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DTYMK (deoxythymidylate kinase (thymidylate kinase))

Identity

Other namesCDC8
PP3731
TMPK
TYMK
HGNC (Hugo) DTYMK
LocusID (NCBI) 1841
Atlas_Id 50236
Location 2q37.3
Location_base_pair Starts at 242615157 and ends at 242626383 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DTYMK   3061
Cards
Entrez_Gene (NCBI)DTYMK  1841  deoxythymidylate kinase (thymidylate kinase)
GeneCards (Weizmann)DTYMK
Ensembl hg19 (Hinxton)ENSG00000168393 [Gene_View]  chr2:242615157-242626383 [Contig_View]  DTYMK [Vega]
Ensembl hg38 (Hinxton)ENSG00000168393 [Gene_View]  chr2:242615157-242626383 [Contig_View]  DTYMK [Vega]
ICGC DataPortalENSG00000168393
TCGA cBioPortalDTYMK
AceView (NCBI)DTYMK
Genatlas (Paris)DTYMK
WikiGenes1841
SOURCE (Princeton)DTYMK
Genomic and cartography
GoldenPath hg19 (UCSC)DTYMK  -     chr2:242615157-242626383 -  2q37.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DTYMK  -     2q37.3   [Description]    (hg38-Dec_2013)
EnsemblDTYMK - 2q37.3 [CytoView hg19]  DTYMK - 2q37.3 [CytoView hg38]
Mapping of homologs : NCBIDTYMK [Mapview hg19]  DTYMK [Mapview hg38]
OMIM188345   
Gene and transcription
Genbank (Entrez)AA446104 AF258562 AK126180 AK223434 AW273041
RefSeq transcript (Entrez)NM_001165031 NM_012145
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_005403 NW_004929308
Consensus coding sequences : CCDS (NCBI)DTYMK
Cluster EST : UnigeneHs.471873 [ NCBI ]
CGAP (NCI)Hs.471873
Alternative Splicing : Fast-db (Paris)GSHG0018481
Alternative Splicing GalleryENSG00000168393
Gene ExpressionDTYMK [ NCBI-GEO ]     DTYMK [ SEEK ]   DTYMK [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP23919 (Uniprot)
NextProtP23919  [Medical]
With graphics : InterProP23919
Splice isoforms : SwissVarP23919 (Swissvar)
Catalytic activity : Enzyme2.7.4.9 [ Enzyme-Expasy ]   2.7.4.92.7.4.9 [ IntEnz-EBI ]   2.7.4.9 [ BRENDA ]   2.7.4.9 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)THYMIDYLATE_KINASE (PS01331)   
Domains : Interpro (EBI)P-loop_NTPase    Thymidylate_kin_CS    Thymidylate_kinase   
Related proteins : CluSTrP23919
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
DMDM Disease mutations1841
Blocks (Seattle)P23919
PDB (SRS)1E2D    1E2E    1E2F    1E2G    1E2Q    1E98    1E99    1E9A    1E9B    1E9C    1E9D    1E9E    1E9F    1NMX    1NMY    1NMZ    1NN0    1NN1    1NN3    1NN5    2XX3   
PDB (PDBSum)1E2D    1E2E    1E2F    1E2G    1E2Q    1E98    1E99    1E9A    1E9B    1E9C    1E9D    1E9E    1E9F    1NMX    1NMY    1NMZ    1NN0    1NN1    1NN3    1NN5    2XX3   
PDB (IMB)1E2D    1E2E    1E2F    1E2G    1E2Q    1E98    1E99    1E9A    1E9B    1E9C    1E9D    1E9E    1E9F    1NMX    1NMY    1NMZ    1NN0    1NN1    1NN3    1NN5    2XX3   
PDB (RSDB)1E2D    1E2E    1E2F    1E2G    1E2Q    1E98    1E99    1E9A    1E9B    1E9C    1E9D    1E9E    1E9F    1NMX    1NMY    1NMZ    1NN0    1NN1    1NN3    1NN5    2XX3   
Human Protein AtlasENSG00000168393
Peptide AtlasP23919
HPRD01773
IPIIPI00013862   IPI00103663   IPI00787559   IPI00892836   IPI00938328   IPI00892966   
Protein Interaction databases
DIP (DOE-UCLA)P23919
