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DRG1 (developmentally regulated GTP binding protein 1)

Identity

Alias_namesNEDD3
developmentally regulated GTP-binding protein 1
Other alias
HGNC (Hugo) DRG1
LocusID (NCBI) 4733
Atlas_Id 40362
Location 22q12.2  [Link to chromosome band 22q12]
Location_base_pair Starts at 31399553 and ends at 31434186 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ARHGAP19 (10q24.1) / DRG1 (22q12.2)DRG1 (22q12.2) / DEPDC5 (22q12.2)DRG1 (22q12.2) / MYO18B (22q12.1)
TMEM214 (2p23.3) / DRG1 (22q12.2)DRG1 22q12.2 / MYO18B 22q12.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DRG1   3029
Cards
Entrez_Gene (NCBI)DRG1  4733  developmentally regulated GTP binding protein 1
AliasesNEDD3
GeneCards (Weizmann)DRG1
Ensembl hg19 (Hinxton)ENSG00000185721 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185721 [Gene_View]  chr22:31399553-31434186 [Contig_View]  DRG1 [Vega]
ICGC DataPortalENSG00000185721
TCGA cBioPortalDRG1
AceView (NCBI)DRG1
Genatlas (Paris)DRG1
WikiGenes4733
SOURCE (Princeton)DRG1
Genetics Home Reference (NIH)DRG1
Genomic and cartography
GoldenPath hg38 (UCSC)DRG1  -     chr22:31399553-31434186 +  22q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DRG1  -     22q12.2   [Description]    (hg19-Feb_2009)
EnsemblDRG1 - 22q12.2 [CytoView hg19]  DRG1 - 22q12.2 [CytoView hg38]
Mapping of homologs : NCBIDRG1 [Mapview hg19]  DRG1 [Mapview hg38]
OMIM603952   
Gene and transcription
Genbank (Entrez)AF078103 AJ005940 AK098576 AK315659 AL133085
RefSeq transcript (Entrez)NM_004147
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DRG1
Cluster EST : UnigeneHs.115242 [ NCBI ]
CGAP (NCI)Hs.115242
Alternative Splicing GalleryENSG00000185721
Gene ExpressionDRG1 [ NCBI-GEO ]   DRG1 [ EBI - ARRAY_EXPRESS ]   DRG1 [ SEEK ]   DRG1 [ MEM ]
Gene Expression Viewer (FireBrowse)DRG1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4733
GTEX Portal (Tissue expression)DRG1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y295   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y295  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y295
Splice isoforms : SwissVarQ9Y295
PhosPhoSitePlusQ9Y295
Domaine pattern : Prosite (Expaxy)G_OBG (PS51710)    GTP1_OBG (PS00905)   
Domains : Interpro (EBI)Beta-grasp_dom    G_OBG    GTP-binding_2    GTP1-OBG_CS    GTP_binding_domain    P-loop_NTPase    Small_GTP-bd_dom    TGS    TGS-like   
Domain families : Pfam (Sanger)MMR_HSR1 (PF01926)    MMR_HSR1_Xtn (PF16897)    TGS (PF02824)   
Domain families : Pfam (NCBI)pfam01926    pfam16897    pfam02824   
Conserved Domain (NCBI)DRG1
DMDM Disease mutations4733
Blocks (Seattle)DRG1
PDB (SRS)2EKI   
PDB (PDBSum)2EKI   
PDB (IMB)2EKI   
PDB (RSDB)2EKI   
Structural Biology KnowledgeBase2EKI   
SCOP (Structural Classification of Proteins)2EKI   
CATH (Classification of proteins structures)2EKI   
SuperfamilyQ9Y295
Human Protein AtlasENSG00000185721
Peptide AtlasQ9Y295
HPRD16034
IPIIPI00031836   IPI00878191   IPI00878823   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y295
IntAct (EBI)Q9Y295
FunCoupENSG00000185721
BioGRIDDRG1
STRING (EMBL)DRG1
ZODIACDRG1
Ontologies - Pathways
QuickGOQ9Y295
Ontology : AmiGOprotein binding  GTP binding  cytosol  polysome  transcription, DNA-templated  multicellular organism development  transcription factor binding  membrane  nuclear body  identical protein binding  
Ontology : EGO-EBIprotein binding  GTP binding  cytosol  polysome  transcription, DNA-templated  multicellular organism development  transcription factor binding  membrane  nuclear body  identical protein binding  
NDEx NetworkDRG1
Atlas of Cancer Signalling NetworkDRG1
Wikipedia pathwaysDRG1
Orthology - Evolution
OrthoDB4733
GeneTree (enSembl)ENSG00000185721
Phylogenetic Trees/Animal Genes : TreeFamDRG1
HOVERGENQ9Y295
HOGENOMQ9Y295
Homologs : HomoloGeneDRG1
Homology/Alignments : Family Browser (UCSC)DRG1
Gene fusions - Rearrangements
Fusion : MitelmanARHGAP19/DRG1 [10q24.1/22q12.2]  [t(10;22)(q24;q12)]  
Fusion : MitelmanDRG1/MYO18B [22q12.2/22q12.1]  [t(22;22)(q12;q12)]  
Fusion: TCGADRG1 22q12.2 MYO18B 22q12.1 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDRG1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DRG1
dbVarDRG1
ClinVarDRG1
1000_GenomesDRG1 
Exome Variant ServerDRG1
ExAC (Exome Aggregation Consortium)DRG1 (select the gene name)
Genetic variants : HAPMAP4733
Genomic Variants (DGV)DRG1 [DGVbeta]
DECIPHERDRG1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDRG1 
Mutations
ICGC Data PortalDRG1 
TCGA Data PortalDRG1 
Broad Tumor PortalDRG1
OASIS PortalDRG1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDRG1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDRG1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DRG1
DgiDB (Drug Gene Interaction Database)DRG1
DoCM (Curated mutations)DRG1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DRG1 (select a term)
intoGenDRG1
Cancer3DDRG1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603952   
Orphanet
MedgenDRG1
Genetic Testing Registry DRG1
NextProtQ9Y295 [Medical]
TSGene4733
GENETestsDRG1
Target ValidationDRG1
Huge Navigator DRG1 [HugePedia]
snp3D : Map Gene to Disease4733
BioCentury BCIQDRG1
ClinGenDRG1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4733
Chemical/Pharm GKB GenePA27483
Clinical trialDRG1
Miscellaneous
canSAR (ICR)DRG1 (select the gene name)
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDRG1
EVEXDRG1
GoPubMedDRG1
iHOPDRG1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:31:45 CEST 2017

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