| Nomenclature |
|---|
| HGNC (Hugo) | DRD2 3023 |
| Cards |
|---|
| Entrez_Gene (NCBI) | DRD2 1813 dopamine receptor D2 |
| Aliases | D2DR; D2R |
| GeneCards (Weizmann) | DRD2 |
| Ensembl hg19 (Hinxton) | ENSG00000149295 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000149295 [Gene_View] chr11:113409595-113475279 [Contig_View] DRD2 [Vega] |
| ICGC DataPortal | ENSG00000149295 |
| TCGA cBioPortal | DRD2 |
| AceView (NCBI) | DRD2 |
| Genatlas (Paris) | DRD2 |
| WikiGenes | 1813 |
| SOURCE (Princeton) | DRD2 |
| Genetics Home Reference (NIH) | DRD2 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | DRD2 - chr11:113409595-113475279 - 11q23.2 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | DRD2 - 11q23.2 [Description] (hg19-Feb_2009) |
| Ensembl | DRD2 - 11q23.2 [CytoView hg19] DRD2 - 11q23.2 [CytoView hg38] |
| Mapping of homologs : NCBI | DRD2 [Mapview hg19] DRD2 [Mapview hg38] |
| OMIM | 126450 159900 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AB209832 AB451480 AF176812 AK308777 BC021195 |
| RefSeq transcript (Entrez) | NM_000795 NM_016574 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | DRD2 |
| Cluster EST : Unigene | Hs.73893 [ NCBI ] |
| CGAP (NCI) | Hs.73893 |
| Alternative Splicing Gallery | ENSG00000149295 |
| Gene Expression | DRD2 [ NCBI-GEO ] DRD2 [ EBI - ARRAY_EXPRESS ]
DRD2 [ SEEK ] DRD2 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | DRD2 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevisible | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 1813 |
| GTEX Portal (Tissue expression) | DRD2 |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P14416 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P14416 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P14416 |
| Splice isoforms : SwissVar | P14416 |
| PhosPhoSitePlus | P14416 |
| Domaine pattern : Prosite (Expaxy) | G_PROTEIN_RECEP_F1_1 (PS00237) G_PROTEIN_RECEP_F1_2 (PS50262) |
| Domains : Interpro (EBI) | Dopamine_D2_rcpt Dopamine_rcpt GPCR_Rhodpsn GPCR_Rhodpsn_7TM |
| Domain families : Pfam (Sanger) | 7tm_1 (PF00001) |
| Domain families : Pfam (NCBI) | pfam00001 |
| Domain families : Smart (EMBL) | 7TM_GPCR_Srsx (SM01381) |
| Conserved Domain (NCBI) | DRD2 |
| DMDM Disease mutations | 1813 |
| Blocks (Seattle) | DRD2 |
| PDB (SRS) | 1I15 5AER |
| PDB (PDBSum) | 1I15 5AER |
| PDB (IMB) | 1I15 5AER |
| PDB (RSDB) | 1I15 5AER |
| Structural Biology KnowledgeBase | 1I15 5AER |
| SCOP (Structural Classification of Proteins) | 1I15 5AER |
| CATH (Classification of proteins structures) | 1I15 5AER |
| Superfamily | P14416 |
| Human Protein Atlas | ENSG00000149295 |
| Peptide Atlas | P14416 |
| HPRD | 00539 |
| IPI | IPI00026590 IPI00219367 IPI00375079 IPI01015464 IPI01015728 IPI01014318 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P14416 |
| IntAct (EBI) | P14416 |
| FunCoup | ENSG00000149295 |
| BioGRID | DRD2 |
| STRING (EMBL) | DRD2 |
| ZODIAC | DRD2 |
| Ontologies - Pathways |
|---|
| QuickGO | P14416 |
| Ontology : AmiGO | dopamine neurotransmitter receptor activity, coupled via Gi/Go temperature homeostasis response to hypoxia acrosomal vesicle synaptic transmission, dopaminergic response to amphetamine neurological system process involved in regulation of systemic arterial blood pressure regulation of heart rate regulation of sodium ion transport G-protein coupled receptor internalization positive regulation of neuroblast proliferation positive regulation of receptor internalization adrenergic receptor activity protein binding plasma membrane plasma membrane integral component of plasma membrane negative regulation of adenylate cyclase activity adenylate cyclase-inhibiting dopamine receptor signaling pathway neuron-neuron synaptic transmission axonogenesis synapse assembly sensory perception of smell long-term memory grooming behavior locomotory behavior adult walking behavior feeding behavior protein localization drug binding negative regulation of cell proliferation associative learning visual learning response to light stimulus response to toxic substance response to iron ion regulation of dopamine secretion postsynaptic density response to inactivity Wnt signaling pathway lateral plasma membrane striatum development orbitofrontal cortex development cerebral cortex GABAergic interneuron migration adenohypophysis development endocytic vesicle negative regulation of cell migration axon dendrite peristalsis synaptic vesicle membrane regulation of cAMP metabolic process auditory behavior activation of protein kinase activity regulation