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DNASE2B (deoxyribonuclease 2 beta)

Identity

Alias_namesdeoxyribonuclease II beta
Alias_symbol (synonym)DLAD
Other alias
HGNC (Hugo) DNASE2B
LocusID (NCBI) 58511
Atlas_Id 62576
Location 1p31.1  [Link to chromosome band 1p31]
Location_base_pair Starts at 84398532 and ends at 84415008 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DNASE2B   28875
Cards
Entrez_Gene (NCBI)DNASE2B  58511  deoxyribonuclease 2 beta
AliasesDLAD
GeneCards (Weizmann)DNASE2B
Ensembl hg19 (Hinxton)ENSG00000137976 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137976 [Gene_View]  chr1:84398532-84415008 [Contig_View]  DNASE2B [Vega]
ICGC DataPortalENSG00000137976
TCGA cBioPortalDNASE2B
AceView (NCBI)DNASE2B
Genatlas (Paris)DNASE2B
WikiGenes58511
SOURCE (Princeton)DNASE2B
Genetics Home Reference (NIH)DNASE2B
Genomic and cartography
GoldenPath hg38 (UCSC)DNASE2B  -     chr1:84398532-84415008 +  1p31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DNASE2B  -     1p31.1   [Description]    (hg19-Feb_2009)
EnsemblDNASE2B - 1p31.1 [CytoView hg19]  DNASE2B - 1p31.1 [CytoView hg38]
Mapping of homologs : NCBIDNASE2B [Mapview hg19]  DNASE2B [Mapview hg38]
OMIM608057   
Gene and transcription
Genbank (Entrez)AF274571 AF333389 BC065182 BC080621 BC126136
RefSeq transcript (Entrez)NM_021233 NM_058248
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DNASE2B
Cluster EST : UnigeneHs.129142 [ NCBI ]
CGAP (NCI)Hs.129142
Alternative Splicing GalleryENSG00000137976
Gene ExpressionDNASE2B [ NCBI-GEO ]   DNASE2B [ EBI - ARRAY_EXPRESS ]   DNASE2B [ SEEK ]   DNASE2B [ MEM ]
Gene Expression Viewer (FireBrowse)DNASE2B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)58511
GTEX Portal (Tissue expression)DNASE2B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WZ79   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WZ79  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WZ79
Splice isoforms : SwissVarQ8WZ79
Catalytic activity : Enzyme3.1.22.1 [ Enzyme-Expasy ]   3.1.22.13.1.22.1 [ IntEnz-EBI ]   3.1.22.1 [ BRENDA ]   3.1.22.1 [ KEGG ]   
PhosPhoSitePlusQ8WZ79
Domains : Interpro (EBI)DNase_II   
Domain families : Pfam (Sanger)DNase_II (PF03265)   
Domain families : Pfam (NCBI)pfam03265   
Conserved Domain (NCBI)DNASE2B
DMDM Disease mutations58511
Blocks (Seattle)DNASE2B
SuperfamilyQ8WZ79
Human Protein AtlasENSG00000137976
Peptide AtlasQ8WZ79
HPRD09728
IPIIPI00103879   IPI00072376   
Protein Interaction databases
DIP (DOE-UCLA)Q8WZ79
IntAct (EBI)Q8WZ79
FunCoupENSG00000137976
BioGRIDDNASE2B
STRING (EMBL)DNASE2B
ZODIACDNASE2B
Ontologies - Pathways
QuickGOQ8WZ79
Ontology : AmiGOdeoxyribonuclease II activity  extracellular region  intracellular  lysosome  apoptotic DNA fragmentation  
Ontology : EGO-EBIdeoxyribonuclease II activity  extracellular region  intracellular  lysosome  apoptotic DNA fragmentation  
Pathways : KEGGLysosome   
NDEx NetworkDNASE2B
Atlas of Cancer Signalling NetworkDNASE2B
Wikipedia pathwaysDNASE2B
Orthology - Evolution
OrthoDB58511
GeneTree (enSembl)ENSG00000137976
Phylogenetic Trees/Animal Genes : TreeFamDNASE2B
HOVERGENQ8WZ79
HOGENOMQ8WZ79
Homologs : HomoloGeneDNASE2B
Homology/Alignments : Family Browser (UCSC)DNASE2B
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDNASE2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DNASE2B
dbVarDNASE2B
ClinVarDNASE2B
1000_GenomesDNASE2B 
Exome Variant ServerDNASE2B
ExAC (Exome Aggregation Consortium)DNASE2B (select the gene name)
Genetic variants : HAPMAP58511
Genomic Variants (DGV)DNASE2B [DGVbeta]
DECIPHERDNASE2B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDNASE2B 
Mutations
ICGC Data PortalDNASE2B 
TCGA Data PortalDNASE2B 
Broad Tumor PortalDNASE2B
OASIS PortalDNASE2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDNASE2B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDNASE2B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DNASE2B
DgiDB (Drug Gene Interaction Database)DNASE2B
DoCM (Curated mutations)DNASE2B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DNASE2B (select a term)
intoGenDNASE2B
Cancer3DDNASE2B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608057   
Orphanet
MedgenDNASE2B
Genetic Testing Registry DNASE2B
NextProtQ8WZ79 [Medical]
TSGene58511
GENETestsDNASE2B
Target ValidationDNASE2B
Huge Navigator DNASE2B [HugePedia]
snp3D : Map Gene to Disease58511
BioCentury BCIQDNASE2B
ClinGenDNASE2B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD58511
Chemical/Pharm GKB GenePA134993904
Clinical trialDNASE2B
Miscellaneous
canSAR (ICR)DNASE2B (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDNASE2B
EVEXDNASE2B
GoPubMedDNASE2B
iHOPDNASE2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 15:46:15 CEST 2017

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