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DTYMK (deoxythymidylate kinase)

Identity

Alias (NCBI)CDC8
PP3731
TMPK
TYMK
HGNC (Hugo) DTYMK
HGNC Alias symbCDC8
TYMK
TMPK
HGNC Alias namedTMP kinase
 thymidylate (dTMP) kinase
HGNC Previous namedeoxythymidylate kinase (thymidylate kinase)
LocusID (NCBI) 1841
Atlas_Id 50236
Location 2q37.3  [Link to chromosome band 2q37]
Location_base_pair Starts at 241675749 and ends at 241686815 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATG4B (2q37.3) / DTYMK (2q37.3)SUPT6H (17q11.2) / DTYMK (2q37.3)ATG4B 2q37.3 / DTYMK 2q37.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)DTYMK   3061
Cards
Entrez_Gene (NCBI)DTYMK    deoxythymidylate kinase
AliasesCDC8; PP3731; TMPK; TYMK
GeneCards (Weizmann)DTYMK
Ensembl hg19 (Hinxton)ENSG00000168393 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168393 [Gene_View]  ENSG00000168393 [Sequence]  chr2:241675749-241686815 [Contig_View]  DTYMK [Vega]
ICGC DataPortalENSG00000168393
TCGA cBioPortalDTYMK
AceView (NCBI)DTYMK
Genatlas (Paris)DTYMK
SOURCE (Princeton)DTYMK
Genetics Home Reference (NIH)DTYMK
Genomic and cartography
GoldenPath hg38 (UCSC)DTYMK  -     chr2:241675749-241686815 -  2q37.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DTYMK  -     2q37.3   [Description]    (hg19-Feb_2009)
GoldenPathDTYMK - 2q37.3 [CytoView hg19]  DTYMK - 2q37.3 [CytoView hg38]
ImmunoBaseENSG00000168393
Genome Data Viewer NCBIDTYMK [Mapview hg19]  
OMIM188345   
Gene and transcription
Genbank (Entrez)AA427388 AA446104 AF258562 AK126180 AK223434
RefSeq transcript (Entrez)NM_001165031 NM_001320902 NM_001320903 NM_001320904 NM_001320905 NM_012145
Consensus coding sequences : CCDS (NCBI)DTYMK
Gene ExpressionDTYMK [ NCBI-GEO ]   DTYMK [ EBI - ARRAY_EXPRESS ]   DTYMK [ SEEK ]   DTYMK [ MEM ]
Gene Expression Viewer (FireBrowse)DTYMK [ Firebrowse - Broad ]
GenevisibleExpression of DTYMK in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1841
GTEX Portal (Tissue expression)DTYMK
Human Protein AtlasENSG00000168393-DTYMK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP23919   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP23919  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP23919
Catalytic activity : Enzyme2.7.4.9 [ Enzyme-Expasy ]   2.7.4.92.7.4.9 [ IntEnz-EBI ]   2.7.4.9 [ BRENDA ]   2.7.4.9 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP23919
Domaine pattern : Prosite (Expaxy)THYMIDYLATE_KINASE (PS01331)   
Domains : Interpro (EBI)P-loop_NTPase    Thymidylate_kin-like_dom    Thymidylate_kin_CS    Thymidylate_kinase   
Domain families : Pfam (Sanger)Thymidylate_kin (PF02223)   
Domain families : Pfam (NCBI)pfam02223   
Conserved Domain (NCBI)DTYMK
PDB (RSDB)1E2D    1E2E    1E2F    1E2G    1E2Q    1E98    1E99    1E9A    1E9B    1E9C    1E9D    1E9E    1E9F    1NMX    1NMY    1NMZ    1NN0    1NN1    1NN3    1NN5    2XX3   
PDB Europe1E2D    1E2E    1E2F    1E2G    1E2Q    1E98    1E99    1E9A    1E9B    1E9C    1E9D    1E9E    1E9F    1NMX    1NMY    1NMZ    1NN0    1NN1    1NN3    1NN5    2XX3   
PDB (PDBSum)1E2D    1E2E    1E2F    1E2G    1E2Q    1E98    1E99    1E9A    1E9B    1E9C    1E9D    1E9E    1E9F    1NMX    1NMY    1NMZ    1NN0    1NN1    1NN3    1NN5    2XX3   
PDB (IMB)1E2D    1E2E    1E2F    1E2G    1E2Q    1E98    1E99    1E9A    1E9B    1E9C    1E9D    1E9E    1E9F    1NMX    1NMY    1NMZ    1NN0    1NN1    1NN3    1NN5    2XX3   
Structural Biology KnowledgeBase1E2D    1E2E    1E2F    1E2G    1E2Q    1E98    1E99    1E9A    1E9B    1E9C    1E9D    1E9E    1E9F    1NMX    1NMY    1NMZ    1NN0    1NN1    1NN3    1NN5    2XX3   
SCOP (Structural Classification of Proteins)1E2D    1E2E    1E2F    1E2G    1E2Q    1E98    1E99    1E9A    1E9B    1E9C    1E9D    1E9E    1E9F    1NMX    1NMY    1NMZ    1NN0    1NN1    1NN3    1NN5    2XX3   
