Atlas of Genetics and Cytogenetics in Oncology and Haematology

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DRD2 (dopamine receptor D2)

Identity

Other aliasD2DR
D2R
HGNC (Hugo) DRD2
LocusID (NCBI) 1813
Atlas_Id 46193
Location 11q23.2  [Link to chromosome band 11q23]
Location_base_pair Starts at 113409595 and ends at 113475279 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DRD2   3023
Cards
Entrez_Gene (NCBI)DRD2  1813  dopamine receptor D2
AliasesD2DR; D2R
GeneCards (Weizmann)DRD2
Ensembl hg19 (Hinxton)ENSG00000149295 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000149295 [Gene_View]  ENSG00000149295 [Sequence]  chr11:113409595-113475279 [Contig_View]  DRD2 [Vega]
ICGC DataPortalENSG00000149295
TCGA cBioPortalDRD2
AceView (NCBI)DRD2
Genatlas (Paris)DRD2
WikiGenes1813
SOURCE (Princeton)DRD2
Genetics Home Reference (NIH)DRD2
Genomic and cartography
GoldenPath hg38 (UCSC)DRD2  -     chr11:113409595-113475279 -  11q23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DRD2  -     11q23.2   [Description]    (hg19-Feb_2009)
GoldenPathDRD2 - 11q23.2 [CytoView hg19]  DRD2 - 11q23.2 [CytoView hg38]
ImmunoBaseENSG00000149295
Mapping of homologs : NCBIDRD2 [Mapview hg19]  DRD2 [Mapview hg38]
OMIM126450   
Gene and transcription
Genbank (Entrez)AB209832 AB451480 AF176812 AK308777 BC021195
RefSeq transcript (Entrez)NM_000795 NM_016574
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DRD2
Alternative Splicing GalleryENSG00000149295
Gene ExpressionDRD2 [ NCBI-GEO ]   DRD2 [ EBI - ARRAY_EXPRESS ]   DRD2 [ SEEK ]   DRD2 [ MEM ]
Gene Expression Viewer (FireBrowse)DRD2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1813
GTEX Portal (Tissue expression)DRD2
Human Protein AtlasENSG00000149295-DRD2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP14416   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP14416  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP14416
Splice isoforms : SwissVarP14416
PhosPhoSitePlusP14416
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)Dopamine_D2_rcpt    Dopamine_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)DRD2
DMDM Disease mutations1813
Blocks (Seattle)DRD2
PDB (RSDB)1I15    5AER    6CM4   
PDB Europe1I15    5AER    6CM4   
PDB (PDBSum)1I15    5AER    6CM4   
PDB (IMB)1I15    5AER    6CM4   
Structural Biology KnowledgeBase1I15    5AER    6CM4   
SCOP (Structural Classification of Proteins)1I15    5AER    6CM4   
CATH (Classification of proteins structures)1I15    5AER    6CM4   
SuperfamilyP14416
Human Protein Atlas [tissue]ENSG00000149295-DRD2 [tissue]
Peptide AtlasP14416
HPRD00539
IPIIPI00026590   IPI00219367   IPI00375079   IPI01015464   IPI01015728   IPI01014318   
Protein Interaction databases
DIP (DOE-UCLA)P14416
IntAct (EBI)P14416
FunCoupENSG00000149295
BioGRIDDRD2
STRING (EMBL)DRD2
ZODIACDRD2
Ontologies - Pathways
QuickGOP14416
Ontology : AmiGOdopamine neurotransmitter receptor activity, coupled via Gi/Go  dopamine neurotransmitter receptor activity, coupled via Gi/Go  temperature homeostasis  response to hypoxia  acrosomal vesicle  negative regulation of protein phosphorylation  synaptic transmission, dopaminergic  response to amphetamine  neurological system process involved in regulation of systemic arterial blood pressure  regulation of heart rate  regulation of sodium ion transport  G protein-coupled receptor internalization  positive regulation of neuroblast proliferation  positive regulation of receptor internalization  adrenergic receptor activity  protein binding  cell  plasma membrane  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  cilium  autophagy  G protein-coupled receptor signaling pathway  adenylate cyclase-modulating G protein-coupled receptor signaling pathway  negative regulation of adenylate cyclase activity  adenylate cyclase-inhibiting dopamine receptor signaling pathway  adenylate cyclase-inhibiting dopamine receptor signaling pathway  neuron-neuron synaptic transmission  axonogenesis  synapse assembly  sensory perception of smell  long-term memory  grooming behavior  locomotory behavior  adult walking behavior  protein localization  drug binding  negative regulation of cell proliferation  associative learning  visual learning  response to light stimulus  response to toxic substance  response to iron ion  regulation of dopamine secretion  postsynaptic density  response to inactivity  Wnt signaling pathway  lateral plasma membrane  striatum development  orbitofrontal cortex development  cerebral cortex GABAergic interneuron migration  adenohypophysis development  endocytic vesicle  negative regulation of cell migration  axon  dendrite  peristalsis  synaptic vesicle membrane  auditory behavior  activation of protein kinase activity  regulation of synaptic transmission, GABAergic  positive regulation of cytokinesis  circadian regulation of gene expression  negative regulation of dopamine secretion  response to histamine  