DNTT (DNA nucleotidylexotransferase)

2003-12-01  

Identity

HGNC
LOCATION
10q24.1
LOCUSID
ALIAS
TDT

Other Information

Locus ID:

NCBI: 1791
MIM: 187410
HGNC: 2983
Ensembl: ENSG00000107447

Variants:

dbSNP: 1791
ClinVar: 1791
TCGA: ENSG00000107447
COSMIC: DNTT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000107447ENST00000371174P04053
ENSG00000107447ENST00000630152P04053

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Non-homologous end-joiningKEGGko03450
Hematopoietic cell lineageKEGGko04640
Non-homologous end-joiningKEGGhsa03450
Hematopoietic cell lineageKEGGhsa04640

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
153561502004Distinct and opposite activities of human terminal deoxynucleotidyltransferase splice variants.10
274994382016Structural Basis for a New Templated Activity by Terminal Deoxynucleotidyl Transferase: Implications for V(D)J Recombination.9
176637232007Identification of functional domains in TdIF1 and its inhibitory mechanism for TdT activity.6
233299992013Immunohistochemical expression of PAX5 and TdT by Merkel cell carcinoma and pulmonary small cell carcinoma: a potential diagnostic pitfall but useful discriminatory marker.4
316501622019Molecular roulette: nucleophosmin mutations in AML are orchestrated through N-nucleotide addition by TdT.2
316501682019Terminal deoxynucleotidyl transferase promotes acute myeloid leukemia by priming FLT3-ITD replication slippage.2
168850572006Terminal deoxynucleotidyl transferase-positive cells in spleen, appendix and branchial cleft cysts in pediatric patients.1
119749162002[Expression and function of terminal deoxynucleotidyl-transferase and discovery of novel DNA polymerase mu].0
237027312013Absence of terminal deoxynucleotidyl transferase expression identifies a subset of high-risk adult T-lymphoblastic leukemia/lymphoma.0

Citation

Dessen P

DNTT (DNA nucleotidylexotransferase)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/40351/dntt