Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

DNASE2 (deoxyribonuclease 2, lysosomal)

Identity

Alias_namesDNL
DNL2
deoxyribonuclease II, lysosomal
Other aliasDNASE2A
HGNC (Hugo) DNASE2
LocusID (NCBI) 1777
Atlas_Id 62575
Location 19p13.13  [Link to chromosome band 19p13]
Location_base_pair Starts at 12875211 and ends at 12881521 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DNASE2 (19p13.2) / C12orf65 (12q24.31)DNASE2 (19p13.2) / DNASE2 (19p13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DNASE2   2960
Cards
Entrez_Gene (NCBI)DNASE2  1777  deoxyribonuclease 2, lysosomal
AliasesDNASE2A; DNL; DNL2
GeneCards (Weizmann)DNASE2
Ensembl hg19 (Hinxton)ENSG00000105612 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105612 [Gene_View]  chr19:12875211-12881521 [Contig_View]  DNASE2 [Vega]
ICGC DataPortalENSG00000105612
TCGA cBioPortalDNASE2
AceView (NCBI)DNASE2
Genatlas (Paris)DNASE2
WikiGenes1777
SOURCE (Princeton)DNASE2
Genetics Home Reference (NIH)DNASE2
Genomic and cartography
GoldenPath hg38 (UCSC)DNASE2  -     chr19:12875211-12881521 -  19p13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DNASE2  -     19p13.13   [Description]    (hg19-Feb_2009)
EnsemblDNASE2 - 19p13.13 [CytoView hg19]  DNASE2 - 19p13.13 [CytoView hg38]
Mapping of homologs : NCBIDNASE2 [Mapview hg19]  DNASE2 [Mapview hg38]
OMIM126350   
Gene and transcription
Genbank (Entrez)AB004574 AF045937 AF047016 AF060222 AK075449
RefSeq transcript (Entrez)NM_001375
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DNASE2
Cluster EST : UnigeneHs.118243 [ NCBI ]
CGAP (NCI)Hs.118243
Alternative Splicing GalleryENSG00000105612
Gene ExpressionDNASE2 [ NCBI-GEO ]   DNASE2 [ EBI - ARRAY_EXPRESS ]   DNASE2 [ SEEK ]   DNASE2 [ MEM ]
Gene Expression Viewer (FireBrowse)DNASE2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1777
GTEX Portal (Tissue expression)DNASE2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00115   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00115  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00115
Splice isoforms : SwissVarO00115
Catalytic activity : Enzyme3.1.22.1 [ Enzyme-Expasy ]   3.1.22.13.1.22.1 [ IntEnz-EBI ]   3.1.22.1 [ BRENDA ]   3.1.22.1 [ KEGG ]   
PhosPhoSitePlusO00115
Domains : Interpro (EBI)DNase_II   
Domain families : Pfam (Sanger)DNase_II (PF03265)   
Domain families : Pfam (NCBI)pfam03265   
Conserved Domain (NCBI)DNASE2
DMDM Disease mutations1777
Blocks (Seattle)DNASE2
SuperfamilyO00115
Human Protein AtlasENSG00000105612
Peptide AtlasO00115
HPRD00531
IPIIPI00010348   IPI00922554   
Protein Interaction databases
DIP (DOE-UCLA)O00115
IntAct (EBI)O00115
FunCoupENSG00000105612
BioGRIDDNASE2
STRING (EMBL)DNASE2
ZODIACDNASE2
Ontologies - Pathways
QuickGOO00115
Ontology : AmiGODNA binding  deoxyribonuclease II activity  intracellular  lysosome  DNA metabolic process  apoptotic DNA fragmentation  erythrocyte differentiation  extracellular exosome  
Ontology : EGO-EBIDNA binding  deoxyribonuclease II activity  intracellular  lysosome  DNA metabolic process  apoptotic DNA fragmentation  erythrocyte differentiation  extracellular exosome  
Pathways : KEGGLysosome   
NDEx NetworkDNASE2
Atlas of Cancer Signalling NetworkDNASE2
Wikipedia pathwaysDNASE2
Orthology - Evolution
OrthoDB1777
GeneTree (enSembl)ENSG00000105612
Phylogenetic Trees/Animal Genes : TreeFamDNASE2
HOVERGENO00115
HOGENOMO00115
Homologs : HomoloGeneDNASE2
Homology/Alignments : Family Browser (UCSC)DNASE2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDNASE2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DNASE2
dbVarDNASE2
ClinVarDNASE2
1000_GenomesDNASE2 
Exome Variant ServerDNASE2
ExAC (Exome Aggregation Consortium)DNASE2 (select the gene name)
Genetic variants : HAPMAP1777
Genomic Variants (DGV)DNASE2 [DGVbeta]
DECIPHERDNASE2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDNASE2 
Mutations
ICGC Data PortalDNASE2 
TCGA Data PortalDNASE2 
Broad Tumor PortalDNASE2
OASIS PortalDNASE2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDNASE2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDNASE2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DNASE2
DgiDB (Drug Gene Interaction Database)DNASE2
DoCM (Curated mutations)DNASE2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DNASE2 (select a term)
intoGenDNASE2
Cancer3DDNASE2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM126350   
Orphanet
MedgenDNASE2
Genetic Testing Registry DNASE2
NextProtO00115 [Medical]
TSGene1777
GENETestsDNASE2
Target ValidationDNASE2
Huge Navigator DNASE2 [HugePedia]
snp3D : Map Gene to Disease1777
BioCentury BCIQDNASE2
ClinGenDNASE2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1777
Chemical/Pharm GKB GenePA27431
Clinical trialDNASE2
Miscellaneous
canSAR (ICR)DNASE2 (select the gene name)
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDNASE2
EVEXDNASE2
GoPubMedDNASE2
iHOPDNASE2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 15:46:15 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.