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DOCK10 (dedicator of cytokinesis 10)

Identity

Alias_symbol (synonym)ZIZ3
KIAA0694
Other aliasDRIP2
Nbla10300
HGNC (Hugo) DOCK10
LocusID (NCBI) 55619
Atlas_Id 50586
Location 2q36.2  [Link to chromosome band 2q36]
Location_base_pair Starts at 224765090 and ends at 224947065 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DOCK10 (2q36.2) / MEG3 (14q32.2)DOCK10 (2q36.2) / RNU5F-1 (1q41)DOCK10 (2q36.2) / RPRD2 (1q21.3)
DOCK10 (2q36.2) / TP53BP1 (15q15.3)SEMA6A (5q23.1) / DOCK10 (2q36.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DOCK10   23479
Cards
Entrez_Gene (NCBI)DOCK10  55619  dedicator of cytokinesis 10
AliasesDRIP2; Nbla10300; ZIZ3
GeneCards (Weizmann)DOCK10
Ensembl hg19 (Hinxton)ENSG00000135905 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135905 [Gene_View]  chr2:224765090-224947065 [Contig_View]  DOCK10 [Vega]
ICGC DataPortalENSG00000135905
TCGA cBioPortalDOCK10
AceView (NCBI)DOCK10
Genatlas (Paris)DOCK10
WikiGenes55619
SOURCE (Princeton)DOCK10
Genetics Home Reference (NIH)DOCK10
Genomic and cartography
GoldenPath hg38 (UCSC)DOCK10  -     chr2:224765090-224947065 -  2q36.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DOCK10  -     2q36.2   [Description]    (hg19-Feb_2009)
EnsemblDOCK10 - 2q36.2 [CytoView hg19]  DOCK10 - 2q36.2 [CytoView hg38]
Mapping of homologs : NCBIDOCK10 [Mapview hg19]  DOCK10 [Mapview hg38]
OMIM611518   
Gene and transcription
Genbank (Entrez)AB014594 AB074179 AF250396 AK000227 AK001253
RefSeq transcript (Entrez)NM_001290263 NM_014689 NM_017718
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DOCK10
Cluster EST : UnigeneHs.46578 [ NCBI ]
CGAP (NCI)Hs.46578
Alternative Splicing GalleryENSG00000135905
Gene ExpressionDOCK10 [ NCBI-GEO ]   DOCK10 [ EBI - ARRAY_EXPRESS ]   DOCK10 [ SEEK ]   DOCK10 [ MEM ]
Gene Expression Viewer (FireBrowse)DOCK10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55619
GTEX Portal (Tissue expression)DOCK10
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96BY6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96BY6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96BY6
Splice isoforms : SwissVarQ96BY6
PhosPhoSitePlusQ96BY6
Domaine pattern : Prosite (Expaxy)DHR_1 (PS51650)    DHR_2 (PS51651)    PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)DHR-1_domain    DHR-2    DOCK    DOCK_C    DOCK_C/D_N    PH_dom-like    PH_domain   
Domain families : Pfam (Sanger)DHR-2 (PF06920)    DOCK-C2 (PF14429)    DUF3398 (PF11878)    PH (PF00169)   
Domain families : Pfam (NCBI)pfam06920    pfam14429    pfam11878    pfam00169   
Domain families : Smart (EMBL)PH (SM00233)  
Conserved Domain (NCBI)DOCK10
DMDM Disease mutations55619
Blocks (Seattle)DOCK10
SuperfamilyQ96BY6
Human Protein AtlasENSG00000135905
Peptide AtlasQ96BY6
HPRD10919
IPIIPI00333770   IPI00375113   IPI01011641   IPI00607899   IPI00916860   IPI00915901   IPI00917452   
Protein Interaction databases
DIP (DOE-UCLA)Q96BY6
IntAct (EBI)Q96BY6
FunCoupENSG00000135905
BioGRIDDOCK10
STRING (EMBL)DOCK10
ZODIACDOCK10
Ontologies - Pathways
QuickGOQ96BY6
Ontology : AmiGOB cell homeostasis  marginal zone B cell differentiation  molecular_function  guanyl-nucleotide exchange factor activity  nucleus  cytoplasm  small GTPase mediated signal transduction  membrane  regulation of cell migration  dendritic spine  positive regulation of GTPase activity  dendritic spine morphogenesis  extracellular exosome  
Ontology : EGO-EBIB cell homeostasis  marginal zone B cell differentiation  molecular_function  guanyl-nucleotide exchange factor activity  nucleus  cytoplasm  small GTPase mediated signal transduction  membrane  regulation of cell migration  dendritic spine  positive regulation of GTPase activity  dendritic spine morphogenesis  extracellular exosome  
NDEx NetworkDOCK10
Atlas of Cancer Signalling NetworkDOCK10
Wikipedia pathwaysDOCK10
Orthology - Evolution
OrthoDB55619
GeneTree (enSembl)ENSG00000135905
Phylogenetic Trees/Animal Genes : TreeFamDOCK10
HOVERGENQ96BY6
HOGENOMQ96BY6
Homologs : HomoloGeneDOCK10
Homology/Alignments : Family Browser (UCSC)DOCK10
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDOCK10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DOCK10
dbVarDOCK10
ClinVarDOCK10
1000_GenomesDOCK10 
Exome Variant ServerDOCK10
ExAC (Exome Aggregation Consortium)DOCK10 (select the gene name)
Genetic variants : HAPMAP55619
Genomic Variants (DGV)DOCK10 [DGVbeta]
DECIPHERDOCK10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDOCK10 
Mutations
ICGC Data PortalDOCK10 
TCGA Data PortalDOCK10 
Broad Tumor PortalDOCK10
OASIS PortalDOCK10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDOCK10  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDOCK10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DOCK10
DgiDB (Drug Gene Interaction Database)DOCK10
DoCM (Curated mutations)DOCK10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DOCK10 (select a term)
intoGenDOCK10
Cancer3DDOCK10(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611518   
Orphanet
MedgenDOCK10
Genetic Testing Registry DOCK10
NextProtQ96BY6 [Medical]
TSGene55619
GENETestsDOCK10
Huge Navigator DOCK10 [HugePedia]
snp3D : Map Gene to Disease55619
BioCentury BCIQDOCK10
ClinGenDOCK10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55619
Chemical/Pharm GKB GenePA134983197
Clinical trialDOCK10
Miscellaneous
canSAR (ICR)DOCK10 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDOCK10
EVEXDOCK10
GoPubMedDOCK10
iHOPDOCK10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:13:42 CEST 2017

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