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DTL (denticleless E3 ubiquitin protein ligase homolog)

Identity

Alias_namesdenticleless homolog (Drosophila)
denticleless E3 ubiquitin protein ligase homolog (Drosophila)
Alias_symbol (synonym)RAMP
L2DTL
DCAF2
CDT2
Other alias
HGNC (Hugo) DTL
LocusID (NCBI) 51514
Atlas_Id 50456
Location 1q32.3  [Link to chromosome band 1q32]
Location_base_pair Starts at 212035553 and ends at 212105006 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AGBL4 (1p33) / DTL (1q32.3)DTL (1q32.3) / AGBL4 (1p33)AGBL4 1p33 / DTL 1q32.3
DTL 1q32.3 / AGBL4 1p33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(1;1)(p33;q32) AGBL4/DTL
t(1;1)(p33;q32) DTL/AGBL4


External links

Nomenclature
HGNC (Hugo)DTL   30288
Cards
Entrez_Gene (NCBI)DTL  51514  denticleless E3 ubiquitin protein ligase homolog
AliasesCDT2; DCAF2; L2DTL; RAMP
GeneCards (Weizmann)DTL
Ensembl hg19 (Hinxton)ENSG00000143476 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143476 [Gene_View]  ENSG00000143476 [Sequence]  chr1:212035553-212105006 [Contig_View]  DTL [Vega]
ICGC DataPortalENSG00000143476
TCGA cBioPortalDTL
AceView (NCBI)DTL
Genatlas (Paris)DTL
WikiGenes51514
SOURCE (Princeton)DTL
Genetics Home Reference (NIH)DTL
Genomic and cartography
GoldenPath hg38 (UCSC)DTL  -     chr1:212035553-212105006 +  1q32.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DTL  -     1q32.3   [Description]    (hg19-Feb_2009)
EnsemblDTL - 1q32.3 [CytoView hg19]  DTL - 1q32.3 [CytoView hg38]
Mapping of homologs : NCBIDTL [Mapview hg19]  DTL [Mapview hg38]
OMIM610617   
Gene and transcription
Genbank (Entrez)AF195765 AF345896 AI800751 AK000742 AK001206
RefSeq transcript (Entrez)NM_001286229 NM_001286230 NM_016448
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DTL
Cluster EST : UnigeneHs.656473 [ NCBI ]
CGAP (NCI)Hs.656473
Alternative Splicing GalleryENSG00000143476
Gene ExpressionDTL [ NCBI-GEO ]   DTL [ EBI - ARRAY_EXPRESS ]   DTL [ SEEK ]   DTL [ MEM ]
Gene Expression Viewer (FireBrowse)DTL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51514
GTEX Portal (Tissue expression)DTL
Human Protein AtlasENSG00000143476-DTL [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NZJ0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NZJ0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NZJ0
Splice isoforms : SwissVarQ9NZJ0
PhosPhoSitePlusQ9NZJ0
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)WD40/YVTN_repeat-like_dom_sf    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom    WD40_repeat_dom_sf   
Domain families : Pfam (Sanger)WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)DTL
DMDM Disease mutations51514
Blocks (Seattle)DTL
SuperfamilyQ9NZJ0
Human Protein Atlas [tissue]ENSG00000143476-DTL [tissue]
Peptide AtlasQ9NZJ0
HPRD17952
IPIIPI00643808   IPI00827740   IPI00910958   IPI01011401   
Protein Interaction databases
DIP (DOE-UCLA)Q9NZJ0
IntAct (EBI)Q9NZJ0
FunCoupENSG00000143476
BioGRIDDTL
STRING (EMBL)DTL
ZODIACDTL
Ontologies - Pathways
QuickGOQ9NZJ0
Ontology : AmiGOprotein polyubiquitination  protein polyubiquitination  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  chromosome  nucleolus  centrosome  cytosol  DNA replication  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  protein monoubiquitination  cellular response to DNA damage stimulus  cellular response to DNA damage stimulus  response to UV  positive regulation of G2/M transition of mitotic cell cycle  translesion synthesis  Cul4A-RING E3 ubiquitin ligase complex  Cul4B-RING E3 ubiquitin ligase complex  nuclear membrane  DNA damage response, detection of DNA damage  post-translational protein modification  positive regulation of protein catabolic process  regulation of cell cycle  signal transduction involved in G2 DNA damage checkpoint  Cul4-RING E3 ubiquitin ligase complex  
Ontology : EGO-EBIprotein polyubiquitination  protein polyubiquitination  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  chromosome  nucleolus  centrosome  cytosol  DNA replication  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  protein monoubiquitination  cellular response to DNA damage stimulus  cellular response to DNA damage stimulus  response to UV  positive regulation of G2/M transition of mitotic cell cycle  translesion synthesis  Cul4A-RING E3 ubiquitin ligase complex  Cul4B-RING E3 ubiquitin ligase complex  nuclear membrane  DNA damage response, detection of DNA damage  post-translational protein modification  positive regulation of protein catabolic process  regulation of cell cycle  signal transduction involved in G2 DNA damage checkpoint  Cul4-RING E3 ubiquitin ligase complex  
NDEx NetworkDTL
Atlas of Cancer Signalling NetworkDTL
Wikipedia pathwaysDTL
Orthology - Evolution
OrthoDB51514
GeneTree (enSembl)ENSG00000143476
Phylogenetic Trees/Animal Genes : TreeFamDTL
HOVERGENQ9NZJ0
HOGENOMQ9NZJ0
Homologs : HomoloGeneDTL
Homology/Alignments : Family Browser (UCSC)DTL
Gene fusions - Rearrangements
Fusion : MitelmanAGBL4/DTL [1p33/1q32.3]  [t(1;1)(p33;q32)]  
Fusion : MitelmanDTL/AGBL4 [1q32.3/1p33]  [t(1;1)(p33;q32)]  
Fusion PortalAGBL4 1p33 DTL 1q32.3 LUAD
Fusion PortalDTL 1q32.3 AGBL4 1p33 LUAD
Fusion : QuiverDTL
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDTL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DTL
dbVarDTL
ClinVarDTL
1000_GenomesDTL 
Exome Variant ServerDTL
ExAC (Exome Aggregation Consortium)ENSG00000143476
GNOMAD BrowserENSG00000143476
Varsome BrowserDTL
Genetic variants : HAPMAP51514
Genomic Variants (DGV)DTL [DGVbeta]
DECIPHERDTL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDTL 
Mutations
ICGC Data PortalDTL 
TCGA Data PortalDTL 
Broad Tumor PortalDTL
OASIS PortalDTL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDTL  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDTL
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DTL
DgiDB (Drug Gene Interaction Database)DTL
DoCM (Curated mutations)DTL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DTL (select a term)
intoGenDTL
Cancer3DDTL(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610617   
Orphanet
DisGeNETDTL
MedgenDTL
Genetic Testing Registry DTL
NextProtQ9NZJ0 [Medical]
TSGene51514
GENETestsDTL
Target ValidationDTL
Huge Navigator DTL [HugePedia]
snp3D : Map Gene to Disease51514
BioCentury BCIQDTL
ClinGenDTL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51514
Chemical/Pharm GKB GenePA142671941
Clinical trialDTL
Miscellaneous
canSAR (ICR)DTL (select the gene name)
Probes
Litterature
PubMed71 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDTL
EVEXDTL
GoPubMedDTL
iHOPDTL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Nov 6 11:03:25 CET 2018

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