSG00000167968
Gene ExpressionDNASE1L2 [ NCBI-GEO ]   DNASE1L2 [ EBI - ARRAY_EXPRESS ]   DNASE1L2 [ SEEK ]   DNASE1L2 [ MEM ]
Gene Expression Viewer (FireBrowse)DNASE1L2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1775
GTEX Portal (Tissue expression)DNASE1L2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92874   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92874  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92874
Splice isoforms : SwissVarQ92874
Catalytic activity : Enzyme3.1.21.- [ Enzyme-Expasy ]   3.1.21.-3.1.21.- [ IntEnz-EBI ]   3.1.21.- [ BRENDA ]   3.1.21.- [ KEGG ]   
PhosPhoSitePlusQ92874
Domaine pattern : Prosite (Expaxy)DNASE_I_1 (PS00919)    DNASE_I_2 (PS00918)   
Domains : Interpro (EBI)Deoxyribonuclease-1_AS    DNase_I    DNASE_I_2    Endo/exonuclease/phosphatase   
Domain families : Pfam (Sanger)Exo_endo_phos (PF03372)   
Domain families : Pfam (NCBI)pfam03372   
Domain families : Smart (EMBL)DNaseIc (SM00476)  
Conserved Domain (NCBI)DNASE1L2
DMDM Disease mutations1775
Blocks (Seattle)DNASE1L2
SuperfamilyQ92874
Human Protein AtlasENSG00000167968
Peptide AtlasQ92874
HPRD04018
IPIIPI00023843   IPI00429065   
Protein Interaction databases
DIP (DOE-UCLA)Q92874
IntAct (EBI)Q92874
FunCoupENSG00000167968
BioGRIDDNASE1L2
STRING (EMBL)DNASE1L2
ZODIACDNASE1L2
Ontologies - Pathways
QuickGOQ92874
Ontology : AmiGOhair follicle development  corneocyte development  DNA binding  endonuclease activity  deoxyribonuclease activity  calcium ion binding  extracellular region  cytoplasm  DNA metabolic process  DNA catabolic process  nucleic acid phosphodiester bond hydrolysis  
Ontology : EGO-EBIhair follicle development  corneocyte development  DNA binding  endonuclease activity  deoxyribonuclease activity  calcium ion binding  extracellular region  cytoplasm  DNA metabolic process  DNA catabolic process  nucleic acid phosphodiester bond hydrolysis  
NDEx NetworkDNASE1L2
Atlas of Cancer Signalling NetworkDNASE1L2
Wikipedia pathwaysDNASE1L2
Orthology - Evolution
OrthoDB1775
GeneTree (enSembl)ENSG00000167968
Phylogenetic Trees/Animal Genes : TreeFamDNASE1L2
HOVERGENQ92874
HOGENOMQ92874
Homologs : HomoloGeneDNASE1L2
Homology/Alignments : Family Browser (UCSC)DNASE1L2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDNASE1L2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DNASE1L2
dbVarDNASE1L2
ClinVarDNASE1L2
1000_GenomesDNASE1L2 
Exome Variant ServerDNASE1L2
ExAC (Exome Aggregation Consortium)DNASE1L2 (select the gene name)
Genetic variants : HAPMAP1775
Genomic Variants (DGV)DNASE1L2 [DGVbeta]
DECIPHERDNASE1L2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDNASE1L2 
Mutations
ICGC Data PortalDNASE1L2 
TCGA Data PortalDNASE1L2 
Broad Tumor PortalDNASE1L2
OASIS PortalDNASE1L2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDNASE1L2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDNASE1L2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DNASE1L2
DgiDB (Drug Gene Interaction Database)DNASE1L2
DoCM (Curated mutations)DNASE1L2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DNASE1L2 (select a term)
intoGenDNASE1L2
Cancer3DDNASE1L2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602622   
Orphanet
MedgenDNASE1L2
Genetic Testing Registry DNASE1L2
NextProtQ92874 [Medical]
TSGene1775
GENETestsDNASE1L2
Target ValidationDNASE1L2
Huge Navigator DNASE1L2 [HugePedia]
snp3D : Map Gene to Disease1775
BioCentury BCIQDNASE1L2
ClinGenDNASE1L2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1775
Chemical/Pharm GKB GenePA27429
Clinical trialDNASE1L2
Miscellaneous
canSAR (ICR)DNASE1L2 (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDNASE1L2
EVEXDNASE1L2
GoPubMedDNASE1L2
iHOPDNASE1L2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 15:46:14 CEST 2017

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