DSN1 (DSN1 component of MIS12 kinetochore complex)

2018-02-01  

Identity

HGNC
LOCATION
20q11.23
LOCUSID
ALIAS
C20orf172,KNL3,MIS13,dJ469A13.2,hKNL-3
FUSION GENES

Other Information

Locus ID:

NCBI: 79980
MIM: 609175
HGNC: 16165
Ensembl: ENSG00000149636

Variants:

dbSNP: 79980
ClinVar: 79980
TCGA: ENSG00000149636
COSMIC: DSN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149636ENST00000373734Q9H410
ENSG00000149636ENST00000373740Q5JW54
ENSG00000149636ENST00000373750Q9H410
ENSG00000149636ENST00000426836Q9H410
ENSG00000149636ENST00000438549Q5JW57
ENSG00000149636ENST00000447406Q5JW53
ENSG00000149636ENST00000448110Q9H410

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
186409742008Phosphorylation of HsMis13 by Aurora B kinase is essential for assembly of functional kinetochore.36
273295862016Over-expression of AURKA, SKA3 and DSN1 contributes to colorectal adenoma to carcinoma progression.17
301366462018Elevated DSN1 expression is associated with poor survival in patients with hepatocellular carcinoma.2

Citation

Dessen P

DSN1 (DSN1 component of MIS12 kinetochore complex)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57289/dsn1