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DOCK6 (dedicator of cytokinesis 6)

Identity

Alias (NCBI)AOS2
ZIR1
HGNC (Hugo) DOCK6
HGNC Alias symbKIAA1395
ZIR1
LocusID (NCBI) 57572
Atlas_Id 54261
Location 19p13.2  [Link to chromosome band 19p13]
Location_base_pair Starts at 11199295 and ends at 11262524 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DOCK6 (19p13.2) / CCDC130 (19p13.2)DOCK6 (19p13.2) / DOCK6 (19p13.2)GRN (17q21.31) / DOCK6 (19p13.2)
RAVER1 (19p13.2) / DOCK6 (19p13.2)SMARCA4 (19p13.2) / DOCK6 (19p13.2)ULK2 (17p11.2) / DOCK6 (19p13.2)
DOCK6 19p13.2 / CCDC130 19p13.2RAVER1 19p13.2 / DOCK6 19p13.2SMARCA4 19p13.2 / DOCK6 19p13.2
ULK2 17p11.2 / DOCK6 19p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(19;19)(p13;p13) DOCK6/CCDC130

External links

Nomenclature
HGNC (Hugo)DOCK6   19189
Cards
Entrez_Gene (NCBI)DOCK6    dedicator of cytokinesis 6
AliasesAOS2; ZIR1
GeneCards (Weizmann)DOCK6
Ensembl hg19 (Hinxton)ENSG00000130158 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000130158 [Gene_View]  ENSG00000130158 [Sequence]  chr19:11199295-11262524 [Contig_View]  DOCK6 [Vega]
ICGC DataPortalENSG00000130158
TCGA cBioPortalDOCK6
AceView (NCBI)DOCK6
Genatlas (Paris)DOCK6
SOURCE (Princeton)DOCK6
Genetics Home Reference (NIH)DOCK6
Genomic and cartography
GoldenPath hg38 (UCSC)DOCK6  -     chr19:11199295-11262524 -  19p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DOCK6  -     19p13.2   [Description]    (hg19-Feb_2009)
GoldenPathDOCK6 - 19p13.2 [CytoView hg19]  DOCK6 - 19p13.2 [CytoView hg38]
ImmunoBaseENSG00000130158
genome Data Viewer NCBIDOCK6 [Mapview hg19]  
OMIM614194   614219   
Gene and transcription
Genbank (Entrez)AB037816 AK022412 AK295664 AK316063 AY927545
RefSeq transcript (Entrez)NM_001367830 NM_020812
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DOCK6
Alternative Splicing GalleryENSG00000130158
Gene ExpressionDOCK6 [ NCBI-GEO ]   DOCK6 [ EBI - ARRAY_EXPRESS ]   DOCK6 [ SEEK ]   DOCK6 [ MEM ]
Gene Expression Viewer (FireBrowse)DOCK6 [ Firebrowse - Broad ]
GenevisibleExpression of DOCK6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57572
GTEX Portal (Tissue expression)DOCK6
Human Protein AtlasENSG00000130158-DOCK6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96HP0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96HP0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96HP0
Splice isoforms : SwissVarQ96HP0
PhosPhoSitePlusQ96HP0
Domaine pattern : Prosite (Expaxy)C2_DOCK (PS51650)    DOCKER (PS51651)   
Domains : Interpro (EBI)C2_Dock-C    C2_domain_sf    DHR-1_domain    DHR-2    DOCK    DOCK_C    DOCK_C/D_N    DOCK_C_lobe_A    DOCK_C_lobe_C   
Domain families : Pfam (Sanger)DHR-2 (PF06920)    DOCK-C2 (PF14429)    DUF3398 (PF11878)   
Domain families : Pfam (NCBI)pfam06920    pfam14429    pfam11878   
Conserved Domain (NCBI)DOCK6
Blocks (Seattle)DOCK6
SuperfamilyQ96HP0
Human Protein Atlas [tissue]ENSG00000130158-DOCK6 [tissue]
Peptide AtlasQ96HP0
HPRD13243
IPIIPI00940115   IPI00184772   
Protein Interaction databases
DIP (DOE-UCLA)Q96HP0
IntAct (EBI)Q96HP0
BioGRIDDOCK6
STRING (EMBL)DOCK6
ZODIACDOCK6
Ontologies - Pathways
QuickGOQ96HP0
Ontology : AmiGOguanyl-nucleotide exchange factor activity  protein binding  cytosol  cytosol  small GTPase mediated signal transduction  blood coagulation  perinuclear region of cytoplasm  regulation of catalytic activity  
Ontology : EGO-EBIguanyl-nucleotide exchange factor activity  protein binding  cytosol  cytosol  small GTPase mediated signal transduction  blood coagulation  perinuclear region of cytoplasm  regulation of catalytic activity  
NDEx NetworkDOCK6
Atlas of Cancer Signalling NetworkDOCK6
Wikipedia pathwaysDOCK6
Orthology - Evolution
OrthoDB57572
GeneTree (enSembl)ENSG00000130158
Phylogenetic Trees/Animal Genes : TreeFamDOCK6
HOGENOMQ96HP0
Homologs : HomoloGeneDOCK6
Homology/Alignments : Family Browser (UCSC)DOCK6
Gene fusions - Rearrangements
Fusion : MitelmanDOCK6/CCDC130 [19p13.2/19p13.2]  
Fusion : MitelmanRAVER1/DOCK6 [19p13.2/19p13.2]  
Fusion : MitelmanSMARCA4/DOCK6 [19p13.2/19p13.2]  
Fusion : MitelmanULK2/DOCK6 [17p11.2/19p13.2]  
Fusion PortalDOCK6 19p13.2 CCDC130 19p13.2 LAML
Fusion PortalRAVER1 19p13.2 DOCK6 19p13.2 GBM
Fusion PortalSMARCA4 19p13.2 DOCK6 19p13.2 LUAD
Fusion PortalULK2 17p11.2 DOCK6 19p13.2 BRCA
Fusion : QuiverDOCK6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDOCK6 [hg38]
dbVarDOCK6
ClinVarDOCK6
MonarchDOCK6
1000_GenomesDOCK6 
Exome Variant ServerDOCK6
GNOMAD BrowserENSG00000130158
Varsome BrowserDOCK6
Genomic Variants (DGV)DOCK6 [DGVbeta]
DECIPHERDOCK6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDOCK6 
Mutations
ICGC Data PortalDOCK6 
TCGA Data PortalDOCK6 
Broad Tumor PortalDOCK6
OASIS PortalDOCK6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDOCK6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDOCK6
Mutations and Diseases : HGMDDOCK6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DOCK6
DgiDB (Drug Gene Interaction Database)DOCK6
DoCM (Curated mutations)DOCK6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DOCK6 (select a term)
intoGenDOCK6
Cancer3DDOCK6(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614194    614219   
Orphanet1294   
DisGeNETDOCK6
MedgenDOCK6
Genetic Testing Registry DOCK6
NextProtQ96HP0 [Medical]
GENETestsDOCK6
Target ValidationDOCK6
Huge Navigator DOCK6 [HugePedia]
ClinGenDOCK6
Clinical trials, drugs, therapy
MyCancerGenomeDOCK6
Protein Interactions : CTD
Pharm GKB GenePA134913824
PharosQ96HP0
Clinical trialDOCK6
Miscellaneous
canSAR (ICR)DOCK6 (select the gene name)
HarmonizomeDOCK6
DataMed IndexDOCK6
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDOCK6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 25 19:18:56 CET 2021
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