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DPP6 (dipeptidyl peptidase like 6)

Identity

Alias_namesdipeptidylpeptidase VI
dipeptidylpeptidase 6
dipeptidyl-peptidase 6
dipeptidyl peptidase 6
Alias_symbol (synonym)DPPX
DPL1
Other aliasMRD33
VF2
HGNC (Hugo) DPP6
LocusID (NCBI) 1804
Atlas_Id 52851
Location 7q36.2  [Link to chromosome band 7q36]
Location_base_pair Starts at 153887097 and ends at 154894290 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADCK2 (7q34) / DPP6 (7q36.2)CCND1 (11q13.3) / DPP6 (7q36.2)COG5 (7q22.3) / DPP6 (7q36.2)
CUL1 (7q36.1) / DPP6 (7q36.2)DPP6 (7q36.2) / DPP6 (7q36.2)DPP6 (7q36.2) / DTNA (18q12.1)
GALNT11 (7q36.1) / DPP6 (7q36.2)INSIG1 (7q36.2) / DPP6 (7q36.2)PAXIP1 (7q36.2) / DPP6 (7q36.2)
TADA2B (4p16.1) / DPP6 (7q36.2)ADCK2 7q34 / DPP6 7q36.2COG5 7q22.3 / DPP6 7q36.2
GALNT11 7q36.1 / DPP6 7q36.2INSIG1 7q36.2 / DPP6 7q36.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DPP6   3010
Cards
Entrez_Gene (NCBI)DPP6  1804  dipeptidyl peptidase like 6
AliasesDPL1; DPPX; MRD33; VF2
GeneCards (Weizmann)DPP6
Ensembl hg19 (Hinxton)ENSG00000130226 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000130226 [Gene_View]  chr7:153887097-154894290 [Contig_View]  DPP6 [Vega]
ICGC DataPortalENSG00000130226
TCGA cBioPortalDPP6
AceView (NCBI)DPP6
Genatlas (Paris)DPP6
WikiGenes1804
SOURCE (Princeton)DPP6
Genetics Home Reference (NIH)DPP6
Genomic and cartography
GoldenPath hg38 (UCSC)DPP6  -     chr7:153887097-154894290 +  7q36.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DPP6  -     7q36.2   [Description]    (hg19-Feb_2009)
EnsemblDPP6 - 7q36.2 [CytoView hg19]  DPP6 - 7q36.2 [CytoView hg38]
Mapping of homologs : NCBIDPP6 [Mapview hg19]  DPP6 [Mapview hg38]
OMIM126141   612956   616311   
Gene and transcription
Genbank (Entrez)AI458476 AK001153 AK126619 AK131502 AK293582
RefSeq transcript (Entrez)NM_001039350 NM_001290252 NM_001290253 NM_001936 NM_130797
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DPP6
Cluster EST : UnigeneHs.703229 [ NCBI ]
CGAP (NCI)Hs.703229
Alternative Splicing GalleryENSG00000130226
Gene ExpressionDPP6 [ NCBI-GEO ]   DPP6 [ EBI - ARRAY_EXPRESS ]   DPP6 [ SEEK ]   DPP6 [ MEM ]
Gene Expression Viewer (FireBrowse)DPP6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1804
GTEX Portal (Tissue expression)DPP6
Human Protein AtlasENSG00000130226-DPP6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP42658   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP42658  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP42658
Splice isoforms : SwissVarP42658
PhosPhoSitePlusP42658
Domains : Interpro (EBI)AB_hydrolase    Peptidase_S9    Peptidase_S9B_N   
Domain families : Pfam (Sanger)DPPIV_N (PF00930)    Peptidase_S9 (PF00326)   
Domain families : Pfam (NCBI)pfam00930    pfam00326   
Conserved Domain (NCBI)DPP6
DMDM Disease mutations1804
Blocks (Seattle)DPP6
PDB (SRS)1XFD   
PDB (PDBSum)1XFD   
PDB (IMB)1XFD   
PDB (RSDB)1XFD   
Structural Biology KnowledgeBase1XFD   
SCOP (Structural Classification of Proteins)1XFD   
CATH (Classification of proteins structures)1XFD   
SuperfamilyP42658
Human Protein Atlas [tissue]ENSG00000130226-DPP6 [tissue]
Peptide AtlasP42658
HPRD00525
IPIIPI00301512   IPI00252731   IPI00855824   IPI00893983   IPI00925157   
Protein Interaction databases
DIP (DOE-UCLA)P42658
IntAct (EBI)P42658
FunCoupENSG00000130226
BioGRIDDPP6
STRING (EMBL)DPP6
