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DTYMK (deoxythymidylate kinase (thymidylate kinase))

Identity

Other namesCDC8
PP3731
TMPK
TYMK
HGNC (Hugo) DTYMK
LocusID (NCBI) 1841
Location 2q37.3
Location_base_pair Starts at 242615157 and ends at 242626383 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DTYMK   3061
Cards
Entrez_Gene (NCBI)DTYMK  1841  deoxythymidylate kinase (thymidylate kinase)
GeneCards (Weizmann)DTYMK
Ensembl (Hinxton)ENSG00000168393 [Gene_View]  chr2:242615157-242626383 [Contig_View]  DTYMK [Vega]
ICGC DataPortalENSG00000168393
AceView (NCBI)DTYMK
Genatlas (Paris)DTYMK
WikiGenes1841
SOURCE (Princeton)NM_001165031 NM_012145
Genomic and cartography
GoldenPath (UCSC)DTYMK  -  2q37.3   chr2:242615157-242626383 -  2q37.3   [Description]    (hg19-Feb_2009)
EnsemblDTYMK - 2q37.3 [CytoView]
Mapping of homologs : NCBIDTYMK [Mapview]
OMIM188345   
Gene and transcription
Genbank (Entrez)AA446104 AF258562 AK126180 AK223434 AW273041
RefSeq transcript (Entrez)NM_001165031 NM_012145
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NT_005403 NW_001838874 NW_004929308
Consensus coding sequences : CCDS (NCBI)DTYMK
Cluster EST : UnigeneHs.471873 [ NCBI ]
CGAP (NCI)Hs.471873
Alternative Splicing : Fast-db (Paris)GSHG0018481
Alternative Splicing GalleryENSG00000168393
Gene ExpressionDTYMK [ NCBI-GEO ]     DTYMK [ SEEK ]   DTYMK [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP23919 (Uniprot)
NextProtP23919  [Medical]
With graphics : InterProP23919
Splice isoforms : SwissVarP23919 (Swissvar)
Catalytic activity : Enzyme2.7.4.9 [ Enzyme-Expasy ]   2.7.4.92.7.4.9 [ IntEnz-EBI ]   2.7.4.9 [ BRENDA ]   2.7.4.9 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)THYMIDYLATE_KINASE (PS01331)   
Domains : Interpro (EBI)P-loop_NTPase    Thymidylate_kin_CS    Thymidylate_kinase   
Related proteins : CluSTrP23919
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
DMDM Disease mutations1841
Blocks (Seattle)P23919
PDB (SRS)1E2D    1E2E    1E2F    1E2G    1E2Q    1E98    1E99    1E9A    1E9B    1E9C    1E9D    1E9E    1E9F    1NMX    1NMY    1NMZ    1NN0    1NN1    1NN3    1NN5    2XX3   
PDB (PDBSum)1E2D    1E2E    1E2F    1E2G    1E2Q    1E98    1E99    1E9A    1E9B    1E9C    1E9D    1E9E    1E9F    1NMX    1NMY    1NMZ    1NN0    1NN1    1NN3    1NN5    2XX3   
PDB (IMB)1E2D    1E2E    1E2F    1E2G    1E2Q    1E98    1E99    1E9A    1E9B    1E9C    1E9D    1E9E    1E9F    1NMX    1NMY    1NMZ    1NN0    1NN1    1NN3    1NN5    2XX3   
PDB (RSDB)1E2D    1E2E    1E2F    1E2G    1E2Q    1E98    1E99    1E9A    1E9B    1E9C    1E9D    1E9E    1E9F    1NMX    1NMY    1NMZ    1NN0    1NN1    1NN3    1NN5    2XX3   
Human Protein AtlasENSG00000168393
Peptide AtlasP23919
HPRD01773
IPIIPI00013862   IPI00103663   IPI00787559   IPI00892836   IPI00938328   IPI00892966   
Protein Interaction databases
DIP (DOE-UCLA)P23919
IntAct (EBI)P23919
FunCoupENSG00000168393
BioGRIDDTYMK
IntegromeDBDTYMK
STRING (EMBL)DTYMK
Ontologies - Pathways
QuickGOP23919
Ontology : AmiGOthymidylate kinase activity  ATP binding  mitochondrial intermembrane space  mitochondrial matrix  cytosol  dTDP biosynthetic process  dTTP biosynthetic process  cell cycle  cell proliferation  nucleobase-containing small molecule interconversion  response to estrogen  small molecule metabolic process  myoblast differentiation  response to cadmium ion  nucleotide phosphorylation  nucleotide phosphorylation  nucleotide phosphorylation  nucleoside monophosphate phosphorylation  nucleoside phosphate kinase activity  nucleobase-containing small molecule metabolic process  cellular response to growth factor stimulus  
Ontology : EGO-EBIthymidylate kinase activity  ATP binding  mitochondrial intermembrane space  mitochondrial matrix  cytosol  dTDP biosynthetic process  dTTP biosynthetic process  cell cycle  cell proliferation  nucleobase-containing small molecule interconversion  response to estrogen  small molecule metabolic process  myoblast differentiation  response to cadmium ion  nucleotide phosphorylation  nucleotide phosphorylation  nucleotide phosphorylation  nucleoside monophosphate phosphorylation  nucleoside phosphate kinase activity  nucleobase-containing small molecule metabolic process  cellular response to growth factor stimulus  
Pathways : KEGGPyrimidine metabolism   
Protein Interaction DatabaseDTYMK
Wikipedia pathwaysDTYMK
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)DTYMK
SNP (GeneSNP Utah)DTYMK
SNP : HGBaseDTYMK
Genetic variants : HAPMAPDTYMK
1000_GenomesDTYMK 
ICGC programENSG00000168393 
CONAN: Copy Number AnalysisDTYMK 
Somatic Mutations in Cancer : COSMICDTYMK 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
DECIPHER (Syndromes)2:242615157-242626383
Mutations and Diseases : HGMDDTYMK
OMIM188345   
MedgenDTYMK
GENETestsDTYMK
Disease Genetic AssociationDTYMK
Huge Navigator DTYMK [HugePedia]  DTYMK [HugeCancerGEM]
Genomic VariantsDTYMK  DTYMK [DGVbeta]
Exome VariantDTYMK
dbVarDTYMK
ClinVarDTYMK
snp3D : Map Gene to Disease1841
General knowledge
Homologs : HomoloGeneDTYMK
Homology/Alignments : Family Browser (UCSC)DTYMK
Phylogenetic Trees/Animal Genes : TreeFamDTYMK
Chemical/Protein Interactions : CTD1841
Chemical/Pharm GKB GenePA150
Clinical trialDTYMK
Cancer Resource (Charite)ENSG00000168393
Other databases
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
CoreMineDTYMK
GoPubMedDTYMK
iHOPDTYMK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Nov 8 17:23:02 CET 2014

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