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DPM1 (dolichyl-phosphate mannosyltransferase subunit 1, catalytic)

Identity

Alias_namescatalytic subunit
Alias_symbol (synonym)MPDS
CDGIE
Other alias
HGNC (Hugo) DPM1
LocusID (NCBI) 8813
Atlas_Id 54264
Location 20q13.13  [Link to chromosome band 20q13]
Location_base_pair Starts at 50934855 and ends at 50958564 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADNP (20q13.13) / DPM1 (20q13.13)CEP250 (20q11.22) / DPM1 (20q13.13)DPM1 (20q13.13) / CD63 (12q13.2)
DPM1 (20q13.13) / CYP4F12 (19p13.12)DPM1 (20q13.13) / DPM1 (20q13.13)DPM1 (20q13.13) / GRID1 (10q23.1)
ADNP 20q13.13 / DPM1 20q13.13DPM1 20q13.13 / CYP4F12 19p13.12DPM1 20q13.13 / GRID1 10q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)DPM1   3005
Cards
Entrez_Gene (NCBI)DPM1  8813  dolichyl-phosphate mannosyltransferase subunit 1, catalytic
AliasesCDGIE; MPDS
GeneCards (Weizmann)DPM1
Ensembl hg19 (Hinxton)ENSG00000000419 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000000419 [Gene_View]  chr20:50934855-50958564 [Contig_View]  DPM1 [Vega]
ICGC DataPortalENSG00000000419
TCGA cBioPortalDPM1
AceView (NCBI)DPM1
Genatlas (Paris)DPM1
WikiGenes8813
SOURCE (Princeton)DPM1
Genetics Home Reference (NIH)DPM1
Genomic and cartography
GoldenPath hg38 (UCSC)DPM1  -     chr20:50934855-50958564 -  20q13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DPM1  -     20q13.13   [Description]    (hg19-Feb_2009)
EnsemblDPM1 - 20q13.13 [CytoView hg19]  DPM1 - 20q13.13 [CytoView hg38]
Mapping of homologs : NCBIDPM1 [Mapview hg19]  DPM1 [Mapview hg38]
OMIM603503   608799   
Gene and transcription
Genbank (Entrez)AF007875 AK289569 BC007073 BC008427 BC008466
RefSeq transcript (Entrez)NM_001317034 NM_001317035 NM_001317036 NM_003859
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DPM1
Cluster EST : UnigeneHs.654951 [ NCBI ]
CGAP (NCI)Hs.654951
Alternative Splicing GalleryENSG00000000419
Gene ExpressionDPM1 [ NCBI-GEO ]   DPM1 [ EBI - ARRAY_EXPRESS ]   DPM1 [ SEEK ]   DPM1 [ MEM ]
Gene Expression Viewer (FireBrowse)DPM1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8813
GTEX Portal (Tissue expression)DPM1
Human Protein AtlasENSG00000000419-DPM1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60762   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60762  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60762
Splice isoforms : SwissVarO60762
Catalytic activity : Enzyme2.4.1.83 [ Enzyme-Expasy ]   2.4.1.832.4.1.83 [ IntEnz-EBI ]   2.4.1.83 [ BRENDA ]   2.4.1.83 [ KEGG ]   
PhosPhoSitePlusO60762
Domains : Interpro (EBI)Glyco_trans_2-like    Nucleotide-diphossugar_trans   
Domain families : Pfam (Sanger)Glycos_transf_2 (PF00535)   
Domain families : Pfam (NCBI)pfam00535   
Conserved Domain (NCBI)DPM1
DMDM Disease mutations8813
Blocks (Seattle)DPM1
SuperfamilyO60762
Human Protein Atlas [tissue]ENSG00000000419-DPM1 [tissue]
Peptide AtlasO60762
HPRD04613
IPIIPI00022018   IPI00796864   IPI00790317   IPI00641116   
Protein Interaction databases
DIP (DOE-UCLA)O60762
IntAct (EBI)O60762
FunCoupENSG00000000419
BioGRIDDPM1
STRING (EMBL)DPM1
ZODIACDPM1
Ontologies - Pathways
QuickGOO60762