response to nicotine  dopamine binding  ionotropic glutamate receptor binding  positive regulation of urine volume  positive regulation of renal sodium excretion  sperm flagellum  positive regulation of multicellular organism growth  response to cocaine  negative regulation of circadian sleep/wake cycle, sleep  dopamine metabolic process  response to drug  response to drug  drinking behavior  identical protein binding  protein homodimerization activity  dendritic spine  perikaryon  regulation of potassium ion transport  regulation of potassium ion transport  response to morphine  pigmentation  regulation of phosphoprotein phosphatase activity  axon terminus  positive regulation of G protein-coupled receptor signaling pathway  negative regulation of blood pressure  negative regulation of innate immune response  positive regulation of transcription by RNA polymerase II  negative regulation of insulin secretion  protein heterodimerization activity  behavioral response to cocaine  behavioral response to cocaine  behavioral response to ethanol  behavioral response to ethanol  regulation of long-term neuronal synaptic plasticity  response to axon injury  branching morphogenesis of a nerve  arachidonic acid secretion  negative regulation of protein secretion  release of sequestered calcium ion into cytosol  negative regulation of cytosolic calcium ion concentration  positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  regulation of dopamine uptake involved in synaptic transmission  positive regulation of dopamine uptake involved in synaptic transmission  regulation of synapse structural plasticity  negative regulation of protein kinase B signaling  negative regulation of protein kinase B signaling  negative regulation of synaptic transmission, glutamatergic  negative regulation of synaptic transmission, glutamatergic  excitatory postsynaptic potential  positive regulation of growth hormone secretion  prepulse inhibition  phospholipase C-activating dopamine receptor signaling pathway  phospholipase C-activating dopamine receptor signaling pathway  negative regulation of dopamine receptor signaling pathway  ciliary membrane  negative regulation of cell death  positive regulation of ERK1 and ERK2 cascade  adenylate cyclase-activating adrenergic receptor signaling pathway  regulation of locomotion involved in locomotory behavior  non-motile cilium  dopaminergic synapse  glutamatergic synapse  GABA-ergic synapse  integral component of postsynaptic membrane  integral component of presynaptic membrane  postsynaptic modulation of chemical synaptic transmission  positive regulation of glial cell-derived neurotrophic factor secretion  positive regulation of long-term synaptic potentiation  negative regulation of voltage-gated calcium channel activity  regulation of synaptic vesicle exocytosis  
Ontology : EGO-EBIdopamine neurotransmitter receptor activity, coupled via Gi/Go  dopamine neurotransmitter receptor activity, coupled via Gi/Go  temperature homeostasis  response to hypoxia  acrosomal vesicle  negative regulation of protein phosphorylation  synaptic transmission, dopaminergic  response to amphetamine  neurological system process involved in regulation of systemic arterial blood pressure  regulation of heart rate  regulation of sodium ion transport  G protein-coupled receptor internalization  positive regulation of neuroblast proliferation  positive regulation of receptor internalization  adrenergic receptor activity  protein binding  cell  plasma membrane  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  cilium  autophagy  G protein-coupled receptor signaling pathway  adenylate cyclase-modulating G protein-coupled receptor signaling pathway  negative regulation of adenylate cyclase activity  adenylate cyclase-inhibiting dopamine receptor signaling pathway  adenylate cyclase-inhibiting dopamine receptor signaling pathway  neuron-neuron synaptic transmission  axonogenesis  synapse assembly  sensory perception of smell  long-term memory  grooming behavior  locomotory behavior  adult walking behavior  protein localization  drug binding  negative regulation of cell proliferation  associative learning  visual learning  response to light stimulus  response to toxic substance  response to iron ion  regulation of dopamine secretion  postsynaptic density  response to inactivity  Wnt signaling pathway  lateral plasma membrane  striatum development  orbitofrontal cortex development  cerebral cortex GABAergic interneuron migration  adenohypophysis development  endocytic vesicle  negative regulation of cell migration  axon  dendrite  peristalsis  synaptic vesicle membrane  auditory behavior  activation of protein kinase activity  regulation of synaptic transmission, GABAergic  positive regulation of cytokinesis  circadian regulation of gene expression  negative regulation of dopamine secretion  response to histamine  response to nicotine  