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DTNB (dystrobrevin beta)

Identity

Alias (NCBI)-
HGNC (Hugo) DTNB
HGNC Previous namedystrobrevin, beta
LocusID (NCBI) 1838
Atlas_Id 54268
Location 2p23.3  [Link to chromosome band 2p23]
Location_base_pair Starts at 25377243 and ends at 25673647 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DTNB (2p23.3) / CNOT4 (7q33)DTNB (2p23.3) / LRRK2 (12q12)DTNB (2p23.3) / RBKS (2p23.2)
DTNB (2p23.3) / SPTLC1 (9q22.31)EXOC6 (10q23.33) / DTNB (2p23.3)RBM39 (20q11.22) / DTNB (2p23.3)
ROCK2 (2p25.1) / DTNB (2p23.3)TMEM138 (11q12.2) / DTNB (2p23.3)DTNB 2p23.3 / CNOT4 7q33
DTNB 2p23.3 / RBKS 2p23.2EXOC6 10q23.33 / DTNB 2p23.3ROCK2 2p25.1 / DTNB 2p23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  DTNB/RBKS (2p23)
t(2;2)(p23;p25) ROCK2/DTNB
t(2;7)(p23;q33) DTNB/CNOT4
t(2;9)(p23;q22) DTNB/SPTLC1
t(2;10)(p23;q23) EXOC6/DTNB

