DTX2 (deltex E3 ubiquitin ligase 2)

2014-11-01  

Identity

HGNC
LOCATION
7q11.23
LOCUSID
ALIAS
RNF58
FUSION GENES

Other Information

Locus ID:

NCBI: 113878
MIM: 613141
HGNC: 15973
Ensembl: ENSG00000091073

Variants:

dbSNP: 113878
ClinVar: 113878
TCGA: ENSG00000091073
COSMIC: DTX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000091073ENST00000324432Q86UW9
ENSG00000091073ENST00000413936Q86UW9
ENSG00000091073ENST00000423646C9JII1
ENSG00000091073ENST00000425780C9JVC8
ENSG00000091073ENST00000429179C9JEH4
ENSG00000091073ENST00000430490Q86UW9
ENSG00000091073ENST00000435251H7C3B8
ENSG00000091073ENST00000435861C9JY61
ENSG00000091073ENST00000438930C9JY61
ENSG00000091073ENST00000442516C9IYX1
ENSG00000091073ENST00000446600E7ET89
ENSG00000091073ENST00000446820Q86UW9
ENSG00000091073ENST00000451769C9JS11
ENSG00000091073ENST00000456590C9JLU8
ENSG00000091073ENST00000457529C9JF39

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Notch signaling pathwayKEGGko04330
Notch signaling pathwayKEGGhsa04330
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
Activated NOTCH1 Transmits Signal to the NucleusREACTOMER-HSA-2122948

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
126709572003The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity.40
172860442006cDNA cloning, characterization and expression analysis of DTX2, a human WWE and RING-finger gene, in human embryos.1

Citation

Dessen P

DTX2 (deltex E3 ubiquitin ligase 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62667/dtx2