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DOCK2 (dedicator of cytokinesis 2)

Identity

Alias (NCBI)IMD40
HGNC (Hugo) DOCK2
HGNC Alias symbKIAA0209
HGNC Previous namededicator of cyto-kinesis 2
LocusID (NCBI) 1794
Atlas_Id 46570
Location 5q35.1  [Link to chromosome band 5q35]
Location_base_pair Starts at 169637275 and ends at 170083382 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BOD1 (5q35.2) / DOCK2 (5q35.1)DOCK2 (5q35.1) / KCTD7 (7q11.21)IKZF2 (2q34) / DOCK2 (5q35.1)
KTN1 (14q22.3) / DOCK2 (5q35.1)MBD2 (18q21.2) / DOCK2 (5q35.1)NUBPL (14q12) / DOCK2 (5q35.1)
SS18 (18q11.2) / DOCK2 (5q35.1)MBD2 18q21.2 / DOCK2 5q35.1NUBPL 14q12 / DOCK2 5q35.1
SS18 18q11.2 / DOCK2 5q35.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)DOCK2   2988
Cards
Entrez_Gene (NCBI)DOCK2    dedicator of cytokinesis 2
AliasesIMD40
GeneCards (Weizmann)DOCK2
Ensembl hg19 (Hinxton)ENSG00000134516 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134516 [Gene_View]  ENSG00000134516 [Sequence]  chr5:169637275-170083382 [Contig_View]  DOCK2 [Vega]
ICGC DataPortalENSG00000134516
TCGA cBioPortalDOCK2
AceView (NCBI)DOCK2
Genatlas (Paris)DOCK2
SOURCE (Princeton)DOCK2
Genetics Home Reference (NIH)DOCK2
Genomic and cartography
GoldenPath hg38 (UCSC)DOCK2  -     chr5:169637275-170083382 +  5q35.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DOCK2  -     5q35.1   [Description]    (hg19-Feb_2009)
GoldenPathDOCK2 - 5q35.1 [CytoView hg19]  DOCK2 - 5q35.1 [CytoView hg38]
ImmunoBaseENSG00000134516
Genome Data Viewer NCBIDOCK2 [Mapview hg19]  
OMIM603122   616433   
Gene and transcription
Genbank (Entrez)AK128107 AK128449 AK130744 BC016996 BC035613
RefSeq transcript (Entrez)NM_004946
Consensus coding sequences : CCDS (NCBI)DOCK2
Gene ExpressionDOCK2 [ NCBI-GEO ]   DOCK2 [ EBI - ARRAY_EXPRESS ]   DOCK2 [ SEEK ]   DOCK2 [ MEM ]
Gene Expression Viewer (FireBrowse)DOCK2 [ Firebrowse - Broad ]
GenevisibleExpression of DOCK2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1794
GTEX Portal (Tissue expression)DOCK2
Human Protein AtlasENSG00000134516-DOCK2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92608   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92608  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92608
PhosPhoSitePlusQ92608
Domaine pattern : Prosite (Expaxy)C2_DOCK (PS51650)    DOCKER (PS51651)    SH3 (PS50002)   
Domains : Interpro (EBI)ARM-type_fold    C2_domain_sf    DHR-1_domain    DHR-2    DOCK    DOCK_2    DOCK_C    DOCK_C_lobe_A    DOCK_C_lobe_C    DOCK_N    DOCK_N_sub1    SH3-like_dom_sf    SH3_domain   
Domain families : Pfam (Sanger)DHR-2 (PF06920)    DOCK-C2 (PF14429)    DOCK_N (PF16172)    SH3_2 (PF07653)   
Domain families : Pfam (NCBI)pfam06920    pfam14429    pfam16172    pfam07653   
Domain families : Smart (EMBL)SH3 (SM00326)  
Conserved Domain (NCBI)DOCK2
PDB (RSDB)2RQR    2YIN    3A98    3B13    6TGB    6TGC   
PDB Europe2RQR    2YIN    3A98    3B13    6TGB    6TGC   
PDB (PDBSum)2RQR    2YIN    3A98    3B13    6TGB    6TGC   
PDB (IMB)2RQR    2YIN    3A98    3B13    6TGB    6TGC   
Structural Biology KnowledgeBase2RQR    2YIN    3A98    3B13    6TGB    6TGC   
SCOP (Structural Classification of Proteins)2RQR    2YIN    3A98    3B13    6TGB    6TGC   
CATH (Classification of proteins structures)2RQR    2YIN    3A98    3B13    6TGB    6TGC   
SuperfamilyQ92608
AlphaFold pdb e-kbQ92608   
Human Protein Atlas [tissue]ENSG00000134516-DOCK2 [tissue]
HPRD09121
Protein Interaction databases
DIP (DOE-UCLA)Q92608
IntAct (EBI)Q92608
BioGRIDDOCK2
STRING (EMBL)DOCK2
