Atlas of Genetics and Cytogenetics in Oncology and Haematology


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DSTYK (dual serine/threonine and tyrosine protein kinase)

Identity

Alias_namesRIPK5
receptor interacting protein kinase 5
Alias_symbol (synonym)KIAA0472
DustyPK
RIP5
Other aliasCAKUT1
HDCMD38P
HGNC (Hugo) DSTYK
LocusID (NCBI) 25778
Atlas_Id 43472
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 205111631 and ends at 205180727 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DSTYK (1q32.1) / BOLA2 (16p11.2)PIK3C2B (1q32.1) / DSTYK (1q32.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DSTYK   29043
Cards
Entrez_Gene (NCBI)DSTYK  25778  dual serine/threonine and tyrosine protein kinase
AliasesCAKUT1; DustyPK; HDCMD38P; RIP5; 
RIPK5
GeneCards (Weizmann)DSTYK
Ensembl hg19 (Hinxton)ENSG00000133059 [Gene_View]  chr1:205111631-205180727 [Contig_View]  DSTYK [Vega]
Ensembl hg38 (Hinxton)ENSG00000133059 [Gene_View]  chr1:205111631-205180727 [Contig_View]  DSTYK [Vega]
ICGC DataPortalENSG00000133059
TCGA cBioPortalDSTYK
AceView (NCBI)DSTYK
Genatlas (Paris)DSTYK
WikiGenes25778
SOURCE (Princeton)DSTYK
Genetics Home Reference (NIH)DSTYK
Genomic and cartography
GoldenPath hg19 (UCSC)DSTYK  -     chr1:205111631-205180727 -  1q32.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DSTYK  -     1q32.1   [Description]    (hg38-Dec_2013)
EnsemblDSTYK - 1q32.1 [CytoView hg19]  DSTYK - 1q32.1 [CytoView hg38]
Mapping of homologs : NCBIDSTYK [Mapview hg19]  DSTYK [Mapview hg38]
OMIM610805   612666   
Gene and transcription
Genbank (Entrez)AB007941 AF068286 AJ420466 AK298011 AY208850
RefSeq transcript (Entrez)NM_015375 NM_199462
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_033904 NT_004487 NW_004929293
Consensus coding sequences : CCDS (NCBI)DSTYK
Cluster EST : UnigeneHs.6874 [ NCBI ]
CGAP (NCI)Hs.6874
Alternative Splicing GalleryENSG00000133059
Gene ExpressionDSTYK [ NCBI-GEO ]   DSTYK [ EBI - ARRAY_EXPRESS ]   DSTYK [ SEEK ]   DSTYK [ MEM ]
Gene Expression Viewer (FireBrowse)DSTYK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)25778
GTEX Portal (Tissue expression)DSTYK
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6XUX3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6XUX3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6XUX3
Splice isoforms : SwissVarQ6XUX3
Catalytic activity : Enzyme2.7.12.1 [ Enzyme-Expasy ]   2.7.12.12.7.12.1 [ IntEnz-EBI ]   2.7.12.1 [ BRENDA ]   2.7.12.1 [ KEGG ]   
PhosPhoSitePlusQ6XUX3
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)   
Domain families : Pfam (NCBI)pfam07714   
Conserved Domain (NCBI)DSTYK
DMDM Disease mutations25778
Blocks (Seattle)DSTYK
SuperfamilyQ6XUX3
Human Protein AtlasENSG00000133059
Peptide AtlasQ6XUX3
HPRD11495
IPIIPI00465346   IPI00396963   IPI00025976   IPI00908903   IPI00743336   
Protein Interaction databases
DIP (DOE-UCLA)Q6XUX3
IntAct (EBI)Q6XUX3
FunCoupENSG00000133059
BioGRIDDSTYK
STRING (EMBL)DSTYK
ZODIACDSTYK
Ontologies - Pathways
QuickGOQ6XUX3
Ontology : AmiGOprotein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  ATP binding  cytoplasm  cytosol  basolateral plasma membrane  apical plasma membrane  peptidyl-tyrosine phosphorylation  cell junction  positive regulation of kinase activity  cellular response to fibroblast growth factor stimulus  positive regulation of fibroblast growth factor receptor signaling pathway  positive regulation of ERK1 and ERK2 cascade  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  ATP binding  cytoplasm  cytosol  basolateral plasma membrane  apical plasma membrane  peptidyl-tyrosine phosphorylation  cell junction  positive regulation of kinase activity  cellular response to fibroblast growth factor stimulus  positive regulation of fibroblast growth factor receptor signaling pathway  positive regulation of ERK1 and ERK2 cascade  
NDEx NetworkDSTYK
Atlas of Cancer Signalling NetworkDSTYK
Wikipedia pathwaysDSTYK
Orthology - Evolution
OrthoDB25778
GeneTree (enSembl)ENSG00000133059
Phylogenetic Trees/Animal Genes : TreeFamDSTYK
HOVERGENQ6XUX3
HOGENOMQ6XUX3
Homologs : HomoloGeneDSTYK
Homology/Alignments : Family Browser (UCSC)DSTYK
Gene fusions - Rearrangements
Fusion : MitelmanPIK3C2B/DSTYK [1q32.1/1q32.1]  [t(1;1)(q32;q32)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDSTYK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DSTYK
dbVarDSTYK
ClinVarDSTYK
1000_GenomesDSTYK 
Exome Variant ServerDSTYK
ExAC (Exome Aggregation Consortium)DSTYK (select the gene name)
Genetic variants : HAPMAP25778
Genomic Variants (DGV)DSTYK [DGVbeta]
DECIPHER (Syndromes)1:205111631-205180727  ENSG00000133059
CONAN: Copy Number AnalysisDSTYK 
Mutations
ICGC Data PortalDSTYK 
TCGA Data PortalDSTYK 
Broad Tumor PortalDSTYK
OASIS PortalDSTYK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDSTYK  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDSTYK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DSTYK
DgiDB (Drug Gene Interaction Database)DSTYK
DoCM (Curated mutations)DSTYK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DSTYK (select a term)
intoGenDSTYK
Cancer3DDSTYK(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610805    612666   
Orphanet12163   
MedgenDSTYK
Genetic Testing Registry DSTYK
NextProtQ6XUX3 [Medical]
TSGene25778
GENETestsDSTYK
Huge Navigator DSTYK [HugePedia]
snp3D : Map Gene to Disease25778
BioCentury BCIQDSTYK
ClinGenDSTYK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD25778
Chemical/Pharm GKB GenePA164718861
Clinical trialDSTYK
Miscellaneous
canSAR (ICR)DSTYK (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDSTYK
EVEXDSTYK
GoPubMedDSTYK
iHOPDSTYK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 30 14:59:26 CEST 2017

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