DRD1 (dopamine receptor D1)

2015-08-01  

Identity

HGNC
LOCATION
5q35.2
LOCUSID
ALIAS
DADR,DRD1A

Other Information

Locus ID:

NCBI: 1812
MIM: 126449
HGNC: 3020
Ensembl: ENSG00000184845

Variants:

dbSNP: 1812
ClinVar: 1812
TCGA: ENSG00000184845
COSMIC: DRD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184845ENST00000393752P21728

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Gap junctionKEGGko04540
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Gap junctionKEGGhsa04540
Parkinson's diseaseKEGGhsa05012
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Cocaine addictionKEGGhsa05030
Cocaine addictionKEGGko05030
Amphetamine addictionKEGGhsa05031
Amphetamine addictionKEGGko05031
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Amine ligand-binding receptorsREACTOMER-HSA-375280
Dopamine receptorsREACTOMER-HSA-390651
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA131548935drotrecogin alfaChemicalVariantAnnotationassociatedPD22310353
PA445876Tobacco Use DisorderDiseaseClinicalAnnotationassociatedPD18092181
PA446771SepsisDiseaseVariantAnnotationassociatedPD22310353
PA447197Attention Deficit Disorder with HyperactivityDiseaseClinicalAnnotationassociatedPD23952191
PA447199Bipolar DisorderDiseaseClinicalAnnotationassociatedPD21047205
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD17092969
PA448687bupropionChemicalClinicalAnnotationassociatedPD
PA449061clozapineChemicalClinicalAnnotationassociatedPD17092969
PA449269dextroamphetamineChemicalClinicalAnnotationassociatedPD23952191
PA449841haloperidolChemicalMultilinkAnnotationassociated27023437
PA450243lithiumChemicalClinicalAnnotationassociatedPD21047205
PA450464methylphenidateChemicalClinicalAnnotationassociatedPD23952191
PA450626nicotineChemicalClinicalAnnotationassociatedPD18092181

References

Pubmed IDYearTitleCitations
185839792008Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.395
191970692009Changes in cortical dopamine D1 receptor binding associated with cognitive training.143
151594032004Dopamine D1 and D2 receptor Co-activation generates a novel phospholipase C-mediated calcium signal.140
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
203517142011Poor replication of candidate genes for major depressive disorder using genome-wide association data.92
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
186898592009Quantitative analysis of the expression of dopamine D1 and D2 receptors in pyramidal and GABAergic neurons of the rat prefrontal cortex.74
176796372007Polymorphisms of the dopamine D4 receptor, clinical outcome, and cortical structure in attention-deficit/hyperactivity disorder.72
126465562003Regulation of dopamine D1 receptor trafficking and desensitization by oligomerization with glutamate N-methyl-D-aspartate receptors.68
186447902008Identification of dopamine D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum.66

Citation

Dessen P

DRD1 (dopamine receptor D1)

Atlas Genet Cytogenet Oncol Haematol. 2015-08-01

Online version: http://atlasgeneticsoncology.org/gene/55334/drd1