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DOK2 (docking protein 2)

Identity

Alias (NCBI)p56DOK
p56dok-2
HGNC (Hugo) DOK2
HGNC Alias symbp56dok-2
Dok-2
HGNC Alias namedownstream of tyrosine kinase 2
HGNC Previous namedocking protein 2, 56kD
 docking protein 2, 56kDa
LocusID (NCBI) 9046
Atlas_Id 40357
Location 8p21.3  [Link to chromosome band 8p21]
Location_base_pair Starts at 21908873 and ends at 21913690 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DOK2 (8p21.3) / DOK2 (8p21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)DOK2   2991
Cards
Entrez_Gene (NCBI)DOK2    docking protein 2
Aliasesp56DOK; p56dok-2
GeneCards (Weizmann)DOK2
Ensembl hg19 (Hinxton)ENSG00000147443 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000147443 [Gene_View]  ENSG00000147443 [Sequence]  chr8:21908873-21913690 [Contig_View]  DOK2 [Vega]
ICGC DataPortalENSG00000147443
TCGA cBioPortalDOK2
AceView (NCBI)DOK2
Genatlas (Paris)DOK2
SOURCE (Princeton)DOK2
Genetics Home Reference (NIH)DOK2
Genomic and cartography
GoldenPath hg38 (UCSC)DOK2  -     chr8:21908873-21913690 -  8p21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DOK2  -     8p21.3   [Description]    (hg19-Feb_2009)
GoldenPathDOK2 - 8p21.3 [CytoView hg19]  DOK2 - 8p21.3 [CytoView hg38]
ImmunoBaseENSG00000147443
genome Data Viewer NCBIDOK2 [Mapview hg19]  
OMIM604997   
Gene and transcription
Genbank (Entrez)AF034970 AK226110 AK292126 AK296671 AL545478
RefSeq transcript (Entrez)NM_001317800 NM_003974 NM_201349
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DOK2
Alternative Splicing GalleryENSG00000147443
Gene ExpressionDOK2 [ NCBI-GEO ]   DOK2 [ EBI - ARRAY_EXPRESS ]   DOK2 [ SEEK ]   DOK2 [ MEM ]
Gene Expression Viewer (FireBrowse)DOK2 [ Firebrowse - Broad ]
GenevisibleExpression of DOK2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9046
GTEX Portal (Tissue expression)DOK2
Human Protein AtlasENSG00000147443-DOK2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60496   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60496  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60496
Splice isoforms : SwissVarO60496
PhosPhoSitePlusO60496
Domaine pattern : Prosite (Expaxy)IRS_PTB (PS51064)    PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)Dok1/2/3_PTB    IRS_PTB    PH-like_dom_sf    PH_domain   
Domain families : Pfam (Sanger)IRS (PF02174)   
Domain families : Pfam (NCBI)pfam02174   
Domain families : Smart (EMBL)PH (SM00233)  PTBI (SM00310)  
Conserved Domain (NCBI)DOK2
Blocks (Seattle)DOK2
PDB (RSDB)2D9W    2DLW   
PDB Europe2D9W    2DLW   
PDB (PDBSum)2D9W    2DLW   
PDB (IMB)2D9W    2DLW   
Structural Biology KnowledgeBase2D9W    2DLW   
SCOP (Structural Classification of Proteins)2D9W    2DLW   
CATH (Classification of proteins structures)2D9W    2DLW   
SuperfamilyO60496
Human Protein Atlas [tissue]ENSG00000147443-DOK2 [tissue]
Peptide AtlasO60496
HPRD05411
IPIIPI00022602   IPI00398771   IPI00984547   IPI00974434   
Protein Interaction databases
DIP (DOE-UCLA)O60496
IntAct (EBI)O60496
BioGRIDDOK2
STRING (EMBL)DOK2
ZODIACDOK2
Ontologies - Pathways
QuickGOO60496
Ontology : AmiGOtransmembrane receptor protein tyrosine kinase adaptor activity  protein binding  cytosol  signal transduction  cell surface receptor signaling pathway  transmembrane receptor protein tyrosine kinase signaling pathway  Ras protein signal transduction  axon guidance  viral process  leukocyte migration  
Ontology : EGO-EBItransmembrane receptor protein tyrosine kinase adaptor activity  protein binding  cytosol  signal transduction  cell surface receptor signaling pathway  transmembrane receptor protein tyrosine kinase signaling pathway  Ras protein signal transduction  axon guidance  viral process  leukocyte migration  
NDEx NetworkDOK2
Atlas of Cancer Signalling NetworkDOK2
Wikipedia pathwaysDOK2
Orthology - Evolution
OrthoDB9046
GeneTree (enSembl)ENSG00000147443
Phylogenetic Trees/Animal Genes : TreeFamDOK2
HOGENOMO60496
Homologs : HomoloGeneDOK2
Homology/Alignments : Family Browser (UCSC)DOK2
Gene fusions - Rearrangements
Fusion : QuiverDOK2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDOK2 [hg38]
dbVarDOK2
ClinVarDOK2
MonarchDOK2
1000_GenomesDOK2 
Exome Variant ServerDOK2
GNOMAD BrowserENSG00000147443
Varsome BrowserDOK2
Genomic Variants (DGV)DOK2 [DGVbeta]
DECIPHERDOK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDOK2 
Mutations
ICGC Data PortalDOK2 
TCGA Data PortalDOK2 
Broad Tumor PortalDOK2
OASIS PortalDOK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDOK2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDOK2
Mutations and Diseases : HGMDDOK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DOK2
DgiDB (Drug Gene Interaction Database)DOK2
DoCM (Curated mutations)DOK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DOK2 (select a term)
intoGenDOK2
Cancer3DDOK2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604997   
Orphanet
DisGeNETDOK2
MedgenDOK2
Genetic Testing Registry DOK2
NextProtO60496 [Medical]
GENETestsDOK2
Target ValidationDOK2
Huge Navigator DOK2 [HugePedia]
ClinGenDOK2
Clinical trials, drugs, therapy
MyCancerGenomeDOK2
Protein Interactions : CTD
Pharm GKB GenePA27457
PharosO60496
Clinical trialDOK2
Miscellaneous
canSAR (ICR)DOK2 (select the gene name)
HarmonizomeDOK2
DataMed IndexDOK2
Probes
Litterature
PubMed51 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDOK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jan 1 18:13:25 CET 2021

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