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DPYD (dihydropyrimidine dehydrogenase)

Identity

Other namesDHP
DHPDHASE
DPD
HGNC (Hugo) DPYD
LocusID (NCBI) 1806
Location 1p21.3
Location_base_pair Starts at 97543300 and ends at 98386615 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DPYD   3012
Entrez_Gene (NCBI)DPYD  1806  dihydropyrimidine dehydrogenase
Cards
GeneCards (Weizmann)DPYD
Ensembl (Hinxton)ENSG00000188641 [Gene_View]  chr1:97543300-98386615 [Contig_View]  DPYD [Vega]
AceView (NCBI)DPYD
Genatlas (Paris)DPYD
SOURCE (Stanford)NM_000110 NM_001160301
Genomic and cartography
GoldenPath (UCSC)DPYD  -  1p21.3   chr1:97543300-98386615 -  1p21.3   [Description]    (hg19-Feb_2009)
EnsemblDPYD - 1p21.3 [CytoView]
Mapping of homologs : NCBIDPYD [Mapview]
OMIM274270   612779   
Gene and transcription
Genbank (Entrez)AB003063 AI124948 AK291217 AK297515 BC008379
RefSeq transcript (SRS)NM_000110 NM_001160301
RefSeq transcript (Entrez)NM_000110 NM_001160301
RefSeq genomic (SRS)AC_000133 NC_000001 NC_018912 NG_008807 NT_032977 NW_001838589 NW_004077990
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NG_008807 NT_032977 NW_001838589 NW_004077990
Consensus coding sequences : CCDS (NCBI)DPYD
Cluster EST : UnigeneHs.335034 [ SRS ] Hs.335034 [ NCBI ]
CGAP (NCI)Hs.335034
Alternative Splicing : Fast-db (Paris)GSHG0002288
Alternative Splicing GalleryENSG00000188641
Gene ExpressionDPYD [ NCBI-GEO ]   DPYD [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ12882 (SRS) Q12882 (Uniprot)
NextProtQ12882
With graphics : InterProQ12882
Splice isoforms : SwissVarQ12882(Swissvar)
Domaine pattern : Prosite (SRS)4FE4S_FER_1 (PS00198)    4FE4S_FER_2 (PS51379)   
Domaine pattern : Prosite (Expaxy)4FE4S_FER_1 (PS00198)    4FE4S_FER_2 (PS51379)   
Domains : Interpro (SRS)4Fe4S_Fe-S-bd    4Fe4S_Fe_S_CS    Aldolase_TIM    Dihydroorotate_DH    Dihydroorotate_DH_1_2    Fum_reductase_C    Helical_ferredxn   
Domains : Interpro (EBI)4Fe4S_Fe-S-bd    4Fe4S_Fe_S_CS    Aldolase_TIM    Dihydroorotate_DH    Dihydroorotate_DH_1_2    Fum_reductase_C    Helical_ferredxn   
Related proteins : CluSTrQ12882
Domain families : Pfam (SRS)DHO_dh (PF01180)   
Domain families : Pfam (Sanger)DHO_dh (PF01180)   
Domain families : Pfam (NCBI)pfam01180   
DMDM1806
Blocks (Seattle)Q12882
Human Protein AtlasENSG00000188641
HPRD02036
IPIIPI00029772   IPI00909357   IPI00095889   
Protein Interaction databases
DIP (DOE-UCLA)Q12882
IntAct (EBI)Q12882
FunCoupENSG00000188641
REACTOMEDPYD
Protein Interaction Database1806
BioGRIDDPYD
InParanoidQ12882
Interologous Interaction database Q12882
IntegromeDBDPYD
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)DPYD
SNP (GeneSNP Utah)DPYD
SNP : HGBaseDPYD
Genetic variants : HAPMAPDPYD
Somatic Mutations in Cancer : COSMICDPYD 
CONAN: Copy Number AnalysisDPYD 
Mutations and Diseases : HGMDDPYD
OMIM274270    612779   
GENETests274270    612779   
Disease Genetic AssociationDPYD
Huge Navigator DPYD [HugePedia]  DPYD [HugeCancerGEM]
Genomic VariantsDPYD  DPYD [DGVbeta]
snp3D : Map Gene to Disease1806
General knowledge
Homologs : HomoloGeneDPYD
Homology/Alignments : Family Browser (UCSC)DPYD
Phylogenetic Trees/Animal Genes : TreeFamDPYD
Catalytic activity : Enzyme1.3.1.2 [ Enzyme-Expasy ]   1.3.1.2 [ Enzyme-SRS ]   1.3.1.2 [ IntEnz-EBI ]   1.3.1.2 [ BRENDA ]   1.3.1.2 [ KEGG ]   
Chemical/Protein Interactions : CTD1806
Chemical/Pharm GKB GenePA145
Clinical trialDPYD
Cancer Resource (Charite)ENSG00000188641
Ontology : AmiGOdihydroorotate oxidase activity  cytoplasm  cytosol  cytosol  purine nucleobase catabolic process  pyrimidine nucleobase metabolic process  pyrimidine nucleobase catabolic process  pyrimidine nucleobase catabolic process  thymine catabolic process  uracil catabolic process  thymidine catabolic process  UMP biosynthetic process  dihydropyrimidine dehydrogenase (NADP+) activity  dihydropyrimidine dehydrogenase (NADP+) activity  dihydropyrimidine dehydrogenase (NADP+) activity  dihydropyrimidine dehydrogenase (NADP+) activity  beta-alanine biosynthetic process  protein homodimerization activity  protein homodimerization activity  small molecule metabolic process  pyrimidine nucleoside catabolic process  metal ion binding  flavin adenine dinucleotide binding  NADP binding  4 iron, 4 sulfur cluster binding  nucleobase-containing small molecule metabolic process  
Ontology : EGO-EBIdihydroorotate oxidase activity  cytoplasm  cytosol  cytosol  purine nucleobase catabolic process  pyrimidine nucleobase metabolic process  pyrimidine nucleobase catabolic process  pyrimidine nucleobase catabolic process  thymine catabolic process  uracil catabolic process  thymidine catabolic process  UMP biosynthetic process  dihydropyrimidine dehydrogenase (NADP+) activity  dihydropyrimidine dehydrogenase (NADP+) activity  dihydropyrimidine dehydrogenase (NADP+) activity  dihydropyrimidine dehydrogenase (NADP+) activity  beta-alanine biosynthetic process  protein homodimerization activity  protein homodimerization activity  small molecule metabolic process  pyrimidine nucleoside catabolic process  metal ion binding  flavin adenine dinucleotide binding  NADP binding  4 iron, 4 sulfur cluster binding  nucleobase-containing small molecule metabolic process  
Pathways : KEGGPyrimidine metabolismPantothenate and CoA biosynthesisbeta-Alanine metabolism
Other databases
Probes
Litterature
PubMed151 Pubmed reference(s) in Entrez
PubGeneDPYD
iHOPDPYD
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:24:26 CEST 2013
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