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DRD3 (dopamine receptor D3)

Identity

Other aliasD3DR
ETM1
FET1
HGNC (Hugo) DRD3
LocusID (NCBI) 1814
Atlas_Id 52045
Location 3q13.31  [Link to chromosome band 3q13]
Location_base_pair Starts at 114128652 and ends at 114179052 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LRBA (4q31.3) / DRD3 (3q13.31)NAALADL2 (3q26.31) / DRD3 (3q13.31)LRBA 4q31.3 / DRD3 3q13.31
NAALADL2 3q26.31 / DRD3 3q13.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DRD3   3024
Cards
Entrez_Gene (NCBI)DRD3  1814  dopamine receptor D3
AliasesD3DR; ETM1; FET1
GeneCards (Weizmann)DRD3
Ensembl hg19 (Hinxton)ENSG00000151577 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000151577 [Gene_View]  chr3:114128652-114179052 [Contig_View]  DRD3 [Vega]
ICGC DataPortalENSG00000151577
TCGA cBioPortalDRD3
AceView (NCBI)DRD3
Genatlas (Paris)DRD3
WikiGenes1814
SOURCE (Princeton)DRD3
Genetics Home Reference (NIH)DRD3
Genomic and cartography
GoldenPath hg38 (UCSC)DRD3  -     chr3:114128652-114179052 -  3q13.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DRD3  -     3q13.31   [Description]    (hg19-Feb_2009)
EnsemblDRD3 - 3q13.31 [CytoView hg19]  DRD3 - 3q13.31 [CytoView hg38]
Mapping of homologs : NCBIDRD3 [Mapview hg19]  DRD3 [Mapview hg38]
OMIM126451   181500   190300   
Gene and transcription
Genbank (Entrez)AK292309 AY228454 AY228455 AY228456 AY228457
RefSeq transcript (Entrez)NM_000796 NM_001282563 NM_001290809 NM_033658 NM_033659 NM_033660 NM_033663
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DRD3
Cluster EST : UnigeneHs.121478 [ NCBI ]
CGAP (NCI)Hs.121478
Alternative Splicing GalleryENSG00000151577
Gene ExpressionDRD3 [ NCBI-GEO ]   DRD3 [ EBI - ARRAY_EXPRESS ]   DRD3 [ SEEK ]   DRD3 [ MEM ]
Gene Expression Viewer (FireBrowse)DRD3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1814
GTEX Portal (Tissue expression)DRD3
Human Protein AtlasENSG00000151577-DRD3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35462   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35462  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35462
Splice isoforms : SwissVarP35462
PhosPhoSitePlusP35462
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)Dopamine_D3_rcpt    Dopamine_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)DRD3
DMDM Disease mutations1814
Blocks (Seattle)DRD3
PDB (SRS)3PBL   
PDB (PDBSum)3PBL   
PDB (IMB)3PBL   
PDB (RSDB)3PBL   
Structural Biology KnowledgeBase3PBL   
SCOP (Structural Classification of Proteins)3PBL   
CATH (Classification of proteins structures)3PBL   
SuperfamilyP35462
Human Protein Atlas [tissue]ENSG00000151577-DRD3 [tissue]
Peptide AtlasP35462
HPRD00540
IPIIPI00018843   IPI00798154   IPI00293405   IPI01008790   
Protein Interaction databases
DIP (DOE-UCLA)P35462
IntAct (EBI)P35462
FunCoupENSG00000151577
BioGRIDDRD3
STRING (EMBL)DRD3
ZODIACDRD3
Ontologies - Pathways
QuickGOP35462
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  dopamine neurotransmitter receptor activity, coupled via Gi/Go  dopamine neurotransmitter receptor activity, coupled via Gi/Go  synaptic transmission, dopaminergic  response to amphetamine  regulation of blood volume by renin-angiotensin  G-protein coupled receptor internalization  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  cellular calcium ion homeostasis  G-protein coupled receptor signaling pathway  adenylate cyclase-activating dopamine receptor signaling pathway  negative regulation of adenylate cyclase activity  adenylate cyclase-inhibiting dopamine receptor signaling pathway  learning or memory  learning  locomotory behavior  drug binding  drug binding  positive regulation of cell proliferation  visual learning  regulation of dopamine secretion  regulation of lipid metabolic process  protein domain specific binding  endocytic vesicle  regulation of cAMP metabolic process  D1 dopamine receptor binding  negative regulation of sodium:proton antiporter activity  positive regulation of cytokinesis  circadian regulation of gene expression  response to histamine  social behavior  dopamine binding  gastric emptying  positive regulation of renal sodium excretion  regulation of multicellular organism growth  response to cocaine  dopamine metabolic process  response to drug  cell projection  response to morphine  apical part of cell  regulation of circadian sleep/wake cycle, sleep  response to ethanol  negative regulation of blood pressure  positive regulation of mitotic nuclear division  positive regulation of transcription from RNA polymerase II promoter  acid secretion  behavioral response to cocaine  behavioral response to cocaine  negative regulation of oligodendrocyte differentiation  arachidonic acid secretion  negative regulation of protein secretion  musculoskeletal