DOT1L (DOT1-like, histone H3 methyltransferase (S. cerevisiae))

Identity

Other names	DKFZp586P1823
	DOT1
	KIAA1814
	KMT4
HGNC	DOT1L
Location	19p13.3
Location_base_pair	Starts at 2115148 and ends at 2183577 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	DOT1L   24948
Entrez_Gene	DOT1L  84444  DOT1-like, histone H3 methyltransferase (S. cerevisiae)
	Cards
GeneCards	DOT1L
Ensembl	DOT1L [Search_View]   ENSG00000104885 [Gene_View]
Genatlas	DOT1L
GeneLynx	DOT1L
eGenome	DOT1L
euGene	84444
	Genomic and cartography
GoldenPath	DOT1L  -  19p13.3   chr19:2115148-2183577 +  19p13.3   [Description]    (hg18-March_2006)
Ensembl	DOT1L - 19p13.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	DOT1L
	Gene and transcription
Genbank	AB058717 [ ENTREZ ]
Genbank	AF509504 [ ENTREZ ]
Genbank	AK074120 [ ENTREZ ]
Genbank	AK095280 [ ENTREZ ]
Genbank	AL080221 [ ENTREZ ]
RefSeq	NM_032482 [ SRS ]    NM_032482 [ ENTREZ ]
RefSeq	AC_000062 [ SRS ]    AC_000062 [ ENTREZ ]
RefSeq	AC_000151 [ SRS ]    AC_000151 [ ENTREZ ]
RefSeq	NC_000019 [ SRS ]    NC_000019 [ ENTREZ ]
RefSeq	NT_011255 [ SRS ]    NT_011255 [ ENTREZ ]
RefSeq	NW_001838476 [ SRS ]    NW_001838476 [ ENTREZ ]
RefSeq	NW_927173 [ SRS ]    NW_927173 [ ENTREZ ]
AceView	DOT1L AceView - NCBI
Unigene	Hs.713641 [ SRS ]    Hs.713641 [ NCBI ]     HS713641 [ spliceNest ]
Fast-db	1638 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q8TEK3 [ SRS]    Q8TEK3 [ EXPASY ]     Q8TEK3 [ INTERPRO ]     Q8TEK3 [ UNIPROT ]
Interpro	IPR000637 AT_hook_DNA_bd [ SRS ]    IPR000637 AT_hook_DNA_bd [ EBI ]
Interpro	IPR013110 DOT1 [ SRS ]    IPR013110 DOT1 [ EBI ]
CluSTr	Q8TEK3
Pfam	PF02178 AT_hook [ SRS ]    PF02178 AT_hook [ Sanger ]    pfam02178 [ NCBI-CDD ]
Pfam	PF08123 DOT1 [ SRS ]    PF08123 DOT1 [ Sanger ]    pfam08123 [ NCBI-CDD ]
Smart	SM00384 AT_hook [EMBL]
Blocks	Q8TEK3
PDB	1NW3 [ SRS ]    1NW3 [ PdbSum ],   1NW3 [ IMB ]   1NW3 [ RSDB ]
HPRD	10455
	Protein Interaction databases
DIP	Q8TEK3
IntAct	Q8TEK3
	Polymorphism : SNP, mutations, diseases
OMIM	607375    [ map ]
GENECLINICS	607375
SNP	DOT1L [dbSNP-NCBI]
SNP	NM_032482 [SNP-NCI]
SNP	DOT1L [GeneSNPs - Utah]  DOT1L] [HGBASE - SRS]
HAPMAP	DOT1L [HAPMAP]
COSMIC	DOT1L [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	DOT1L
	General knowledge
Family Browser	DOT1L [UCSC Family Browser]
SOURCE	NM_032482
SMD	Hs.713641
SAGE	Hs.713641
Enzyme	2.1.1.43 [ Enzyme-Expasy ]   2.1.1.43 [ Enzyme-SRS ]   2.1.1.43 [ IntEnz-EBI ]   2.1.1.43 [ BRENDA ]   2.1.1.43 [ KEGG ]   2.1.1.43 [ WIT ]
GO	DNA binding [Amigo]  DNA binding
GO	nucleus [Amigo]  nucleus
GO	methyltransferase activity [Amigo]  methyltransferase activity
GO	chromatin modification [Amigo]  chromatin modification
GO	transferase activity [Amigo]  transferase activity
GO	histone-lysine N-methyltransferase activity [Amigo]  histone-lysine N-methyltransferase activity
KEGG	Lysine degradation
PubGene	DOT1L
TreeFam	DOT1L
CTD	84444 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	DOT1L Related clones (RZPD - Berlin)
	PubMed
PubMed	11 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 18 14:38:54 2008