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DOK4 (docking protein 4)

Identity

Alias (NCBI)IRS-5
IRS5
HGNC (Hugo) DOK4
HGNC Alias symbFLJ10488
LocusID (NCBI) 55715
Atlas_Id 50679
Location 16q21  [Link to chromosome band 16q21]
Location_base_pair Starts at 57471922 and ends at 57486493 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)DOK4   19868
Cards
Entrez_Gene (NCBI)DOK4    docking protein 4
AliasesIRS-5; IRS5
GeneCards (Weizmann)DOK4
Ensembl hg19 (Hinxton)ENSG00000125170 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125170 [Gene_View]  ENSG00000125170 [Sequence]  chr16:57471922-57486493 [Contig_View]  DOK4 [Vega]
ICGC DataPortalENSG00000125170
TCGA cBioPortalDOK4
AceView (NCBI)DOK4
Genatlas (Paris)DOK4
SOURCE (Princeton)DOK4
Genetics Home Reference (NIH)DOK4
Genomic and cartography
GoldenPath hg38 (UCSC)DOK4  -     chr16:57471922-57486493 -  16q21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DOK4  -     16q21   [Description]    (hg19-Feb_2009)
GoldenPathDOK4 - 16q21 [CytoView hg19]  DOK4 - 16q21 [CytoView hg38]
ImmunoBaseENSG00000125170
Genome Data Viewer NCBIDOK4 [Mapview hg19]  
OMIM608333   
Gene and transcription
Genbank (Entrez)AF466369 AK001350 AK307270 AK315426 AW163719
RefSeq transcript (Entrez)NM_001330556 NM_001369618 NM_001369619 NM_001369620 NM_001369621 NM_001394652 NM_001394653 NM_001394654 NM_001394655 NM_001394656 NM_001394657 NM_001394658 NM_001394659 NM_001394660 NM_001394661 NM_018110
Consensus coding sequences : CCDS (NCBI)DOK4
Gene ExpressionDOK4 [ NCBI-GEO ]   DOK4 [ EBI - ARRAY_EXPRESS ]   DOK4 [ SEEK ]   DOK4 [ MEM ]
Gene Expression Viewer (FireBrowse)DOK4 [ Firebrowse - Broad ]
GenevisibleExpression of DOK4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55715
GTEX Portal (Tissue expression)DOK4
Human Protein AtlasENSG00000125170-DOK4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TEW6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TEW6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TEW6
PhosPhoSitePlusQ8TEW6
Domaine pattern : Prosite (Expaxy)IRS_PTB (PS51064)   
Domains : Interpro (EBI)DOK4/5/6_PH    IRS_PTB    PH-like_dom_sf    PH_domain   
Domain families : Pfam (Sanger)IRS (PF02174)   
Domain families : Pfam (NCBI)pfam02174   
Domain families : Smart (EMBL)PH (SM00233)  PTBI (SM00310)  
Conserved Domain (NCBI)DOK4
SuperfamilyQ8TEW6
AlphaFold pdb e-kbQ8TEW6   
Human Protein Atlas [tissue]ENSG00000125170-DOK4 [tissue]
HPRD16316
Protein Interaction databases
DIP (DOE-UCLA)Q8TEW6
IntAct (EBI)Q8TEW6
BioGRIDDOK4
STRING (EMBL)DOK4
ZODIACDOK4
Ontologies - Pathways
QuickGOQ8TEW6
Ontology : AmiGOprotein binding  cytosol  transmembrane receptor protein tyrosine kinase signaling pathway  axon guidance  positive regulation of MAPK cascade  
Ontology : EGO-EBIprotein binding  cytosol  transmembrane receptor protein tyrosine kinase signaling pathway  axon guidance  positive regulation of MAPK cascade  
NDEx NetworkDOK4
Atlas of Cancer Signalling NetworkDOK4
Wikipedia pathwaysDOK4
Orthology - Evolution
OrthoDB55715
GeneTree (enSembl)ENSG00000125170
Phylogenetic Trees/Animal Genes : TreeFamDOK4
Homologs : HomoloGeneDOK4
Homology/Alignments : Family Browser (UCSC)DOK4
Gene fusions - Rearrangements
Fusion : QuiverDOK4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDOK4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DOK4
dbVarDOK4
ClinVarDOK4
MonarchDOK4
1000_GenomesDOK4 
Exome Variant ServerDOK4
GNOMAD BrowserENSG00000125170
Varsome BrowserDOK4
ACMGDOK4 variants
VarityQ8TEW6
Genomic Variants (DGV)DOK4 [DGVbeta]
DECIPHERDOK4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDOK4 
Mutations
ICGC Data PortalDOK4 
TCGA Data PortalDOK4 
Broad Tumor PortalDOK4
OASIS PortalDOK4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDOK4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDOK4
Mutations and Diseases : HGMDDOK4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDOK4
DgiDB (Drug Gene Interaction Database)DOK4
DoCM (Curated mutations)DOK4
CIViC (Clinical Interpretations of Variants in Cancer)DOK4
Cancer3DDOK4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608333   
Orphanet
DisGeNETDOK4
MedgenDOK4
Genetic Testing Registry DOK4
NextProtQ8TEW6 [Medical]
GENETestsDOK4
Target ValidationDOK4
Huge Navigator DOK4 [HugePedia]
ClinGenDOK4
Clinical trials, drugs, therapy
MyCancerGenomeDOK4
Protein Interactions : CTDDOK4
Pharm GKB GenePA134892921
PharosQ8TEW6
Clinical trialDOK4
Miscellaneous
canSAR (ICR)DOK4
HarmonizomeDOK4
DataMed IndexDOK4
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDOK4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:07:12 CEST 2021

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