Atlas of Genetics and Cytogenetics in Oncology and Haematology


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DPYSL2 (dihydropyrimidinase like 2)

Identity

Alias_namesdihydropyrimidinase-like 2
Alias_symbol (synonym)DRP-2
DHPRP2
CRMP2
DRP2
Other aliasCRMP-2
N2A3
ULIP-2
ULIP2
HGNC (Hugo) DPYSL2
LocusID (NCBI) 1808
Atlas_Id 50096
Location 8p21.2  [Link to chromosome band 8p21]
Location_base_pair Starts at 26371709 and ends at 26515693 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DPYSL2 (8p21.2) / C22orf46 (22q13.2)DPYSL2 (8p21.2) / IWS1 (2q14.3)DPYSL2 (8p21.2) / NFU1 (2p13.3)
DPYSL2 (8p21.2) / RGS3 (9q32)DPYSL2 (8p21.2) / RP11-360L9.4 ()DPYSL2 (8p21.2) / RPL15 (3p24.2)
DPYSL2 (8p21.2) / SDF2L1 (22q11.21)DPYSL2 (8p21.2) / SPIN1 (9q22.1)PDE7A (8q13.1) / DPYSL2 (8p21.2)
RTN1 (14q23.1) / DPYSL2 (8p21.2)SFTPB (2p11.2) / DPYSL2 (8p21.2)DPYSL2 8p21.2 RP11-360L9.4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)DPYSL2   3014
Cards
Entrez_Gene (NCBI)DPYSL2  1808  dihydropyrimidinase like 2
AliasesCRMP-2; CRMP2; DHPRP2; DRP-2; 
DRP2; N2A3; ULIP-2; ULIP2
GeneCards (Weizmann)DPYSL2
Ensembl hg19 (Hinxton)ENSG00000092964 [Gene_View]  chr8:26371709-26515693 [Contig_View]  DPYSL2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000092964 [Gene_View]  chr8:26371709-26515693 [Contig_View]  DPYSL2 [Vega]
ICGC DataPortalENSG00000092964
TCGA cBioPortalDPYSL2
AceView (NCBI)DPYSL2
Genatlas (Paris)DPYSL2
WikiGenes1808
SOURCE (Princeton)DPYSL2
Genetics Home Reference (NIH)DPYSL2
Genomic and cartography
GoldenPath hg19 (UCSC)DPYSL2  -     chr8:26371709-26515693 +  8p21.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DPYSL2  -     8p21.2   [Description]    (hg38-Dec_2013)
EnsemblDPYSL2 - 8p21.2 [CytoView hg19]  DPYSL2 - 8p21.2 [CytoView hg38]
Mapping of homologs : NCBIDPYSL2 [Mapview hg19]  DPYSL2 [Mapview hg38]
OMIM602463   
Gene and transcription
Genbank (Entrez)AB209195 AB370194 AB370195 AK092377 AK223557
RefSeq transcript (Entrez)NM_001197293 NM_001244604 NM_001386
RefSeq genomic (Entrez)NC_000008 NC_018919 NG_030020 NT_167187 NW_004929337
Consensus coding sequences : CCDS (NCBI)DPYSL2
Cluster EST : UnigeneHs.593187 [ NCBI ]
CGAP (NCI)Hs.593187
Alternative Splicing GalleryENSG00000092964
Gene ExpressionDPYSL2 [ NCBI-GEO ]   DPYSL2 [ EBI - ARRAY_EXPRESS ]   DPYSL2 [ SEEK ]   DPYSL2 [ MEM ]
Gene Expression Viewer (FireBrowse)DPYSL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1808
GTEX Portal (Tissue expression)DPYSL2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16555   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16555  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16555
Splice isoforms : SwissVarQ16555
PhosPhoSitePlusQ16555
Domains : Interpro (EBI)Amidohydro-rel    DRP2    Hydantoinase/dihydroPyrase    Metal-dep_hydrolase_composite    Metal_Hydrolase   
Domain families : Pfam (Sanger)Amidohydro_1 (PF01979)   
Domain families : Pfam (NCBI)pfam01979   
Conserved Domain (NCBI)DPYSL2
DMDM Disease mutations1808
Blocks (Seattle)DPYSL2
PDB (SRS)2GSE    2VM8   
PDB (PDBSum)2GSE    2VM8   
PDB (IMB)2GSE    2VM8   
PDB (RSDB)2GSE    2VM8   
Structural Biology KnowledgeBase2GSE    2VM8   
SCOP (Structural Classification of Proteins)2GSE    2VM8   
CATH (Classification of proteins structures)2GSE    2VM8   
SuperfamilyQ16555
Human Protein AtlasENSG00000092964
Peptide AtlasQ16555
HPRD03914
IPIIPI00257508   IPI01009306   IPI00883655   IPI00984387   IPI00974211   
Protein Interaction databases
