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DOCK4 (dedicator of cytokinesis 4)

Identity

Alias_symbol (synonym)FLJ34238
KIAA0716
Other alias-
HGNC (Hugo) DOCK4
LocusID (NCBI) 9732
Atlas_Id 53973
Location 7q31.1  [Link to chromosome band 7q31]
Location_base_pair Starts at 111726108 and ends at 112206407 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DGAT2 (11q13.5) / DOCK4 (7q31.1)DOCK4 (7q31.1) / IMMP2L (7q31.1)DOCK4 (7q31.1) / RUBCN (3q29)
DOCK4 7q31.1 / IMMP2L 7q31.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DOCK4   19192
Cards
Entrez_Gene (NCBI)DOCK4  9732  dedicator of cytokinesis 4
Aliases
GeneCards (Weizmann)DOCK4
Ensembl hg19 (Hinxton)ENSG00000128512 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000128512 [Gene_View]  chr7:111726108-112206407 [Contig_View]  DOCK4 [Vega]
ICGC DataPortalENSG00000128512
TCGA cBioPortalDOCK4
AceView (NCBI)DOCK4
Genatlas (Paris)DOCK4
WikiGenes9732
SOURCE (Princeton)DOCK4
Genetics Home Reference (NIH)DOCK4
Genomic and cartography
GoldenPath hg38 (UCSC)DOCK4  -     chr7:111726108-112206407 -  7q31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DOCK4  -     7q31.1   [Description]    (hg19-Feb_2009)
EnsemblDOCK4 - 7q31.1 [CytoView hg19]  DOCK4 - 7q31.1 [CytoView hg38]
Mapping of homologs : NCBIDOCK4 [Mapview hg19]  DOCK4 [Mapview hg38]
OMIM607679   
Gene and transcription
Genbank (Entrez)AB018259 AF085922 AK055497 AK091557 AK098050
RefSeq transcript (Entrez)NM_014705
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DOCK4
Cluster EST : UnigeneHs.654652 [ NCBI ]
CGAP (NCI)Hs.654652
Alternative Splicing GalleryENSG00000128512
Gene ExpressionDOCK4 [ NCBI-GEO ]   DOCK4 [ EBI - ARRAY_EXPRESS ]   DOCK4 [ SEEK ]   DOCK4 [ MEM ]
Gene Expression Viewer (FireBrowse)DOCK4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9732
GTEX Portal (Tissue expression)DOCK4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N1I0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N1I0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N1I0
Splice isoforms : SwissVarQ8N1I0
PhosPhoSitePlusQ8N1I0
Domaine pattern : Prosite (Expaxy)DHR_1 (PS51650)    DHR_2 (PS51651)    SH3 (PS50002)   
Domains : Interpro (EBI)DHR-1_domain    DHR-2    DOCK    DOCK3/4    DOCK_C    DOCK_N    SH3_2    SH3_domain   
Domain families : Pfam (Sanger)DHR-2 (PF06920)    DOCK-C2 (PF14429)    DOCK_N (PF16172)    SH3_2 (PF07653)   
Domain families : Pfam (NCBI)pfam06920    pfam14429    pfam16172    pfam07653   
Domain families : Smart (EMBL)SH3 (SM00326)  
Conserved Domain (NCBI)DOCK4
DMDM Disease mutations9732
Blocks (Seattle)DOCK4
SuperfamilyQ8N1I0
Human Protein AtlasENSG00000128512
Peptide AtlasQ8N1I0
HPRD07407
IPIIPI00297415   IPI00006024   IPI00334728   IPI00166163   IPI01012263   IPI00784294   IPI01015271   IPI00926298   IPI00926492   IPI00926823   IPI00926951   
Protein Interaction databases
DIP (DOE-UCLA)Q8N1I0
IntAct (EBI)Q8N1I0
FunCoupENSG00000128512
BioGRIDDOCK4
STRING (EMBL)DOCK4
ZODIACDOCK4
Ontologies - Pathways
QuickGOQ8N1I0
Ontology : AmiGOguanyl-nucleotide exchange factor activity  GTPase activator activity  protein binding  nucleolus  Golgi apparatus  cytosol  plasma membrane  small GTPase mediated signal transduction  membrane  SH3 domain binding  PDZ domain binding  receptor tyrosine kinase binding  stereocilium  stereocilium bundle  positive regulation of GTPase activity  Rac GTPase binding  cell chemotaxis  negative regulation of vascular smooth muscle contraction  positive regulation of vascular associated smooth muscle cell migration  
Ontology : EGO-EBIguanyl-nucleotide exchange factor activity  GTPase activator activity  protein binding  nucleolus  Golgi apparatus  cytosol  plasma membrane  small GTPase mediated signal transduction  membrane  SH3 domain binding  PDZ domain binding  receptor tyrosine kinase binding  stereocilium  stereocilium bundle  positive regulation of GTPase activity  Rac GTPase binding  cell chemotaxis  negative regulation of vascular smooth muscle contraction  positive regulation of vascular associated smooth muscle cell migration  
Pathways : KEGGRap1 signaling pathway   
NDEx NetworkDOCK4
Atlas of Cancer Signalling NetworkDOCK4
Wikipedia pathwaysDOCK4
Orthology - Evolution
OrthoDB9732
GeneTree (enSembl)ENSG00000128512
Phylogenetic Trees/Animal Genes : TreeFamDOCK4
HOVERGENQ8N1I0
HOGENOMQ8N1I0
Homologs : HomoloGeneDOCK4
Homology/Alignments : Family Browser (UCSC)DOCK4
Gene fusions - Rearrangements
Fusion : MitelmanDOCK4/IMMP2L [7q31.1/7q31.1]  
Fusion: TCGADOCK4 7q31.1 IMMP2L 7q31.1 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDOCK4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DOCK4
dbVarDOCK4
ClinVarDOCK4
1000_GenomesDOCK4 
Exome Variant ServerDOCK4
ExAC (Exome Aggregation Consortium)DOCK4 (select the gene name)
Genetic variants : HAPMAP9732
Genomic Variants (DGV)DOCK4 [DGVbeta]
DECIPHERDOCK4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDOCK4 
Mutations
ICGC Data PortalDOCK4 
TCGA Data PortalDOCK4 
Broad Tumor PortalDOCK4
OASIS PortalDOCK4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDOCK4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDOCK4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DOCK4
DgiDB (Drug Gene Interaction Database)DOCK4
DoCM (Curated mutations)DOCK4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DOCK4 (select a term)
intoGenDOCK4
Cancer3DDOCK4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607679   
Orphanet
MedgenDOCK4
Genetic Testing Registry DOCK4
NextProtQ8N1I0 [Medical]
TSGene9732
GENETestsDOCK4
Huge Navigator DOCK4 [HugePedia]
snp3D : Map Gene to Disease9732
BioCentury BCIQDOCK4
ClinGenDOCK4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9732
Chemical/Pharm GKB GenePA134939318
Clinical trialDOCK4
Miscellaneous
canSAR (ICR)DOCK4 (select the gene name)
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDOCK4
EVEXDOCK4
GoPubMedDOCK4
iHOPDOCK4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:13:42 CEST 2017

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