DRAM2 (DNA damage regulated autophagy modulator 2)

2010-02-01  

Identity

HGNC
LOCATION
1p13.3
LOCUSID
ALIAS
CORD21,PRO180,TMEM77,WWFQ154

Other Information

Locus ID:

NCBI: 128338
MIM: 613360
HGNC: 28769
Ensembl: ENSG00000156171

Variants:

dbSNP: 128338
ClinVar: 128338
TCGA: ENSG00000156171
COSMIC: DRAM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156171ENST00000286692Q6UX65
ENSG00000156171ENST00000286692A0A024R0B7
ENSG00000156171ENST00000496430S4R2Z2
ENSG00000156171ENST00000539140Q6UX65
ENSG00000156171ENST00000539140A0A024R0B7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
195568852009Analysis of DRAM-related proteins reveals evolutionarily conserved and divergent roles in the control of autophagy.28
277645732017MIR144* inhibits antimicrobial responses against Mycobacterium tuberculosis in human monocytes and macrophages by targeting the autophagy protein DRAM2.27
215846982012The expression of damage-regulated autophagy modulator 2 (DRAM2) contributes to autophagy induction.16
198957842009Reduced expression of DRAM2/TMEM77 in tumor cells interferes with cell death.13
259832452015Biallelic mutations in the autophagy regulator DRAM2 cause retinal dystrophy with early macular involvement.12
267204602015Disease Expression in Autosomal Recessive Retinal Dystrophy Associated With Mutations in the DRAM2 Gene.4
265096682015Genetic Variants on Chromosome 1p13.3 Are Associated with Non-ST Elevation Myocardial Infarction and the Expression of DRAM2 in the Finnish Population.3
313941022019Characterization of the cone-rod dystrophy retinal phenotype caused by novel homozygous DRAM2 mutations.1

Citation

Dessen P

DRAM2 (DNA damage regulated autophagy modulator 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-02-01

Online version: http://atlasgeneticsoncology.org/gene/51330/dram2