DRAP1 (DR1 associated protein 1)

2014-11-01  

Identity

HGNC
DRAP1
LOCATION
11q13.1
LOCUSID
10589
ALIAS
NC2-alpha
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10589
MIM: 602289
HGNC: 3019
Ensembl: ENSG00000175550

Variants:

dbSNP: 10589
ClinVar: 10589
TCGA: ENSG00000175550
COSMIC: DRAP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175550ENST00000312515Q14919
ENSG00000175550ENST00000376991C9JCC6
ENSG00000175550ENST00000525501E9PNC7
ENSG00000175550ENST00000527119E9PMW2
ENSG00000175550ENST00000532933E9PQX9

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by ActivinREACTOMER-HSA-1502540
Developmental BiologyREACTOMER-HSA-1266738
Signaling by NODALREACTOMER-HSA-1181150

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
179941032007NC2 mobilizes TBP on core promoter TATA boxes.37
175488132007Global distribution of negative cofactor 2 subunit-alpha on human promoters.18
155098072004NC2alpha interacts with BTAF1 and stimulates its ATP-dependent association with TATA-binding protein.15
124777122003Hypoxia actively represses transcription by inducing negative cofactor 2 (Dr1/DrAP1) and blocking preinitiation complex assembly.13
192040052009Regulation of nuclear import and export of negative cofactor 2.7

Citation

Dessen P

DRAP1 (DR1 associated protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62636/drap1