dopamine binding  ionotropic glutamate receptor binding  positive regulation of urine volume  positive regulation of renal sodium excretion  sperm flagellum  positive regulation of multicellular organism growth  response to cocaine  negative regulation of circadian sleep/wake cycle, sleep  dopamine metabolic process  response to drug  response to drug  drinking behavior  identical protein binding  protein homodimerization activity  dendritic spine  perikaryon  regulation of potassium ion transport  regulation of potassium ion transport  response to morphine  pigmentation  regulation of phosphoprotein phosphatase activity  axon terminus  positive regulation of G protein-coupled receptor signaling pathway  negative regulation of blood pressure  negative regulation of innate immune response  positive regulation of transcription by RNA polymerase II  negative regulation of insulin secretion  protein heterodimerization activity  behavioral response to cocaine  behavioral response to cocaine  behavioral response to ethanol  behavioral response to ethanol  regulation of long-term neuronal synaptic plasticity  response to axon injury  branching morphogenesis of a nerve  arachidonic acid secretion  negative regulation of protein secretion  release of sequestered calcium ion into cytosol  negative regulation of cytosolic calcium ion concentration  positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  regulation of dopamine uptake involved in synaptic transmission  positive regulation of dopamine uptake involved in synaptic transmission  regulation of synapse structural plasticity  negative regulation of protein kinase B signaling  negative regulation of protein kinase B signaling  negative regulation of synaptic transmission, glutamatergic  negative regulation of synaptic transmission, glutamatergic  excitatory postsynaptic potential  positive regulation of growth hormone secretion  prepulse inhibition  phospholipase C-activating dopamine receptor signaling pathway  phospholipase C-activating dopamine receptor signaling pathway  negative regulation of dopamine receptor signaling pathway  ciliary membrane  negative regulation of cell death  positive regulation of ERK1 and ERK2 cascade  adenylate cyclase-activating adrenergic receptor signaling pathway  regulation of locomotion involved in locomotory behavior  non-motile cilium  dopaminergic synapse  glutamatergic synapse  GABA-ergic synapse  integral component of postsynaptic membrane  integral component of presynaptic membrane  postsynaptic modulation of chemical synaptic transmission  positive regulation of glial cell-derived neurotrophic factor secretion  positive regulation of long-term synaptic potentiation  negative regulation of voltage-gated calcium channel activity  regulation of synaptic vesicle exocytosis  
Pathways : KEGGRap1 signaling pathway    Neuroactive ligand-receptor interaction    Gap junction    Dopaminergic synapse    Parkinson's disease    Cocaine addiction    Alcoholism   
NDEx NetworkDRD2
Atlas of Cancer Signalling NetworkDRD2
Wikipedia pathwaysDRD2
Orthology - Evolution
OrthoDB1813
GeneTree (enSembl)ENSG00000149295
Phylogenetic Trees/Animal Genes : TreeFamDRD2
HOGENOMP14416
Homologs : HomoloGeneDRD2
Homology/Alignments : Family Browser (UCSC)DRD2
Gene fusions - Rearrangements
Fusion : QuiverDRD2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDRD2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DRD2
dbVarDRD2
ClinVarDRD2
1000_GenomesDRD2 
Exome Variant ServerDRD2
ExAC (Exome Aggregation Consortium)ENSG00000149295
GNOMAD BrowserENSG00000149295
Varsome BrowserDRD2
Genetic variants : HAPMAP1813
Genomic Variants (DGV)DRD2 [DGVbeta]
DECIPHERDRD2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDRD2 
Mutations
ICGC Data PortalDRD2 
TCGA Data PortalDRD2 
Broad Tumor PortalDRD2
OASIS PortalDRD2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDRD2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDRD2
Mutations and Diseases : HGMDDRD2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DRD2
DgiDB (Drug Gene Interaction Database)DRD2
DoCM (Curated mutations)DRD2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DRD2 (select a term)
intoGenDRD2
Cancer3DDRD2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM126450   
Orphanet10437   
DisGeNETDRD2
MedgenDRD2
Genetic Testing Registry DRD2
NextProtP14416 [Medical]
TSGene1813
GENETestsDRD2
Target ValidationDRD2
Huge Navigator DRD2 [HugePedia]
snp3D : Map Gene to Disease1813
BioCentury BCIQDRD2
ClinGenDRD2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1813
Chemical/Pharm GKB GenePA27478
Clinical trialDRD2
Miscellaneous
canSAR (ICR)DRD2 (select the gene name)
DataMed IndexDRD2
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDRD2
EVEXDRD2
GoPubMedDRD2
iHOPDRD2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Feb 19 16:41:47 CET 2020
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