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DTX2 (deltex E3 ubiquitin ligase 2)

Identity

Alias (NCBI)RNF58
HGNC (Hugo) DTX2
HGNC Alias symbRNF58
KIAA1528
HGNC Previous namedeltex (Drosophila) homolog 2
 deltex homolog 2 (Drosophila)
 deltex 2, E3 ubiquitin ligase
LocusID (NCBI) 113878
Atlas_Id 62667
Location 7q11.23  [Link to chromosome band 7q11]
Location_base_pair Starts at 76461655 and ends at 76505995 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DTX2 (7q11.23) / NUB1 (7q36.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(7;21)(q11;q22) RUNX1/UPK3B/DTX2


External links

Nomenclature
HGNC (Hugo)DTX2   15973
Cards
Entrez_Gene (NCBI)DTX2    deltex E3 ubiquitin ligase 2
AliasesRNF58
GeneCards (Weizmann)DTX2
Ensembl hg19 (Hinxton)ENSG00000091073 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000091073 [Gene_View]  ENSG00000091073 [Sequence]  chr7:76461655-76505995 [Contig_View]  DTX2 [Vega]
ICGC DataPortalENSG00000091073
TCGA cBioPortalDTX2
AceView (NCBI)DTX2
Genatlas (Paris)DTX2
SOURCE (Princeton)DTX2
Genetics Home Reference (NIH)DTX2
Genomic and cartography
GoldenPath hg38 (UCSC)DTX2  -     chr7:76461655-76505995 +  7q11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DTX2  -     7q11.23   [Description]    (hg19-Feb_2009)
GoldenPathDTX2 - 7q11.23 [CytoView hg19]  DTX2 - 7q11.23 [CytoView hg38]
ImmunoBaseENSG00000091073
genome Data Viewer NCBIDTX2 [Mapview hg19]  
OMIM613141   
Gene and transcription
Genbank (Entrez)AB040961 AK023924 AK026252 AK293226 AY225124
RefSeq transcript (Entrez)NM_001102594 NM_001102595 NM_001102596 NM_020892
RefSeq genomic (Entrez)NC_000007 NT_187561
Consensus coding sequences : CCDS (NCBI)DTX2
Alternative Splicing GalleryENSG00000091073
Gene ExpressionDTX2 [ NCBI-GEO ]   DTX2 [ EBI - ARRAY_EXPRESS ]   DTX2 [ SEEK ]   DTX2 [ MEM ]
Gene Expression Viewer (FireBrowse)DTX2 [ Firebrowse - Broad ]
GenevisibleExpression of DTX2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)113878
GTEX Portal (Tissue expression)DTX2
Human Protein AtlasENSG00000091073-DTX2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86UW9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86UW9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86UW9
Splice isoforms : SwissVarQ86UW9
PhosPhoSitePlusQ86UW9
Domaine pattern : Prosite (Expaxy)WWE (PS50918)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)Deltex_C    Deltex_C_sf    Deltex_fam    WWE-dom    WWE-dom_subgr    WWE_dom_sf    Znf_C3HC4_RING-type    Znf_RING    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)DTC (PF18102)    WWE (PF02825)    zf-C3HC4 (PF00097)   
Domain families : Pfam (NCBI)pfam18102    pfam02825    pfam00097   
Domain families : Smart (EMBL)RING (SM00184)  WWE (SM00678)  
Conserved Domain (NCBI)DTX2
Blocks (Seattle)DTX2
PDB (RSDB)6IR0    6Y22    6Y2X    6Y3J   
PDB Europe6IR0    6Y22    6Y2X    6Y3J   
PDB (PDBSum)6IR0    6Y22    6Y2X    6Y3J   
PDB (IMB)6IR0    6Y22    6Y2X    6Y3J   
Structural Biology KnowledgeBase6IR0    6Y22    6Y2X    6Y3J   
SCOP (Structural Classification of Proteins)6IR0    6Y22    6Y2X    6Y3J   
CATH (Classification of proteins structures)6IR0    6Y22    6Y2X    6Y3J   
AlphaFold pdb e-kbQ86UW9   
SuperfamilyQ86UW9
Human Protein Atlas [tissue]ENSG00000091073-DTX2 [tissue]
Peptide AtlasQ86UW9
HPRD16841
IPIIPI00292746   IPI00377117   IPI00925551   IPI00867656   IPI00927865   IPI00927119   IPI00927324   IPI00926700   IPI00925285   IPI00924624   IPI00925993   IPI00927607   IPI00925794   IPI00925715   
Protein Interaction databases
DIP (DOE-UCLA)Q86UW9
IntAct (EBI)Q86UW9
BioGRIDDTX2
STRING (EMBL)DTX2
ZODIACDTX2
Ontologies - Pathways
QuickGOQ86UW9
Ontology : AmiGOprotein binding  nucleoplasm  nucleoplasm  cytoplasm  Notch signaling pathway  zinc ion binding  protein ubiquitination  protein ubiquitination  nuclear membrane  ubiquitin protein ligase activity  
Ontology : EGO-EBIprotein binding  nucleoplasm  nucleoplasm  cytoplasm  Notch signaling pathway  zinc ion binding  protein ubiquitination  protein ubiquitination  nuclear membrane  ubiquitin protein ligase activity  
Pathways : KEGGNotch signaling pathway   
NDEx NetworkDTX2
Atlas of Cancer Signalling NetworkDTX2
Wikipedia pathwaysDTX2
Orthology - Evolution
OrthoDB113878
GeneTree (enSembl)ENSG00000091073
Phylogenetic Trees/Animal Genes : TreeFamDTX2
HOGENOMQ86UW9
Homologs : HomoloGeneDTX2
Homology/Alignments : Family Browser (UCSC)DTX2
Gene fusions - Rearrangements
Fusion : QuiverDTX2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDTX2 [hg38]
dbVarDTX2
ClinVarDTX2
MonarchDTX2
1000_GenomesDTX2 
Exome Variant ServerDTX2
GNOMAD BrowserENSG00000091073
Varsome BrowserDTX2
Genomic Variants (DGV)DTX2 [DGVbeta]
DECIPHERDTX2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDTX2 
Mutations
ICGC Data PortalDTX2 
TCGA Data PortalDTX2 
Broad Tumor PortalDTX2
OASIS PortalDTX2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDTX2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDTX2
Mutations and Diseases : HGMDDTX2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutasearch DTX2
DgiDB (Drug Gene Interaction Database)DTX2
DoCM (Curated mutations)DTX2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DTX2 (select a term)
intoGenDTX2
Cancer3DDTX2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613141   
Orphanet
DisGeNETDTX2
MedgenDTX2
Genetic Testing Registry DTX2
NextProtQ86UW9 [Medical]
GENETestsDTX2
Target ValidationDTX2
Huge Navigator DTX2 [HugePedia]
ClinGenDTX2
Clinical trials, drugs, therapy
MyCancerGenomeDTX2
Protein Interactions : CTD
Pharm GKB GenePA27515
PharosQ86UW9
Clinical trialDTX2
Miscellaneous
canSAR (ICR)DTX2 (select the gene name)
HarmonizomeDTX2
DataMed IndexDTX2
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDTX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 28 16:54:49 CEST 2021

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