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DOCK8 (dedicator of cytokinesis 8)

Identity

Alias_symbol (synonym)FLJ00026
FLJ00152
ZIR8
FLJ00346
HGNC (Hugo) DOCK8
LocusID (NCBI) 81704
Atlas_Id 51268
Location 9p24.3  [Link to chromosome band 9p24]
Location_base_pair Starts at 273048 and ends at 465259 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AK3 (9p24.1) / DOCK8 (9p24.3)CTNND1 (11q12.1) / DOCK8 (9p24.3)DOCK8 (9p24.3) / CBWD1 (9p24.3)
DOCK8 (9p24.3) / DOCK8 (9p24.3)DOCK8 (9p24.3) / EDA (Xq13.1)DOCK8 (9p24.3) / JAK2 (9p24.1)
DOCK8 (9p24.3) / OSBP (11q12.1)EDA (Xq13.1) / DOCK8 (9p24.3)KANK1 (9p24.3) / DOCK8 (9p24.3)
SLC20A2 (8p11.21) / DOCK8 (9p24.3)AK3 9p24.1 / DOCK8 9p24.3CTNND1 11q12.1 / DOCK8 9p24.3
DOCK8 9p24.3 / JAK2 9p24.1DOCK8 9p24.3 / OSBP 11q12.1KANK1 9p24.3 / DOCK8 9p24.3
SLC20A2 8p11.21 / DOCK8 9p24.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)DOCK8   19191
LRG (Locus Reference Genomic)LRG_196
Cards
Entrez_Gene (NCBI)DOCK8  81704  dedicator of cytokinesis 8
AliasesHEL-205; MRD2; ZIR8
GeneCards (Weizmann)DOCK8
Ensembl hg19 (Hinxton)ENSG00000107099 [Gene_View]  chr9:273048-465259 [Contig_View]  DOCK8 [Vega]
Ensembl hg38 (Hinxton)ENSG00000107099 [Gene_View]  chr9:273048-465259 [Contig_View]  DOCK8 [Vega]
ICGC DataPortalENSG00000107099
TCGA cBioPortalDOCK8
AceView (NCBI)DOCK8
Genatlas (Paris)DOCK8
WikiGenes81704
SOURCE (Princeton)DOCK8
Genetics Home Reference (NIH)DOCK8
Genomic and cartography
GoldenPath hg19 (UCSC)DOCK8  -     chr9:273048-465259 +  9p24.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DOCK8  -     9p24.3   [Description]    (hg38-Dec_2013)
EnsemblDOCK8 - 9p24.3 [CytoView hg19]  DOCK8 - 9p24.3 [CytoView hg38]
Mapping of homologs : NCBIDOCK8 [Mapview hg19]  DOCK8 [Mapview hg38]
OMIM243700   611432   614113   
Gene and transcription
Genbank (Entrez)AB191037 AF194407 AK024436 AK074081 AK090429
RefSeq transcript (Entrez)NM_001190458 NM_001193536 NM_203447
RefSeq genomic (Entrez)NC_000009 NC_018920 NG_017007 NT_008413 NW_004929342
Consensus coding sequences : CCDS (NCBI)DOCK8
Cluster EST : UnigeneHs.132599 [ NCBI ]
CGAP (NCI)Hs.132599
Alternative Splicing GalleryENSG00000107099
Gene ExpressionDOCK8 [ NCBI-GEO ]   DOCK8 [ EBI - ARRAY_EXPRESS ]   DOCK8 [ SEEK ]   DOCK8 [ MEM ]
Gene Expression Viewer (FireBrowse)DOCK8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)81704
GTEX Portal (Tissue expression)DOCK8
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NF50   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NF50  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NF50
Splice isoforms : SwissVarQ8NF50
PhosPhoSitePlusQ8NF50
Domaine pattern : Prosite (Expaxy)DHR_1 (PS51650)    DHR_2 (PS51651)   
Domains : Interpro (EBI)ARM-type_fold    DHR-1_domain    DHR-2    DOCK    DOCK_C    DOCK_C/D_N   
Domain families : Pfam (Sanger)DHR-2 (PF06920)    DOCK-C2 (PF14429)    DUF3398 (PF11878)   
Domain families : Pfam (NCBI)pfam06920    pfam14429    pfam11878   
Conserved Domain (NCBI)DOCK8
DMDM Disease mutations81704
Blocks (Seattle)DOCK8
SuperfamilyQ8NF50
Human Protein AtlasENSG00000107099
Peptide AtlasQ8NF50
HPRD10920
IPIIPI00797373   IPI00856108   IPI00942335   IPI01025533   IPI00657658   IPI00945909   IPI00946711   IPI00973254   IPI00946073   IPI00945728   IPI00977252   
Protein Interaction databases
DIP (DOE-UCLA)Q8NF50
IntAct (EBI)Q8NF50
FunCoupENSG00000107099
BioGRIDDOCK8
