Identity
HGNC
LOCATION
3q13.31
LOCUSID
ALIAS
D3DR,ETM1,FET1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1814
MIM: 126451
HGNC: 3024
Ensembl: ENSG00000151577
Variants:
dbSNP: 1814
ClinVar: 1814
TCGA: ENSG00000151577
COSMIC: DRD3
RNA/Proteins
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10066 | duloxetine | Chemical | ClinicalAnnotation | associated | PD | 22249355 | |
| PA153906318 | Autism Spectrum Disorder | Disease | ClinicalAnnotation | associated | PD | 23856854 | |
| PA164742949 | pramipexole | Chemical | ClinicalAnnotation | associated | PD | 19396436 | |
| PA444339 | Hallucinations | Disease | ClinicalAnnotation | associated | PD | 30794329 | |
| PA445208 | Pain | Disease | VariantAnnotation | not associated | PD | 21398039 | |
| PA445254 | Parkinson Disease | Disease | ClinicalAnnotation | associated | PD | 19396436, 27779245, 30794329 | |
| PA447196 | Anxiety Disorders | Disease | ClinicalAnnotation | associated | PD | 22249355 | |
| PA447198 | Autistic Disorder | Disease | ClinicalAnnotation | associated | PD | 19997080 | |
| PA447199 | Bipolar Disorder | Disease | ClinicalAnnotation | associated | PD | 19506579 | |
| PA447216 | Schizophrenia | Disease | ClinicalAnnotation | associated | PD | 18320559, 19506579, 20029384, 21332319 | |
| PA447230 | HIV | Disease | ClinicalAnnotation | associated | PD | 21491142 | |
| PA447321 | Depressive Disorder, Major | Disease | ClinicalAnnotation | associated | PD | 22926616 | |
| PA449061 | clozapine | Chemical | ClinicalAnnotation | associated | PD | 20029384, 21332319 | |
| PA450213 | levodopa | Chemical | ClinicalAnnotation | associated | PD | 27779245, 30794329 | |
| PA450403 | methamphetamine | Chemical | ClinicalAnnotation | associated | PD | 21491142 | |
| PA450464 | methylphenidate | Chemical | ClinicalAnnotation | associated | PD | 23856854 | |
| PA450688 | olanzapine | Chemical | ClinicalAnnotation | associated | PD | 18320559 | |
| PA450801 | paroxetine | Chemical | ClinicalAnnotation | associated | PD | 22926616 | |
| PA451201 | quetiapine | Chemical | ClinicalAnnotation | associated | PK | 25025989 | |
| PA451257 | risperidone | Chemical | ClinicalAnnotation | associated | PD | 19506579, 19997080 | |
| PA452618 | opioids | Chemical | VariantAnnotation | not associated | PD | 21398039 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38363619 | 2024 | DRD3 Predicts Cognitive Impairment and Anxiety in Parkinson's Disease: Susceptibility and Protective Effects. | 0 |
| 38431040 | 2024 | Association of dopamine receptor D3 polymorphism with Levodopa-induced Dyskinesia: A study on Parkinson's disease patients from India. | 0 |
| 38927672 | 2024 | Polymorphisms in the Dopaminergic Receptor D3 Gene Correlate with Disease Progression Rate in Relapsing-Remitting Multiple Sclerosis Patients. | 0 |
| 38363619 | 2024 | DRD3 Predicts Cognitive Impairment and Anxiety in Parkinson's Disease: Susceptibility and Protective Effects. | 0 |
| 38431040 | 2024 | Association of dopamine receptor D3 polymorphism with Levodopa-induced Dyskinesia: A study on Parkinson's disease patients from India. | 0 |
| 38927672 | 2024 | Polymorphisms in the Dopaminergic Receptor D3 Gene Correlate with Disease Progression Rate in Relapsing-Remitting Multiple Sclerosis Patients. | 0 |
| 36154848 | 2023 | The genetic influence of the DRD3 rs6280 polymorphism (Ser9Gly) on functional connectivity and gray matter volume of the hippocampus in patients with first-episode, drug-naïve schizophrenia. | 1 |
| 36154848 | 2023 | The genetic influence of the DRD3 rs6280 polymorphism (Ser9Gly) on functional connectivity and gray matter volume of the hippocampus in patients with first-episode, drug-naïve schizophrenia. | 1 |
| 35128830 | 2022 | New Insight into the human genetic diversity in North African populations by genotyping of SNPs in DRD3, CSMD1 and NRG1 genes. | 2 |
| 35285297 | 2022 | HUMAN STUDY COMT and DRD3 haplotype-associated pain intensity and acute care utilization in adult sickle cell disease. | 3 |
| 35835396 | 2022 | DRD3 Ser9Gly polymorphism and treatment response to antipsychotics in schizophrenia: A meta-analysis. | 2 |
| 35904302 | 2022 | [Association of gene polymorphisms DRD3 rs6280, COMT rs4680 and HTR2A rs7322347 with schizophrenia]. | 0 |
| 36456906 | 2022 | Dopamine receptor D3 is related to prognosis in human hepatocellular carcinoma and inhibits tumor growth. | 1 |
| 35128830 | 2022 | New Insight into the human genetic diversity in North African populations by genotyping of SNPs in DRD3, CSMD1 and NRG1 genes. | 2 |
| 35285297 | 2022 | HUMAN STUDY COMT and DRD3 haplotype-associated pain intensity and acute care utilization in adult sickle cell disease. | 3 |
Citation
Dessen P
DRD3 (dopamine receptor D3)
Atlas Genet Cytogenet Oncol Haematol. 2011-02-01
Online version: http://atlasgeneticsoncology.org/gene/52045/drd3