Ontology : AmiGOdolichyl-phosphate-mannose-protein mannosyltransferase activity  dolichyl-phosphate beta-D-mannosyltransferase activity  protein binding  nucleus  endoplasmic reticulum  endoplasmic reticulum membrane  endoplasmic reticulum membrane  GPI anchor biosynthetic process  membrane  protein N-linked glycosylation via asparagine  dolichol metabolic process  dolichol-phosphate-mannose synthase complex  protein mannosylation  protein O-linked mannosylation  
Ontology : EGO-EBIdolichyl-phosphate-mannose-protein mannosyltransferase activity  dolichyl-phosphate beta-D-mannosyltransferase activity  protein binding  nucleus  endoplasmic reticulum  endoplasmic reticulum membrane  endoplasmic reticulum membrane  GPI anchor biosynthetic process  membrane  protein N-linked glycosylation via asparagine  dolichol metabolic process  dolichol-phosphate-mannose synthase complex  protein mannosylation  protein O-linked mannosylation  
Pathways : KEGGN-Glycan biosynthesis   
NDEx NetworkDPM1
Atlas of Cancer Signalling NetworkDPM1
Wikipedia pathwaysDPM1
Orthology - Evolution
OrthoDB8813
GeneTree (enSembl)ENSG00000000419
Phylogenetic Trees/Animal Genes : TreeFamDPM1
HOVERGENO60762
HOGENOMO60762
Homologs : HomoloGeneDPM1
Homology/Alignments : Family Browser (UCSC)DPM1
Gene fusions - Rearrangements
Fusion : MitelmanADNP/DPM1 [20q13.13/20q13.13]  [t(20;20)(q13;q13)]  
Fusion : MitelmanCEP250/DPM1 [20q11.22/20q13.13]  [inv(20)(q11q13)]  
Fusion : MitelmanDPM1/CYP4F12 [20q13.13/19p13.12]  [t(19;20)(p13;q13)]  
Fusion : MitelmanDPM1/GRID1 [20q13.13/10q23.1]  [t(10;20)(q23;q13)]  
Fusion: TCGA_MDACCADNP 20q13.13 DPM1 20q13.13 BRCA
Fusion: TCGA_MDACCDPM1 20q13.13 CYP4F12 19p13.12 OV
Fusion: TCGA_MDACCDPM1 20q13.13 GRID1 10q23.1 LAML
Tumor Fusion PortalDPM1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDPM1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DPM1
dbVarDPM1
ClinVarDPM1
1000_GenomesDPM1 
Exome Variant ServerDPM1
ExAC (Exome Aggregation Consortium)ENSG00000000419
GNOMAD BrowserENSG00000000419
Genetic variants : HAPMAP8813
Genomic Variants (DGV)DPM1 [DGVbeta]
DECIPHERDPM1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDPM1 
Mutations
ICGC Data PortalDPM1 
TCGA Data PortalDPM1 
Broad Tumor PortalDPM1
OASIS PortalDPM1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDPM1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDPM1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch DPM1
DgiDB (Drug Gene Interaction Database)DPM1
DoCM (Curated mutations)DPM1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DPM1 (select a term)
intoGenDPM1
Cancer3DDPM1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603503    608799   
Orphanet11348   
DisGeNETDPM1
MedgenDPM1
Genetic Testing Registry DPM1
NextProtO60762 [Medical]
TSGene8813
GENETestsDPM1
Target ValidationDPM1
Huge Navigator DPM1 [HugePedia]
snp3D : Map Gene to Disease8813
BioCentury BCIQDPM1
ClinGenDPM1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8813
Chemical/Pharm GKB GenePA27463
Clinical trialDPM1
Miscellaneous
canSAR (ICR)DPM1 (select the gene name)
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDPM1
EVEXDPM1
GoPubMedDPM1
iHOPDPM1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:11:05 CET 2017

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