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DPY30 (dpy-30, histone methyltransferase complex regulatory subunit)

Identity

Alias_namesdpy-30 homolog (C. elegans)
Alias_symbol (synonym)Saf19
HDPY-30
Cps25
Other alias
HGNC (Hugo) DPY30
LocusID (NCBI) 84661
Atlas_Id 55728
Location 2p22.3  [Link to chromosome band 2p22]
Location_base_pair Starts at 32023892 and ends at 32039835 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MEMO1 (2p23.1) / DPY30 (2p22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(2;2)(p22;p22) MEMO1/DPY30


External links

Nomenclature
HGNC (Hugo)DPY30   24590
Cards
Entrez_Gene (NCBI)DPY30  84661  dpy-30, histone methyltransferase complex regulatory subunit
AliasesCps25; HDPY-30; Saf19
GeneCards (Weizmann)DPY30
Ensembl hg19 (Hinxton)ENSG00000162961 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000162961 [Gene_View]  ENSG00000162961 [Sequence]  chr2:32023892-32039835 [Contig_View]  DPY30 [Vega]
ICGC DataPortalENSG00000162961
TCGA cBioPortalDPY30
AceView (NCBI)DPY30
Genatlas (Paris)DPY30
WikiGenes84661
SOURCE (Princeton)DPY30
Genetics Home Reference (NIH)DPY30
Genomic and cartography
GoldenPath hg38 (UCSC)DPY30  -     chr2:32023892-32039835 -  2p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DPY30  -     2p22.3   [Description]    (hg19-Feb_2009)
EnsemblDPY30 - 2p22.3 [CytoView hg19]  DPY30 - 2p22.3 [CytoView hg38]
Mapping of homologs : NCBIDPY30 [Mapview hg19]  DPY30 [Mapview hg38]
OMIM612032   
Gene and transcription
Genbank (Entrez)AA442557 AF226998 AV725116 BC015970 BG187724
RefSeq transcript (Entrez)NM_001321209 NM_001321210 NM_032574
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DPY30
Cluster EST : UnigeneHs.679657 [ NCBI ]
CGAP (NCI)Hs.679657
Alternative Splicing GalleryENSG00000162961
Gene ExpressionDPY30 [ NCBI-GEO ]   DPY30 [ EBI - ARRAY_EXPRESS ]   DPY30 [ SEEK ]   DPY30 [ MEM ]
Gene Expression Viewer (FireBrowse)DPY30 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84661
GTEX Portal (Tissue expression)DPY30
Human Protein AtlasENSG00000162961-DPY30 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9C005   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9C005  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9C005
Splice isoforms : SwissVarQ9C005
PhosPhoSitePlusQ9C005
Domains : Interpro (EBI)Dpy-30_motif   
Domain families : Pfam (Sanger)Dpy-30 (PF05186)   
Domain families : Pfam (NCBI)pfam05186   
Conserved Domain (NCBI)DPY30
DMDM Disease mutations84661
Blocks (Seattle)DPY30
PDB (SRS)3G36    4RIQ    4RT4    4RTA   
PDB (PDBSum)3G36    4RIQ    4RT4    4RTA   
PDB (IMB)3G36    4RIQ    4RT4    4RTA   
PDB (RSDB)3G36    4RIQ    4RT4    4RTA   
Structural Biology KnowledgeBase3G36    4RIQ    4RT4    4RTA   
SCOP (Structural Classification of Proteins)3G36    4RIQ    4RT4    4RTA   
CATH (Classification of proteins structures)3G36    4RIQ    4RT4    4RTA   
SuperfamilyQ9C005
Human Protein Atlas [tissue]ENSG00000162961-DPY30 [tissue]
Peptide AtlasQ9C005
HPRD17434
IPIIPI00028109   IPI00893460   IPI00893312   IPI00893184   
Protein Interaction databases
DIP (DOE-UCLA)Q9C005
IntAct (EBI)Q9C005
FunCoupENSG00000162961
BioGRIDDPY30
STRING (EMBL)DPY30
ZODIACDPY30
Ontologies - Pathways
QuickGOQ9C005
Ontology : AmiGOchromosome, telomeric region  protein binding  nucleus  nucleoplasm  nucleoplasm  Golgi apparatus  trans-Golgi network  chromatin silencing at telomere  transcription, DNA-templated  endosomal transport  histone-lysine N-methyltransferase activity  histone methyltransferase complex  histone methyltransferase activity (H3-K4 specific)  identical protein binding  protein homodimerization activity  MLL3/4 complex  regulation of megakaryocyte differentiation  Set1C/COMPASS complex  histone H3-K4 methylation  
Ontology : EGO-EBIchromosome, telomeric region  protein binding  nucleus  nucleoplasm  nucleoplasm  Golgi apparatus  trans-Golgi network  chromatin silencing at telomere  transcription, DNA-templated  endosomal transport  histone-lysine N-methyltransferase activity  histone methyltransferase complex  histone methyltransferase activity (H3-K4 specific)  identical protein binding  protein homodimerization activity  MLL3/4 complex  regulation of megakaryocyte differentiation  Set1C/COMPASS complex  histone H3-K4 methylation  
NDEx NetworkDPY30
Atlas of Cancer Signalling NetworkDPY30
Wikipedia pathwaysDPY30
Orthology - Evolution
OrthoDB84661
GeneTree (enSembl)ENSG00000162961
Phylogenetic Trees/Animal Genes : TreeFamDPY30
HOVERGENQ9C005
HOGENOMQ9C005
Homologs : HomoloGeneDPY30
Homology/Alignments : Family Browser (UCSC)DPY30
Gene fusions - Rearrangements
Fusion : QuiverDPY30
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDPY30 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DPY30
dbVarDPY30
ClinVarDPY30
1000_GenomesDPY30 
Exome Variant ServerDPY30
ExAC (Exome Aggregation Consortium)ENSG00000162961
GNOMAD BrowserENSG00000162961
Genetic variants : HAPMAP84661
Genomic Variants (DGV)DPY30 [DGVbeta]
DECIPHERDPY30 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDPY30 
Mutations
ICGC Data PortalDPY30 
TCGA Data PortalDPY30 
Broad Tumor PortalDPY30
OASIS PortalDPY30 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDPY30  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDPY30
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DPY30
DgiDB (Drug Gene Interaction Database)DPY30
DoCM (Curated mutations)DPY30 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DPY30 (select a term)
intoGenDPY30
Cancer3DDPY30(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612032   
Orphanet
DisGeNETDPY30
MedgenDPY30
Genetic Testing Registry DPY30
NextProtQ9C005 [Medical]
TSGene84661
GENETestsDPY30
Target ValidationDPY30
Huge Navigator DPY30 [HugePedia]
snp3D : Map Gene to Disease84661
BioCentury BCIQDPY30
ClinGenDPY30
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84661
Chemical/Pharm GKB GenePA162384063
Clinical trialDPY30
Miscellaneous
canSAR (ICR)DPY30 (select the gene name)
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDPY30
EVEXDPY30
GoPubMedDPY30
iHOPDPY30
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:23:13 CEST 2018

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