DPYSL2 (dihydropyrimidinase like 2)

2008-04-01  

Identity

HGNC
LOCATION
8p21.2
LOCUSID
ALIAS
CRMP-2,CRMP2,DHPRP2,DRP-2,DRP2,N2A3,ULIP-2,ULIP2
FUSION GENES

Other Information

Locus ID:

NCBI: 1808
MIM: 602463
HGNC: 3014
Ensembl: ENSG00000092964

Variants:

dbSNP: 1808
ClinVar: 1808
TCGA: ENSG00000092964
COSMIC: DPYSL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000092964ENST00000311151Q16555
ENSG00000092964ENST00000493789E5RFU4
ENSG00000092964ENST00000521913A0A1C7CYX9
ENSG00000092964ENST00000523027Q16555

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
CRMPs in Sema3A signalingREACTOMER-HSA-399956
L1CAM interactionsREACTOMER-HSA-373760
Recycling pathway of L1REACTOMER-HSA-437239

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
185839792008Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.395
163809052005Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios.131
162606072005CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation.89
212713042011Collapsin response mediator protein-2: an emerging pathologic feature and therapeutic target for neurodisease indications.72
166116312006Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo.71
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
176834812007Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression.60
191102652009Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophrenia.43
194059532009Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation.38
238368882013CRMP2 protein SUMOylation modulates NaV1.7 channel trafficking.38

Citation

Dessen P

DPYSL2 (dihydropyrimidinase like 2)

Atlas Genet Cytogenet Oncol Haematol. 2008-04-01

Online version: http://atlasgeneticsoncology.org/gene/50096/dpysl2