IntAct (EBI)P23919
FunCoupENSG00000168393
BioGRIDDTYMK
IntegromeDBDTYMK
STRING (EMBL)DTYMK
Ontologies - Pathways
QuickGOP23919
Ontology : AmiGOthymidylate kinase activity  ATP binding  nucleus  mitochondrion  mitochondrial intermembrane space  mitochondrial matrix  cytosol  cytosol  dUDP biosynthetic process  dTDP biosynthetic process  dTTP biosynthetic process  dTTP biosynthetic process  cell cycle  cell proliferation  uridylate kinase activity  nucleobase-containing small molecule interconversion  response to estrogen  small molecule metabolic process  myoblast differentiation  response to cadmium ion  nucleotide phosphorylation  nucleotide phosphorylation  nucleotide phosphorylation  nucleotide phosphorylation  nucleoside monophosphate phosphorylation  nucleoside phosphate kinase activity  nucleobase-containing small molecule metabolic process  cellular response to growth factor stimulus  
Ontology : EGO-EBIthymidylate kinase activity  ATP binding  nucleus  mitochondrion  mitochondrial intermembrane space  mitochondrial matrix  cytosol  cytosol  dUDP biosynthetic process  dTDP biosynthetic process  dTTP biosynthetic process  dTTP biosynthetic process  cell cycle  cell proliferation  uridylate kinase activity  nucleobase-containing small molecule interconversion  response to estrogen  small molecule metabolic process  myoblast differentiation  response to cadmium ion  nucleotide phosphorylation  nucleotide phosphorylation  nucleotide phosphorylation  nucleotide phosphorylation  nucleoside monophosphate phosphorylation  nucleoside phosphate kinase activity  nucleobase-containing small molecule metabolic process  cellular response to growth factor stimulus  
Pathways : KEGGPyrimidine metabolism   
Protein Interaction DatabaseDTYMK
DoCM (Curated mutations)DTYMK
Wikipedia pathwaysDTYMK
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerDTYMK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DTYMK
dbVarDTYMK
ClinVarDTYMK
1000_GenomesDTYMK 
Exome Variant ServerDTYMK
SNP (GeneSNP Utah)DTYMK
SNP : HGBaseDTYMK
Genetic variants : HAPMAPDTYMK
Genomic Variants (DGV)DTYMK [DGVbeta]
Mutations
ICGC Data PortalDTYMK 
TCGA Data PortalDTYMK 
Tumor PortalDTYMK
Somatic Mutations in Cancer : COSMICDTYMK 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)2:242615157-242626383
CONAN: Copy Number AnalysisDTYMK 
Mutations and Diseases : HGMDDTYMK
OMIM188345   
MedgenDTYMK
NextProtP23919 [Medical]
GENETestsDTYMK
Disease Genetic AssociationDTYMK
Huge Navigator DTYMK [HugePedia]  DTYMK [HugeCancerGEM]
snp3D : Map Gene to Disease1841
DGIdb (Drug Gene Interaction db)DTYMK
General knowledge
Homologs : HomoloGeneDTYMK
Homology/Alignments : Family Browser (UCSC)DTYMK
Phylogenetic Trees/Animal Genes : TreeFamDTYMK
Chemical/Protein Interactions : CTD1841
Chemical/Pharm GKB GenePA150
Clinical trialDTYMK
Cancer Resource (Charite)ENSG00000168393
Other databases
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
CoreMineDTYMK
GoPubMedDTYMK
iHOPDTYMK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 20 19:11:07 CEST 2015

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