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DSCR3 (DSCR3 arrestin fold containing)

Identity

Alias_namesDown syndrome critical region 3
Alias_symbol (synonym)DCRA
Other aliasDSCRA
HGNC (Hugo) DSCR3
LocusID (NCBI) 10311
Atlas_Id 62652
Location 21q22.13  [Link to chromosome band 21q22]
Location_base_pair Starts at 37223420 and ends at 37268108 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BACH1 (21q21.3) / DSCR3 (21q22.13)DSCR3 (21q22.13) / BACH1 (21q21.3)DSCR3 (21q22.13) / IGSF5 (21q22.2)
DSCR3 (21q22.13) / MACROD2 (20p12.1)DSCR3 (21q22.13) / NIPBL (5p13.2)HLA-E (6p21.33) / DSCR3 (21q22.13)
DSCR3 BACH1DSCR3 MACROD2DSCR3 IGSF5
DSCR3 NIPBL

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DSCR3   3044
Cards
Entrez_Gene (NCBI)DSCR3  10311  DSCR3 arrestin fold containing
AliasesDCRA; DSCRA
GeneCards (Weizmann)DSCR3
Ensembl hg19 (Hinxton)ENSG00000157538 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000157538 [Gene_View]  chr21:37223420-37268108 [Contig_View]  DSCR3 [Vega]
ICGC DataPortalENSG00000157538
TCGA cBioPortalDSCR3
AceView (NCBI)DSCR3
Genatlas (Paris)DSCR3
WikiGenes10311
SOURCE (Princeton)DSCR3
Genetics Home Reference (NIH)DSCR3
Genomic and cartography
GoldenPath hg38 (UCSC)DSCR3  -     chr21:37223420-37268108 -  21q22.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DSCR3  -     21q22.13   [Description]    (hg19-Feb_2009)
EnsemblDSCR3 - 21q22.13 [CytoView hg19]  DSCR3 - 21q22.13 [CytoView hg38]
Mapping of homologs : NCBIDSCR3 [Mapview hg19]  DSCR3 [Mapview hg38]
OMIM605298   
Gene and transcription
Genbank (Entrez)AJ001867 AK126461 AK299662 AK300024 AK303624
RefSeq transcript (Entrez)NM_001331018 NM_001331021 NM_001331022 NM_006052
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DSCR3
Cluster EST : UnigeneHs.369488 [ NCBI ]
CGAP (NCI)Hs.369488
Alternative Splicing GalleryENSG00000157538
Gene ExpressionDSCR3 [ NCBI-GEO ]   DSCR3 [ EBI - ARRAY_EXPRESS ]   DSCR3 [ SEEK ]   DSCR3 [ MEM ]
Gene Expression Viewer (FireBrowse)DSCR3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10311
GTEX Portal (Tissue expression)DSCR3
Human Protein AtlasENSG00000157538-DSCR3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14972   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14972  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14972
Splice isoforms : SwissVarO14972
PhosPhoSitePlusO14972
Domains : Interpro (EBI)Ig_E-set    Vps26-related   
Domain families : Pfam (Sanger)Vps26 (PF03643)   
Domain families : Pfam (NCBI)pfam03643   
Conserved Domain (NCBI)DSCR3
DMDM Disease mutations10311
Blocks (Seattle)DSCR3
SuperfamilyO14972
Human Protein Atlas [tissue]ENSG00000157538-DSCR3 [tissue]
Peptide AtlasO14972
HPRD10390
IPIIPI00298946   IPI00922353   IPI00385046   IPI00789523   IPI00790030   IPI00790720   IPI00916796   
Protein Interaction databases
DIP (DOE-UCLA)O14972
IntAct (EBI)O14972
FunCoupENSG00000157538
BioGRIDDSCR3
STRING (EMBL)DSCR3
ZODIACDSCR3
Ontologies - Pathways
QuickGOO14972
Ontology : AmiGOmolecular_function  nucleus  endosome  intracellular protein transport  biological_process  protein transporter activity  
Ontology : EGO-EBImolecular_function  nucleus  endosome  intracellular protein transport  biological_process  protein transporter activity  
NDEx NetworkDSCR3
Atlas of Cancer Signalling NetworkDSCR3
Wikipedia pathwaysDSCR3
Orthology - Evolution
OrthoDB10311
GeneTree (enSembl)ENSG00000157538
Phylogenetic Trees/Animal Genes : TreeFamDSCR3
HOVERGENO14972
HOGENOMO14972
Homologs : HomoloGeneDSCR3
Homology/Alignments : Family Browser (UCSC)DSCR3
Gene fusions - Rearrangements
Fusion: TCGADSCR3 BACH1
Fusion: TCGADSCR3 MACROD2
Fusion: TCGADSCR3 IGSF5
Fusion: TCGADSCR3 NIPBL
Fusion: Tumor Portal DSCR3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDSCR3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DSCR3
dbVarDSCR3
ClinVarDSCR3
1000_GenomesDSCR3 
Exome Variant ServerDSCR3
ExAC (Exome Aggregation Consortium)ENSG00000157538
GNOMAD BrowserENSG00000157538
Genetic variants : HAPMAP10311
Genomic Variants (DGV)DSCR3 [DGVbeta]
DECIPHERDSCR3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDSCR3 
Mutations
ICGC Data PortalDSCR3 
TCGA Data PortalDSCR3 
Broad Tumor PortalDSCR3
OASIS PortalDSCR3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDSCR3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDSCR3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DSCR3
DgiDB (Drug Gene Interaction Database)DSCR3
DoCM (Curated mutations)DSCR3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DSCR3 (select a term)
intoGenDSCR3
Cancer3DDSCR3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605298   
Orphanet
MedgenDSCR3
Genetic Testing Registry DSCR3
NextProtO14972 [Medical]
TSGene10311
GENETestsDSCR3
Target ValidationDSCR3
Huge Navigator DSCR3 [HugePedia]
snp3D : Map Gene to Disease10311
BioCentury BCIQDSCR3
ClinGenDSCR3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10311
Chemical/Pharm GKB GenePA27496
Clinical trialDSCR3
Miscellaneous
canSAR (ICR)DSCR3 (select the gene name)
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDSCR3
EVEXDSCR3
GoPubMedDSCR3
iHOPDSCR3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 11:45:12 CET 2017

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