DOK3 (docking protein 3)

2010-05-01  

Identity

HGNC
DOK3
LOCATION
5q35.3
LOCUSID
79930
ALIAS
DOKL
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79930
MIM: 611435
HGNC: 24583
Ensembl: ENSG00000146094

Variants:

dbSNP: 79930
ClinVar: 79930
TCGA: ENSG00000146094
COSMIC: DOK3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000146094ENST00000312943Q7L591
ENSG00000146094ENST00000357198Q7L591
ENSG00000146094ENST00000357198A0A024R7M5
ENSG00000146094ENST00000377112Q7L591
ENSG00000146094ENST00000501403D6RAM3
ENSG00000146094ENST00000502885D6R951
ENSG00000146094ENST00000506493D6R977
ENSG00000146094ENST00000509310D6RAZ9
ENSG00000146094ENST00000510380D6RC22
ENSG00000146094ENST00000510389D6RF29
ENSG00000146094ENST00000510898D6RAM3

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
201399802010Identification of DOK genes as lung tumor suppressors.47
196822412009Proteomic analysis of integrin alphaIIbbeta3 outside-in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactions.16
164360512006Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases.15
227619382012DOK3 negatively regulates LPS responses and endotoxin tolerance.13
232232292013The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters.7
265859452016Searching for candidate genes in familial BRCAX mutation carriers with prostate cancer.2
272654732016Expression of DOK1, 2, and 3 genes in HTLV-1-infected T cells.1

Citation

Dessen P

DOK3 (docking protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2010-05-01

Online version: http://atlasgeneticsoncology.org/gene/51481/dok3