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DOCK8 (dedicator of cytokinesis 8)

Identity

Other namesHEL-205
MRD2
ZIR8
HGNC (Hugo) DOCK8
LocusID (NCBI) 81704
Atlas_Id 51268
Location 9p24.3
Location_base_pair Starts at 273048 and ends at 465259 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas)

Solid Tumors AmeloblastomID5945

External links

Nomenclature
HGNC (Hugo)DOCK8   19191
Cards
Entrez_Gene (NCBI)DOCK8  81704  dedicator of cytokinesis 8
GeneCards (Weizmann)DOCK8
Ensembl hg19 (Hinxton)ENSG00000107099 [Gene_View]  chr9:273048-465259 [Contig_View]  DOCK8 [Vega]
Ensembl hg38 (Hinxton)ENSG00000107099 [Gene_View]  chr9:273048-465259 [Contig_View]  DOCK8 [Vega]
ICGC DataPortalENSG00000107099
TCGA cBioPortalDOCK8
AceView (NCBI)DOCK8
Genatlas (Paris)DOCK8
WikiGenes81704
SOURCE (Princeton)DOCK8
Genomic and cartography
GoldenPath hg19 (UCSC)DOCK8  -     chr9:273048-465259 +  9p24.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DOCK8  -     9p24.3   [Description]    (hg38-Dec_2013)
EnsemblDOCK8 - 9p24.3 [CytoView hg19]  DOCK8 - 9p24.3 [CytoView hg38]
Mapping of homologs : NCBIDOCK8 [Mapview hg19]  DOCK8 [Mapview hg38]
OMIM243700   611432   614113   
Gene and transcription
Genbank (Entrez)AB191037 AF194407 AK024436 AK074081 AK090429
RefSeq transcript (Entrez)NM_001190458 NM_001193536 NM_203447
RefSeq genomic (Entrez)NC_000009 NC_018920 NG_017007 NT_008413 NW_004929342
Consensus coding sequences : CCDS (NCBI)DOCK8
Cluster EST : UnigeneHs.132599 [ NCBI ]
CGAP (NCI)Hs.132599
Alternative Splicing : Fast-db (Paris)GSHG0029976
Alternative Splicing GalleryENSG00000107099
Gene ExpressionDOCK8 [ NCBI-GEO ]     DOCK8 [ SEEK ]   DOCK8 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NF50 (Uniprot)
NextProtQ8NF50  [Medical]
With graphics : InterProQ8NF50
Splice isoforms : SwissVarQ8NF50 (Swissvar)
Domaine pattern : Prosite (Expaxy)DHR_1 (PS51650)    DHR_2 (PS51651)   
Domains : Interpro (EBI)ARM-type_fold    DHR-1_domain    DHR-2    DOCK    DOCK_C    DOCK_C/D_N   
Related proteins : CluSTrQ8NF50
Domain families : Pfam (Sanger)Ded_cyto (PF06920)    DOCK-C2 (PF14429)    DUF3398 (PF11878)   
Domain families : Pfam (NCBI)pfam06920    pfam14429    pfam11878   
DMDM Disease mutations81704
Blocks (Seattle)Q8NF50
Human Protein AtlasENSG00000107099
Peptide AtlasQ8NF50
HPRD10920
IPIIPI00797373   IPI00856108   IPI00942335   IPI01025533   IPI00657658   IPI00945909   IPI00946711   IPI00973254   IPI00946073   IPI00945728   IPI00977252   
Protein Interaction databases
DIP (DOE-UCLA)Q8NF50
IntAct (EBI)Q8NF50
FunCoupENSG00000107099
BioGRIDDOCK8
IntegromeDBDOCK8
STRING (EMBL)DOCK8
Ontologies - Pathways
QuickGOQ8NF50
Ontology : AmiGOimmunological synapse formation  guanyl-nucleotide exchange factor activity  protein binding  cytosol  small GTPase mediated signal transduction  blood coagulation  membrane  cell leading edge  dendritic cell migration  positive regulation of GTPase activity  memory T cell proliferation  negative regulation of T cell apoptotic process  
Ontology : EGO-EBIimmunological synapse formation  guanyl-nucleotide exchange factor activity  protein binding  cytosol  small GTPase mediated signal transduction  blood coagulation  membrane  cell leading edge  dendritic cell migration  positive regulation of GTPase activity  memory T cell proliferation  negative regulation of T cell apoptotic process  
Protein Interaction DatabaseDOCK8
DoCM (Curated mutations)DOCK8
Wikipedia pathwaysDOCK8
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerDOCK8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DOCK8
dbVarDOCK8
ClinVarDOCK8
1000_GenomesDOCK8 
Exome Variant ServerDOCK8
SNP (GeneSNP Utah)DOCK8
SNP : HGBaseDOCK8
Genetic variants : HAPMAPDOCK8
Genomic Variants (DGV)DOCK8 [DGVbeta]
Mutations
ICGC Data PortalDOCK8 
TCGA Data PortalDOCK8 
Tumor PortalDOCK8
Somatic Mutations in Cancer : COSMICDOCK8 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
LOVD (Leiden Open Variation Database)LOVD at NCBI
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)9:273048-465259
CONAN: Copy Number AnalysisDOCK8 
Mutations and Diseases : HGMDDOCK8
OMIM243700    611432    614113   
MedgenDOCK8
NextProtQ8NF50 [Medical]
GENETestsDOCK8
Disease Genetic AssociationDOCK8
Huge Navigator DOCK8 [HugePedia]  DOCK8 [HugeCancerGEM]
snp3D : Map Gene to Disease81704
DGIdb (Drug Gene Interaction db)DOCK8
General knowledge
Homologs : HomoloGeneDOCK8
Homology/Alignments : Family Browser (UCSC)DOCK8
Phylogenetic Trees/Animal Genes : TreeFamDOCK8
Chemical/Protein Interactions : CTD81704
Chemical/Pharm GKB GenePA134918866
Clinical trialDOCK8
Cancer Resource (Charite)ENSG00000107099
Other databases
Probes
Litterature
PubMed51 Pubmed reference(s) in Entrez
CoreMineDOCK8
GoPubMedDOCK8
iHOPDOCK8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Apr 13 14:20:35 CEST 2015

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