of synaptic transmission, GABAergic positive regulation of cytokinesis circadian regulation of gene expression negative regulation of dopamine secretion response to histamine response to nicotine dopamine binding ionotropic glutamate receptor binding positive regulation of urine volume positive regulation of renal sodium excretion sperm flagellum positive regulation of multicellular organism growth response to cocaine negative regulation of circadian sleep/wake cycle, sleep dopamine metabolic process response to drug response to drug identical protein binding protein homodimerization activity dendritic spine perikaryon regulation of potassium ion transport regulation of potassium ion transport response to morphine pigmentation regulation of phosphoprotein phosphatase activity axon terminus positive regulation of G-protein coupled receptor protein signaling pathway negative regulation of blood pressure negative regulation of innate immune response positive regulation of transcription from RNA polymerase II promoter phosphatidylinositol metabolic process negative regulation of insulin secretion protein heterodimerization activity behavioral response to cocaine behavioral response to cocaine behavioral response to ethanol behavioral response to ethanol regulation of long-term neuronal synaptic plasticity response to axon injury branching morphogenesis of a nerve arachidonic acid secretion negative regulation of protein secretion release of sequestered calcium ion into cytosol negative regulation of cytosolic calcium ion concentration regulation of dopamine uptake involved in synaptic transmission positive regulation of dopamine uptake involved in synaptic transmission regulation of synapse structural plasticity negative regulation of protein kinase B signaling negative regulation of protein kinase B signaling negative regulation of synaptic transmission, glutamatergic negative regulation of synaptic transmission, glutamatergic positive regulation of growth hormone secretion prepulse inhibition phospholipase C-activating dopamine receptor signaling pathway negative regulation of dopamine receptor signaling pathway ciliary membrane positive regulation of ERK1 and ERK2 cascade adenylate cyclase-activating adrenergic receptor signaling pathway regulation of locomotion involved in locomotory behavior non-motile cilium chemical synaptic transmission, postsynaptic positive regulation of glial cell-derived neurotrophic factor secretion positive regulation of long-term synaptic potentiation negative regulation of voltage-gated calcium channel activity |
| Ontology : EGO-EBI | dopamine neurotransmitter receptor activity, coupled via Gi/Go temperature homeostasis response to hypoxia acrosomal vesicle synaptic transmission, dopaminergic response to amphetamine neurological system process involved in regulation of systemic arterial blood pressure regulation of heart rate regulation of sodium ion transport G-protein coupled receptor internalization positive regulation of neuroblast proliferation positive regulation of receptor internalization adrenergic receptor activity protein binding plasma membrane plasma membrane integral component of plasma membrane negative regulation of adenylate cyclase activity adenylate cyclase-inhibiting dopamine receptor signaling pathway neuron-neuron synaptic transmission axonogenesis synapse assembly sensory perception of smell long-term memory grooming behavior locomotory behavior adult walking behavior feeding behavior protein localization drug binding negative regulation of cell proliferation associative learning visual learning response to light stimulus response to toxic substance response to iron ion regulation of dopamine secretion postsynaptic density response to inactivity Wnt signaling pathway lateral plasma membrane striatum development orbitofrontal cortex development cerebral cortex GABAergic interneuron migration adenohypophysis development endocytic vesicle negative regulation of cell migration axon dendrite peristalsis synaptic vesicle membrane regulation of cAMP metabolic process auditory behavior activation of protein kinase activity regulation of synaptic transmission, GABAergic positive regulation of cytokinesis circadian regulation of gene expression negative regulation of dopamine secretion response to histamine response to nicotine dopamine binding ionotropic glutamate receptor binding positive regulation of urine volume positive regulation of renal sodium excretion sperm flagellum positive regulation of multicellular organism growth