Atlas of Genetics and Cytogenetics in Oncology and Haematology

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DTX1 (deltex E3 ubiquitin ligase 1)

Identity

Alias (NCBI)RNF140
hDx-1
HGNC (Hugo) DTX1
HGNC Alias symbhDx-1
RNF140
HGNC Previous namedeltex homolog 1 (Drosophila)
LocusID (NCBI) 1840
Atlas_Id 40370
Location 12q24.13  [Link to chromosome band 12q24]
Location_base_pair Starts at 113057857 and ends at 113098028 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CHD4 (12p13.31) / DTX1 (12q24.13)CHD4 12p13.31 / DTX1 12q24.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(12;12)(p13;q24) CHD4/DTX1

External links

Nomenclature
HGNC (Hugo)DTX1   3060
Cards
Entrez_Gene (NCBI)DTX1  1840  deltex E3 ubiquitin ligase 1
AliasesRNF140; hDx-1
GeneCards (Weizmann)DTX1
Ensembl hg19 (Hinxton)ENSG00000135144 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135144 [Gene_View]  ENSG00000135144 [Sequence]  chr12:113057857-113098028 [Contig_View]  DTX1 [Vega]
ICGC DataPortalENSG00000135144
TCGA cBioPortalDTX1
AceView (NCBI)DTX1
Genatlas (Paris)DTX1
WikiGenes1840
SOURCE (Princeton)DTX1
Genetics Home Reference (NIH)DTX1
Genomic and cartography
GoldenPath hg38 (UCSC)DTX1  -     chr12:113057857-113098028 +  12q24.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DTX1  -     12q24.13   [Description]    (hg19-Feb_2009)
GoldenPathDTX1 - 12q24.13 [CytoView hg19]  DTX1 - 12q24.13 [CytoView hg38]
ImmunoBaseENSG00000135144
genome Data Viewer NCBIDTX1 [Mapview hg19]  
OMIM602582   
Gene and transcription
Genbank (Entrez)AF053700 BC005816 BC008321 BC048216
RefSeq transcript (Entrez)NM_004416
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DTX1
Alternative Splicing GalleryENSG00000135144
Gene ExpressionDTX1 [ NCBI-GEO ]   DTX1 [ EBI - ARRAY_EXPRESS ]   DTX1 [ SEEK ]   DTX1 [ MEM ]
Gene Expression Viewer (FireBrowse)DTX1 [ Firebrowse - Broad ]
GenevisibleExpression of DTX1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1840
GTEX Portal (Tissue expression)DTX1
Human Protein AtlasENSG00000135144-DTX1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86Y01   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86Y01  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86Y01
Splice isoforms : SwissVarQ86Y01
PhosPhoSitePlusQ86Y01
Domaine pattern : Prosite (Expaxy)WWE (PS50918)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)Deltex_C    Deltex_C_sf    Deltex_fam    WWE-dom    WWE-dom_subgr    WWE_dom_sf    Znf_C3HC4_RING-type    Znf_RING    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)DTC (PF18102)    WWE (PF02825)    zf-C3HC4 (PF00097)   
Domain families : Pfam (NCBI)pfam18102    pfam02825    pfam00097   
Domain families : Smart (EMBL)RING (SM00184)  WWE (SM00678)  
Conserved Domain (NCBI)DTX1
DMDM Disease mutations1840
Blocks (Seattle)DTX1
SuperfamilyQ86Y01
Human Protein Atlas [tissue]ENSG00000135144-DTX1 [tissue]
Peptide AtlasQ86Y01
HPRD03991
IPIIPI00004554   
Protein Interaction databases
DIP (DOE-UCLA)Q86Y01
IntAct (EBI)Q86Y01
FunCoupENSG00000135144
BioGRIDDTX1
STRING (EMBL)DTX1
ZODIACDTX1
Ontologies - Pathways
QuickGOQ86Y01
Ontology : AmiGOtranscription coactivator activity  Notch binding  protein binding  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  transcription, DNA-templated  transcription by RNA polymerase II  cell surface receptor signaling pathway  Notch signaling pathway  Notch signaling pathway  zinc ion binding  regulation of Notch signaling pathway  glial cell differentiation  protein ubiquitination  protein ubiquitination  nuclear body  SH3 domain binding  ubiquitin protein ligase binding  negative regulation of T cell differentiation  negative regulation of neuron differentiation  ubiquitin protein ligase activity  positive regulation of nucleic acid-templated transcription  cellular response to leukemia inhibitory factor  
Ontology : EGO-EBItranscription coactivator activity  Notch binding  protein binding  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  transcription, DNA-templated  transcription by RNA polymerase II  cell surface receptor signaling pathway  Notch signaling pathway  Notch signaling pathway  zinc ion binding  regulation of Notch signaling pathway  glial cell differentiation  protein ubiquitination  protein ubiquitination  nuclear body  SH3 domain binding  ubiquitin protein ligase binding  negative regulation of T cell differentiation  negative regulation of neuron differentiation  ubiquitin protein ligase activity  positive regulation of nucleic acid-templated transcription  cellular response to leukemia inhibitory factor  
Pathways : KEGGNotch signaling pathway   
NDEx NetworkDTX1
Atlas of Cancer Signalling NetworkDTX1
Wikipedia pathwaysDTX1
Orthology - Evolution
OrthoDB1840
GeneTree (enSembl)ENSG00000135144
Phylogenetic Trees/Animal Genes : TreeFamDTX1
HOGENOMQ86Y01
Homologs : HomoloGeneDTX1
Homology/Alignments : Family Browser (UCSC)DTX1
Gene fusions - Rearrangements
Fusion : MitelmanCHD4/DTX1 [12p13.31/12q24.13]  
Fusion PortalCHD4 12p13.31 DTX1 12q24.13 BRCA
Fusion : QuiverDTX1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDTX1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DTX1
dbVarDTX1
ClinVarDTX1
MonarchDTX1
1000_GenomesDTX1 
Exome Variant ServerDTX1
GNOMAD BrowserENSG00000135144
Varsome BrowserDTX1
Genetic variants : HAPMAP1840
Genomic Variants (DGV)DTX1 [DGVbeta]
DECIPHERDTX1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDTX1 
Mutations
ICGC Data PortalDTX1 
TCGA Data PortalDTX1 
Broad Tumor PortalDTX1
OASIS PortalDTX1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDTX1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDTX1
Mutations and Diseases : HGMDDTX1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DTX1
DgiDB (Drug Gene Interaction Database)DTX1
DoCM (Curated mutations)DTX1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DTX1 (select a term)
intoGenDTX1
Cancer3DDTX1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602582   
Orphanet
DisGeNETDTX1
MedgenDTX1
Genetic Testing Registry DTX1
NextProtQ86Y01 [Medical]
TSGene1840
GENETestsDTX1
Target ValidationDTX1
Huge Navigator DTX1 [HugePedia]
snp3D : Map Gene to Disease1840
BioCentury BCIQDTX1
ClinGenDTX1
Clinical trials, drugs, therapy
Protein Interactions : CTD1840
Pharm GKB GenePA27514
Clinical trialDTX1
Miscellaneous
canSAR (ICR)DTX1 (select the gene name)
HarmonizomeDTX1
DataMed IndexDTX1
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDTX1
EVEXDTX1
GoPubMedDTX1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:09:25 CEST 2020
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