DOCK4 (dedicator of cytokinesis 4)

2014-06-01  

Identity

HGNC
LOCATION
7q31.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 9732
MIM: 607679
HGNC: 19192
Ensembl: ENSG00000128512

Variants:

dbSNP: 9732
ClinVar: 9732
TCGA: ENSG00000128512
COSMIC: DOCK4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128512ENST00000417165C9JDB3
ENSG00000128512ENST00000423057H0Y7H7
ENSG00000128512ENST00000428053F8WES4
ENSG00000128512ENST00000428084Q8N1I0
ENSG00000128512ENST00000437129C9J7D9
ENSG00000128512ENST00000437633Q8N1I0
ENSG00000128512ENST00000445943H0Y599
ENSG00000128512ENST00000450156C9J637
ENSG00000128512ENST00000494651F5GXW1
ENSG00000128512ENST00000658652A0A590UJ51
ENSG00000128512ENST00000664131A0A590UJM5

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231

References

Pubmed IDYearTitleCitations
193839112009Analysis of DNA copy number alterations in ovarian serous tumors identifies new molecular genetic changes in low-grade and high-grade carcinomas.77
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
194016822010High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility.52
194016822010High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility.52
203464432010Characterization of a family with rare deletions in CNTNAP5 and DOCK4 suggests novel risk loci for autism and dyslexia.52
203464432010Characterization of a family with rare deletions in CNTNAP5 and DOCK4 suggests novel risk loci for autism and dyslexia.52
170279672006Dock4 is regulated by RhoG and promotes Rac-dependent cell migration.38
195282332009Cell migration is regulated by platelet-derived growth factor receptor endocytosis.31
186416882008Molecular association between beta-catenin degradation complex and Rac guanine exchange factor DOCK4 is essential for Wnt/beta-catenin signaling.27
261298942015A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis.27

Citation

Dessen P

DOCK4 (dedicator of cytokinesis 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/53973/dock4