DNER (delta/notch like EGF repeat containing)

2014-01-01  

Identity

HGNC
LOCATION
2q36.3
LOCUSID
ALIAS
UNQ26,bet
FUSION GENES

Other Information

Locus ID:

NCBI: 92737
MIM: 607299
HGNC: 24456
Ensembl: ENSG00000187957

Variants:

dbSNP: 92737
ClinVar: 92737
TCGA: ENSG00000187957
COSMIC: DNER

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187957ENST00000341772Q8NFT8

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
Activated NOTCH1 Transmits Signal to the NucleusREACTOMER-HSA-2122948

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
282096152017Targeted Degradation of BET Proteins in Triple-Negative Breast Cancer.42
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
119508332002Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons.26
241016742014A genome-wide association study in American Indians implicates DNER as a susceptibility locus for type 2 diabetes.26
272409902016Bromodomain and extra-terminal (BET) family proteins: New therapeutic targets in major diseases.20
203677512010Polarized targeting of DNER into dendritic plasma membrane in hippocampal neurons depends on endocytosis.8
200707332010DNER modulates adipogenesis of human adipose tissue-derived mesenchymal stem cells via regulation of cell proliferation.7
277177112016BET bromodomain is a novel regulator of TAZ and its activity.7
276225122016Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand.4
310609022019The Notch ligand DNER regulates macrophage IFNγ release in chronic obstructive pulmonary disease.2

Citation

Dessen P

DNER (delta/notch like EGF repeat containing)

Atlas Genet Cytogenet Oncol Haematol. 2014-01-01

Online version: http://atlasgeneticsoncology.org/gene/53665/dner