DR1 (down-regulator of transcription 1)

2016-10-01  

Identity

HGNC
LOCATION
1p22.1
LOCUSID
ALIAS
NC2,NC2-BETA,NC2B,NCB2

Other Information

Locus ID:

NCBI: 1810
MIM: 601482
HGNC: 3017
Ensembl: ENSG00000117505

Variants:

dbSNP: 1810
ClinVar: 1810
TCGA: ENSG00000117505
COSMIC: DR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117505ENST00000370267Q01658
ENSG00000117505ENST00000370267Q658N3
ENSG00000117505ENST00000370272Q01658
ENSG00000117505ENST00000370272Q658N3

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
205347412010Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.108
188383862008Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein.87
155744132005Efficient binding of NC2.TATA-binding protein to DNA in the absence of TATA.18
175847392007The initiator core promoter element antagonizes repression of TATA-directed transcription by negative cofactor NC2.13
192040052009Regulation of nuclear import and export of negative cofactor 2.7
255896572015A host susceptibility gene, DR1, facilitates influenza A virus replication by suppressing host innate immunity and enhancing viral RNA replication.7
202306192010Basal core promoters control the equilibrium between negative cofactor 2 and preinitiation complexes in human cells.5
297172112018Up-regulation of microRNA-203 in influenza A virus infection inhibits viral replication by targeting DR1.5
199657672010Dr1 (NC2) is present at tRNA genes and represses their transcription in human cells.4
281811342017The effect and mechanism of dopamine D1 receptors on the proliferation of osteosarcoma cells.3

Citation

Dessen P

DR1 (down-regulator of transcription 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56578/dr1