ZODIACDOCK2
Ontologies - Pathways
QuickGOQ92608
Ontology : AmiGOmembrane raft polarization  establishment of T cell polarity  immunological synapse formation  myeloid dendritic cell activation involved in immune response  guanyl-nucleotide exchange factor activity  protein binding  extracellular region  cytosol  cytoskeleton  chemotaxis  small GTPase mediated signal transduction  membrane  actin cytoskeleton organization  specific granule lumen  T cell receptor binding  neutrophil degranulation  macropinocytosis  positive thymic T cell selection  negative thymic T cell selection  alpha-beta T cell proliferation  regulation of defense response to virus by virus  positive regulation of phagocytosis  regulation of catalytic activity  extracellular exosome  
Ontology : EGO-EBImembrane raft polarization  establishment of T cell polarity  immunological synapse formation  myeloid dendritic cell activation involved in immune response  guanyl-nucleotide exchange factor activity  protein binding  extracellular region  cytosol  cytoskeleton  chemotaxis  small GTPase mediated signal transduction  membrane  actin cytoskeleton organization  specific granule lumen  T cell receptor binding  neutrophil degranulation  macropinocytosis  positive thymic T cell selection  negative thymic T cell selection  alpha-beta T cell proliferation  regulation of defense response to virus by virus  positive regulation of phagocytosis  regulation of catalytic activity  extracellular exosome  
Pathways : KEGGChemokine signaling pathway    Fc gamma R-mediated phagocytosis   
NDEx NetworkDOCK2
Atlas of Cancer Signalling NetworkDOCK2
Wikipedia pathwaysDOCK2
Orthology - Evolution
OrthoDB1794
GeneTree (enSembl)ENSG00000134516
Phylogenetic Trees/Animal Genes : TreeFamDOCK2
Homologs : HomoloGeneDOCK2
Homology/Alignments : Family Browser (UCSC)DOCK2
Gene fusions - Rearrangements
Fusion : MitelmanMBD2/DOCK2 [18q21.2/5q35.1]  
Fusion : MitelmanNUBPL/DOCK2 [14q12/5q35.1]  
Fusion : MitelmanSS18/DOCK2 [18q11.2/5q35.1]  
Fusion : QuiverDOCK2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDOCK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DOCK2
dbVarDOCK2
ClinVarDOCK2
MonarchDOCK2
1000_GenomesDOCK2 
Exome Variant ServerDOCK2
GNOMAD BrowserENSG00000134516
Varsome BrowserDOCK2
ACMGDOCK2 variants
VarityQ92608
Genomic Variants (DGV)DOCK2 [DGVbeta]
DECIPHERDOCK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDOCK2 
Mutations
ICGC Data PortalDOCK2 
TCGA Data PortalDOCK2 
Broad Tumor PortalDOCK2
OASIS PortalDOCK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDOCK2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDOCK2
Mutations and Diseases : HGMDDOCK2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDOCK2
DgiDB (Drug Gene Interaction Database)DOCK2
DoCM (Curated mutations)DOCK2
CIViC (Clinical Interpretations of Variants in Cancer)DOCK2
Cancer3DDOCK2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603122    616433   
Orphanet23534   
DisGeNETDOCK2
MedgenDOCK2
Genetic Testing Registry DOCK2
NextProtQ92608 [Medical]
GENETestsDOCK2
Target ValidationDOCK2
Huge Navigator DOCK2 [HugePedia]
ClinGenDOCK2
Clinical trials, drugs, therapy
MyCancerGenomeDOCK2
Protein Interactions : CTDDOCK2
Pharm GKB GenePA27454
PharosQ92608
Clinical trialDOCK2
Miscellaneous
canSAR (ICR)DOCK2
HarmonizomeDOCK2
DataMed IndexDOCK2
Probes
Litterature
PubMed92 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDOCK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:07:10 CEST 2021

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