External links

Nomenclature
HGNC (Hugo)DTNB   3058
Cards
Entrez_Gene (NCBI)DTNB  1838  dystrobrevin beta
Aliases
GeneCards (Weizmann)DTNB
Ensembl hg19 (Hinxton)ENSG00000138101 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138101 [Gene_View]  ENSG00000138101 [Sequence]  chr2:25377243-25673647 [Contig_View]  DTNB [Vega]
ICGC DataPortalENSG00000138101
TCGA cBioPortalDTNB
AceView (NCBI)DTNB
Genatlas (Paris)DTNB
WikiGenes1838
SOURCE (Princeton)DTNB
Genetics Home Reference (NIH)DTNB
Genomic and cartography
GoldenPath hg38 (UCSC)DTNB  -     chr2:25377243-25673647 -  2p23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DTNB  -     2p23.3   [Description]    (hg19-Feb_2009)
GoldenPathDTNB - 2p23.3 [CytoView hg19]  DTNB - 2p23.3 [CytoView hg38]
ImmunoBaseENSG00000138101
genome Data Viewer NCBIDTNB [Mapview hg19]  
OMIM602415   
Gene and transcription
Genbank (Entrez)AF022728 AF070567 AI608704 AK094494 AK225724
RefSeq transcript (Entrez)NM_001256303 NM_001256304 NM_001256308 NM_001320932 NM_001320933 NM_001320934 NM_001320935 NM_001320936 NM_001320937 NM_001351381 NM_001351382 NM_001351383 NM_001351384 NM_001351385 NM_001351386 NM_001351387 NM_001351388 NM_001351389 NM_001351390 NM_001351391 NM_001351392 NM_001351393 NM_001351394 NM_001351395 NM_021907 NM_033147 NM_033148 NM_183360 NM_183361
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DTNB
Alternative Splicing GalleryENSG00000138101
Gene ExpressionDTNB [ NCBI-GEO ]   DTNB [ EBI - ARRAY_EXPRESS ]   DTNB [ SEEK ]   DTNB [ MEM ]
Gene Expression Viewer (FireBrowse)DTNB [ Firebrowse - Broad ]
GenevisibleExpression of DTNB in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1838
GTEX Portal (Tissue expression)DTNB
Human Protein AtlasENSG00000138101-DTNB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60941   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60941  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60941
Splice isoforms : SwissVarO60941
PhosPhoSitePlusO60941
Domaine pattern : Prosite (Expaxy)ZF_ZZ_1 (PS01357)    ZF_ZZ_2 (PS50135)   
Domains : Interpro (EBI)Distrobrevin    EF-hand-dom_pair    EF-hand_dom_typ1    EF-hand_dom_typ2    Znf_ZZ   
Domain families : Pfam (Sanger)EF-hand_2 (PF09068)    EF-hand_3 (PF09069)    ZZ (PF00569)   
Domain families : Pfam (NCBI)pfam09068    pfam09069    pfam00569   
Domain families : Smart (EMBL)ZnF_ZZ (SM00291)  
Conserved Domain (NCBI)DTNB
DMDM Disease mutations1838
Blocks (Seattle)DTNB
SuperfamilyO60941
Human Protein Atlas [tissue]ENSG00000138101-DTNB [tissue]
Peptide AtlasO60941
HPRD09091
IPIIPI00299362   IPI00219529   IPI00219530   IPI00373897   IPI01013439   IPI01011160   IPI01011718   IPI00748576   IPI00941442   IPI00892600   IPI00892714   IPI00871737   IPI01026126   IPI00894499   
Protein Interaction databases
DIP (DOE-UCLA)O60941
IntAct (EBI)O60941
FunCoupENSG00000138101
BioGRIDDTNB
STRING (EMBL)DTNB
ZODIACDTNB
Ontologies - Pathways
QuickGOO60941
Ontology : AmiGOprotein binding  cytoplasm  plasma membrane  zinc ion binding  synapse  synaptic signaling  
Ontology : EGO-EBIprotein binding  cytoplasm  plasma membrane  zinc ion binding  synapse  synaptic signaling  
NDEx NetworkDTNB
Atlas of Cancer Signalling NetworkDTNB
Wikipedia pathwaysDTNB
Orthology - Evolution
OrthoDB1838
GeneTree (enSembl)ENSG00000138101
Phylogenetic Trees/Animal Genes : TreeFamDTNB
HOGENOMO60941
Homologs : HomoloGeneDTNB
Homology/Alignments : Family Browser (UCSC)DTNB
Gene fusions - Rearrangements
Fusion : MitelmanDTNB/CNOT4 [2p23.3/7q33]  
Fusion : MitelmanDTNB/RBKS [2p23.3/2p23.2]  
Fusion : MitelmanDTNB/SPTLC1 [2p23.3/9q22.31]  
Fusion : MitelmanEXOC6/DTNB [10q23.33/2p23.3]  
Fusion : MitelmanROCK2/DTNB [2p25.1/2p23.3]  
Fusion PortalDTNB 2p23.3 CNOT4 7q33 HNSC
Fusion PortalDTNB 2p23.3 RBKS 2p23.2 BRCA
Fusion PortalEXOC6 10q23.33 DTNB 2p23.3 HNSC
Fusion PortalROCK2 2p25.1 DTNB 2p23.3 LUAD
Fusion : QuiverDTNB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDTNB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DTNB
dbVarDTNB
ClinVarDTNB
MonarchDTNB
1000_GenomesDTNB 
Exome Variant ServerDTNB
GNOMAD BrowserENSG00000138101
Varsome BrowserDTNB
Genetic variants : HAPMAP1838
Genomic Variants (DGV)DTNB [DGVbeta]
DECIPHERDTNB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDTNB 
Mutations
ICGC Data PortalDTNB 
TCGA Data PortalDTNB 
Broad Tumor PortalDTNB
OASIS PortalDTNB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDTNB  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDTNB
Mutations and Diseases : HGMDDTNB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DTNB
DgiDB (Drug Gene Interaction Database)DTNB
DoCM (Curated mutations)DTNB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DTNB (select a term)
intoGenDTNB
Cancer3DDTNB(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602415   
Orphanet
DisGeNETDTNB
MedgenDTNB
Genetic Testing Registry DTNB
NextProtO60941 [Medical]
TSGene1838
GENETestsDTNB
Target ValidationDTNB
Huge Navigator DTNB [HugePedia]
snp3D : Map Gene to Disease1838
BioCentury BCIQDTNB
ClinGenDTNB
Clinical trials, drugs, therapy
Protein Interactions : CTD1838
Pharm GKB GenePA27511
Clinical trialDTNB
Miscellaneous
canSAR (ICR)DTNB (select the gene name)
HarmonizomeDTNB
DataMed IndexDTNB
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDTNB
EVEXDTNB
GoPubMedDTNB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:09:24 CEST 2020
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