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DSN1 (DSN1 homolog, MIS12 kinetochore complex component)

Identity

Other aliasC20orf172
KNL3
MIS13
dJ469A13.2
hKNL-3
HGNC (Hugo) DSN1
LocusID (NCBI) 79980
Atlas_Id 57289
Location 20q11.23  [Link to chromosome band 20q11]
Location_base_pair Starts at 36751791 and ends at 36773751 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NPEPL1 (20q13.32) / DSN1 (20q11.23)SLC35C2 (20q13.12) / DSN1 (20q11.23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(20;20)(q11;q13) NPEPL1/DSN1


External links

Nomenclature
HGNC (Hugo)DSN1   16165
Cards
Entrez_Gene (NCBI)DSN1  79980  DSN1 homolog, MIS12 kinetochore complex component
AliasesC20orf172; KNL3; MIS13; dJ469A13.2; 
hKNL-3
GeneCards (Weizmann)DSN1
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]   [Sequence]  chr20:36751791-36773751 [Contig_View]  DSN1 [Vega]
TCGA cBioPortalDSN1
AceView (NCBI)DSN1
Genatlas (Paris)DSN1
WikiGenes79980
SOURCE (Princeton)DSN1
Genetics Home Reference (NIH)DSN1
Genomic and cartography
GoldenPath hg38 (UCSC)DSN1  -     chr20:36751791-36773751 -  20q11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DSN1  -     20q11.23   [Description]    (hg19-Feb_2009)
EnsemblDSN1 - 20q11.23 [CytoView hg19]  DSN1 - 20q11.23 [CytoView hg38]
Mapping of homologs : NCBIDSN1 [Mapview hg19]  DSN1 [Mapview hg38]
OMIM609175   
Gene and transcription
Genbank (Entrez)AA534892 AK023408 AK093031 AK290738 AK301671
RefSeq transcript (Entrez)NM_001145315 NM_001145316 NM_001145317 NM_001145318 NM_024918
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DSN1
Cluster EST : UnigeneHs.632268 [ NCBI ]
CGAP (NCI)Hs.632268
Gene ExpressionDSN1 [ NCBI-GEO ]   DSN1 [ EBI - ARRAY_EXPRESS ]   DSN1 [ SEEK ]   DSN1 [ MEM ]
Gene Expression Viewer (FireBrowse)DSN1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79980
GTEX Portal (Tissue expression)DSN1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H410   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H410  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H410
Splice isoforms : SwissVarQ9H410
PhosPhoSitePlusQ9H410
Domains : Interpro (EBI)Dsn1/Mis13   
Domain families : Pfam (Sanger)MIS13 (PF08202)   
Domain families : Pfam (NCBI)pfam08202   
Conserved Domain (NCBI)DSN1
DMDM Disease mutations79980
Blocks (Seattle)DSN1
PDB (SRS)5LSI    5LSJ    5LSK   
PDB (PDBSum)5LSI    5LSJ    5LSK   
PDB (IMB)5LSI    5LSJ    5LSK   
PDB (RSDB)5LSI    5LSJ    5LSK   
Structural Biology KnowledgeBase5LSI    5LSJ    5LSK   
SCOP (Structural Classification of Proteins)5LSI    5LSJ    5LSK   
CATH (Classification of proteins structures)5LSI    5LSJ    5LSK   
SuperfamilyQ9H410
Peptide AtlasQ9H410
IPIIPI00016580   IPI00843750   IPI00827925   IPI00884119   IPI00641008   IPI00642473   
Protein Interaction databases
DIP (DOE-UCLA)Q9H410
IntAct (EBI)Q9H410
BioGRIDDSN1
STRING (EMBL)DSN1
ZODIACDSN1
Ontologies - Pathways
QuickGOQ9H410
Ontology : AmiGOmitotic sister chromatid segregation  MIS12/MIND type complex  condensed chromosome kinetochore  nuclear MIS12/MIND complex  spindle pole  condensed nuclear chromosome inner kinetochore  fibrillar center  protein binding  extracellular region  nucleus  nucleolus  cytosol  cytosol  nuclear body  azurophil granule lumen  neutrophil degranulation  cell division  
Ontology : EGO-EBImitotic sister chromatid segregation  MIS12/MIND type complex  condensed chromosome kinetochore  nuclear MIS12/MIND complex  spindle pole  condensed nuclear chromosome inner kinetochore  fibrillar center  protein binding  extracellular region  nucleus  nucleolus  cytosol  cytosol  nuclear body  azurophil granule lumen  neutrophil degranulation  cell division  
NDEx NetworkDSN1
Atlas of Cancer Signalling NetworkDSN1
Wikipedia pathwaysDSN1
Orthology - Evolution
OrthoDB79980
Phylogenetic Trees/Animal Genes : TreeFamDSN1
HOVERGENQ9H410
HOGENOMQ9H410
Homologs : HomoloGeneDSN1
Homology/Alignments : Family Browser (UCSC)DSN1
Gene fusions - Rearrangements
Fusion : QuiverDSN1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDSN1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DSN1
dbVarDSN1
ClinVarDSN1
1000_GenomesDSN1 
Exome Variant ServerDSN1
Varsome BrowserDSN1
Genetic variants : HAPMAP79980
Genomic Variants (DGV)DSN1 [DGVbeta]
DECIPHERDSN1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDSN1 
Mutations
ICGC Data PortalDSN1 
TCGA Data PortalDSN1 
Broad Tumor PortalDSN1
OASIS PortalDSN1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDSN1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDSN1
BioMutasearch DSN1
DgiDB (Drug Gene Interaction Database)DSN1
DoCM (Curated mutations)DSN1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DSN1 (select a term)
intoGenDSN1
Cancer3DDSN1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609175   
Orphanet
DisGeNETDSN1
MedgenDSN1
Genetic Testing Registry DSN1
NextProtQ9H410 [Medical]
TSGene79980
GENETestsDSN1
Target ValidationDSN1
Huge Navigator DSN1 [HugePedia]
snp3D : Map Gene to Disease79980
BioCentury BCIQDSN1
ClinGenDSN1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79980
Chemical/Pharm GKB GenePA162384106
Clinical trialDSN1
Miscellaneous
canSAR (ICR)DSN1 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDSN1
EVEXDSN1
GoPubMedDSN1
iHOPDSN1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:20:07 CEST 2018

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