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DRD5 (dopamine receptor D5)

Identity

Alias_namesDRD1L2
Alias_symbol (synonym)DRD1B
Other aliasDBDR
HGNC (Hugo) DRD5
LocusID (NCBI) 1816
Atlas_Id 62641
Location 4p16.1  [Link to chromosome band 4p16]
Location_base_pair Starts at 9783258 and ends at 9785633 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DRD5   3026
Cards
Entrez_Gene (NCBI)DRD5  1816  dopamine receptor D5
AliasesDBDR; DRD1B; DRD1L2
GeneCards (Weizmann)DRD5
Ensembl hg19 (Hinxton)ENSG00000169676 [Gene_View]  chr4:9783258-9785633 [Contig_View]  DRD5 [Vega]
Ensembl hg38 (Hinxton)ENSG00000169676 [Gene_View]  chr4:9783258-9785633 [Contig_View]  DRD5 [Vega]
ICGC DataPortalENSG00000169676
TCGA cBioPortalDRD5
AceView (NCBI)DRD5
Genatlas (Paris)DRD5
WikiGenes1816
SOURCE (Princeton)DRD5
Genetics Home Reference (NIH)DRD5
Genomic and cartography
GoldenPath hg19 (UCSC)DRD5  -     chr4:9783258-9785633 +  4p16.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DRD5  -     4p16.1   [Description]    (hg38-Dec_2013)
EnsemblDRD5 - 4p16.1 [CytoView hg19]  DRD5 - 4p16.1 [CytoView hg38]
Mapping of homologs : NCBIDRD5 [Mapview hg19]  DRD5 [Mapview hg38]
OMIM126453   143465   606798   
Gene and transcription
Genbank (Entrez)AK313897 AY136750 BC009748 DQ891933 DQ895120
RefSeq transcript (Entrez)NM_000798
RefSeq genomic (Entrez)NC_000004 NC_018915 NG_012024 NT_006316 NW_004929315
Consensus coding sequences : CCDS (NCBI)DRD5
Cluster EST : UnigeneHs.380681 [ NCBI ]
CGAP (NCI)Hs.380681
Alternative Splicing GalleryENSG00000169676
Gene ExpressionDRD5 [ NCBI-GEO ]   DRD5 [ EBI - ARRAY_EXPRESS ]   DRD5 [ SEEK ]   DRD5 [ MEM ]
Gene Expression Viewer (FireBrowse)DRD5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1816
GTEX Portal (Tissue expression)DRD5
Protein : pattern, domain, 3D structure
UniProt/SwissProtP21918   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP21918  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP21918
Splice isoforms : SwissVarP21918
PhosPhoSitePlusP21918
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)Dopamine_D5_rcpt    Dopamine_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)DRD5
DMDM Disease mutations1816
Blocks (Seattle)DRD5
SuperfamilyP21918
Human Protein AtlasENSG00000169676
Peptide AtlasP21918
HPRD00542
Protein Interaction databases
DIP (DOE-UCLA)P21918
IntAct (EBI)P21918
FunCoupENSG00000169676
BioGRIDDRD5
STRING (EMBL)DRD5
ZODIACDRD5
Ontologies - Pathways
QuickGOP21918
Ontology : AmiGOdopamine neurotransmitter receptor activity, coupled via Gs  synaptic transmission, dopaminergic  synaptic transmission, dopaminergic  response to amphetamine  regulation of systemic arterial blood pressure by vasopressin  norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure  dopamine neurotransmitter receptor activity  plasma membrane  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  cellular calcium ion homeostasis  adenylate cyclase-activating G-protein coupled receptor signaling pathway  activation of adenylate cyclase activity  adenylate cyclase-activating dopamine receptor signaling pathway  synaptic transmission  sensory perception of chemical stimulus  learning  G-protein coupled amine receptor activity  associative learning  positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway  transmission of nerve impulse  nonmotile primary cilium  brush border membrane  negative regulation of NAD(P)H oxidase activity  dopamine binding  wound healing  response to cocaine  positive regulation of adenylate cyclase activity  positive regulation of adenylate cyclase activity  negative regulation of blood pressure  regulation of female receptivity  sensitization  phospholipase C-activating dopamine receptor signaling pathway  ciliary membrane  long term synaptic depression  cellular response to catecholamine stimulus  reactive oxygen species metabolic process  
Ontology : EGO-EBIdopamine neurotransmitter receptor activity, coupled via Gs  synaptic transmission, dopaminergic  synaptic transmission, dopaminergic  response to amphetamine  regulation of systemic arterial blood pressure by vasopressin  norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure  dopamine neurotransmitter receptor activity  plasma membrane  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  cellular calcium ion homeostasis  adenylate cyclase-activating G-protein coupled receptor signaling pathway  activation of adenylate cyclase activity  adenylate cyclase-activating dopamine receptor signaling pathway  synaptic transmission  sensory perception of chemical stimulus  learning  G-protein coupled amine receptor activity  associative learning  positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway  transmission of nerve impulse  nonmotile primary cilium  brush border membrane  negative regulation of NAD(P)H oxidase activity  dopamine binding  wound healing  response to cocaine  positive regulation of adenylate cyclase activity  positive regulation of adenylate cyclase activity  negative regulation of blood pressure  regulation of female receptivity  sensitization  phospholipase C-activating dopamine receptor signaling pathway  ciliary membrane  long term synaptic depression  cellular response to catecholamine stimulus  reactive oxygen species metabolic process  
Pathways : KEGGCalcium signaling pathway    Neuroactive ligand-receptor interaction    Dopaminergic synapse   
NDEx NetworkDRD5
Atlas of Cancer Signalling NetworkDRD5
Wikipedia pathwaysDRD5
Orthology - Evolution
OrthoDB1816
GeneTree (enSembl)ENSG00000169676
Phylogenetic Trees/Animal Genes : TreeFamDRD5
HOVERGENP21918
HOGENOMP21918
Homologs : HomoloGeneDRD5
Homology/Alignments : Family Browser (UCSC)DRD5
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDRD5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DRD5
dbVarDRD5
ClinVarDRD5
1000_GenomesDRD5 
Exome Variant ServerDRD5
ExAC (Exome Aggregation Consortium)DRD5 (select the gene name)
Genetic variants : HAPMAP1816
Genomic Variants (DGV)DRD5 [DGVbeta]
DECIPHER (Syndromes)4:9783258-9785633  ENSG00000169676
CONAN: Copy Number AnalysisDRD5 
Mutations
ICGC Data PortalDRD5 
TCGA Data PortalDRD5 
Broad Tumor PortalDRD5
OASIS PortalDRD5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDRD5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDRD5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DRD5
DgiDB (Drug Gene Interaction Database)DRD5
DoCM (Curated mutations)DRD5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DRD5 (select a term)
intoGenDRD5
Cancer3DDRD5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM126453    143465    606798   
Orphanet
MedgenDRD5
Genetic Testing Registry DRD5
NextProtP21918 [Medical]
TSGene1816
GENETestsDRD5
Huge Navigator DRD5 [HugePedia]
snp3D : Map Gene to Disease1816
BioCentury BCIQDRD5
ClinGenDRD5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1816
Chemical/Pharm GKB GenePA148
Clinical trialDRD5
Miscellaneous
canSAR (ICR)DRD5 (select the gene name)
Probes
Litterature
PubMed104 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDRD5
EVEXDRD5
GoPubMedDRD5
iHOPDRD5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:02:15 CET 2017

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