STRING (EMBL)DOCK8
ZODIACDOCK8
Ontologies - Pathways
QuickGOQ8NF50
Ontology : AmiGOimmunological synapse formation  guanyl-nucleotide exchange factor activity  protein binding  cytosol  small GTPase mediated signal transduction  blood coagulation  membrane  cell leading edge  dendritic cell migration  positive regulation of GTPase activity  memory T cell proliferation  negative regulation of T cell apoptotic process  
Ontology : EGO-EBIimmunological synapse formation  guanyl-nucleotide exchange factor activity  protein binding  cytosol  small GTPase mediated signal transduction  blood coagulation  membrane  cell leading edge  dendritic cell migration  positive regulation of GTPase activity  memory T cell proliferation  negative regulation of T cell apoptotic process  
NDEx NetworkDOCK8
Atlas of Cancer Signalling NetworkDOCK8
Wikipedia pathwaysDOCK8
Orthology - Evolution
OrthoDB81704
GeneTree (enSembl)ENSG00000107099
Phylogenetic Trees/Animal Genes : TreeFamDOCK8
HOVERGENQ8NF50
HOGENOMQ8NF50
Homologs : HomoloGeneDOCK8
Homology/Alignments : Family Browser (UCSC)DOCK8
Gene fusions - Rearrangements
Fusion : MitelmanAK3/DOCK8 [9p24.1/9p24.3]  [t(9;9)(p24;p24)]  
Fusion : MitelmanCTNND1/DOCK8 [11q12.1/9p24.3]  [t(9;11)(p24;q12)]  
Fusion : MitelmanDOCK8/JAK2 [9p24.3/9p24.1]  [t(9;9)(p24;p24)]  
Fusion : MitelmanDOCK8/OSBP [9p24.3/11q12.1]  [t(9;11)(p24;q12)]  
Fusion : MitelmanKANK1/DOCK8 [9p24.3/9p24.3]  [t(9;9)(p24;p24)]  
Fusion : MitelmanSLC20A2/DOCK8 [8p11.21/9p24.3]  [t(8;9)(p11;p24)]  
Fusion: TCGAAK3 9p24.1 DOCK8 9p24.3 KIRC
Fusion: TCGACTNND1 11q12.1 DOCK8 9p24.3 LUAD
Fusion: TCGADOCK8 9p24.3 JAK2 9p24.1 KIRC
Fusion: TCGADOCK8 9p24.3 OSBP 11q12.1 LUAD
Fusion: TCGAKANK1 9p24.3 DOCK8 9p24.3 BRCA LUAD
Fusion: TCGASLC20A2 8p11.21 DOCK8 9p24.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDOCK8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DOCK8
dbVarDOCK8
ClinVarDOCK8
1000_GenomesDOCK8 
Exome Variant ServerDOCK8
ExAC (Exome Aggregation Consortium)DOCK8 (select the gene name)
Genetic variants : HAPMAP81704
Genomic Variants (DGV)DOCK8 [DGVbeta]
DECIPHER (Syndromes)9:273048-465259  ENSG00000107099
CONAN: Copy Number AnalysisDOCK8 
Mutations
ICGC Data PortalDOCK8 
TCGA Data PortalDOCK8 
Broad Tumor PortalDOCK8
OASIS PortalDOCK8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDOCK8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDOCK8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
LOVD (Leiden Open Variation Database)LOVD at NCBI
BioMutasearch DOCK8
DgiDB (Drug Gene Interaction Database)DOCK8
DoCM (Curated mutations)DOCK8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DOCK8 (select a term)
intoGenDOCK8
Cancer3DDOCK8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM243700    611432    614113   
Orphanet18028    18853   
MedgenDOCK8
Genetic Testing Registry DOCK8
NextProtQ8NF50 [Medical]
TSGene81704
GENETestsDOCK8
Huge Navigator DOCK8 [HugePedia]
snp3D : Map Gene to Disease81704
BioCentury BCIQDOCK8
ClinGenDOCK8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD81704
Chemical/Pharm GKB GenePA134918866
Clinical trialDOCK8
Miscellaneous
canSAR (ICR)DOCK8 (select the gene name)
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDOCK8
EVEXDOCK8
GoPubMedDOCK8
iHOPDOCK8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:36:02 CET 2016

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