DOCK7 (dedicator of cytokinesis 7)

2014-11-01 Affiliation

Identity

HGNC

DOCK7

LOCATION

1p31.3

LOCUSID

85440

ALIAS

DEE23,EIEE23,ZIR2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 85440
MIM: 615730
HGNC: 19190
Ensembl: ENSG00000116641

Variants:

dbSNP: 85440
ClinVar: 85440
TCGA: ENSG00000116641
COSMIC: DOCK7

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000116641	ENST00000251157	Q96N67
ENSG00000116641	ENST00000340370	Q96N67
ENSG00000116641	ENST00000404627	Q96N67
ENSG00000116641	ENST00000454575	Q96N67
ENSG00000116641	ENST00000464312	A0A0U1RQT6
ENSG00000116641	ENST00000614472	A0A0C4DGY6
ENSG00000116641	ENST00000634223	A0A0U1RQG7
ENSG00000116641	ENST00000634264	Q96N67
ENSG00000116641	ENST00000634652	A0A0U1RRC1
ENSG00000116641	ENST00000634929	A0A0U1RQJ5
ENSG00000116641	ENST00000635088	A0A0U1RR97
ENSG00000116641	ENST00000635123	Q96N67
ENSG00000116641	ENST00000635253	Q96N67
ENSG00000116641	ENST00000635827	A0A1B0GVW2
ENSG00000116641	ENST00000637208	A0A1B0GUE9
ENSG00000116641	ENST00000637255	A0A1B0GWE0

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Hemostasis	REACTOME	R-HSA-109582
Factors involved in megakaryocyte development and platelet production	REACTOME	R-HSA-983231
Signal Transduction	REACTOME	R-HSA-162582
Signaling by MET	REACTOME	R-HSA-6806834
MET promotes cell motility	REACTOME	R-HSA-8875878
MET activates RAP1 and RAC1	REACTOME	R-HSA-8875555

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
19240061	2009	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.	75
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
18426980	2008	ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration.	47
20972250	2011	Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population.	20
23718289	2013	Prenylation and membrane localization of Cdc42 are essential for activation by DOCK7.	16
26744084	2016	Association between the DOCK7, PCSK9 and GALNT2 Gene Polymorphisms and Serum Lipid levels.	13
24814191	2014	Mutations in DOCK7 in individuals with epileptic encephalopathy and cortical blindness.	12
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	11
24518591	2014	Guanine nucleotide exchange factor Dock7 mediates HGF-induced glioblastoma cell invasion via Rac activation.	11

Citation

Dessen P

DOCK7 (dedicator of cytokinesis 7)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62591/dock7