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DNTT (DNA nucleotidylexotransferase)

Identity

Alias (NCBI)TDT
HGNC (Hugo) DNTT
HGNC Alias symbTDT
HGNC Alias nameTerminal deoxynucleotidyltransferase
HGNC Previous namedeoxynucleotidyltransferase, terminal
LocusID (NCBI) 1791
Atlas_Id 40351
Location 10q24.1  [Link to chromosome band 10q24]
Location_base_pair Starts at 96304434 and ends at 96338564 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(10;10)(q24;q24) DNTT/BLNK


External links

 

Nomenclature
HGNC (Hugo)DNTT   2983
Cards
Entrez_Gene (NCBI)DNTT    DNA nucleotidylexotransferase
AliasesTDT
GeneCards (Weizmann)DNTT
Ensembl hg19 (Hinxton)ENSG00000107447 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107447 [Gene_View]  ENSG00000107447 [Sequence]  chr10:96304434-96338564 [Contig_View]  DNTT [Vega]
ICGC DataPortalENSG00000107447
TCGA cBioPortalDNTT
AceView (NCBI)DNTT
Genatlas (Paris)DNTT
SOURCE (Princeton)DNTT
Genetics Home Reference (NIH)DNTT
Genomic and cartography
GoldenPath hg38 (UCSC)DNTT  -     chr10:96304434-96338564 +  10q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DNTT  -     10q24.1   [Description]    (hg19-Feb_2009)
GoldenPathDNTT - 10q24.1 [CytoView hg19]  DNTT - 10q24.1 [CytoView hg38]
ImmunoBaseENSG00000107447
Genome Data Viewer NCBIDNTT [Mapview hg19]  
OMIM187410   
Gene and transcription
Genbank (Entrez)AB046378 AK130771 AK223317 AK313615 BC012920
RefSeq transcript (Entrez)NM_001017520 NM_004088
Consensus coding sequences : CCDS (NCBI)DNTT
Gene ExpressionDNTT [ NCBI-GEO ]   DNTT [ EBI - ARRAY_EXPRESS ]   DNTT [ SEEK ]   DNTT [ MEM ]
Gene Expression Viewer (FireBrowse)DNTT [ Firebrowse - Broad ]
GenevisibleExpression of DNTT in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1791
GTEX Portal (Tissue expression)DNTT
Human Protein AtlasENSG00000107447-DNTT [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04053   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP04053  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP04053
PhosPhoSitePlusP04053
Domaine pattern : Prosite (Expaxy)BRCT (PS50172)    DNA_POLYMERASE_X (PS00522)   
Domains : Interpro (EBI)BRCT_dom    BRCT_dom_sf    DNA-dir_DNA_pol_X    DNA_pol-X_BS    DNA_pol_b-like_N    DNA_pol_B_palm_palm    DNA_pol_lambd_fingers_domain    DNA_pol_lamdba_lyase_dom_sf    DNA_Pol_thumb_sf    DNA_pol_X    NT_sf    PolB_thumb    TdT    TdT/Mu   
Domain families : Pfam (Sanger)BRCT (PF00533)    DNA_pol_B_palm (PF14792)    DNA_pol_B_thumb (PF14791)    DNA_pol_lambd_f (PF10391)    HHH_8 (PF14716)   
Domain families : Pfam (NCBI)pfam00533    pfam14792    pfam14791    pfam10391    pfam14716   
Domain families : Smart (EMBL)BRCT (SM00292)  POLXc (SM00483)  
Conserved Domain (NCBI)DNTT
PDB (RSDB)2COE    5W4E   
PDB Europe2COE    5W4E   
PDB (PDBSum)2COE    5W4E   
PDB (IMB)2COE    5W4E   
Structural Biology KnowledgeBase2COE    5W4E   
SCOP (Structural Classification of Proteins)2COE    5W4E   
CATH (Classification of proteins structures)2COE    5W4E   
SuperfamilyP04053
AlphaFold pdb e-kbP04053   
Human Protein Atlas [tissue]ENSG00000107447-DNTT [tissue]
HPRD08925
Protein Interaction databases
DIP (DOE-UCLA)P04053
IntAct (EBI)P04053
BioGRIDDNTT
STRING (EMBL)DNTT
ZODIACDNTT
Ontologies - Pathways
QuickGOP04053
Ontology : AmiGOeuchromatin  DNA binding  DNA-directed DNA polymerase activity  DNA nucleotidylexotransferase activity  DNA nucleotidylexotransferase activity  protein binding  nucleus  nucleus  nucleoplasm  cytosol  DNA metabolic process  double-strand break repair via nonhomologous end joining  DNA modification  nuclear matrix  response to ATP  metal ion binding  DNA biosynthetic process  
Ontology : EGO-EBIeuchromatin  DNA binding  DNA-directed DNA polymerase activity  DNA nucleotidylexotransferase activity  DNA nucleotidylexotransferase activity  protein binding  nucleus  nucleus  nucleoplasm  cytosol  DNA metabolic process  double-strand break repair via nonhomologous end joining  DNA modification  nuclear matrix  response to ATP  metal ion binding  DNA biosynthetic process  
Pathways : KEGGNon-homologous end-joining    Hematopoietic cell lineage   
NDEx NetworkDNTT
Atlas of Cancer Signalling NetworkDNTT
Wikipedia pathwaysDNTT
Orthology - Evolution
OrthoDB1791
GeneTree (enSembl)ENSG00000107447
Phylogenetic Trees/Animal Genes : TreeFamDNTT
Homologs : HomoloGeneDNTT
Homology/Alignments : Family Browser (UCSC)DNTT
Gene fusions - Rearrangements
Fusion : QuiverDNTT
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDNTT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DNTT
dbVarDNTT
ClinVarDNTT
MonarchDNTT
1000_GenomesDNTT 
Exome Variant ServerDNTT
GNOMAD BrowserENSG00000107447
Varsome BrowserDNTT
ACMGDNTT variants
VarityP04053
Genomic Variants (DGV)DNTT [DGVbeta]
DECIPHERDNTT [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDNTT 
Mutations
ICGC Data PortalDNTT 
TCGA Data PortalDNTT 
Broad Tumor PortalDNTT
OASIS PortalDNTT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDNTT  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDNTT
Mutations and Diseases : HGMDDNTT
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDNTT
DgiDB (Drug Gene Interaction Database)DNTT
DoCM (Curated mutations)DNTT
CIViC (Clinical Interpretations of Variants in Cancer)DNTT
Cancer3DDNTT
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM187410   
Orphanet
DisGeNETDNTT
MedgenDNTT
Genetic Testing Registry DNTT
NextProtP04053 [Medical]
GENETestsDNTT
Target ValidationDNTT
Huge Navigator DNTT [HugePedia]
ClinGenDNTT
Clinical trials, drugs, therapy
MyCancerGenomeDNTT
Protein Interactions : CTDDNTT
Pharm GKB GenePA27449
PharosP04053
Clinical trialDNTT
Miscellaneous
canSAR (ICR)DNTT
HarmonizomeDNTT
DataMed IndexDNTT
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDNTT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:07:09 CEST 2021

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