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DRD4 (dopamine receptor D4)

Identity

Other aliasD4DR
HGNC (Hugo) DRD4
LocusID (NCBI) 1815
Atlas_Id 54266
Location 11p15.5  [Link to chromosome band 11p15]
Location_base_pair Starts at 637305 and ends at 640705 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CD151 (11p15.5) / DRD4 (11p15.5)SART1 (11q13.1) / DRD4 (11p15.5)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DRD4   3025
Cards
Entrez_Gene (NCBI)DRD4  1815  dopamine receptor D4
AliasesD4DR
GeneCards (Weizmann)DRD4
Ensembl hg19 (Hinxton)ENSG00000069696 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000069696 [Gene_View]  chr11:637305-640705 [Contig_View]  DRD4 [Vega]
ICGC DataPortalENSG00000069696
TCGA cBioPortalDRD4
AceView (NCBI)DRD4
Genatlas (Paris)DRD4
WikiGenes1815
SOURCE (Princeton)DRD4
Genetics Home Reference (NIH)DRD4
Genomic and cartography
GoldenPath hg38 (UCSC)DRD4  -     chr11:637305-640705 +  11p15.5   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DRD4  -     11p15.5   [Description]    (hg19-Feb_2009)
EnsemblDRD4 - 11p15.5 [CytoView hg19]  DRD4 - 11p15.5 [CytoView hg38]
Mapping of homologs : NCBIDRD4 [Mapview hg19]  DRD4 [Mapview hg38]
OMIM126452   143465   601696   
Gene and transcription
Genbank (Entrez)BC172267 BM674709 EU432112 L12398 S76942
RefSeq transcript (Entrez)NM_000797
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_021241 NT_187586
Consensus coding sequences : CCDS (NCBI)DRD4
Cluster EST : UnigeneHs.99922 [ NCBI ]
CGAP (NCI)Hs.99922
Alternative Splicing GalleryENSG00000069696
Gene ExpressionDRD4 [ NCBI-GEO ]   DRD4 [ EBI - ARRAY_EXPRESS ]   DRD4 [ SEEK ]   DRD4 [ MEM ]
Gene Expression Viewer (FireBrowse)DRD4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1815
GTEX Portal (Tissue expression)DRD4
Human Protein AtlasENSG00000069696-DRD4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP21917   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP21917  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP21917
Splice isoforms : SwissVarP21917
PhosPhoSitePlusP21917
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)Dopamine_D4_rcpt    Dopamine_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)DRD4
DMDM Disease mutations1815
Blocks (Seattle)DRD4
SuperfamilyP21917
Human Protein Atlas [tissue]ENSG00000069696-DRD4 [tissue]
Peptide AtlasP21917
HPRD00541
IPIIPI00011225   IPI00969065   IPI01017900   IPI01021010   IPI01019044   
Protein Interaction databases
DIP (DOE-UCLA)P21917
IntAct (EBI)P21917
FunCoupENSG00000069696
BioGRIDDRD4
STRING (EMBL)DRD4
ZODIACDRD4
Ontologies - Pathways
QuickGOP21917
Ontology : AmiGOactivation of MAPK activity  dopamine neurotransmitter receptor activity, coupled via Gi/Go  dopamine neurotransmitter receptor activity, coupled via Gi/Go  behavioral fear response  response to amphetamine  dopamine neurotransmitter receptor activity  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  cellular calcium ion homeostasis  negative regulation of adenylate cyclase activity  adenylate cyclase-inhibiting dopamine receptor signaling pathway  dopamine receptor signaling pathway  drug binding  adult locomotory behavior  potassium channel regulator activity  membrane  SH3 domain binding  negative regulation of cAMP biosynthetic process  positive regulation of sodium:proton antiporter activity  positive regulation of kinase activity  response to histamine  social behavior  dopamine binding  regulation of dopamine metabolic process  dopamine metabolic process  fear response  regulation of circadian rhythm  identical protein binding  behavioral response to cocaine  behavioral response to ethanol  rhythmic process  arachidonic acid secretion  negative regulation of protein secretion  positive regulation of dopamine uptake involved in synaptic transmission  inhibitory postsynaptic potential  postsynapse  negative regulation of voltage-gated calcium channel activity  
Ontology : EGO-EBIactivation of MAPK activity  dopamine neurotransmitter receptor activity, coupled via Gi/Go  dopamine neurotransmitter receptor activity, coupled via Gi/Go  behavioral fear response  response to amphetamine  dopamine neurotransmitter receptor activity  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  cellular calcium ion homeostasis  negative regulation of adenylate cyclase activity  adenylate cyclase-inhibiting dopamine receptor signaling pathway  dopamine receptor signaling pathway  drug binding  adult locomotory behavior  potassium channel regulator activity  membrane  SH3 domain binding  negative regulation of cAMP biosynthetic process  positive regulation of sodium:proton antiporter activity  positive regulation of kinase activity  response to histamine  social behavior  dopamine binding  regulation of dopamine metabolic process  dopamine metabolic process  fear response  regulation of circadian rhythm  identical protein binding  behavioral response to cocaine  behavioral response to ethanol  rhythmic process  arachidonic acid secretion  negative regulation of protein secretion  positive regulation of dopamine uptake involved in synaptic transmission  inhibitory postsynaptic potential  postsynapse  negative regulation of voltage-gated calcium channel activity  
Pathways : KEGGNeuroactive ligand-receptor interaction    Dopaminergic synapse   
NDEx NetworkDRD4
Atlas of Cancer Signalling NetworkDRD4
Wikipedia pathwaysDRD4
Orthology - Evolution
OrthoDB1815
GeneTree (enSembl)ENSG00000069696
Phylogenetic Trees/Animal Genes : TreeFamDRD4
HOVERGENP21917
HOGENOMP21917
Homologs : HomoloGeneDRD4
Homology/Alignments : Family Browser (UCSC)DRD4
Gene fusions - Rearrangements
Fusion : MitelmanCD151/DRD4 [11p15.5/11p15.5]  [t(11;11)(p15;p15)]  
Tumor Fusion PortalDRD4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDRD4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DRD4
dbVarDRD4
ClinVarDRD4
1000_GenomesDRD4 
Exome Variant ServerDRD4
ExAC (Exome Aggregation Consortium)ENSG00000069696
GNOMAD BrowserENSG00000069696
Genetic variants : HAPMAP1815
Genomic Variants (DGV)DRD4 [DGVbeta]
DECIPHERDRD4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDRD4 
Mutations
ICGC Data PortalDRD4 
TCGA Data PortalDRD4 
Broad Tumor PortalDRD4
OASIS PortalDRD4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDRD4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDRD4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DRD4
DgiDB (Drug Gene Interaction Database)DRD4
DoCM (Curated mutations)DRD4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DRD4 (select a term)
intoGenDRD4
Cancer3DDRD4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM126452    143465    601696   
Orphanet
DisGeNETDRD4
MedgenDRD4
Genetic Testing Registry DRD4
NextProtP21917 [Medical]
TSGene1815
GENETestsDRD4
Target ValidationDRD4
Huge Navigator DRD4 [HugePedia]
snp3D : Map Gene to Disease1815
BioCentury BCIQDRD4
ClinGenDRD4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1815
Chemical/Pharm GKB GenePA27480
Clinical trialDRD4
Miscellaneous
canSAR (ICR)DRD4 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDRD4
EVEXDRD4
GoPubMedDRD4
iHOPDRD4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:11:10 CET 2017

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