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DRD1 (dopamine receptor D1)

Identity

Other aliasDADR
DRD1A
HGNC (Hugo) DRD1
LocusID (NCBI) 1812
Atlas_Id 55334
Location 5q35.2  [Link to chromosome band 5q35]
Location_base_pair Starts at 175440672 and ends at 175444160 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DRD1   3020
Cards
Entrez_Gene (NCBI)DRD1  1812  dopamine receptor D1
AliasesDADR; DRD1A
GeneCards (Weizmann)DRD1
Ensembl hg19 (Hinxton)ENSG00000184845 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000184845 [Gene_View]  chr5:175440672-175444160 [Contig_View]  DRD1 [Vega]
ICGC DataPortalENSG00000184845
TCGA cBioPortalDRD1
AceView (NCBI)DRD1
Genatlas (Paris)DRD1
WikiGenes1812
SOURCE (Princeton)DRD1
Genetics Home Reference (NIH)DRD1
Genomic and cartography
GoldenPath hg38 (UCSC)DRD1  -     chr5:175440672-175444160 -  5q35.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DRD1  -     5q35.2   [Description]    (hg19-Feb_2009)
EnsemblDRD1 - 5q35.2 [CytoView hg19]  DRD1 - 5q35.2 [CytoView hg38]
Mapping of homologs : NCBIDRD1 [Mapview hg19]  DRD1 [Mapview hg38]
OMIM126449   
Gene and transcription
Genbank (Entrez)AF498961 AK314031 BC074978 BC074979 BC096837
RefSeq transcript (Entrez)NM_000794
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DRD1
Cluster EST : UnigeneHs.2624 [ NCBI ]
CGAP (NCI)Hs.2624
Alternative Splicing GalleryENSG00000184845
Gene ExpressionDRD1 [ NCBI-GEO ]   DRD1 [ EBI - ARRAY_EXPRESS ]   DRD1 [ SEEK ]   DRD1 [ MEM ]
Gene Expression Viewer (FireBrowse)DRD1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1812
GTEX Portal (Tissue expression)DRD1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP21728   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP21728  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP21728
Splice isoforms : SwissVarP21728
PhosPhoSitePlusP21728
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)Dopamine_D1_rcpt    Dopamine_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)DRD1
DMDM Disease mutations1812
Blocks (Seattle)DRD1
PDB (SRS)1OZ5   
PDB (PDBSum)1OZ5   
PDB (IMB)1OZ5   
PDB (RSDB)1OZ5   
Structural Biology KnowledgeBase1OZ5   
SCOP (Structural Classification of Proteins)1OZ5   
CATH (Classification of proteins structures)1OZ5   
SuperfamilyP21728
Human Protein AtlasENSG00000184845
Peptide AtlasP21728
HPRD00538
IPIIPI00010289   
Protein Interaction databases
DIP (DOE-UCLA)P21728
IntAct (EBI)P21728
FunCoupENSG00000184845
BioGRIDDRD1
STRING (EMBL)DRD1
ZODIACDRD1
Ontologies - Pathways
QuickGOP21728
Ontology : AmiGOdopamine neurotransmitter receptor activity, coupled via Gs  dopamine neurotransmitter receptor activity, coupled via Gs  temperature homeostasis  conditioned taste aversion  behavioral fear response  synaptic transmission, dopaminergic  response to amphetamine  dopamine neurotransmitter receptor activity  protein binding  nucleus  endoplasmic reticulum membrane  plasma membrane  plasma membrane  integral component of plasma membrane  protein import into nucleus  G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  adenylate cyclase-activating G-protein coupled receptor signaling pathway  activation of adenylate cyclase activity  adenylate cyclase-activating dopamine receptor signaling pathway  synapse assembly  learning  memory  mating behavior  grooming behavior  adult walking behavior  visual learning  positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway  positive regulation of gene expression  astrocyte development  dopamine transport  transmission of nerve impulse  neuronal action potential  dentate gyrus development  striatum development  cerebral cortex GABAergic interneuron migration  positive regulation of cell migration  peristalsis  positive regulation of cAMP biosynthetic process  operant conditioning  dopamine binding  regulation of dopamine metabolic process  vasodilation  dopamine metabolic process  response to drug  maternal behavior  positive regulation of potassium ion transport  glucose import  habituation  sensitization  behavioral response to cocaine  positive regulation of release of sequestered calcium ion into cytosol  positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway  regulation of dopamine uptake involved in synaptic transmission  positive regulation of synaptic transmission, glutamatergic  prepulse inhibition  phospholipase C-activating dopamine receptor signaling pathway  phospholipase C-activating dopamine receptor signaling pathway  ciliary membrane  long-term synaptic potentiation  long term synaptic depression  cellular response to catecholamine stimulus  non-motile cilium  cellular response to dopamine  
