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DTYMK (deoxythymidylate kinase)

Identity

Alias_namesdeoxythymidylate kinase (thymidylate kinase)
Alias_symbol (synonym)CDC8
TYMK
TMPK
HGNC (Hugo) DTYMK
LocusID (NCBI) 1841
Atlas_Id 50236
Location 2q37.3  [Link to chromosome band 2q37]
Location_base_pair Starts at 242615157 and ends at 242626383 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ATG4B (2q37.3) / DTYMK (2q37.3)SUPT6H (17q11.2) / DTYMK (2q37.3)ATG4B 2q37.3 / DTYMK 2q37.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DTYMK   3061
Cards
Entrez_Gene (NCBI)DTYMK  1841  deoxythymidylate kinase
AliasesCDC8; PP3731; TMPK; TYMK
GeneCards (Weizmann)DTYMK
Ensembl hg19 (Hinxton)ENSG00000168393 [Gene_View]  chr2:242615157-242626383 [Contig_View]  DTYMK [Vega]
Ensembl hg38 (Hinxton)ENSG00000168393 [Gene_View]  chr2:242615157-242626383 [Contig_View]  DTYMK [Vega]
ICGC DataPortalENSG00000168393
TCGA cBioPortalDTYMK
AceView (NCBI)DTYMK
Genatlas (Paris)DTYMK
WikiGenes1841
SOURCE (Princeton)DTYMK
Genetics Home Reference (NIH)DTYMK
Genomic and cartography
GoldenPath hg19 (UCSC)DTYMK  -     chr2:242615157-242626383 -  2q37.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DTYMK  -     2q37.3   [Description]    (hg38-Dec_2013)
EnsemblDTYMK - 2q37.3 [CytoView hg19]  DTYMK - 2q37.3 [CytoView hg38]
Mapping of homologs : NCBIDTYMK [Mapview hg19]  DTYMK [Mapview hg38]
OMIM188345   
Gene and transcription
Genbank (Entrez)AA427388 AA446104 AF258562 AK126180 AK223434
RefSeq transcript (Entrez)NM_001165031 NM_001320902 NM_001320903 NM_001320904 NM_001320905 NM_012145
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_005403 NW_004929308
Consensus coding sequences : CCDS (NCBI)DTYMK
Cluster EST : UnigeneHs.471873 [ NCBI ]
CGAP (NCI)Hs.471873
Alternative Splicing GalleryENSG00000168393
Gene ExpressionDTYMK [ NCBI-GEO ]   DTYMK [ EBI - ARRAY_EXPRESS ]   DTYMK [ SEEK ]   DTYMK [ MEM ]
Gene Expression Viewer (FireBrowse)DTYMK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1841
GTEX Portal (Tissue expression)DTYMK
Protein : pattern, domain, 3D structure
UniProt/SwissProtP23919   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP23919  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP23919
Splice isoforms : SwissVarP23919
Catalytic activity : Enzyme2.7.4.9 [ Enzyme-Expasy ]   2.7.4.92.7.4.9 [ IntEnz-EBI ]   2.7.4.9 [ BRENDA ]   2.7.4.9 [ KEGG ]   
PhosPhoSitePlusP23919
Domaine pattern : Prosite (Expaxy)THYMIDYLATE_KINASE (PS01331)   
Domains : Interpro (EBI)P-loop_NTPase    Thymidylate_kin_CS    Thymidylate_kinase   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)DTYMK
DMDM Disease mutations1841
Blocks (Seattle)DTYMK
PDB (SRS)1E2D    1E2E    1E2F    1E2G    1E2Q    1E98    1E99    1E9A    1E9B    1E9C    1E9D    1E9E    1E9F    1NMX    1NMY    1NMZ    1NN0    1NN1    1NN3    1NN5    2XX3   
PDB (PDBSum)1E2D    1E2E    1E2F    1E2G    1E2Q    1E98    1E99    1E9A    1E9B    1E9C    1E9D    1E9E    1E9F    1NMX    1NMY    1NMZ    1NN0    1NN1    1NN3    1NN5    2XX3   
PDB (IMB)1E2D    1E2E    1E2F    1E2G    1E2Q    1E98    1E99    1E9A    1E9B    1E9C    1E9D    1E9E    1E9F    1NMX    1NMY    1NMZ    1NN0    1NN1    1NN3    1NN5    2XX3   
PDB (RSDB)1E2D    1E2E    1E2F    1E2G    1E2Q    1E98    1E99    1E9A    1E9B    1E9C    1E9D    1E9E    1E9F    1NMX    1NMY    1NMZ    1NN0    1NN1    1NN3    1NN5    2XX3   
Structural Biology KnowledgeBase1E2D    1E2E    1E2F    1E2G    1E2Q    1E98    1E99    1E9A    1E9B    1E9C    1E9D    1E9E    1E9F    1NMX    1NMY    1NMZ    1NN0    1NN1    1NN3    1NN5    2XX3   
SCOP (Structural Classification of Proteins)1E2D    1E2E    1E2F    1E2G    1E2Q    1E98    1E99    1E9A    1E9B    1E9C    1E9D    1E9E    1E9F    1NMX    1NMY    1NMZ    1NN0    1NN1    1NN3    1NN5    2XX3   