movement, spinal reflex action  regulation of dopamine uptake involved in synaptic transmission  negative regulation of protein kinase B signaling  prepulse inhibition  negative regulation of dopamine receptor signaling pathway  positive regulation of dopamine receptor signaling pathway  regulation of locomotion involved in locomotory behavior  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  dopamine neurotransmitter receptor activity, coupled via Gi/Go  dopamine neurotransmitter receptor activity, coupled via Gi/Go  synaptic transmission, dopaminergic  response to amphetamine  regulation of blood volume by renin-angiotensin  G-protein coupled receptor internalization  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  cellular calcium ion homeostasis  G-protein coupled receptor signaling pathway  adenylate cyclase-activating dopamine receptor signaling pathway  negative regulation of adenylate cyclase activity  adenylate cyclase-inhibiting dopamine receptor signaling pathway  learning or memory  learning  locomotory behavior  drug binding  drug binding  positive regulation of cell proliferation  visual learning  regulation of dopamine secretion  regulation of lipid metabolic process  protein domain specific binding  endocytic vesicle  regulation of cAMP metabolic process  D1 dopamine receptor binding  negative regulation of sodium:proton antiporter activity  positive regulation of cytokinesis  circadian regulation of gene expression  response to histamine  social behavior  dopamine binding  gastric emptying  positive regulation of renal sodium excretion  regulation of multicellular organism growth  response to cocaine  dopamine metabolic process  response to drug  cell projection  response to morphine  apical part of cell  regulation of circadian sleep/wake cycle, sleep  response to ethanol  negative regulation of blood pressure  positive regulation of mitotic nuclear division  positive regulation of transcription from RNA polymerase II promoter  acid secretion  behavioral response to cocaine  behavioral response to cocaine  negative regulation of oligodendrocyte differentiation  arachidonic acid secretion  negative regulation of protein secretion  musculoskeletal movement, spinal reflex action  regulation of dopamine uptake involved in synaptic transmission  negative regulation of protein kinase B signaling  prepulse inhibition  negative regulation of dopamine receptor signaling pathway  positive regulation of dopamine receptor signaling pathway  regulation of locomotion involved in locomotory behavior  
Pathways : KEGGNeuroactive ligand-receptor interaction    Dopaminergic synapse   
NDEx NetworkDRD3
Atlas of Cancer Signalling NetworkDRD3
Wikipedia pathwaysDRD3
Orthology - Evolution
OrthoDB1814
GeneTree (enSembl)ENSG00000151577
Phylogenetic Trees/Animal Genes : TreeFamDRD3
HOVERGENP35462
HOGENOMP35462
Homologs : HomoloGeneDRD3
Homology/Alignments : Family Browser (UCSC)DRD3
Gene fusions - Rearrangements
Fusion : MitelmanLRBA/DRD3 [4q31.3/3q13.31]  [t(3;4)(q13;q31)]  
Fusion : MitelmanNAALADL2/DRD3 [3q26.31/3q13.31]  [t(3;3)(q13;q26)]  
Fusion: TCGA_MDACCLRBA 4q31.3 DRD3 3q13.31 LUAD
Fusion: TCGA_MDACCNAALADL2 3q26.31 DRD3 3q13.31 HNSC
Tumor Fusion PortalDRD3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDRD3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DRD3
dbVarDRD3
ClinVarDRD3
1000_GenomesDRD3 
Exome Variant ServerDRD3
ExAC (Exome Aggregation Consortium)ENSG00000151577
GNOMAD BrowserENSG00000151577
Genetic variants : HAPMAP1814
Genomic Variants (DGV)DRD3 [DGVbeta]
DECIPHERDRD3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDRD3 
Mutations
ICGC Data PortalDRD3 
TCGA Data PortalDRD3 
Broad Tumor PortalDRD3
OASIS PortalDRD3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDRD3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDRD3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DRD3
DgiDB (Drug Gene Interaction Database)DRD3
DoCM (Curated mutations)DRD3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DRD3 (select a term)
intoGenDRD3
Cancer3DDRD3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM126451    181500    190300   
Orphanet
DisGeNETDRD3
MedgenDRD3
Genetic Testing Registry DRD3
NextProtP35462 [Medical]
TSGene1814
GENETestsDRD3
Target ValidationDRD3
Huge Navigator DRD3 [HugePedia]
snp3D : Map Gene to Disease1814
BioCentury BCIQDRD3
ClinGenDRD3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1814
Chemical/Pharm GKB GenePA27479
Clinical trialDRD3
Miscellaneous
canSAR (ICR)DRD3 (select the gene name)
Probes
Litterature
PubMed348 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDRD3
EVEXDRD3
GoPubMedDRD3
iHOPDRD3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:11:10 CET 2017

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