DOK5 (docking protein 5)

2014-08-01  

Identity

HGNC
DOK5
LOCATION
20q13.2
LOCUSID
55816
ALIAS
C20orf180,IRS-6,IRS6
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55816
MIM: 608334
HGNC: 16173
Ensembl: ENSG00000101134

Variants:

dbSNP: 55816
ClinVar: 55816
TCGA: ENSG00000101134
COSMIC: DOK5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101134ENST00000262593Q9P104
ENSG00000101134ENST00000395939Q9P104

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
RET signalingREACTOMER-HSA-8853659

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164760860pegaspargaseChemicalClinicalAnnotationassociatedPD26590194
PA445187OsteonecrosisDiseaseClinicalAnnotationassociatedPD26590194
PA446155Precursor Cell Lymphoblastic Leukemia-LymphomaDiseaseClinicalAnnotationassociatedPD26590194
PA449165cyclophosphamideChemicalClinicalAnnotationassociatedPD26590194
PA449177cytarabineChemicalClinicalAnnotationassociatedPD26590194
PA449212daunorubicinChemicalClinicalAnnotationassociatedPD26590194
PA449247dexamethasoneChemicalClinicalAnnotationassociatedPD26590194
PA449412doxorubicinChemicalClinicalAnnotationassociatedPD26590194
PA450428methotrexateChemicalClinicalAnnotationassociatedPD26590194
PA451100prednisoneChemicalClinicalAnnotationassociatedPD26590194
PA451663thioguanineChemicalClinicalAnnotationassociatedPD26590194
PA451879vincristineChemicalClinicalAnnotationassociatedPD26590194

References

Pubmed IDYearTitleCitations
127302412003Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5.53
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38
201879682010Evaluation of DOK5 as a susceptibility gene for type 2 diabetes and obesity in North Indian population.16
201879682010Evaluation of DOK5 as a susceptibility gene for type 2 diabetes and obesity in North Indian population.16
125959002003DOK4 and DOK5: new Dok-related genes expressed in human T cells.8
245510652014The membrane-associated adaptor protein DOK5 is upregulated in systemic sclerosis and associated with IGFBP-5-induced fibrosis.8
202159242010A genome-wide association study of amygdala activation in youths with and without bipolar disorder.7
202159242010A genome-wide association study of amygdala activation in youths with and without bipolar disorder.7

Citation

Dessen P

DOK5 (docking protein 5)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54262/dok5