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DPF2 (double PHD fingers 2)

Identity

Alias_namesREQ
requiem, apoptosis response zinc finger gene
D4, zinc and double PHD fingers family 2
Alias_symbol (synonym)ubi-d4
BAF45d
Other aliasUBID4
HGNC (Hugo) DPF2
LocusID (NCBI) 5977
Atlas_Id 40358
Location 11q13.1  [Link to chromosome band 11q13]
Location_base_pair Starts at 65333754 and ends at 65352980 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DPF2 (11q13.1) / POLA2 (11q13.1)DPF2 (11q13.1) / SART1 (11q13.1)DPF2 (11q13.1) / TRIM49C (11q14.3)
FRMD8 (11q13.1) / DPF2 (11q13.1)METTL12 (11q12.3) / DPF2 (11q13.1)ZNHIT1 (7q22.1) / DPF2 (11q13.1)
DPF2 11q13.1 / POLA2 11q13.1DPF2 11q13.1 TRIM49L2FRMD8 11q13.1 / DPF2 11q13.1
METTL12 11q12.3 / DPF2 11q13.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  DPF2/POLA2 (11q13)
FRMD8/DPF2 (11q13)
t(11;11)(q13;q14) DPF2/TRIM49C


External links

Nomenclature
HGNC (Hugo)DPF2   9964
Cards
Entrez_Gene (NCBI)DPF2  5977  double PHD fingers 2
AliasesREQ; UBID4; ubi-d4
GeneCards (Weizmann)DPF2
Ensembl hg19 (Hinxton)ENSG00000133884 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133884 [Gene_View]  ENSG00000133884 [Sequence]  chr11:65333754-65352980 [Contig_View]  DPF2 [Vega]
ICGC DataPortalENSG00000133884
TCGA cBioPortalDPF2
AceView (NCBI)DPF2
Genatlas (Paris)DPF2
WikiGenes5977
SOURCE (Princeton)DPF2
Genetics Home Reference (NIH)DPF2
Genomic and cartography
GoldenPath hg38 (UCSC)DPF2  -     chr11:65333754-65352980 +  11q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DPF2  -     11q13.1   [Description]    (hg19-Feb_2009)
EnsemblDPF2 - 11q13.1 [CytoView hg19]  DPF2 - 11q13.1 [CytoView hg38]
Mapping of homologs : NCBIDPF2 [Mapview hg19]  DPF2 [Mapview hg38]
OMIM601671   
Gene and transcription
Genbank (Entrez)AF001433 AI381588 AK096796 AK291944 AK300061
RefSeq transcript (Entrez)NM_001330308 NM_006268
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DPF2
Cluster EST : UnigeneHs.633609 [ NCBI ]
CGAP (NCI)Hs.633609
Alternative Splicing GalleryENSG00000133884
Gene ExpressionDPF2 [ NCBI-GEO ]   DPF2 [ EBI - ARRAY_EXPRESS ]   DPF2 [ SEEK ]   DPF2 [ MEM ]
Gene Expression Viewer (FireBrowse)DPF2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5977
GTEX Portal (Tissue expression)DPF2
Human Protein AtlasENSG00000133884-DPF2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92785   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92785  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92785
Splice isoforms : SwissVarQ92785
PhosPhoSitePlusQ92785
Domaine pattern : Prosite (Expaxy)ZF_PHD_1 (PS01359)    ZF_PHD_2 (PS50016)    ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)Requiem/DPF_N_dom    Znf_C2H2_sf    Znf_C2H2_type    Znf_FYVE_PHD    Znf_PHD    Znf_PHD-finger    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)PHD (PF00628)    Requiem_N (PF14051)   
Domain families : Pfam (NCBI)pfam00628    pfam14051   
Domain families : Smart (EMBL)PHD (SM00249)  ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)DPF2
DMDM Disease mutations5977
Blocks (Seattle)DPF2
PDB (SRS)3IUF    5B79    5VDC   
PDB (PDBSum)3IUF    5B79    5VDC   
PDB (IMB)3IUF    5B79    5VDC   
PDB (RSDB)3IUF    5B79    5VDC   
Structural Biology KnowledgeBase3IUF    5B79    5VDC   
SCOP (Structural Classification of Proteins)3IUF    5B79    5VDC   
CATH (Classification of proteins structures)3IUF    5B79    5VDC   
SuperfamilyQ92785
Human Protein Atlas [tissue]ENSG00000133884-DPF2 [tissue]
Peptide AtlasQ92785
HPRD03394
IPIIPI00983171   IPI00908945   IPI00023322   IPI00978647   IPI00978019   
Protein Interaction databases
