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DPYD (dihydropyrimidine dehydrogenase)

Identity

Other namesDHP
DHPDHASE
DPD
HGNC (Hugo) DPYD
LocusID (NCBI) 1806
Location 1p21.3
Location_base_pair Starts at 97543300 and ends at 98386615 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DPYD   3012
Cards
Entrez_Gene (NCBI)DPYD  1806  dihydropyrimidine dehydrogenase
GeneCards (Weizmann)DPYD
Ensembl hg19 (Hinxton)ENSG00000188641 [Gene_View]  chr1:97543300-98386615 [Contig_View]  DPYD [Vega]
Ensembl hg38 (Hinxton)ENSG00000188641 [Gene_View]  chr1:97543300-98386615 [Contig_View]  DPYD [Vega]
ICGC DataPortalENSG00000188641
cBioPortalDPYD
AceView (NCBI)DPYD
Genatlas (Paris)DPYD
WikiGenes1806
SOURCE (Princeton)DPYD
Genomic and cartography
GoldenPath hg19 (UCSC)DPYD  -     chr1:97543300-98386615 -  1p21.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DPYD  -     1p21.3   [Description]    (hg38-Dec_2013)
EnsemblDPYD - 1p21.3 [CytoView hg19]  DPYD - 1p21.3 [CytoView hg38]
Mapping of homologs : NCBIDPYD [Mapview hg19]  DPYD [Mapview hg38]
OMIM274270   612779   
Gene and transcription
Genbank (Entrez)AB003063 AI124948 AK291217 AK297515 BC008379
RefSeq transcript (Entrez)NM_000110 NM_001160301
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NG_008807 NT_032977 NW_001838589 NW_004929290
Consensus coding sequences : CCDS (NCBI)DPYD
Cluster EST : UnigeneHs.335034 [ NCBI ]
CGAP (NCI)Hs.335034
Alternative Splicing : Fast-db (Paris)GSHG0002288
Alternative Splicing GalleryENSG00000188641
Gene ExpressionDPYD [ NCBI-GEO ]     DPYD [ SEEK ]   DPYD [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ12882 (Uniprot)
NextProtQ12882  [Medical]
With graphics : InterProQ12882
Splice isoforms : SwissVarQ12882 (Swissvar)
Catalytic activity : Enzyme1.3.1.2 [ Enzyme-Expasy ]   1.3.1.21.3.1.2 [ IntEnz-EBI ]   1.3.1.2 [ BRENDA ]   1.3.1.2 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)4FE4S_FER_1 (PS00198)    4FE4S_FER_2 (PS51379)   
Domains : Interpro (EBI)4Fe4S_Fe-S-bd    4Fe4S_Fe_S_CS    Aldolase_TIM    Dihydroorotate_DH    Dihydroorotate_DH_1_2    DPD_II    Helical_ferredxn   
Related proteins : CluSTrQ12882
Domain families : Pfam (Sanger)DHO_dh (PF01180)    Fer4_20 (PF14691)   
Domain families : Pfam (NCBI)pfam01180    pfam14691   
DMDM Disease mutations1806
Blocks (Seattle)Q12882
Human Protein AtlasENSG00000188641
Peptide AtlasQ12882
HPRD02036
IPIIPI00029772   IPI00909357   IPI00095889   
Protein Interaction databases
DIP (DOE-UCLA)Q12882
IntAct (EBI)Q12882
FunCoupENSG00000188641
BioGRIDDPYD
IntegromeDBDPYD
STRING (EMBL)DPYD
Ontologies - Pathways
QuickGOQ12882
Ontology : AmiGOdihydroorotate oxidase activity  cytoplasm  cytosol  cytosol  purine nucleobase catabolic process  pyrimidine nucleobase metabolic process  pyrimidine nucleobase catabolic process  pyrimidine nucleobase catabolic process  thymine catabolic process  uracil catabolic process  thymidine catabolic process  UMP biosynthetic process  dihydropyrimidine dehydrogenase (NADP+) activity  dihydropyrimidine dehydrogenase (NADP+) activity  dihydropyrimidine dehydrogenase (NADP+) activity  dihydropyrimidine dehydrogenase (NADP+) activity  beta-alanine biosynthetic process  protein homodimerization activity  protein homodimerization activity  small molecule metabolic process  pyrimidine nucleoside catabolic process  metal ion binding  flavin adenine dinucleotide binding  NADP binding  4 iron, 4 sulfur cluster binding  nucleobase-containing small molecule metabolic process  oxidation-reduction process  
Ontology : EGO-EBIdihydroorotate oxidase activity  cytoplasm  cytosol  cytosol  purine nucleobase catabolic process  pyrimidine nucleobase metabolic process  pyrimidine nucleobase catabolic process  pyrimidine nucleobase catabolic process  thymine catabolic process  uracil catabolic process  thymidine catabolic process  UMP biosynthetic process  dihydropyrimidine dehydrogenase (NADP+) activity  dihydropyrimidine dehydrogenase (NADP+) activity  dihydropyrimidine dehydrogenase (NADP+) activity  dihydropyrimidine dehydrogenase (NADP+) activity  beta-alanine biosynthetic process  protein homodimerization activity  protein homodimerization activity  small molecule metabolic process  pyrimidine nucleoside catabolic process  metal ion binding  flavin adenine dinucleotide binding  NADP binding  4 iron, 4 sulfur cluster binding  nucleobase-containing small molecule metabolic process  oxidation-reduction process  
Pathways : KEGGPyrimidine metabolism    beta-Alanine metabolism    Pantothenate and CoA biosynthesis    Drug metabolism - other enzymes   
Protein Interaction DatabaseDPYD
DoCM (Curated mutations)DPYD
Wikipedia pathwaysDPYD
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerDPYD [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DPYD
dbVarDPYD
ClinVarDPYD
1000_GenomesDPYD 
Exome Variant ServerDPYD
SNP (GeneSNP Utah)DPYD
SNP : HGBaseDPYD
Genetic variants : HAPMAPDPYD
Genomic VariantsDPYD  DPYD [DGVbeta]
Mutations
ICGC Data PortalENSG00000188641 
Somatic Mutations in Cancer : COSMICDPYD 
CONAN: Copy Number AnalysisDPYD 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:97543300-98386615
Mutations and Diseases : HGMDDPYD
OMIM274270    612779   
MedgenDPYD
NextProtQ12882 [Medical]
GENETestsDPYD
Disease Genetic AssociationDPYD
Huge Navigator DPYD [HugePedia]  DPYD [HugeCancerGEM]
snp3D : Map Gene to Disease1806
DGIdb (Drug Gene Interaction db)DPYD
General knowledge
Homologs : HomoloGeneDPYD
Homology/Alignments : Family Browser (UCSC)DPYD
Phylogenetic Trees/Animal Genes : TreeFamDPYD
Chemical/Protein Interactions : CTD1806
Chemical/Pharm GKB GenePA145
Clinical trialDPYD
Cancer Resource (Charite)ENSG00000188641
Other databases
Probes
Litterature
PubMed170 Pubmed reference(s) in Entrez
CoreMineDPYD
GoPubMedDPYD
iHOPDPYD
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 21:16:21 CET 2014

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