Ontology : EGO-EBIdopamine neurotransmitter receptor activity, coupled via Gs  dopamine neurotransmitter receptor activity, coupled via Gs  temperature homeostasis  conditioned taste aversion  behavioral fear response  synaptic transmission, dopaminergic  response to amphetamine  dopamine neurotransmitter receptor activity  protein binding  nucleus  endoplasmic reticulum membrane  plasma membrane  plasma membrane  integral component of plasma membrane  protein import into nucleus  G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  adenylate cyclase-activating G-protein coupled receptor signaling pathway  activation of adenylate cyclase activity  adenylate cyclase-activating dopamine receptor signaling pathway  synapse assembly  learning  memory  mating behavior  grooming behavior  adult walking behavior  visual learning  positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway  positive regulation of gene expression  astrocyte development  dopamine transport  transmission of nerve impulse  neuronal action potential  dentate gyrus development  striatum development  cerebral cortex GABAergic interneuron migration  positive regulation of cell migration  peristalsis  positive regulation of cAMP biosynthetic process  operant conditioning  dopamine binding  regulation of dopamine metabolic process  vasodilation  dopamine metabolic process  response to drug  maternal behavior  positive regulation of potassium ion transport  glucose import  habituation  sensitization  behavioral response to cocaine  positive regulation of release of sequestered calcium ion into cytosol  positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway  regulation of dopamine uptake involved in synaptic transmission  positive regulation of synaptic transmission, glutamatergic  prepulse inhibition  phospholipase C-activating dopamine receptor signaling pathway  phospholipase C-activating dopamine receptor signaling pathway  ciliary membrane  long-term synaptic potentiation  long term synaptic depression  cellular response to catecholamine stimulus  non-motile cilium  cellular response to dopamine  
Pathways : BIOCARTARegulation of ck1/cdk5 by type 1 glutamate receptors [Genes]   
Pathways : KEGG   
NDEx NetworkDRD1
Atlas of Cancer Signalling NetworkDRD1
Wikipedia pathwaysDRD1
Orthology - Evolution
OrthoDB1812
GeneTree (enSembl)ENSG00000184845
Phylogenetic Trees/Animal Genes : TreeFamDRD1
HOVERGENP21728
HOGENOMP21728
Homologs : HomoloGeneDRD1
Homology/Alignments : Family Browser (UCSC)DRD1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDRD1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DRD1
dbVarDRD1
ClinVarDRD1
1000_GenomesDRD1 
Exome Variant ServerDRD1
ExAC (Exome Aggregation Consortium)DRD1 (select the gene name)
Genetic variants : HAPMAP1812
Genomic Variants (DGV)DRD1 [DGVbeta]
DECIPHERDRD1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDRD1 
Mutations
ICGC Data PortalDRD1 
TCGA Data PortalDRD1 
Broad Tumor PortalDRD1
OASIS PortalDRD1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDRD1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDRD1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DRD1
DgiDB (Drug Gene Interaction Database)DRD1
DoCM (Curated mutations)DRD1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DRD1 (select a term)
intoGenDRD1
Cancer3DDRD1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM126449   
Orphanet
MedgenDRD1
Genetic Testing Registry DRD1
NextProtP21728 [Medical]
TSGene1812
GENETestsDRD1
Target ValidationDRD1
Huge Navigator DRD1 [HugePedia]
snp3D : Map Gene to Disease1812
BioCentury BCIQDRD1
ClinGenDRD1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1812
Chemical/Pharm GKB GenePA147
Clinical trialDRD1
Miscellaneous
canSAR (ICR)DRD1 (select the gene name)
Probes
Litterature
PubMed251 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDRD1
EVEXDRD1
GoPubMedDRD1
iHOPDRD1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:06:00 CEST 2017

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