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DOCK2 (dedicator of cytokinesis 2)

Identity

Alias_namesdedicator of cyto-kinesis 2
Alias_symbol (synonym)KIAA0209
Other aliasIMD40
HGNC (Hugo) DOCK2
LocusID (NCBI) 1794
Atlas_Id 46570
Location 5q35.1  [Link to chromosome band 5q35]
Location_base_pair Starts at 169637247 and ends at 170083382 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BOD1 (5q35.2) / DOCK2 (5q35.1)DOCK2 (5q35.1) / KCTD7 (7q11.21)IKZF2 (2q34) / DOCK2 (5q35.1)
KTN1 (14q22.3) / DOCK2 (5q35.1)MBD2 (18q21.2) / DOCK2 (5q35.1)NUBPL (14q12) / DOCK2 (5q35.1)
SS18 (18q11.2) / DOCK2 (5q35.1)MBD2 18q21.2 / DOCK2 5q35.1NUBPL 14q12 / DOCK2 5q35.1
SS18 18q11.2 / DOCK2 5q35.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DOCK2   2988
Cards
Entrez_Gene (NCBI)DOCK2  1794  dedicator of cytokinesis 2
AliasesIMD40
GeneCards (Weizmann)DOCK2
Ensembl hg19 (Hinxton)ENSG00000134516 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134516 [Gene_View]  chr5:169637247-170083382 [Contig_View]  DOCK2 [Vega]
ICGC DataPortalENSG00000134516
TCGA cBioPortalDOCK2
AceView (NCBI)DOCK2
Genatlas (Paris)DOCK2
WikiGenes1794
SOURCE (Princeton)DOCK2
Genetics Home Reference (NIH)DOCK2
Genomic and cartography
GoldenPath hg38 (UCSC)DOCK2  -     chr5:169637247-170083382 +  5q35.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DOCK2  -     5q35.1   [Description]    (hg19-Feb_2009)
EnsemblDOCK2 - 5q35.1 [CytoView hg19]  DOCK2 - 5q35.1 [CytoView hg38]
Mapping of homologs : NCBIDOCK2 [Mapview hg19]  DOCK2 [Mapview hg38]
OMIM603122   616433   
Gene and transcription
Genbank (Entrez)AK128107 AK128449 AK130744 BC016996 BC035613
RefSeq transcript (Entrez)NM_004946
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DOCK2
Cluster EST : UnigeneHs.586174 [ NCBI ]
CGAP (NCI)Hs.586174
Alternative Splicing GalleryENSG00000134516
Gene ExpressionDOCK2 [ NCBI-GEO ]   DOCK2 [ EBI - ARRAY_EXPRESS ]   DOCK2 [ SEEK ]   DOCK2 [ MEM ]
Gene Expression Viewer (FireBrowse)DOCK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1794
GTEX Portal (Tissue expression)DOCK2
Human Protein AtlasENSG00000134516-DOCK2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92608   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92608  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92608
Splice isoforms : SwissVarQ92608
PhosPhoSitePlusQ92608
Domaine pattern : Prosite (Expaxy)DHR_1 (PS51650)    DHR_2 (PS51651)    SH3 (PS50002)   
Domains : Interpro (EBI)ARM-type_fold    DHR-1_domain    DHR-2    DOCK    DOCK_2    DOCK_C    DOCK_N    SH3_domain   
Domain families : Pfam (Sanger)DHR-2 (PF06920)    DOCK-C2 (PF14429)    DOCK_N (PF16172)   
Domain families : Pfam (NCBI)pfam06920    pfam14429    pfam16172   
Domain families : Smart (EMBL)SH3 (SM00326)  
Conserved Domain (NCBI)DOCK2
DMDM Disease mutations1794
Blocks (Seattle)DOCK2
PDB (SRS)2RQR    2YIN    3A98    3B13   
PDB (PDBSum)2RQR    2YIN    3A98    3B13   
PDB (IMB)2RQR    2YIN    3A98    3B13   
PDB (RSDB)2RQR    2YIN    3A98    3B13   
Structural Biology KnowledgeBase2RQR    2YIN    3A98    3B13   
SCOP (Structural Classification of Proteins)2RQR    2YIN    3A98    3B13   
CATH (Classification of proteins structures)2RQR    2YIN    3A98    3B13   
SuperfamilyQ92608
Human Protein Atlas [tissue]ENSG00000134516-DOCK2 [tissue]
Peptide AtlasQ92608
HPRD09121
IPIIPI00022449   IPI00099332   IPI00442455   IPI00982650   IPI00980708   IPI00980856   IPI00973147   
Protein Interaction databases
DIP (DOE-UCLA)Q92608
IntAct (EBI)Q92608
FunCoupENSG00000134516
BioGRIDDOCK2
STRING (EMBL)DOCK2
ZODIACDOCK2
Ontologies - Pathways
QuickGOQ92608