CATH (Classification of proteins structures)1E2D    1E2E    1E2F    1E2G    1E2Q    1E98    1E99    1E9A    1E9B    1E9C    1E9D    1E9E    1E9F    1NMX    1NMY    1NMZ    1NN0    1NN1    1NN3    1NN5    2XX3   
SuperfamilyP23919
Human Protein AtlasENSG00000168393
Peptide AtlasP23919
HPRD01773
IPIIPI00013862   IPI00103663   IPI00787559   IPI00892836   IPI00938328   IPI00892966   
Protein Interaction databases
DIP (DOE-UCLA)P23919
IntAct (EBI)P23919
FunCoupENSG00000168393
BioGRIDDTYMK
STRING (EMBL)DTYMK
ZODIACDTYMK
Ontologies - Pathways
QuickGOP23919
Ontology : AmiGOthymidylate kinase activity  ATP binding  nucleus  mitochondrion  mitochondrial intermembrane space  mitochondrial matrix  cytosol  cytosol  dUDP biosynthetic process  dTDP biosynthetic process  dTTP biosynthetic process  dTTP biosynthetic process  cell cycle  cell proliferation  uridylate kinase activity  nucleobase-containing small molecule interconversion  response to estrogen  myoblast differentiation  response to cadmium ion  nucleotide phosphorylation  nucleotide phosphorylation  nucleotide phosphorylation  nucleotide phosphorylation  nucleoside monophosphate phosphorylation  nucleoside phosphate kinase activity  cellular response to growth factor stimulus  
Ontology : EGO-EBIthymidylate kinase activity  ATP binding  nucleus  mitochondrion  mitochondrial intermembrane space  mitochondrial matrix  cytosol  cytosol  dUDP biosynthetic process  dTDP biosynthetic process  dTTP biosynthetic process  dTTP biosynthetic process  cell cycle  cell proliferation  uridylate kinase activity  nucleobase-containing small molecule interconversion  response to estrogen  myoblast differentiation  response to cadmium ion  nucleotide phosphorylation  nucleotide phosphorylation  nucleotide phosphorylation  nucleotide phosphorylation  nucleoside monophosphate phosphorylation  nucleoside phosphate kinase activity  cellular response to growth factor stimulus  
Pathways : KEGGPyrimidine metabolism   
NDEx NetworkDTYMK
Atlas of Cancer Signalling NetworkDTYMK
Wikipedia pathwaysDTYMK
Orthology - Evolution
OrthoDB1841
GeneTree (enSembl)ENSG00000168393
Phylogenetic Trees/Animal Genes : TreeFamDTYMK
HOVERGENP23919
HOGENOMP23919
Homologs : HomoloGeneDTYMK
Homology/Alignments : Family Browser (UCSC)DTYMK
Gene fusions - Rearrangements
Fusion : MitelmanATG4B/DTYMK [2q37.3/2q37.3]  [t(2;2)(q37;q37)]  
Fusion: TCGAATG4B 2q37.3 DTYMK 2q37.3 GBM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDTYMK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DTYMK
dbVarDTYMK
ClinVarDTYMK
1000_GenomesDTYMK 
Exome Variant ServerDTYMK
ExAC (Exome Aggregation Consortium)DTYMK (select the gene name)
Genetic variants : HAPMAP1841
Genomic Variants (DGV)DTYMK [DGVbeta]
DECIPHER (Syndromes)2:242615157-242626383  ENSG00000168393
CONAN: Copy Number AnalysisDTYMK 
Mutations
ICGC Data PortalDTYMK 
TCGA Data PortalDTYMK 
Broad Tumor PortalDTYMK
OASIS PortalDTYMK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDTYMK  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDTYMK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DTYMK
DgiDB (Drug Gene Interaction Database)DTYMK
DoCM (Curated mutations)DTYMK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DTYMK (select a term)
intoGenDTYMK
Cancer3DDTYMK(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM188345   
Orphanet
MedgenDTYMK
Genetic Testing Registry DTYMK
NextProtP23919 [Medical]
TSGene1841
GENETestsDTYMK
Huge Navigator DTYMK [HugePedia]
snp3D : Map Gene to Disease1841
BioCentury BCIQDTYMK
ClinGenDTYMK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1841
Chemical/Pharm GKB GenePA150
Clinical trialDTYMK
Miscellaneous
canSAR (ICR)DTYMK (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDTYMK
EVEXDTYMK
GoPubMedDTYMK
iHOPDTYMK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Nov 18 19:36:11 CET 2016

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