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DROSHA (drosha ribonuclease III)

Identity

Alias_namesRNASEN
ribonuclease type III, nuclear
drosha, ribonuclease type III
Alias_symbol (synonym)RNASE3L
Etohi2
HSA242976
RN3
Other aliasETOHI2
RANSE3L
HGNC (Hugo) DROSHA
LocusID (NCBI) 29102
Atlas_Id 51768
Location 5p13.3  [Link to chromosome band 5p13]
Location_base_pair Starts at 31400495 and ends at 31532175 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ANKH (5p15.2) / DROSHA (5p13.3)DROSHA (5p13.3) / TERT (5p15.33)SNHG3 (1p35.3) / DROSHA (5p13.3)
DROSHA 5p13.3 / TERT 5p15.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DROSHA   17904
Cards
Entrez_Gene (NCBI)DROSHA  29102  drosha ribonuclease III
AliasesETOHI2; HSA242976; RANSE3L; RN3; 
RNASE3L; RNASEN
GeneCards (Weizmann)DROSHA
Ensembl hg19 (Hinxton)ENSG00000113360 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113360 [Gene_View]  chr5:31400495-31532175 [Contig_View]  DROSHA [Vega]
ICGC DataPortalENSG00000113360
TCGA cBioPortalDROSHA
AceView (NCBI)DROSHA
Genatlas (Paris)DROSHA
WikiGenes29102
SOURCE (Princeton)DROSHA
Genetics Home Reference (NIH)DROSHA
Genomic and cartography
GoldenPath hg38 (UCSC)DROSHA  -     chr5:31400495-31532175 -  5p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DROSHA  -     5p13.3   [Description]    (hg19-Feb_2009)
EnsemblDROSHA - 5p13.3 [CytoView hg19]  DROSHA - 5p13.3 [CytoView hg38]
Mapping of homologs : NCBIDROSHA [Mapview hg19]  DROSHA [Mapview hg38]
OMIM608828   
Gene and transcription
Genbank (Entrez)AA917625 AB209501 AF116910 AF189011 AJ242976
RefSeq transcript (Entrez)NM_001100412 NM_013235
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DROSHA
Cluster EST : UnigeneHs.97997 [ NCBI ]
CGAP (NCI)Hs.97997
Alternative Splicing GalleryENSG00000113360
Gene ExpressionDROSHA [ NCBI-GEO ]   DROSHA [ EBI - ARRAY_EXPRESS ]   DROSHA [ SEEK ]   DROSHA [ MEM ]
Gene Expression Viewer (FireBrowse)DROSHA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29102
GTEX Portal (Tissue expression)DROSHA
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NRR4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NRR4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NRR4
Splice isoforms : SwissVarQ9NRR4
PhosPhoSitePlusQ9NRR4
Domaine pattern : Prosite (Expaxy)DS_RBD (PS50137)    RNASE_3_1 (PS00517)    RNASE_3_2 (PS50142)   
Domains : Interpro (EBI)dsRBD_dom    RNase_III    RNase_III_dom   
Domain families : Pfam (Sanger)dsrm (PF00035)    Ribonucleas_3_3 (PF14622)    Ribonuclease_3 (PF00636)   
Domain families : Pfam (NCBI)pfam00035    pfam14622    pfam00636   
Domain families : Smart (EMBL)DSRM (SM00358)  RIBOc (SM00535)  
Conserved Domain (NCBI)DROSHA
DMDM Disease mutations29102
Blocks (Seattle)DROSHA
PDB (SRS)2KHX    2NA2    5B16   
PDB (PDBSum)2KHX    2NA2    5B16   
PDB (IMB)2KHX    2NA2    5B16   
PDB (RSDB)2KHX    2NA2    5B16   
Structural Biology KnowledgeBase2KHX    2NA2    5B16   
SCOP (Structural Classification of Proteins)2KHX    2NA2    5B16   
CATH (Classification of proteins structures)2KHX    2NA2    5B16   
SuperfamilyQ9NRR4
Human Protein AtlasENSG00000113360
Peptide AtlasQ9NRR4
HPRD10196
IPIIPI00300956   IPI00219990   IPI00942044   IPI00515032   IPI00982646   
Protein Interaction databases
DIP (DOE-UCLA)Q9NRR4
IntAct (EBI)Q9NRR4
FunCoupENSG00000113360
BioGRIDDROSHA
STRING (EMBL)DROSHA
ZODIACDROSHA
Ontologies - Pathways
QuickGOQ9NRR4
