Atlas of Genetics and Cytogenetics in Oncology and Haematology

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DOK1 (docking protein 1)

Identity

Alias_namesdocking protein 1, 62kD (downstream of tyrosine kinase 1)
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
Alias_symbol (synonym)p62dok
Other aliasP62DOK
pp62
HGNC (Hugo) DOK1
LocusID (NCBI) 1796
Atlas_Id 40356
Location 2p13.1  [Link to chromosome band 2p13]
Location_base_pair Starts at 74554160 and ends at 74557551 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DOK1   2990
Cards
Entrez_Gene (NCBI)DOK1  1796  docking protein 1
AliasesP62DOK; pp62
GeneCards (Weizmann)DOK1
Ensembl hg19 (Hinxton)ENSG00000115325 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115325 [Gene_View]  ENSG00000115325 [Sequence]  chr2:74554160-74557551 [Contig_View]  DOK1 [Vega]
ICGC DataPortalENSG00000115325
TCGA cBioPortalDOK1
AceView (NCBI)DOK1
Genatlas (Paris)DOK1
WikiGenes1796
SOURCE (Princeton)DOK1
Genetics Home Reference (NIH)DOK1
Genomic and cartography
GoldenPath hg38 (UCSC)DOK1  -     chr2:74554160-74557551 +  2p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DOK1  -     2p13.1   [Description]    (hg19-Feb_2009)
GoldenPathDOK1 - 2p13.1 [CytoView hg19]  DOK1 - 2p13.1 [CytoView hg38]
ImmunoBaseENSG00000115325
Mapping of homologs : NCBIDOK1 [Mapview hg19]  DOK1 [Mapview hg38]
OMIM602919   
Gene and transcription
Genbank (Entrez)AF035299 AF180527 AK055944 AK127127 AK127656
RefSeq transcript (Entrez)NM_001197260 NM_001318866 NM_001318867 NM_001318868 NM_001318869 NM_001381
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DOK1
Cluster EST : UnigeneHs.103854 [ NCBI ]
CGAP (NCI)Hs.103854
Alternative Splicing GalleryENSG00000115325
Gene ExpressionDOK1 [ NCBI-GEO ]   DOK1 [ EBI - ARRAY_EXPRESS ]   DOK1 [ SEEK ]   DOK1 [ MEM ]
Gene Expression Viewer (FireBrowse)DOK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1796
GTEX Portal (Tissue expression)DOK1
Human Protein AtlasENSG00000115325-DOK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99704   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99704  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99704
Splice isoforms : SwissVarQ99704
PhosPhoSitePlusQ99704
Domaine pattern : Prosite (Expaxy)IRS_PTB (PS51064)   
Domains : Interpro (EBI)Dok1/2/3_PTB    IRS_PTB    PH-like_dom_sf    PH_domain   
Domain families : Pfam (Sanger)IRS (PF02174)    PH (PF00169)   
Domain families : Pfam (NCBI)pfam02174    pfam00169   
Domain families : Smart (EMBL)PH (SM00233)  PTBI (SM00310)  
Conserved Domain (NCBI)DOK1
DMDM Disease mutations1796
Blocks (Seattle)DOK1
PDB (RSDB)2V76   
PDB Europe2V76   
PDB (PDBSum)2V76   
PDB (IMB)2V76   
Structural Biology KnowledgeBase2V76   
SCOP (Structural Classification of Proteins)2V76   
CATH (Classification of proteins structures)2V76   
SuperfamilyQ99704
Human Protein Atlas [tissue]ENSG00000115325-DOK1 [tissue]
Peptide AtlasQ99704
HPRD04228
IPIIPI00015287   IPI00218542   IPI00917613   IPI00917764   
Protein Interaction databases
DIP (DOE-UCLA)Q99704
IntAct (EBI)Q99704
FunCoupENSG00000115325
BioGRIDDOK1
STRING (EMBL)DOK1
ZODIACDOK1
Ontologies - Pathways
QuickGOQ99704
Ontology : AmiGOprotein binding  nucleus  cytosol  cytosol  signal transduction  cell surface receptor signaling pathway  transmembrane receptor protein tyrosine kinase signaling pathway  Ras protein signal transduction  axon guidance  macrophage colony-stimulating factor signaling pathway  positive regulation of epidermal growth factor receptor signaling pathway  perinuclear region of cytoplasm  
Ontology : EGO-EBIprotein binding  nucleus  cytosol  cytosol  signal transduction  cell surface receptor signaling pathway  transmembrane receptor protein tyrosine kinase signaling pathway  Ras protein signal transduction  axon guidance  macrophage colony-stimulating factor signaling pathway  positive regulation of epidermal growth factor receptor signaling pathway  perinuclear region of cytoplasm  
Pathways : KEGGMeasles   
NDEx NetworkDOK1
Atlas of Cancer Signalling NetworkDOK1
Wikipedia pathwaysDOK1
Orthology - Evolution
OrthoDB1796
GeneTree (enSembl)ENSG00000115325
Phylogenetic Trees/Animal Genes : TreeFamDOK1
HOGENOMQ99704
Homologs : HomoloGeneDOK1
Homology/Alignments : Family Browser (UCSC)DOK1
Gene fusions - Rearrangements
Fusion : QuiverDOK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDOK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DOK1
dbVarDOK1
ClinVarDOK1
1000_GenomesDOK1 
Exome Variant ServerDOK1
ExAC (Exome Aggregation Consortium)ENSG00000115325
GNOMAD BrowserENSG00000115325
Varsome BrowserDOK1
Genetic variants : HAPMAP1796
Genomic Variants (DGV)DOK1 [DGVbeta]
DECIPHERDOK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDOK1 
Mutations
ICGC Data PortalDOK1 
TCGA Data PortalDOK1 
Broad Tumor PortalDOK1
OASIS PortalDOK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDOK1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDOK1
Mutations and Diseases : HGMDDOK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DOK1
DgiDB (Drug Gene Interaction Database)DOK1
DoCM (Curated mutations)DOK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DOK1 (select a term)
intoGenDOK1
Cancer3DDOK1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602919   
Orphanet
DisGeNETDOK1
MedgenDOK1
Genetic Testing Registry DOK1
NextProtQ99704 [Medical]
TSGene1796
GENETestsDOK1
Target ValidationDOK1
Huge Navigator DOK1 [HugePedia]
snp3D : Map Gene to Disease1796
BioCentury BCIQDOK1
ClinGenDOK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1796
Chemical/Pharm GKB GenePA27456
Clinical trialDOK1
Miscellaneous
canSAR (ICR)DOK1 (select the gene name)
DataMed IndexDOK1
Probes
Litterature
PubMed94 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDOK1
EVEXDOK1
GoPubMedDOK1
iHOPDOK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 12 15:31:58 CEST 2019
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