Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

DPYS (dihydropyrimidinase)

Identity

Other namesDHP
DHPase
HGNC (Hugo) DPYS
LocusID (NCBI) 1807
Location 8q22.3
Location_base_pair Starts at 105391652 and ends at 105479277 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DPYS   3013
Entrez_Gene (NCBI)DPYS  1807  dihydropyrimidinase
Cards
GeneCards (Weizmann)DPYS
Ensembl (Hinxton)ENSG00000147647 [Gene_View]  chr8:105391652-105479277 [Contig_View]  DPYS [Vega]
AceView (NCBI)DPYS
Genatlas (Paris)DPYS
SOURCE (Stanford)NM_001385
Genomic and cartography
GoldenPath (UCSC)DPYS  -  8q22.3   chr8:105391652-105479277 -  8q22.3   [Description]    (hg19-Feb_2009)
EnsemblDPYS - 8q22.3 [CytoView]
Mapping of homologs : NCBIDPYS [Mapview]
OMIM222748   613326   
Gene and transcription
Genbank (Entrez)AK311261 BC034395 D78011 JF432195
RefSeq transcript (SRS)NM_001385
RefSeq transcript (Entrez)NM_001385
RefSeq genomic (SRS)AC_000140 NC_000008 NC_018919 NG_008840 NT_008046 NW_001839136 NW_004078037
RefSeq genomic (Entrez)AC_000140 NC_000008 NC_018919 NG_008840 NT_008046 NW_001839136 NW_004078037
Consensus coding sequences : CCDS (NCBI)DPYS
Cluster EST : UnigeneHs.443161 [ SRS ] Hs.443161 [ NCBI ]
CGAP (NCI)Hs.443161
Alternative Splicing : Fast-db (Paris)GSHG0029772
Alternative Splicing GalleryENSG00000147647
Gene ExpressionDPYS [ NCBI-GEO ]   DPYS [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14117 (SRS) Q14117 (Uniprot)
NextProtQ14117
With graphics : InterProQ14117
Splice isoforms : SwissVarQ14117(Swissvar)
Domains : Interpro (SRS)Amidohydro_1    Hydantoinase/dihydroPyrase    Metal-dep_hydrolase_composite   
Domains : Interpro (EBI)Amidohydro_1    Hydantoinase/dihydroPyrase    Metal-dep_hydrolase_composite   
Related proteins : CluSTrQ14117
Domain families : Pfam (SRS)Amidohydro_1 (PF01979)   
Domain families : Pfam (Sanger)Amidohydro_1 (PF01979)   
Domain families : Pfam (NCBI)pfam01979   
DMDM1807
Blocks (Seattle)Q14117
PDB (SRS)2VR2   
PDB (PDBSum)2VR2   
PDB (IMB)2VR2   
PDB (RSDB)2VR2   
Human Protein AtlasENSG00000147647
HPRD01960
IPIIPI00028910   IPI00973715   IPI00983100   
Protein Interaction databases
DIP (DOE-UCLA)Q14117
IntAct (EBI)Q14117
FunCoupENSG00000147647
REACTOMEDPYS
Protein Interaction Database1807
BioGRIDDPYS
InParanoidQ14117
Interologous Interaction database Q14117
IntegromeDBDPYS
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)DPYS
SNP (GeneSNP Utah)DPYS
SNP : HGBaseDPYS
Genetic variants : HAPMAPDPYS
Somatic Mutations in Cancer : COSMICDPYS 
CONAN: Copy Number AnalysisDPYS 
Mutations and Diseases : HGMDDPYS
OMIM222748    613326   
GENETests222748    613326   
Disease Genetic AssociationDPYS
Huge Navigator DPYS [HugePedia]  DPYS [HugeCancerGEM]
Genomic VariantsDPYS  DPYS [DGVbeta]
snp3D : Map Gene to Disease1807
General knowledge
Homologs : HomoloGeneDPYS
Homology/Alignments : Family Browser (UCSC)DPYS
Phylogenetic Trees/Animal Genes : TreeFamDPYS
Catalytic activity : Enzyme3.5.2.2 [ Enzyme-Expasy ]   3.5.2.2 [ Enzyme-SRS ]   3.5.2.2 [ IntEnz-EBI ]   3.5.2.2 [ BRENDA ]   3.5.2.2 [ KEGG ]   
Chemical/Protein Interactions : CTD1807
Chemical/Pharm GKB GenePA146
Clinical trialDPYS
Cancer Resource (Charite)ENSG00000147647
Ontology : AmiGOuracil binding  thymine binding  dihydropyrimidinase activity  dihydropyrimidinase activity  dihydropyrimidinase activity  cytosol  cytosol  pyrimidine nucleobase metabolic process  pyrimidine nucleobase catabolic process  thymine catabolic process  uracil catabolic process  uracil catabolic process  zinc ion binding  amino acid binding  beta-alanine metabolic process  small molecule metabolic process  pyrimidine nucleoside catabolic process  metal ion binding  phosphoprotein binding  protein homotetramerization  nucleobase-containing small molecule metabolic process  
Ontology : EGO-EBIuracil binding  thymine binding  dihydropyrimidinase activity  dihydropyrimidinase activity  dihydropyrimidinase activity  cytosol  cytosol  pyrimidine nucleobase metabolic process  pyrimidine nucleobase catabolic process  thymine catabolic process  uracil catabolic process  uracil catabolic process  zinc ion binding  amino acid binding  beta-alanine metabolic process  small molecule metabolic process  pyrimidine nucleoside catabolic process  metal ion binding  phosphoprotein binding  protein homotetramerization  nucleobase-containing small molecule metabolic process  
Pathways : KEGGPantothenate and CoA biosynthesisPyrimidine metabolismbeta-Alanine metabolism
Other databases
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
PubGeneDPYS
iHOPDPYS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:25:00 CEST 2013
Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.