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DPYD (dihydropyrimidine dehydrogenase)

Identity

Other namesDHP
DHPDHASE
DPD
HGNC (Hugo) DPYD
LocusID (NCBI) 1806
Atlas_Id 40361
Location 1p21.3  [Link to chromosome band 1p21]
Location_base_pair Starts at 97543300 and ends at 98386615 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DPYD (1p21.3) / COX5B (2q11.2)DPYD (1p21.3) / CSNK1G1 (15q22.31)DPYD (1p21.3) / EDIL3 (5q14.3)
DPYD (1p21.3) / KXD1 (19p13.11)DPYD (1p21.3) / LOC100507373 (19p13.12)DPYD (1p21.3) / NRIP3 (11p15.4)
DPYD (1p21.3) / STAB2 (12q23.3)NBPF9 (1q21.1) / DPYD (1p21.3)SRRM2 (16p13.3) / DPYD (1p21.3)
UNK (17q25.1) / DPYD (1p21.3)DPYD 1p21.3 / CSNK1G1 15q22.31DPYD 1p21.3 / EDIL3 5q14.3
DPYD 1p21.3 / STAB2 12q23.3UNK 17q25.1 / DPYD 1p21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 0 ]
  Lung: Translocations in Squamous Cell Carcinoma

External links

Nomenclature
HGNC (Hugo)DPYD   3012
Cards
Entrez_Gene (NCBI)DPYD  1806  dihydropyrimidine dehydrogenase
AliasesDHP; DHPDHASE; DPD
GeneCards (Weizmann)DPYD
Ensembl hg19 (Hinxton)ENSG00000188641 [Gene_View]  chr1:97543300-98386615 [Contig_View]  DPYD [Vega]
Ensembl hg38 (Hinxton)ENSG00000188641 [Gene_View]  chr1:97543300-98386615 [Contig_View]  DPYD [Vega]
ICGC DataPortalENSG00000188641
TCGA cBioPortalDPYD
AceView (NCBI)DPYD
Genatlas (Paris)DPYD
WikiGenes1806
SOURCE (Princeton)DPYD
Genomic and cartography
GoldenPath hg19 (UCSC)DPYD  -     chr1:97543300-98386615 -  1p21.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DPYD  -     1p21.3   [Description]    (hg38-Dec_2013)
EnsemblDPYD - 1p21.3 [CytoView hg19]  DPYD - 1p21.3 [CytoView hg38]
Mapping of homologs : NCBIDPYD [Mapview hg19]  DPYD [Mapview hg38]
OMIM274270   612779   
Gene and transcription
Genbank (Entrez)AB003063 AI124948 AK291217 AK297515 BC008379
RefSeq transcript (Entrez)NM_000110 NM_001160301
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_008807 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)DPYD
Cluster EST : UnigeneHs.335034 [ NCBI ]
CGAP (NCI)Hs.335034
Alternative Splicing GalleryENSG00000188641
Gene ExpressionDPYD [ NCBI-GEO ]   DPYD [ EBI - ARRAY_EXPRESS ]   DPYD [ SEEK ]   DPYD [ MEM ]
Gene Expression Viewer (FireBrowse)DPYD [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1806
GTEX Portal (Tissue expression)DPYD
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ12882 (Uniprot)
NextProtQ12882  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ12882
Splice isoforms : SwissVarQ12882 (Swissvar)
Catalytic activity : Enzyme1.3.1.2 [ Enzyme-Expasy ]   1.3.1.21.3.1.2 [ IntEnz-EBI ]   1.3.1.2 [ BRENDA ]   1.3.1.2 [ KEGG ]   
PhosPhoSitePlusQ12882
Domaine pattern : Prosite (Expaxy)4FE4S_FER_1 (PS00198)    4FE4S_FER_2 (PS51379)   
Domains : Interpro (EBI)4Fe4S_Fe-S-bd    4Fe4S_Fe_S_CS    Aldolase_TIM    Dihydroorotate_DH    DPD_II    FAD/NAD-binding_dom    Helical_ferredxn   
Domain families : Pfam (Sanger)DHO_dh (PF01180)    Fer4_20 (PF14691)    Pyr_redox_2 (PF07992)   
Domain families : Pfam (NCBI)pfam01180    pfam14691    pfam07992   
DMDM Disease mutations1806
Blocks (Seattle)DPYD
SuperfamilyQ12882
Human Protein AtlasENSG00000188641
Peptide AtlasQ12882
HPRD02036
IPIIPI00029772   IPI00909357   IPI00095889   
Protein Interaction databases
DIP (DOE-UCLA)Q12882
IntAct (EBI)Q12882
FunCoupENSG00000188641
BioGRIDDPYD
STRING (EMBL)DPYD
ZODIACDPYD
Ontologies - Pathways
QuickGOQ12882
