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DTX2 (deltex 2, E3 ubiquitin ligase)

Identity

Alias_namesdeltex (Drosophila) homolog 2
deltex homolog 2 (Drosophila)
deltex 2, E3 ubiquitin ligase
Alias_symbol (synonym)RNF58
KIAA1528
Other alias
HGNC (Hugo) DTX2
LocusID (NCBI) 113878
Atlas_Id 62667
Location 7q11.23  [Link to chromosome band 7q11]
Location_base_pair Starts at 76090972 and ends at 76135312 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DTX2 (7q11.23) / NUB1 (7q36.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DTX2   15973
Cards
Entrez_Gene (NCBI)DTX2  113878  deltex 2, E3 ubiquitin ligase
AliasesRNF58
GeneCards (Weizmann)DTX2
Ensembl hg19 (Hinxton)ENSG00000091073 [Gene_View]  chr7:76090972-76135312 [Contig_View]  DTX2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000091073 [Gene_View]  chr7:76090972-76135312 [Contig_View]  DTX2 [Vega]
ICGC DataPortalENSG00000091073
TCGA cBioPortalDTX2
AceView (NCBI)DTX2
Genatlas (Paris)DTX2
WikiGenes113878
SOURCE (Princeton)DTX2
Genetics Home Reference (NIH)DTX2
Genomic and cartography
GoldenPath hg19 (UCSC)DTX2  -     chr7:76090972-76135312 +  7q11.23   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DTX2  -     7q11.23   [Description]    (hg38-Dec_2013)
EnsemblDTX2 - 7q11.23 [CytoView hg19]  DTX2 - 7q11.23 [CytoView hg38]
Mapping of homologs : NCBIDTX2 [Mapview hg19]  DTX2 [Mapview hg38]
OMIM613141   
Gene and transcription
Genbank (Entrez)AB040961 AK023924 AK026252 AK293226 AY225124
RefSeq transcript (Entrez)NM_001102594 NM_001102595 NM_001102596 NM_020892
RefSeq genomic (Entrez)NC_000007 NC_018918 NT_007933 NT_187561 NW_004929332
Consensus coding sequences : CCDS (NCBI)DTX2
Cluster EST : UnigeneHs.187058 [ NCBI ]
CGAP (NCI)Hs.187058
Alternative Splicing GalleryENSG00000091073
Gene ExpressionDTX2 [ NCBI-GEO ]   DTX2 [ EBI - ARRAY_EXPRESS ]   DTX2 [ SEEK ]   DTX2 [ MEM ]
Gene Expression Viewer (FireBrowse)DTX2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)113878
GTEX Portal (Tissue expression)DTX2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86UW9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86UW9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86UW9
Splice isoforms : SwissVarQ86UW9
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
PhosPhoSitePlusQ86UW9
Domaine pattern : Prosite (Expaxy)WWE (PS50918)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)WWE-dom    WWE-dom_subgr    Znf_C3HC4_RING-type    Znf_RING    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)WWE (PF02825)    zf-C3HC4 (PF00097)   
Domain families : Pfam (NCBI)pfam02825    pfam00097   
Domain families : Smart (EMBL)RING (SM00184)  WWE (SM00678)  
Conserved Domain (NCBI)DTX2
DMDM Disease mutations113878
Blocks (Seattle)DTX2
SuperfamilyQ86UW9
Human Protein AtlasENSG00000091073
Peptide AtlasQ86UW9
HPRD16841
IPIIPI00292746   IPI00377117   IPI00925551   IPI00867656   IPI00927865   IPI00927119   IPI00927324   IPI00926700   IPI00925285   IPI00924624   IPI00925993   IPI00927607   IPI00925794   IPI00925715   
Protein Interaction databases
DIP (DOE-UCLA)Q86UW9
IntAct (EBI)Q86UW9
FunCoupENSG00000091073
BioGRIDDTX2
STRING (EMBL)DTX2
ZODIACDTX2
Ontologies - Pathways
QuickGOQ86UW9
Ontology : AmiGOprotein binding  nucleoplasm  cytoplasm  Notch signaling pathway  zinc ion binding  protein ubiquitination  ligase activity  nuclear membrane  
Ontology : EGO-EBIprotein binding  nucleoplasm  cytoplasm  Notch signaling pathway  zinc ion binding  protein ubiquitination  ligase activity  nuclear membrane  
Pathways : KEGGNotch signaling pathway   
NDEx NetworkDTX2
Atlas of Cancer Signalling NetworkDTX2
Wikipedia pathwaysDTX2
Orthology - Evolution
OrthoDB113878
GeneTree (enSembl)ENSG00000091073
Phylogenetic Trees/Animal Genes : TreeFamDTX2
HOVERGENQ86UW9
HOGENOMQ86UW9
Homologs : HomoloGeneDTX2
Homology/Alignments : Family Browser (UCSC)DTX2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDTX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DTX2
dbVarDTX2
ClinVarDTX2
1000_GenomesDTX2 
Exome Variant ServerDTX2
ExAC (Exome Aggregation Consortium)DTX2 (select the gene name)
Genetic variants : HAPMAP113878
Genomic Variants (DGV)DTX2 [DGVbeta]
DECIPHER (Syndromes)7:76090972-76135312  ENSG00000091073
CONAN: Copy Number AnalysisDTX2 
Mutations
ICGC Data PortalDTX2 
TCGA Data PortalDTX2 
Broad Tumor PortalDTX2
OASIS PortalDTX2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDTX2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDTX2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DTX2
DgiDB (Drug Gene Interaction Database)DTX2
DoCM (Curated mutations)DTX2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DTX2 (select a term)
intoGenDTX2
Cancer3DDTX2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613141   
Orphanet
MedgenDTX2
Genetic Testing Registry DTX2
NextProtQ86UW9 [Medical]
TSGene113878
GENETestsDTX2
Huge Navigator DTX2 [HugePedia]
snp3D : Map Gene to Disease113878
BioCentury BCIQDTX2
ClinGenDTX2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD113878
Chemical/Pharm GKB GenePA27515
Clinical trialDTX2
Miscellaneous
canSAR (ICR)DTX2 (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDTX2
EVEXDTX2
GoPubMedDTX2
iHOPDTX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:02:19 CET 2017

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