DIP (DOE-UCLA)Q16555
IntAct (EBI)Q16555
FunCoupENSG00000092964
BioGRIDDPYSL2
STRING (EMBL)DPYSL2
ZODIACDPYSL2
Ontologies - Pathways
QuickGOQ16555
Ontology : AmiGOresponse to amphetamine  dihydropyrimidinase activity  protein binding  mitochondrion  cytosol  cytosol  microtubule  nucleobase-containing compound metabolic process  endocytosis  cytoskeleton organization  signal transduction  nervous system development  axon guidance  microtubule binding  positive regulation of glutamate secretion  membrane  protein kinase binding  spinal cord development  olfactory bulb development  dendrite  growth cone  regulation of axon extension  response to cocaine  response to drug  neuronal cell body  terminal bouton  myelin sheath  protein complex  synaptic vesicle transport  extracellular exosome  
Ontology : EGO-EBIresponse to amphetamine  dihydropyrimidinase activity  protein binding  mitochondrion  cytosol  cytosol  microtubule  nucleobase-containing compound metabolic process  endocytosis  cytoskeleton organization  signal transduction  nervous system development  axon guidance  microtubule binding  positive regulation of glutamate secretion  membrane  protein kinase binding  spinal cord development  olfactory bulb development  dendrite  growth cone  regulation of axon extension  response to cocaine  response to drug  neuronal cell body  terminal bouton  myelin sheath  protein complex  synaptic vesicle transport  extracellular exosome  
Pathways : KEGGAxon guidance   
NDEx NetworkDPYSL2
Atlas of Cancer Signalling NetworkDPYSL2
Wikipedia pathwaysDPYSL2
Orthology - Evolution
OrthoDB1808
GeneTree (enSembl)ENSG00000092964
Phylogenetic Trees/Animal Genes : TreeFamDPYSL2
HOVERGENQ16555
HOGENOMQ16555
Homologs : HomoloGeneDPYSL2
Homology/Alignments : Family Browser (UCSC)DPYSL2
Gene fusions - Rearrangements
Fusion : MitelmanSFTPB/DPYSL2 [2p11.2/8p21.2]  [t(2;8)(p11;p21)]  
Fusion: TCGADPYSL2 8p21.2 RP11-360L9.4 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDPYSL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DPYSL2
dbVarDPYSL2
ClinVarDPYSL2
1000_GenomesDPYSL2 
Exome Variant ServerDPYSL2
ExAC (Exome Aggregation Consortium)DPYSL2 (select the gene name)
Genetic variants : HAPMAP1808
Genomic Variants (DGV)DPYSL2 [DGVbeta]
DECIPHER (Syndromes)8:26371709-26515693  ENSG00000092964
CONAN: Copy Number AnalysisDPYSL2 
Mutations
ICGC Data PortalDPYSL2 
TCGA Data PortalDPYSL2 
Broad Tumor PortalDPYSL2
OASIS PortalDPYSL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDPYSL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDPYSL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DPYSL2
DgiDB (Drug Gene Interaction Database)DPYSL2
DoCM (Curated mutations)DPYSL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DPYSL2 (select a term)
intoGenDPYSL2
Cancer3DDPYSL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602463   
Orphanet
MedgenDPYSL2
Genetic Testing Registry DPYSL2
NextProtQ16555 [Medical]
TSGene1808
GENETestsDPYSL2
Huge Navigator DPYSL2 [HugePedia]
snp3D : Map Gene to Disease1808
BioCentury BCIQDPYSL2
ClinGenDPYSL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1808
Chemical/Pharm GKB GenePA27472
Clinical trialDPYSL2
Miscellaneous
canSAR (ICR)DPYSL2 (select the gene name)
Probes
Litterature
PubMed97 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDPYSL2
EVEXDPYSL2
GoPubMedDPYSL2
iHOPDPYSL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:03:49 CET 2017

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