DIP (DOE-UCLA)Q92785
IntAct (EBI)Q92785
FunCoupENSG00000133884
BioGRIDDPF2
STRING (EMBL)DPF2
ZODIACDPF2
Ontologies - Pathways
QuickGOQ92785
Ontology : AmiGOhistone acetyltransferase complex  nuclear chromatin  nuclear chromatin  RNA polymerase II proximal promoter sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  histone acetyltransferase activity  protein binding  nucleus  nucleoplasm  centrosome  cytosol  transcription, DNA-templated  regulation of transcription by RNA polymerase II  apoptotic process  nervous system development  histone binding  intracellular membrane-bounded organelle  negative regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  metal ion binding  nBAF complex  apoptotic signaling pathway  
Ontology : EGO-EBIhistone acetyltransferase complex  nuclear chromatin  nuclear chromatin  RNA polymerase II proximal promoter sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  histone acetyltransferase activity  protein binding  nucleus  nucleoplasm  centrosome  cytosol  transcription, DNA-templated  regulation of transcription by RNA polymerase II  apoptotic process  nervous system development  histone binding  intracellular membrane-bounded organelle  negative regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  metal ion binding  nBAF complex  apoptotic signaling pathway  
NDEx NetworkDPF2
Atlas of Cancer Signalling NetworkDPF2
Wikipedia pathwaysDPF2
Orthology - Evolution
OrthoDB5977
GeneTree (enSembl)ENSG00000133884
Phylogenetic Trees/Animal Genes : TreeFamDPF2
HOVERGENQ92785
HOGENOMQ92785
Homologs : HomoloGeneDPF2
Homology/Alignments : Family Browser (UCSC)DPF2
Gene fusions - Rearrangements
Fusion : MitelmanDPF2/POLA2 [11q13.1/11q13.1]  
Fusion : MitelmanDPF2/TRIM49C [11q13.1/11q14.3]  [t(11;11)(q13;q14)]  
Fusion : MitelmanFRMD8/DPF2 [11q13.1/11q13.1]  [t(11;11)(q13;q13)]  
Fusion : MitelmanMETTL12/DPF2 [11q12.3/11q13.1]  [t(11;11)(q12;q13)]  
Fusion PortalDPF2 11q13.1 POLA2 11q13.1 GBM
Fusion PortalDPF2 11q13.1 TRIM49L2 BRCA
Fusion PortalFRMD8 11q13.1 DPF2 11q13.1 LUAD
Fusion PortalMETTL12 11q12.3 DPF2 11q13.1 GBM
Fusion : QuiverDPF2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDPF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DPF2
dbVarDPF2
ClinVarDPF2
1000_GenomesDPF2 
Exome Variant ServerDPF2
ExAC (Exome Aggregation Consortium)ENSG00000133884
GNOMAD BrowserENSG00000133884
Varsome BrowserDPF2
Genetic variants : HAPMAP5977
Genomic Variants (DGV)DPF2 [DGVbeta]
DECIPHERDPF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDPF2 
Mutations
ICGC Data PortalDPF2 
TCGA Data PortalDPF2 
Broad Tumor PortalDPF2
OASIS PortalDPF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDPF2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDPF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DPF2
DgiDB (Drug Gene Interaction Database)DPF2
DoCM (Curated mutations)DPF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DPF2 (select a term)
intoGenDPF2
Cancer3DDPF2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601671   
Orphanet
DisGeNETDPF2
MedgenDPF2
Genetic Testing Registry DPF2
NextProtQ92785 [Medical]
TSGene5977
GENETestsDPF2
Target ValidationDPF2
Huge Navigator DPF2 [HugePedia]
snp3D : Map Gene to Disease5977
BioCentury BCIQDPF2
ClinGenDPF2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5977
Chemical/Pharm GKB GenePA34331
Clinical trialDPF2
Miscellaneous
canSAR (ICR)DPF2 (select the gene name)
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDPF2
EVEXDPF2
GoPubMedDPF2
iHOPDPF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:19:55 CEST 2018

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