response to cocaine negative regulation of circadian sleep/wake cycle, sleep dopamine metabolic process response to drug response to drug identical protein binding protein homodimerization activity dendritic spine perikaryon regulation of potassium ion transport regulation of potassium ion transport response to morphine pigmentation regulation of phosphoprotein phosphatase activity axon terminus positive regulation of G-protein coupled receptor protein signaling pathway negative regulation of blood pressure negative regulation of innate immune response positive regulation of transcription from RNA polymerase II promoter phosphatidylinositol metabolic process negative regulation of insulin secretion protein heterodimerization activity behavioral response to cocaine behavioral response to cocaine behavioral response to ethanol behavioral response to ethanol regulation of long-term neuronal synaptic plasticity response to axon injury branching morphogenesis of a nerve arachidonic acid secretion negative regulation of protein secretion release of sequestered calcium ion into cytosol negative regulation of cytosolic calcium ion concentration regulation of dopamine uptake involved in synaptic transmission positive regulation of dopamine uptake involved in synaptic transmission regulation of synapse structural plasticity negative regulation of protein kinase B signaling negative regulation of protein kinase B signaling negative regulation of synaptic transmission, glutamatergic negative regulation of synaptic transmission, glutamatergic positive regulation of growth hormone secretion prepulse inhibition phospholipase C-activating dopamine receptor signaling pathway negative regulation of dopamine receptor signaling pathway ciliary membrane positive regulation of ERK1 and ERK2 cascade adenylate cyclase-activating adrenergic receptor signaling pathway regulation of locomotion involved in locomotory behavior non-motile cilium chemical synaptic transmission, postsynaptic positive regulation of glial cell-derived neurotrophic factor secretion positive regulation of long-term synaptic potentiation negative regulation of voltage-gated calcium channel activity |
| Pathways : BIOCARTA | Regulation of ck1/cdk5 by type 1 glutamate receptors [Genes] |
| Pathways : KEGG | Rap1 signaling pathway Neuroactive ligand-receptor interaction Gap junction Dopaminergic synapse Parkinson's disease Cocaine addiction Alcoholism |
| NDEx Network | DRD2 |
| Atlas of Cancer Signalling Network | DRD2 |
| Wikipedia pathways | DRD2 |
| Orthology - Evolution |
|---|
| OrthoDB | 1813 |
| GeneTree (enSembl) | ENSG00000149295 |
| Phylogenetic Trees/Animal Genes : TreeFam | DRD2 |
| HOVERGEN | P14416 |
| HOGENOM | P14416 |
| Homologs : HomoloGene | DRD2 |
| Homology/Alignments : Family Browser (UCSC) | DRD2 |
| Gene fusions - Rearrangements |
|---|
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | DRD2 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | DRD2 |
| dbVar | DRD2 |
| ClinVar | DRD2 |
| 1000_Genomes | DRD2 |
| Exome Variant Server | DRD2 |
| ExAC (Exome Aggregation Consortium) | DRD2 (select the gene name) |
| Genetic variants : HAPMAP | 1813 |
| Genomic Variants (DGV) | DRD2 [DGVbeta] |
| DECIPHER | DRD2 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | DRD2 |
| Mutations |
|---|
| ICGC Data Portal | DRD2 |
| TCGA Data Portal | DRD2 |
| Broad Tumor Portal | DRD2 |
| OASIS Portal | DRD2 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | DRD2 [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | DRD2 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search DRD2 |
| DgiDB (Drug Gene Interaction Database) | DRD2 |
| DoCM (Curated mutations) | DRD2 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | DRD2 (select a term) |
| intoGen | DRD2 |
| Cancer3D | DRD2(select the gene name) |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 126450 159900 |
| Orphanet | 10437 |
| Medgen | DRD2 |
| Genetic Testing Registry | DRD2
|
| NextProt | P14416 [Medical] |
| TSGene | 1813 |
| GENETests | DRD2 |
| Target Validation | DRD2 |
| Huge Navigator |
DRD2 [HugePedia] |
| snp3D : Map Gene to Disease | 1813 |
| BioCentury BCIQ | DRD2 |
| ClinGen | DRD2 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 1813 |
| Chemical/Pharm GKB Gene | PA27478 |
| Clinical trial | DRD2 |
| Miscellaneous |
|---|
| canSAR (ICR) | DRD2 (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 499 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | DRD2 |
| EVEX | DRD2 |
| GoPubMed | DRD2 |
| iHOP | DRD2 |