Ontology : AmiGOprotein binding  cytoplasm  cytosol  cytosol  purine nucleobase catabolic process  pyrimidine nucleobase catabolic process  pyrimidine nucleobase catabolic process  thymine catabolic process  uracil catabolic process  thymidine catabolic process  dihydropyrimidine dehydrogenase (NADP+) activity  dihydropyrimidine dehydrogenase (NADP+) activity  dihydropyrimidine dehydrogenase (NADP+) activity  dihydropyrimidine dehydrogenase (NADP+) activity  beta-alanine biosynthetic process  protein homodimerization activity  protein homodimerization activity  pyrimidine nucleoside catabolic process  metal ion binding  flavin adenine dinucleotide binding  NADP binding  4 iron, 4 sulfur cluster binding  oxidation-reduction process  
Ontology : EGO-EBIprotein binding  cytoplasm  cytosol  cytosol  purine nucleobase catabolic process  pyrimidine nucleobase catabolic process  pyrimidine nucleobase catabolic process  thymine catabolic process  uracil catabolic process  thymidine catabolic process  dihydropyrimidine dehydrogenase (NADP+) activity  dihydropyrimidine dehydrogenase (NADP+) activity  dihydropyrimidine dehydrogenase (NADP+) activity  dihydropyrimidine dehydrogenase (NADP+) activity  beta-alanine biosynthetic process  protein homodimerization activity  protein homodimerization activity  pyrimidine nucleoside catabolic process  metal ion binding  flavin adenine dinucleotide binding  NADP binding  4 iron, 4 sulfur cluster binding  oxidation-reduction process  
Pathways : KEGGPyrimidine metabolism    beta-Alanine metabolism    Pantothenate and CoA biosynthesis    Drug metabolism - other enzymes   
NDEx Network
Atlas of Cancer Signalling NetworkDPYD
Wikipedia pathwaysDPYD
Orthology - Evolution
OrthoDB1806
GeneTree (enSembl)ENSG00000188641
Phylogenetic Trees/Animal Genes : TreeFamDPYD
Homologs : HomoloGeneDPYD
Homology/Alignments : Family Browser (UCSC)DPYD
Gene fusions - Rearrangements
Fusion: TCGADPYD 1p21.3 CSNK1G1 15q22.31 OV
Fusion: TCGADPYD 1p21.3 EDIL3 5q14.3 BRCA
Fusion: TCGADPYD 1p21.3 STAB2 12q23.3 BRCA
Fusion: TCGAUNK 17q25.1 DPYD 1p21.3 LUSC
Polymorphisms : SNP, variants
NCBI Variation ViewerDPYD [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DPYD
dbVarDPYD
ClinVarDPYD
1000_GenomesDPYD 
Exome Variant ServerDPYD
ExAC (Exome Aggregation Consortium)DPYD (select the gene name)
Genetic variants : HAPMAP1806
Genomic Variants (DGV)DPYD [DGVbeta]
Mutations
ICGC Data PortalDPYD 
TCGA Data PortalDPYD 
Broad Tumor PortalDPYD
OASIS PortalDPYD [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDPYD 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DPYD
DgiDB (Drug Gene Interaction Database)DPYD
DoCM (Curated mutations)DPYD (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DPYD (select a term)
intoGenDPYD
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:97543300-98386615  ENSG00000188641
CONAN: Copy Number AnalysisDPYD 
Mutations and Diseases : HGMDDPYD
OMIM274270    612779   
MedgenDPYD
Genetic Testing Registry DPYD
NextProtQ12882 [Medical]
TSGene1806
GENETestsDPYD
Huge Navigator DPYD [HugePedia]
snp3D : Map Gene to Disease1806
BioCentury BCIQDPYD
ClinGenDPYD
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1806
Chemical/Pharm GKB GenePA145
Clinical trialDPYD
Miscellaneous
canSAR (ICR)DPYD (select the gene name)
Probes
Litterature
PubMed183 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDPYD
EVEXDPYD
GoPubMedDPYD
iHOPDPYD
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 9 19:01:52 CEST 2016

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