Ontology : AmiGOlipopolysaccharide binding  RNA binding  ribonuclease III activity  protein binding  nucleus  nucleoplasm  nucleolus  plasma membrane  focal adhesion  miRNA metabolic process  positive regulation of gene expression  rRNA catabolic process  DEAD/H-box RNA helicase binding  gene silencing by RNA  primary miRNA processing  primary miRNA processing  pre-miRNA processing  ribosome biogenesis  protein homodimerization activity  regulation of regulatory T cell differentiation  SMAD binding  metal ion binding  regulation of inflammatory response  defense response to Gram-negative bacterium  defense response to Gram-positive bacterium  R-SMAD binding  microprocessor complex  primary miRNA binding  primary miRNA binding  RNA phosphodiester bond hydrolysis, endonucleolytic  regulation of miRNA metabolic process  
Ontology : EGO-EBIlipopolysaccharide binding  RNA binding  ribonuclease III activity  protein binding  nucleus  nucleoplasm  nucleolus  plasma membrane  focal adhesion  miRNA metabolic process  positive regulation of gene expression  rRNA catabolic process  DEAD/H-box RNA helicase binding  gene silencing by RNA  primary miRNA processing  primary miRNA processing  pre-miRNA processing  ribosome biogenesis  protein homodimerization activity  regulation of regulatory T cell differentiation  SMAD binding  metal ion binding  regulation of inflammatory response  defense response to Gram-negative bacterium  defense response to Gram-positive bacterium  R-SMAD binding  microprocessor complex  primary miRNA binding  primary miRNA binding  RNA phosphodiester bond hydrolysis, endonucleolytic  regulation of miRNA metabolic process  
Pathways : KEGGRibosome biogenesis in eukaryotes    Proteoglycans in cancer   
NDEx NetworkDROSHA
Atlas of Cancer Signalling NetworkDROSHA
Wikipedia pathwaysDROSHA
Orthology - Evolution
OrthoDB29102
GeneTree (enSembl)ENSG00000113360
Phylogenetic Trees/Animal Genes : TreeFamDROSHA
HOVERGENQ9NRR4
HOGENOMQ9NRR4
Homologs : HomoloGeneDROSHA
Homology/Alignments : Family Browser (UCSC)DROSHA
Gene fusions - Rearrangements
Fusion : MitelmanDROSHA/TERT [5p13.3/5p15.33]  
Fusion: TCGADROSHA 5p13.3 TERT 5p15.33 SKCM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDROSHA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DROSHA
dbVarDROSHA
ClinVarDROSHA
1000_GenomesDROSHA 
Exome Variant ServerDROSHA
ExAC (Exome Aggregation Consortium)DROSHA (select the gene name)
Genetic variants : HAPMAP29102
Genomic Variants (DGV)DROSHA [DGVbeta]
DECIPHERDROSHA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDROSHA 
Mutations
ICGC Data PortalDROSHA 
TCGA Data PortalDROSHA 
Broad Tumor PortalDROSHA
OASIS PortalDROSHA [ Somatic mutations - Copy number]
Cancer Gene: CensusDROSHA 
Somatic Mutations in Cancer : COSMICDROSHA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDROSHA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DROSHA
DgiDB (Drug Gene Interaction Database)DROSHA
DoCM (Curated mutations)DROSHA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DROSHA (select a term)
intoGenDROSHA
Cancer3DDROSHA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608828   
Orphanet
MedgenDROSHA
Genetic Testing Registry DROSHA
NextProtQ9NRR4 [Medical]
TSGene29102
GENETestsDROSHA
Target ValidationDROSHA
Huge Navigator DROSHA [HugePedia]
snp3D : Map Gene to Disease29102
BioCentury BCIQDROSHA
ClinGenDROSHA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD29102
Chemical/Pharm GKB GenePA142671060
Clinical trialDROSHA
Miscellaneous
canSAR (ICR)DROSHA (select the gene name)
Probes
Litterature
PubMed129 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDROSHA
EVEXDROSHA
GoPubMedDROSHA
iHOPDROSHA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:31:45 CEST 2017

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