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DOK5 (docking protein 5)

Identity

Alias_namesC20orf180
chromosome 20 open reading frame 180
Alias_symbol (synonym)dJ805C22.1
Other aliasIRS-6
IRS6
HGNC (Hugo) DOK5
LocusID (NCBI) 55816
Atlas_Id 54262
Location 20q13.2  [Link to chromosome band 20q13]
Location_base_pair Starts at 54475472 and ends at 54495154 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CBFA2T2 (20q11.21) / DOK5 (20q13.2)DOK5 (20q13.2) / CLEC17A (19p13.12)STARD3 (17q12) / DOK5 (20q13.2)
SYTL2 (11q14.1) / DOK5 (20q13.2)CBFA2T2 20q11.21 / DOK5 20q13.2DOK5 20q13.2 / CLEC17A 19p13.12
SYTL2 11q14.1 / DOK5 20q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DOK5   16173
Cards
Entrez_Gene (NCBI)DOK5  55816  docking protein 5
AliasesC20orf180; IRS-6; IRS6
GeneCards (Weizmann)DOK5
Ensembl hg19 (Hinxton)ENSG00000101134 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101134 [Gene_View]  chr20:54475472-54495154 [Contig_View]  DOK5 [Vega]
ICGC DataPortalENSG00000101134
TCGA cBioPortalDOK5
AceView (NCBI)DOK5
Genatlas (Paris)DOK5
WikiGenes55816
SOURCE (Princeton)DOK5
Genetics Home Reference (NIH)DOK5
Genomic and cartography
GoldenPath hg38 (UCSC)DOK5  -     chr20:54475472-54495154 +  20q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DOK5  -     20q13.2   [Description]    (hg19-Feb_2009)
EnsemblDOK5 - 20q13.2 [CytoView hg19]  DOK5 - 20q13.2 [CytoView hg38]
Mapping of homologs : NCBIDOK5 [Mapview hg19]  DOK5 [Mapview hg38]
OMIM608334   
Gene and transcription
Genbank (Entrez)AF132732 AF466368 AI822030 AK313222 AL050069
RefSeq transcript (Entrez)NM_001294161 NM_018431 NM_177959
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DOK5
Cluster EST : UnigeneHs.656582 [ NCBI ]
CGAP (NCI)Hs.656582
Alternative Splicing GalleryENSG00000101134
Gene ExpressionDOK5 [ NCBI-GEO ]   DOK5 [ EBI - ARRAY_EXPRESS ]   DOK5 [ SEEK ]   DOK5 [ MEM ]
Gene Expression Viewer (FireBrowse)DOK5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55816
GTEX Portal (Tissue expression)DOK5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P104   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P104  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P104
Splice isoforms : SwissVarQ9P104
PhosPhoSitePlusQ9P104
Domaine pattern : Prosite (Expaxy)IRS_PTB (PS51064)   
Domains : Interpro (EBI)IRS_PTB    PH_dom-like    PH_domain   
Domain families : Pfam (Sanger)IRS (PF02174)   
Domain families : Pfam (NCBI)pfam02174   
Domain families : Smart (EMBL)PH (SM00233)  PTBI (SM00310)  
Conserved Domain (NCBI)DOK5
DMDM Disease mutations55816
Blocks (Seattle)DOK5
PDB (SRS)1J0W   
PDB (PDBSum)1J0W   
PDB (IMB)1J0W   
PDB (RSDB)1J0W   
Structural Biology KnowledgeBase1J0W   
SCOP (Structural Classification of Proteins)1J0W   
CATH (Classification of proteins structures)1J0W   
SuperfamilyQ9P104
Human Protein AtlasENSG00000101134
Peptide AtlasQ9P104
HPRD16317
IPIIPI00020443   IPI00219471   
Protein Interaction databases
DIP (DOE-UCLA)Q9P104
IntAct (EBI)Q9P104
FunCoupENSG00000101134
BioGRIDDOK5
STRING (EMBL)DOK5
ZODIACDOK5
Ontologies - Pathways
QuickGOQ9P104
Ontology : AmiGOMAPK cascade  signal transducer activity, downstream of receptor  insulin receptor binding  cytosol  transmembrane receptor protein tyrosine kinase signaling pathway  axon guidance  regulation of neurotrophin TRK receptor signaling pathway  
Ontology : EGO-EBIMAPK cascade  signal transducer activity, downstream of receptor  insulin receptor binding  cytosol  transmembrane receptor protein tyrosine kinase signaling pathway  axon guidance  regulation of neurotrophin TRK receptor signaling pathway  
NDEx NetworkDOK5
Atlas of Cancer Signalling NetworkDOK5
Wikipedia pathwaysDOK5
Orthology - Evolution
OrthoDB55816
GeneTree (enSembl)ENSG00000101134
Phylogenetic Trees/Animal Genes : TreeFamDOK5
HOVERGENQ9P104
HOGENOMQ9P104
Homologs : HomoloGeneDOK5
Homology/Alignments : Family Browser (UCSC)DOK5
Gene fusions - Rearrangements
Fusion : MitelmanCBFA2T2/DOK5 [20q11.21/20q13.2]  [t(20;20)(q11;q13)]  
Fusion : MitelmanDOK5/CLEC17A [20q13.2/19p13.12]  [t(19;20)(p13;q13)]  
Fusion : MitelmanSTARD3/DOK5 [17q12/20q13.2]  [t(17;20)(q12;q13)]  
Fusion : MitelmanSYTL2/DOK5 [11q14.1/20q13.2]  [t(11;20)(q14;q13)]  
Fusion: TCGACBFA2T2 20q11.21 DOK5 20q13.2 LUAD
Fusion: TCGADOK5 20q13.2 CLEC17A 19p13.12 OV
Fusion: TCGASYTL2 11q14.1 DOK5 20q13.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDOK5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DOK5
dbVarDOK5
ClinVarDOK5
1000_GenomesDOK5 
Exome Variant ServerDOK5
ExAC (Exome Aggregation Consortium)DOK5 (select the gene name)
Genetic variants : HAPMAP55816
Genomic Variants (DGV)DOK5 [DGVbeta]
DECIPHERDOK5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDOK5 
Mutations
ICGC Data PortalDOK5 
TCGA Data PortalDOK5 
Broad Tumor PortalDOK5
OASIS PortalDOK5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDOK5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDOK5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DOK5
DgiDB (Drug Gene Interaction Database)DOK5
DoCM (Curated mutations)DOK5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DOK5 (select a term)
intoGenDOK5
Cancer3DDOK5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608334   
Orphanet
MedgenDOK5
Genetic Testing Registry DOK5
NextProtQ9P104 [Medical]
TSGene55816
GENETestsDOK5
Target ValidationDOK5
Huge Navigator DOK5 [HugePedia]
snp3D : Map Gene to Disease55816
BioCentury BCIQDOK5
ClinGenDOK5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55816
Chemical/Pharm GKB GenePA25724
Clinical trialDOK5
Miscellaneous
canSAR (ICR)DOK5 (select the gene name)
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDOK5
EVEXDOK5
GoPubMedDOK5
iHOPDOK5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 16:59:50 CEST 2017

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