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DTX4 (deltex E3 ubiquitin ligase 4)

Identity

Alias_namesdeltex homolog 4 (Drosophila)
Alias_symbol (synonym)KIAA0937
RNF155
Other alias
HGNC (Hugo) DTX4
LocusID (NCBI) 23220
Atlas_Id 62669
Location 11q12.1  [Link to chromosome band 11q12]
Location_base_pair Starts at 59171430 and ends at 59208587 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DTX4 (11q12.1) / CCDC102B (18q22.1)FCHSD2 (11q13.4) / DTX4 (11q12.1)MRPL48 (11q13.4) / DTX4 (11q12.1)
TMEM91 (19q13.2) / DTX4 (11q12.1)MRPL48 DTX4FCHSD2 DTX4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DTX4   29151
Cards
Entrez_Gene (NCBI)DTX4  23220  deltex E3 ubiquitin ligase 4
AliasesRNF155
GeneCards (Weizmann)DTX4
Ensembl hg19 (Hinxton)ENSG00000110042 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110042 [Gene_View]  chr11:59171430-59208587 [Contig_View]  DTX4 [Vega]
ICGC DataPortalENSG00000110042
TCGA cBioPortalDTX4
AceView (NCBI)DTX4
Genatlas (Paris)DTX4
WikiGenes23220
SOURCE (Princeton)DTX4
Genetics Home Reference (NIH)DTX4
Genomic and cartography
GoldenPath hg38 (UCSC)DTX4  -     chr11:59171430-59208587 +  11q12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DTX4  -     11q12.1   [Description]    (hg19-Feb_2009)
EnsemblDTX4 - 11q12.1 [CytoView hg19]  DTX4 - 11q12.1 [CytoView hg38]
Mapping of homologs : NCBIDTX4 [Mapview hg19]  DTX4 [Mapview hg38]
OMIM616110   
Gene and transcription
Genbank (Entrez)AB023154 AF086290 BC015592 BC119011 BC122861
RefSeq transcript (Entrez)NM_001300727 NM_015177
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DTX4
Cluster EST : UnigeneHs.523696 [ NCBI ]
CGAP (NCI)Hs.523696
Alternative Splicing GalleryENSG00000110042
Gene ExpressionDTX4 [ NCBI-GEO ]   DTX4 [ EBI - ARRAY_EXPRESS ]   DTX4 [ SEEK ]   DTX4 [ MEM ]
Gene Expression Viewer (FireBrowse)DTX4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23220
GTEX Portal (Tissue expression)DTX4
Human Protein AtlasENSG00000110042-DTX4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y2E6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y2E6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y2E6
Splice isoforms : SwissVarQ9Y2E6
PhosPhoSitePlusQ9Y2E6
Domaine pattern : Prosite (Expaxy)WWE (PS50918)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)WWE-dom    WWE-dom_subgr    Znf_C3HC4_RING-type    Znf_RING    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)WWE (PF02825)    zf-C3HC4 (PF00097)   
Domain families : Pfam (NCBI)pfam02825    pfam00097   
Domain families : Smart (EMBL)RING (SM00184)  WWE (SM00678)  
Conserved Domain (NCBI)DTX4
DMDM Disease mutations23220
Blocks (Seattle)DTX4
SuperfamilyQ9Y2E6
Human Protein Atlas [tissue]ENSG00000110042-DTX4 [tissue]
Peptide AtlasQ9Y2E6
IPIIPI00848268   IPI00847948   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y2E6
IntAct (EBI)Q9Y2E6
FunCoupENSG00000110042
BioGRIDDTX4
STRING (EMBL)DTX4
ZODIACDTX4
Ontologies - Pathways
QuickGOQ9Y2E6
Ontology : AmiGOubiquitin-protein transferase activity  cytosol  Notch signaling pathway  zinc ion binding  protein ubiquitination  regulation of type I interferon production  
Ontology : EGO-EBIubiquitin-protein transferase activity  cytosol  Notch signaling pathway  zinc ion binding  protein ubiquitination  regulation of type I interferon production  
Pathways : KEGGNotch signaling pathway   
NDEx NetworkDTX4
Atlas of Cancer Signalling NetworkDTX4
Wikipedia pathwaysDTX4
Orthology - Evolution
OrthoDB23220
GeneTree (enSembl)ENSG00000110042
Phylogenetic Trees/Animal Genes : TreeFamDTX4
HOVERGENQ9Y2E6
HOGENOMQ9Y2E6
Homologs : HomoloGeneDTX4
Homology/Alignments : Family Browser (UCSC)DTX4
Gene fusions - Rearrangements
Fusion: TCGA_MDACCMRPL48 DTX4
Fusion: TCGA_MDACCFCHSD2 DTX4
Tumor Fusion PortalDTX4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDTX4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DTX4
dbVarDTX4
ClinVarDTX4
1000_GenomesDTX4 
Exome Variant ServerDTX4
ExAC (Exome Aggregation Consortium)ENSG00000110042
GNOMAD BrowserENSG00000110042
Genetic variants : HAPMAP23220
Genomic Variants (DGV)DTX4 [DGVbeta]
DECIPHERDTX4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDTX4 
Mutations
ICGC Data PortalDTX4 
TCGA Data PortalDTX4 
Broad Tumor PortalDTX4
OASIS PortalDTX4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDTX4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDTX4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DTX4
DgiDB (Drug Gene Interaction Database)DTX4
DoCM (Curated mutations)DTX4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DTX4 (select a term)
intoGenDTX4
Cancer3DDTX4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616110   
Orphanet
DisGeNETDTX4
MedgenDTX4
Genetic Testing Registry DTX4
NextProtQ9Y2E6 [Medical]
TSGene23220
GENETestsDTX4
Target ValidationDTX4
Huge Navigator DTX4 [HugePedia]
snp3D : Map Gene to Disease23220
BioCentury BCIQDTX4
ClinGenDTX4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23220
Chemical/Pharm GKB GenePA134930720
Clinical trialDTX4
Miscellaneous
canSAR (ICR)DTX4 (select the gene name)
Probes
Litterature
PubMed7 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDTX4
EVEXDTX4
GoPubMedDTX4
iHOPDTX4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 13:23:20 CET 2017

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