DTX3L (deltex E3 ubiquitin ligase 3L)

2008-12-01  

Identity

HGNC
LOCATION
3q21.1
LOCUSID
ALIAS
BBAP,RNF143
FUSION GENES

Other Information

Locus ID:

NCBI: 151636
MIM: 613143
HGNC: 30323
Ensembl: ENSG00000163840

Variants:

dbSNP: 151636
ClinVar: 151636
TCGA: ENSG00000163840
COSMIC: DTX3L

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163840ENST00000296161Q8TDB6
ENSG00000163840ENST00000383661Q8TDB6

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Notch signaling pathwayKEGGko04330
Notch signaling pathwayKEGGhsa04330
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198187142009BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response.47
126709572003The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity.40
168097712006BAL1 and BBAP are regulated by a gamma interferon-responsive bidirectional promoter and are overexpressed in diffuse large B-cell lymphomas with a prominent inflammatory infiltrate.36
186187152008Integrated genomic and transcriptional profiling identifies chromosomal loci with altered gene expression in cervical cancer.32
232302722013BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8.31
285257422017Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9.21
248860892014DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells.18
247900972014The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4.17
224114082012Fold of the conserved DTC domain in Deltex proteins.2
286538812017Effects of DTX3L on the cell proliferation, adhesion, and drug resistance of multiple myeloma cells.2

Citation

Dessen P

DTX3L (deltex E3 ubiquitin ligase 3L)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50567/dtx3l