Ontology : AmiGOmembrane raft polarization  establishment of T cell polarity  immunological synapse formation  myeloid dendritic cell activation involved in immune response  GTPase activator activity  protein binding  extracellular region  cytosol  cytoskeleton  chemotaxis  small GTPase mediated signal transduction  membrane  actin cytoskeleton organization  Rac guanyl-nucleotide exchange factor activity  specific granule lumen  T cell receptor binding  neutrophil degranulation  positive regulation of GTPase activity  macropinocytosis  positive thymic T cell selection  negative thymic T cell selection  alpha-beta T cell proliferation  regulation of defense response to virus by virus  positive regulation of phagocytosis  extracellular exosome  
Ontology : EGO-EBImembrane raft polarization  establishment of T cell polarity  immunological synapse formation  myeloid dendritic cell activation involved in immune response  GTPase activator activity  protein binding  extracellular region  cytosol  cytoskeleton  chemotaxis  small GTPase mediated signal transduction  membrane  actin cytoskeleton organization  Rac guanyl-nucleotide exchange factor activity  specific granule lumen  T cell receptor binding  neutrophil degranulation  positive regulation of GTPase activity  macropinocytosis  positive thymic T cell selection  negative thymic T cell selection  alpha-beta T cell proliferation  regulation of defense response to virus by virus  positive regulation of phagocytosis  extracellular exosome  
Pathways : KEGGChemokine signaling pathway    Fc gamma R-mediated phagocytosis   
NDEx NetworkDOCK2
Atlas of Cancer Signalling NetworkDOCK2
Wikipedia pathwaysDOCK2
Orthology - Evolution
OrthoDB1794
GeneTree (enSembl)ENSG00000134516
Phylogenetic Trees/Animal Genes : TreeFamDOCK2
HOVERGENQ92608
HOGENOMQ92608
Homologs : HomoloGeneDOCK2
Homology/Alignments : Family Browser (UCSC)DOCK2
Gene fusions - Rearrangements
Fusion : MitelmanMBD2/DOCK2 [18q21.2/5q35.1]  [t(5;18)(q35;q21)]  
Fusion : MitelmanNUBPL/DOCK2 [14q12/5q35.1]  [t(5;14)(q35;q12)]  
Fusion : MitelmanSS18/DOCK2 [18q11.2/5q35.1]  [t(5;18)(q35;q11)]  
Fusion: TCGA_MDACCMBD2 18q21.2 DOCK2 5q35.1 BRCA
Fusion: TCGA_MDACCNUBPL 14q12 DOCK2 5q35.1 OV
Fusion: TCGA_MDACCSS18 18q11.2 DOCK2 5q35.1 PRAD
Tumor Fusion PortalDOCK2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDOCK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DOCK2
dbVarDOCK2
ClinVarDOCK2
1000_GenomesDOCK2 
Exome Variant ServerDOCK2
ExAC (Exome Aggregation Consortium)ENSG00000134516
GNOMAD BrowserENSG00000134516
Genetic variants : HAPMAP1794
Genomic Variants (DGV)DOCK2 [DGVbeta]
DECIPHERDOCK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDOCK2 
Mutations
ICGC Data PortalDOCK2 
TCGA Data PortalDOCK2 
Broad Tumor PortalDOCK2
OASIS PortalDOCK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDOCK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDOCK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DOCK2
DgiDB (Drug Gene Interaction Database)DOCK2
DoCM (Curated mutations)DOCK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DOCK2 (select a term)
intoGenDOCK2
Cancer3DDOCK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603122    616433   
Orphanet23534   
DisGeNETDOCK2
MedgenDOCK2
Genetic Testing Registry DOCK2
NextProtQ92608 [Medical]
TSGene1794
GENETestsDOCK2
Target ValidationDOCK2
Huge Navigator DOCK2 [HugePedia]
snp3D : Map Gene to Disease1794
BioCentury BCIQDOCK2
ClinGenDOCK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1794
Chemical/Pharm GKB GenePA27454
Clinical trialDOCK2
Miscellaneous
canSAR (ICR)DOCK2 (select the gene name)
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDOCK2
EVEXDOCK2
GoPubMedDOCK2
iHOPDOCK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:11:00 CET 2017

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