DRG2 (developmentally regulated GTP binding protein 2)

2016-10-01  

Identity

HGNC
DRG2
LOCATION
17p11.2
LOCUSID
1819
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1819
MIM: 602986
HGNC: 3030
Ensembl: ENSG00000108591

Variants:

dbSNP: 1819
ClinVar: 1819
TCGA: ENSG00000108591
COSMIC: DRG2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108591ENST00000225729P55039
ENSG00000108591ENST00000395726A8MZF9
ENSG00000108591ENST00000467099J3QLF3
ENSG00000108591ENST00000496428J3QLF3
ENSG00000108591ENST00000577450J3QL90
ENSG00000108591ENST00000579224J3QRI9
ENSG00000108591ENST00000579601J3QR71
ENSG00000108591ENST00000580055J3QKW7
ENSG00000108591ENST00000580929J3KRL5
ENSG00000108591ENST00000582314J3QLF3
ENSG00000108591ENST00000582419J3QQI1
ENSG00000108591ENST00000583355J3QKV7

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
276698262016DRG2 Regulates G2/M Progression via the Cyclin B1-Cdk1 Complex.16
151138312004Overexpression of DRG2 increases G2/M phase cells and decreases sensitivity to nocodazole-induced apoptosis.9
265823922016Developmentally regulated GTP-binding protein 2 coordinates Rab5 activity and transferrin recycling.7
212966922011Transcription factor Sp1 regulates basal transcription of the human DRG2 gene.5
265721002016MicroRNA‑1915‑3p prevents the apoptosis of lung cancer cells by downregulating DRG2 and PBX2.4
302818722018Functional intronic variant of SLC5A10 affects DRG2 expression and survival outcomes of early-stage non-small-cell lung cancer.3
283638672017Developmentally regulated GTP-binding protein 2 depletion leads to mitochondrial dysfunction through downregulation of dynamin-related protein 1.2
304537312018DRG2 Deficiency Causes Impaired Microtubule Dynamics in HeLa Cells.2
311999312019DRG2 knockdown induces Golgi fragmentation via GSK3β phosphorylation and microtubule stabilization.1

Citation

Dessen P

DRG2 (developmentally regulated GTP binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56604/drg2