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DOCK3 (dedicator of cytokinesis 3)

Identity

Alias_namesdedicator of cyto-kinesis 3
Alias_symbol (synonym)KIAA0299
MOCA
PBP
Other alias
HGNC (Hugo) DOCK3
LocusID (NCBI) 1795
Atlas_Id 40355
Location 3p21.2  [Link to chromosome band 3p21]
Location_base_pair Starts at 50675241 and ends at 51384198 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DOCK3 (3p21.2) / DOCK3 (3p21.2)DOCK3 (3p21.2) / SMARCC1 (3p21.31)RBM6 (3p21.31) / DOCK3 (3p21.2)
SMARCC1 (3p21.31) / DOCK3 (3p21.2)SMG1 (16p12.3) / DOCK3 (3p21.2)DOCK3 3p21.2 / SMARCC1 3p21.31
SMARCC1 3p21.31 / DOCK3 3p21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DOCK3   2989
Cards
Entrez_Gene (NCBI)DOCK3  1795  dedicator of cytokinesis 3
AliasesMOCA; PBP
GeneCards (Weizmann)DOCK3
Ensembl hg19 (Hinxton)ENSG00000088538 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000088538 [Gene_View]  chr3:50675241-51384198 [Contig_View]  DOCK3 [Vega]
ICGC DataPortalENSG00000088538
TCGA cBioPortalDOCK3
AceView (NCBI)DOCK3
Genatlas (Paris)DOCK3
WikiGenes1795
SOURCE (Princeton)DOCK3
Genetics Home Reference (NIH)DOCK3
Genomic and cartography
GoldenPath hg38 (UCSC)DOCK3  -     chr3:50675241-51384198 +  3p21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DOCK3  -     3p21.2   [Description]    (hg19-Feb_2009)
EnsemblDOCK3 - 3p21.2 [CytoView hg19]  DOCK3 - 3p21.2 [CytoView hg38]
Mapping of homologs : NCBIDOCK3 [Mapview hg19]  DOCK3 [Mapview hg38]
OMIM603123   
Gene and transcription
Genbank (Entrez)AB002297 AK310984 AY145303 AY254099 BC037933
RefSeq transcript (Entrez)NM_004947
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DOCK3
Cluster EST : UnigeneHs.476284 [ NCBI ]
CGAP (NCI)Hs.476284
Alternative Splicing GalleryENSG00000088538
Gene ExpressionDOCK3 [ NCBI-GEO ]   DOCK3 [ EBI - ARRAY_EXPRESS ]   DOCK3 [ SEEK ]   DOCK3 [ MEM ]
Gene Expression Viewer (FireBrowse)DOCK3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1795
GTEX Portal (Tissue expression)DOCK3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IZD9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IZD9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IZD9
Splice isoforms : SwissVarQ8IZD9
PhosPhoSitePlusQ8IZD9
Domaine pattern : Prosite (Expaxy)DHR_1 (PS51650)    DHR_2 (PS51651)    SH3 (PS50002)   
Domains : Interpro (EBI)ARM-type_fold    DHR-1_domain    DHR-2    DOCK    DOCK3/4    DOCK_C    DOCK_N    SH3_2    SH3_domain   
Domain families : Pfam (Sanger)DHR-2 (PF06920)    DOCK-C2 (PF14429)    DOCK_N (PF16172)    SH3_2 (PF07653)   
Domain families : Pfam (NCBI)pfam06920    pfam14429    pfam16172    pfam07653   
Domain families : Smart (EMBL)SH3 (SM00326)  
Conserved Domain (NCBI)DOCK3
DMDM Disease mutations1795
Blocks (Seattle)DOCK3
SuperfamilyQ8IZD9
Human Protein AtlasENSG00000088538
Peptide AtlasQ8IZD9
HPRD10341
IPIIPI00217985   IPI00942397   
Protein Interaction databases
DIP (DOE-UCLA)Q8IZD9
IntAct (EBI)Q8IZD9
FunCoupENSG00000088538
BioGRIDDOCK3
STRING (EMBL)DOCK3
ZODIACDOCK3
Ontologies - Pathways
QuickGOQ8IZD9
Ontology : AmiGOguanyl-nucleotide exchange factor activity  protein binding  cytosol  small GTPase mediated signal transduction  SH3 domain binding  positive regulation of GTPase activity  
Ontology : EGO-EBIguanyl-nucleotide exchange factor activity  protein binding  cytosol  small GTPase mediated signal transduction  SH3 domain binding  positive regulation of GTPase activity  
NDEx NetworkDOCK3
Atlas of Cancer Signalling NetworkDOCK3
Wikipedia pathwaysDOCK3
Orthology - Evolution
OrthoDB1795
GeneTree (enSembl)ENSG00000088538
Phylogenetic Trees/Animal Genes : TreeFamDOCK3
HOVERGENQ8IZD9
HOGENOMQ8IZD9
Homologs : HomoloGeneDOCK3
Homology/Alignments : Family Browser (UCSC)DOCK3
Gene fusions - Rearrangements
Fusion : MitelmanDOCK3/SMARCC1 [3p21.2/3p21.31]  
Fusion : MitelmanSMARCC1/DOCK3 [3p21.31/3p21.2]  [t(3;3)(p21;p21)]  
Fusion: TCGADOCK3 3p21.2 SMARCC1 3p21.31 LUAD
Fusion: TCGASMARCC1 3p21.31 DOCK3 3p21.2 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDOCK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DOCK3
dbVarDOCK3
ClinVarDOCK3
1000_GenomesDOCK3 
Exome Variant ServerDOCK3
ExAC (Exome Aggregation Consortium)DOCK3 (select the gene name)
Genetic variants : HAPMAP1795
Genomic Variants (DGV)DOCK3 [DGVbeta]
DECIPHERDOCK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDOCK3 
Mutations
ICGC Data PortalDOCK3 
TCGA Data PortalDOCK3 
Broad Tumor PortalDOCK3
OASIS PortalDOCK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDOCK3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDOCK3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DOCK3
DgiDB (Drug Gene Interaction Database)DOCK3
DoCM (Curated mutations)DOCK3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DOCK3 (select a term)
intoGenDOCK3
Cancer3DDOCK3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603123   
Orphanet
MedgenDOCK3
Genetic Testing Registry DOCK3
NextProtQ8IZD9 [Medical]
TSGene1795
GENETestsDOCK3
Target ValidationDOCK3
Huge Navigator DOCK3 [HugePedia]
snp3D : Map Gene to Disease1795
BioCentury BCIQDOCK3
ClinGenDOCK3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1795
Chemical/Pharm GKB GenePA27455
Clinical trialDOCK3
Miscellaneous
canSAR (ICR)DOCK3 (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDOCK3
EVEXDOCK3
GoPubMedDOCK3
iHOPDOCK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:31:35 CEST 2017

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