DNASE2B (deoxyribonuclease 2 beta)

2014-11-01 Affiliation

Identity

HGNC

DNASE2B

LOCATION

1p22.3

LOCUSID

58511

ALIAS

DLAD

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 58511
MIM: 608057
HGNC: 28875
Ensembl: ENSG00000137976

Variants:

dbSNP: 58511
ClinVar: 58511
TCGA: ENSG00000137976
COSMIC: DNASE2B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000137976	ENST00000370662	Q8WZ79
ENSG00000137976	ENST00000370665	Q8WZ79

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Lysosome	KEGG	ko04142
Lysosome	KEGG	hsa04142

References

Pubmed ID	Year	Title	Citations
20201924	2010	Genome-wide association study of alcohol dependence implicates a region on chromosome 11.	159
23507146	2013	HSF4 regulates DLAD expression and promotes lens de-nucleation.	13
20800603	2010	Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.	12
21390259	2011	DNase 2 is the main DNA-degrading enzyme of the stratum corneum.	12
11700027	2001	Isolation and characterization of the DLAD/Dlad genes, which lie head-to-head with the genes for urate oxidase.	1

Citation

Dessen P

DNASE2B (deoxyribonuclease 2 beta)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62576/dnase2b