Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

DNMT3L (DNA (cytosine-5-)-methyltransferase 3-like)

Identity

Alias_namesDNA (cytosine-5-)-methyltransferase 3-like
Alias_symbol (synonym)MGC1090
Other alias-
HGNC (Hugo) DNMT3L
LocusID (NCBI) 29947
Atlas_Id 46801
Location 21q22.3  [Link to chromosome band 21q22]
Location_base_pair Starts at 45666222 and ends at 45682099 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
IGFBP2 (2q35) / DNMT3L (21q22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DNMT3L   2980
Cards
Entrez_Gene (NCBI)DNMT3L  29947  DNA (cytosine-5-)-methyltransferase 3-like
Aliases
GeneCards (Weizmann)DNMT3L
Ensembl hg19 (Hinxton)ENSG00000142182 [Gene_View]  chr21:45666222-45682099 [Contig_View]  DNMT3L [Vega]
Ensembl hg38 (Hinxton)ENSG00000142182 [Gene_View]  chr21:45666222-45682099 [Contig_View]  DNMT3L [Vega]
ICGC DataPortalENSG00000142182
TCGA cBioPortalDNMT3L
AceView (NCBI)DNMT3L
Genatlas (Paris)DNMT3L
WikiGenes29947
SOURCE (Princeton)DNMT3L
Genetics Home Reference (NIH)DNMT3L
Genomic and cartography
GoldenPath hg19 (UCSC)DNMT3L  -     chr21:45666222-45682099 -  21q22.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DNMT3L  -     21q22.3   [Description]    (hg38-Dec_2013)
EnsemblDNMT3L - 21q22.3 [CytoView hg19]  DNMT3L - 21q22.3 [CytoView hg38]
Mapping of homologs : NCBIDNMT3L [Mapview hg19]  DNMT3L [Mapview hg38]
OMIM606588   
Gene and transcription
Genbank (Entrez)AF194032 BC002560 BQ028660 DQ892177 DQ895372
RefSeq transcript (Entrez)NM_013369 NM_175867
RefSeq genomic (Entrez)NC_000021 NC_018932 NT_011512 NW_004929427
Consensus coding sequences : CCDS (NCBI)DNMT3L
Cluster EST : UnigeneHs.592165 [ NCBI ]
CGAP (NCI)Hs.592165
Alternative Splicing GalleryENSG00000142182
Gene ExpressionDNMT3L [ NCBI-GEO ]   DNMT3L [ EBI - ARRAY_EXPRESS ]   DNMT3L [ SEEK ]   DNMT3L [ MEM ]
Gene Expression Viewer (FireBrowse)DNMT3L [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29947
GTEX Portal (Tissue expression)DNMT3L
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UJW3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UJW3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UJW3
Splice isoforms : SwissVarQ9UJW3
PhosPhoSitePlusQ9UJW3
Domaine pattern : Prosite (Expaxy)ADD (PS51533)   
Domains : Interpro (EBI)ADD    DNMT3L    Znf_FYVE_PHD    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)DNMT3L
DMDM Disease mutations29947
Blocks (Seattle)DNMT3L
PDB (SRS)2PV0    2PVC    2QRV    4U7P    4U7T   
PDB (PDBSum)2PV0    2PVC    2QRV    4U7P    4U7T   
PDB (IMB)2PV0    2PVC    2QRV    4U7P    4U7T   
PDB (RSDB)2PV0    2PVC    2QRV    4U7P    4U7T   
Structural Biology KnowledgeBase2PV0    2PVC    2QRV    4U7P    4U7T   
SCOP (Structural Classification of Proteins)2PV0    2PVC    2QRV    4U7P    4U7T   
CATH (Classification of proteins structures)2PV0    2PVC    2QRV    4U7P    4U7T   
SuperfamilyQ9UJW3
Human Protein AtlasENSG00000142182
Peptide AtlasQ9UJW3
HPRD09417
IPIIPI00002935   IPI00375360   IPI00792339   IPI00791705   
Protein Interaction databases
DIP (DOE-UCLA)Q9UJW3
IntAct (EBI)Q9UJW3
FunCoupENSG00000142182
BioGRIDDNMT3L
STRING (EMBL)DNMT3L
ZODIACDNMT3L
Ontologies - Pathways
QuickGOQ9UJW3
Ontology : AmiGOprotein binding  nucleus  nucleus  cytosol  DNA methylation  regulation of gene expression by genetic imprinting  spermatogenesis  enzyme activator activity  enzyme binding  positive regulation of catalytic activity  negative regulation of transcription, DNA-templated  metal ion binding  
Ontology : EGO-EBIprotein binding  nucleus  nucleus  cytosol  DNA methylation  regulation of gene expression by genetic imprinting  spermatogenesis  enzyme activator activity  enzyme binding  positive regulation of catalytic activity  negative regulation of transcription, DNA-templated  metal ion binding  
NDEx NetworkDNMT3L
Atlas of Cancer Signalling NetworkDNMT3L
Wikipedia pathwaysDNMT3L
Orthology - Evolution
OrthoDB29947
GeneTree (enSembl)ENSG00000142182
Phylogenetic Trees/Animal Genes : TreeFamDNMT3L
HOVERGENQ9UJW3
HOGENOMQ9UJW3
Homologs : HomoloGeneDNMT3L
Homology/Alignments : Family Browser (UCSC)DNMT3L
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDNMT3L [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DNMT3L
dbVarDNMT3L
ClinVarDNMT3L
1000_GenomesDNMT3L 
Exome Variant ServerDNMT3L
ExAC (Exome Aggregation Consortium)DNMT3L (select the gene name)
Genetic variants : HAPMAP29947
Genomic Variants (DGV)DNMT3L [DGVbeta]
DECIPHER (Syndromes)21:45666222-45682099  ENSG00000142182
CONAN: Copy Number AnalysisDNMT3L 
Mutations
ICGC Data PortalDNMT3L 
TCGA Data PortalDNMT3L 
Broad Tumor PortalDNMT3L
OASIS PortalDNMT3L [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDNMT3L  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDNMT3L
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DNMT3L
DgiDB (Drug Gene Interaction Database)DNMT3L
DoCM (Curated mutations)DNMT3L (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DNMT3L (select a term)
intoGenDNMT3L
Cancer3DDNMT3L(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606588   
Orphanet
MedgenDNMT3L
Genetic Testing Registry DNMT3L
NextProtQ9UJW3 [Medical]
TSGene29947
GENETestsDNMT3L
Huge Navigator DNMT3L [HugePedia]
snp3D : Map Gene to Disease29947
BioCentury BCIQDNMT3L
ClinGenDNMT3L
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD29947
Chemical/Pharm GKB GenePA27447
Clinical trialDNMT3L
Miscellaneous
canSAR (ICR)DNMT3L (select the gene name)
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDNMT3L
EVEXDNMT3L
GoPubMedDNMT3L
iHOPDNMT3L
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:03:40 CET 2017

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.