CATH (Classification of proteins structures)1E2D    1E2E    1E2F    1E2G    1E2Q    1E98    1E99    1E9A    1E9B    1E9C    1E9D    1E9E    1E9F    1NMX    1NMY    1NMZ    1NN0    1NN1    1NN3    1NN5    2XX3   
SuperfamilyP23919
AlphaFold pdb e-kbP23919   
Human Protein Atlas [tissue]ENSG00000168393-DTYMK [tissue]
HPRD01773
Protein Interaction databases
DIP (DOE-UCLA)P23919
IntAct (EBI)P23919
BioGRIDDTYMK
STRING (EMBL)DTYMK
ZODIACDTYMK
Ontologies - Pathways
QuickGOP23919
Ontology : AmiGOnucleoside diphosphate kinase activity  thymidylate kinase activity  thymidylate kinase activity  ATP binding  nucleus  cytoplasm  mitochondrion  mitochondrial intermembrane space  mitochondrial matrix  cytosol  cytosol  nucleoside diphosphate phosphorylation  dUDP biosynthetic process  dTDP biosynthetic process  dTTP biosynthetic process  dTTP biosynthetic process  uridylate kinase activity  nucleobase-containing small molecule interconversion  response to estrogen  myoblast differentiation  thymidine biosynthetic process  response to cadmium ion  nucleoside monophosphate phosphorylation  cellular response to growth factor stimulus  
Ontology : EGO-EBInucleoside diphosphate kinase activity  thymidylate kinase activity  thymidylate kinase activity  ATP binding  nucleus  cytoplasm  mitochondrion  mitochondrial intermembrane space  mitochondrial matrix  cytosol  cytosol  nucleoside diphosphate phosphorylation  dUDP biosynthetic process  dTDP biosynthetic process  dTTP biosynthetic process  dTTP biosynthetic process  uridylate kinase activity  nucleobase-containing small molecule interconversion  response to estrogen  myoblast differentiation  thymidine biosynthetic process  response to cadmium ion  nucleoside monophosphate phosphorylation  cellular response to growth factor stimulus  
Pathways : KEGGPyrimidine metabolism   
NDEx NetworkDTYMK
Atlas of Cancer Signalling NetworkDTYMK
Wikipedia pathwaysDTYMK
Orthology - Evolution
OrthoDB1841
GeneTree (enSembl)ENSG00000168393
Phylogenetic Trees/Animal Genes : TreeFamDTYMK
Homologs : HomoloGeneDTYMK
Homology/Alignments : Family Browser (UCSC)DTYMK
Gene fusions - Rearrangements
Fusion : MitelmanATG4B/DTYMK [2q37.3/2q37.3]  
Fusion : QuiverDTYMK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDTYMK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DTYMK
dbVarDTYMK
ClinVarDTYMK
MonarchDTYMK
1000_GenomesDTYMK 
Exome Variant ServerDTYMK
GNOMAD BrowserENSG00000168393
Varsome BrowserDTYMK
ACMGDTYMK variants
VarityP23919
Genomic Variants (DGV)DTYMK [DGVbeta]
DECIPHERDTYMK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDTYMK 
Mutations
ICGC Data PortalDTYMK 
TCGA Data PortalDTYMK 
Broad Tumor PortalDTYMK
OASIS PortalDTYMK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDTYMK  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDTYMK
Mutations and Diseases : HGMDDTYMK
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDTYMK
DgiDB (Drug Gene Interaction Database)DTYMK
DoCM (Curated mutations)DTYMK
CIViC (Clinical Interpretations of Variants in Cancer)DTYMK
Cancer3DDTYMK
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM188345   
Orphanet
DisGeNETDTYMK
MedgenDTYMK
Genetic Testing Registry DTYMK
NextProtP23919 [Medical]
GENETestsDTYMK
Target ValidationDTYMK
Huge Navigator DTYMK [HugePedia]
ClinGenDTYMK
Clinical trials, drugs, therapy
MyCancerGenomeDTYMK
Protein Interactions : CTDDTYMK
Pharm GKB GenePA150
Pharm GKB PathwaysPA165859361   
PharosP23919
Clinical trialDTYMK
Miscellaneous
canSAR (ICR)DTYMK
HarmonizomeDTYMK
DataMed IndexDTYMK
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDTYMK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:07:24 CEST 2021

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