ZODIACDPP6
Ontologies - Pathways
QuickGOP42658
Ontology : AmiGOplasma membrane  proteolysis  voltage-gated potassium channel complex  serine-type peptidase activity  dipeptidyl-peptidase activity  potassium channel regulator activity  potassium channel regulator activity  integral component of membrane  regulation of molecular function  extracellular exosome  protein localization to plasma membrane  regulation of potassium ion transmembrane transport  regulation of potassium ion transmembrane transport  
Ontology : EGO-EBIplasma membrane  proteolysis  voltage-gated potassium channel complex  serine-type peptidase activity  dipeptidyl-peptidase activity  potassium channel regulator activity  potassium channel regulator activity  integral component of membrane  regulation of molecular function  extracellular exosome  protein localization to plasma membrane  regulation of potassium ion transmembrane transport  regulation of potassium ion transmembrane transport  
NDEx NetworkDPP6
Atlas of Cancer Signalling NetworkDPP6
Wikipedia pathwaysDPP6
Orthology - Evolution
OrthoDB1804
GeneTree (enSembl)ENSG00000130226
Phylogenetic Trees/Animal Genes : TreeFamDPP6
HOVERGENP42658
HOGENOMP42658
Homologs : HomoloGeneDPP6
Homology/Alignments : Family Browser (UCSC)DPP6
Gene fusions - Rearrangements
Fusion : MitelmanADCK2/DPP6 [7q34/7q36.2]  [t(7;7)(q34;q36)]  
Fusion : MitelmanCOG5/DPP6 [7q22.3/7q36.2]  [t(7;7)(q31;q36)]  
Fusion : MitelmanCUL1/DPP6 [7q36.1/7q36.2]  [t(7;7)(q36;q36)]  
Fusion : MitelmanGALNT11/DPP6 [7q36.1/7q36.2]  [t(7;7)(q36;q36)]  
Fusion : MitelmanINSIG1/DPP6 [7q36.2/7q36.2]  [t(7;7)(q36;q36)]  
Fusion: TCGA_MDACCADCK2 7q34 DPP6 7q36.2 BRCA
Fusion: TCGA_MDACCCOG5 7q22.3 DPP6 7q36.2 BRCA
Fusion: TCGA_MDACCGALNT11 7q36.1 DPP6 7q36.2 LUAD
Fusion: TCGA_MDACCINSIG1 7q36.2 DPP6 7q36.2 BRCA
Tumor Fusion PortalDPP6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDPP6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DPP6
dbVarDPP6
ClinVarDPP6
1000_GenomesDPP6 
Exome Variant ServerDPP6
ExAC (Exome Aggregation Consortium)ENSG00000130226
GNOMAD BrowserENSG00000130226
Genetic variants : HAPMAP1804
Genomic Variants (DGV)DPP6 [DGVbeta]
DECIPHERDPP6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDPP6 
Mutations
ICGC Data PortalDPP6 
TCGA Data PortalDPP6 
Broad Tumor PortalDPP6
OASIS PortalDPP6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDPP6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDPP6
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DPP6
DgiDB (Drug Gene Interaction Database)DPP6
DoCM (Curated mutations)DPP6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DPP6 (select a term)
intoGenDPP6
Cancer3DDPP6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM126141    612956    616311   
Orphanet2325    19072   
DisGeNETDPP6
MedgenDPP6
Genetic Testing Registry DPP6
NextProtP42658 [Medical]
TSGene1804
GENETestsDPP6
Target ValidationDPP6
Huge Navigator DPP6 [HugePedia]
snp3D : Map Gene to Disease1804
BioCentury BCIQDPP6
ClinGenDPP6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1804
Chemical/Pharm GKB GenePA27468
Clinical trialDPP6
Miscellaneous
canSAR (ICR)DPP6 (select the gene name)
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDPP6
EVEXDPP6
GoPubMedDPP6
iHOPDPP6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:11:05 CET 2017

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