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DOLK (dolichol kinase)

Identity

Alias (NCBI)CDG1M
DK
DK1
SEC59
TMEM15
HGNC (Hugo) DOLK
HGNC Alias symbKIAA1094
DK1
HGNC Alias namedolichol kinase 1
HGNC Previous nameTMEM15
HGNC Previous nametransmembrane protein 15
LocusID (NCBI) 22845
Atlas_Id 62596
Location 9q34.11  [Link to chromosome band 9q34]
Location_base_pair Starts at 128945530 and ends at 128947603 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)DOLK   23406
LRG (Locus Reference Genomic)LRG_744
Cards
Entrez_Gene (NCBI)DOLK    dolichol kinase
AliasesCDG1M; DK; DK1; SEC59; 
TMEM15
GeneCards (Weizmann)DOLK
Ensembl hg19 (Hinxton)ENSG00000175283 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175283 [Gene_View]  ENSG00000175283 [Sequence]  chr9:128945530-128947603 [Contig_View]  DOLK [Vega]
ICGC DataPortalENSG00000175283
TCGA cBioPortalDOLK
AceView (NCBI)DOLK
Genatlas (Paris)DOLK
SOURCE (Princeton)DOLK
Genetics Home Reference (NIH)DOLK
Genomic and cartography
GoldenPath hg38 (UCSC)DOLK  -     chr9:128945530-128947603 -  9q34.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DOLK  -     9q34.11   [Description]    (hg19-Feb_2009)
GoldenPathDOLK - 9q34.11 [CytoView hg19]  DOLK - 9q34.11 [CytoView hg38]
ImmunoBaseENSG00000175283
Genome Data Viewer NCBIDOLK [Mapview hg19]  
OMIM610746   610768   
Gene and transcription
Genbank (Entrez)AB029017 AK225402 AK300180 AY358759 BC035556
RefSeq transcript (Entrez)NM_014908
Consensus coding sequences : CCDS (NCBI)DOLK
Gene ExpressionDOLK [ NCBI-GEO ]   DOLK [ EBI - ARRAY_EXPRESS ]   DOLK [ SEEK ]   DOLK [ MEM ]
Gene Expression Viewer (FireBrowse)DOLK [ Firebrowse - Broad ]
GenevisibleExpression of DOLK in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22845
GTEX Portal (Tissue expression)DOLK
Human Protein AtlasENSG00000175283-DOLK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UPQ8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UPQ8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UPQ8
Catalytic activity : Enzyme2.7.1.108 [ Enzyme-Expasy ]   2.7.1.1082.7.1.108 [ IntEnz-EBI ]   2.7.1.108 [ BRENDA ]   2.7.1.108 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9UPQ8
Domains : Interpro (EBI)DOLK    Polypren_kinase   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)DOLK
SuperfamilyQ9UPQ8
AlphaFold pdb e-kbQ9UPQ8   
Human Protein Atlas [tissue]ENSG00000175283-DOLK [tissue]
HPRD15525
Protein Interaction databases
DIP (DOE-UCLA)Q9UPQ8
IntAct (EBI)Q9UPQ8
BioGRIDDOLK
STRING (EMBL)DOLK
ZODIACDOLK
Ontologies - Pathways
QuickGOQ9UPQ8
Ontology : AmiGOdolichol kinase activity  dolichol kinase activity  protein binding  endoplasmic reticulum membrane  dolichyl diphosphate biosynthetic process  phosphorylation  integral component of endoplasmic reticulum membrane  integral component of endoplasmic reticulum membrane  dolichyl monophosphate biosynthetic process  dolichyl monophosphate biosynthetic process  
Ontology : EGO-EBIdolichol kinase activity  dolichol kinase activity  protein binding  endoplasmic reticulum membrane  dolichyl diphosphate biosynthetic process  phosphorylation  integral component of endoplasmic reticulum membrane  integral component of endoplasmic reticulum membrane  dolichyl monophosphate biosynthetic process  dolichyl monophosphate biosynthetic process  
NDEx NetworkDOLK
Atlas of Cancer Signalling NetworkDOLK
Wikipedia pathwaysDOLK
Orthology - Evolution
OrthoDB22845
GeneTree (enSembl)ENSG00000175283
Phylogenetic Trees/Animal Genes : TreeFamDOLK
Homologs : HomoloGeneDOLK
Homology/Alignments : Family Browser (UCSC)DOLK
Gene fusions - Rearrangements
Fusion : QuiverDOLK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDOLK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DOLK
dbVarDOLK
ClinVarDOLK
MonarchDOLK
1000_GenomesDOLK 
Exome Variant ServerDOLK
GNOMAD BrowserENSG00000175283
Varsome BrowserDOLK
ACMGDOLK variants
VarityQ9UPQ8
Genomic Variants (DGV)DOLK [DGVbeta]
DECIPHERDOLK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDOLK 
Mutations
ICGC Data PortalDOLK 
TCGA Data PortalDOLK 
Broad Tumor PortalDOLK
OASIS PortalDOLK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDOLK  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDOLK
Mutations and Diseases : HGMDDOLK
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDOLK
DgiDB (Drug Gene Interaction Database)DOLK
DoCM (Curated mutations)DOLK
CIViC (Clinical Interpretations of Variants in Cancer)DOLK
Cancer3DDOLK
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610746    610768   
Orphanet635    12108   
DisGeNETDOLK
MedgenDOLK
Genetic Testing Registry DOLK
NextProtQ9UPQ8 [Medical]
GENETestsDOLK
Target ValidationDOLK
Huge Navigator DOLK [HugePedia]
ClinGenDOLK
Clinical trials, drugs, therapy
MyCancerGenomeDOLK
Protein Interactions : CTDDOLK
Pharm GKB GenePA162384054
PharosQ9UPQ8
Clinical trialDOLK
Miscellaneous
canSAR (ICR)DOLK
HarmonizomeDOLK
DataMed IndexDOLK
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDOLK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:48:16 CEST 2021

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